RESEARCH

Mortality measures from sample-based surveillance: evidence of the epidemiological transition in Viet Nam

Évaluations de la mortalité à partir de la surveillance basée sur l'échantillonnage: les preuves de la transition épidémiologique au Viet Nam

Mortalidad medida por la vigilancia basada en muestras: pruebas de la transición epidemiológica en Viet Nam

Nguyen Phuong Hoa^I; Chalapati Rao^II,*; Damian G Hoy^II; Nguyen Duc Hinh^I; Nguyen Thi Kim Chuc^I; Duc Anh Ngo^III

^IHanoi Medical University, Hanoi, Vietnam
^IIUniversity of Queensland, School of Population Health, Herston, RD, Herston, Australia, 4006
^IIISchool of Health Sciences, University of South Australia, Adelaide, Australia

ABSTRACT

OBJECTIVE: To report methods and results from a national sample mortality surveillance programme implemented in Viet Nam in 2009.
METHODS: A national sample of 192 communes located in 16 provinces and covering a population of approximately 2.6 million was selected using multi-stage cluster sampling. Deaths for 2009 were identified from several local data sources. Record reconciliation and capture-recapture methods were used to compile data and assess completeness of the records. Life tables were computed using reported and adjusted age-specific death rates. Each death was followed up by verbal autopsy to ascertain the probable cause(s) of death. Underlying causes were certified and coded according to international guidelines.
FINDINGS: A total of 9921 deaths were identified in the sample population. Completeness of death records was estimated to be 81%. Adjusted life expectancies at birth were 70.4 and 78.7 years for males and females, respectively. Stroke was the leading cause of death in both sexes. Other prominent causes were road traffic accidents, cancers and HIV infection in males, and cardiovascular conditions, pneumonia and diabetes in females.
CONCLUSION: Viet Nam is undergoing the epidemiological transition. Although data are relatively complete, they could be further improved through strengthened local collaboration. Medical certification for deaths in hospitals, and shorter recall periods for verbal autopsy interviews would improve cause of death ascertainment.

RÉSUMÉ

OBJECTIF: Rapporter les méthodes et les résultats d'un programme national de surveillance de la mortalité basée sur l'échantillonnage, mis en place au Viet Nam en 2009.
MÉTHODES: Un échantillon national de 192 communes situées dans 16 provinces et couvrant une population d'environ 2,6 millions de personnes a été sélectionné par échantillonnage en grappes à plusieurs degrés. Pour l'année 2009, les décès ont été identifiés sur la base de plusieurs sources d'informations locales. Le recoupement des dossiers ainsi que des méthodes de capture-recapture ont été utilisés pour compiler les informations et évaluer l'exhaustivité des dossiers. Les tables de mortalité ont été calculées en utilisant les taux de mortalité présentés et ajustés par âge. Chaque décès a été suivi d'une autopsie orale pour déterminer la ou les causes probables de la mort. Les causes sous-jacentes ont été certifiées et codées selon les normes internationales.
RÉSULTATS: Un nombre total de 9921 décès a été identifié dans la population de l'échantillon. L'exhaustivité des dossiers de décès a été estimée à 81%. Les espérances de vie à la naissance étaient, après ajustement, de respectivement 70,4 et 78,7 ans pour les hommes et les femmes. L'accident vasculaire cérébral représentait la principale cause de décès pour les deux sexes. D'autres causes importantes comprenaient les accidents de la route, les cancers et l'infection par le VIH chez les hommes, et les maladies cardiovasculaires, la pneumonie et le diabète chez les femmes.
CONCLUSION: Le Viet Nam est en pleine transition épidémiologique. Bien que les données soient relativement complètes, elles pourraient être encore améliorées par une collaboration locale renforcée. Une certification médicale des décès dans les hôpitaux ainsi que des délais de rappel plus courts pour les entretiens d'autopsie orale permettraient d'améliorer la constatation de la cause de la mort.

RESUMEN

OBJECTIVO: Informar de métodos y resultados de un programa nacional de vigilancia de la mortalidad mediante muestras realizado en Viet Nam en 2009.
MÉTODOS: Se seleccionó una muestra nacional de 192 municipios localizados en 16 provincias y que abarcan una población de aproximadamente 2,6 millones mediante muestreo por conglomerados multietápico. Las muertes de 2009 se identificaron por varias fuentes de datos locales. Se emplearon métodos de captura-recaptura y reconciliación de registros para recopilar datos y evaluar la integridad de los registros. Se computaron las tablas de mortalidad mediante tasas de mortalidad por edad registradas y ajustadas. Cada muerte iba acompañada de una autopsia verbal para establecer la(s) probable(s) causa(s) de la muerte. Las causas subyacentes se certificaron y codificaron según las directrices internacionales.
RESULTADOS: Se identificó un total de 9921 muertes en la población del muestreo. Se calculó que la integridad de los registros de mortalidad fue del 81%. La esperanza de vida ajustada al nacer fue de 70,4 y 78,7 años para hombres y mujeres, respectivamente. Los accidentes cerebrovasculares fueron la principal causa en ambos sexos. Otras causas destacadas fueron los accidentes de tránsito, el cáncer y la infección por el VIH en hombres, y las enfermedades cardiovasculares, la neumonía y la diabetes en las mujeres.
CONCLUSIÓN: Viet Nam está experimentando una transición epidemiológica. Aunque los datos son relativamente completos, podrían mejorarse considerablemente mediante una mayor colaboración local. Los certificados médicos de las defunciones en los hospitales y periodos recordatorios más breves para las entrevistas de las autopsias verbales mejorarían la causa de la comprobación de las muertes.

Introduction

Key mortality indicators, such as age-specific death rates, life expectancy at birth and the leading causes of death in a population, are essential for population health assessment. Data on these standard international mortality indicators are needed in developing countries for comparative analysis, health policy, monitoring and evaluation, and epidemiological research. However, in such countries vital registration systems, which are the optimal source of these data, are seldom fully functional. ¹ This is the case in Viet Nam, a densely populated developing country of 88 million people located in south-eastern Asia whose population structure is rapidly changing because of declining fertility and mortality and a transition in causes of death. ² The country's population distribution is also changing as a result of socioeconomic development and rapid urbanization. Thus, accurate measures of mortality by age, sex and cause of death from death registration systems are urgently needed to assess the on-going demographic and epidemiological transition, plan the provision of health care and design effective prevention strategies.

In light of the absence of vital registration data for Viet Nam, we undertook a detailed review of the national Vietnamese vital registration system in 2006 using a mixed-methods approach. ³ The review found highly incomplete death registration and a failure to conform to international standards for reporting the cause of death. We recommended implementing a capacity-building initiative to improve the vital registration system, especially the death registration process. In response, activities have been conducted over the past four years to establish a national sample mortality surveillance system in Viet Nam consisting of passive surveillance to identify deaths from routine local data sources at the commune level, followed by a household verbal autopsy interview to ascertain the cause of each identified death. This paper reports the overall and cause-specific mortality measures generated during the first wave of these activities and discusses ways to move forward and improve the availability of local mortality data throughout the country.

Methods

Population sampling plan

Viet Nam has approximately 11 000 communes distributed across 63 provinces. We used multi-stage cluster sampling to select the surveillance population. Based on prior age-specific mortality estimates for Viet Nam, we calculated that the population under surveillance would need to yield approximately 11 000 deaths to allow us to measure age- and sex-specific mortality rates within a 15% tolerable margin of error for three broad cause of death groups: Group 1, communicable, maternal, perinatal and nutritional disorders; Group 2, non-communicable diseases; Group 3, injuries. ⁴ This translated into an estimated total surveillance population of approximately 2.5 million people.

The Viet Nam General Statistics Office selected the communes to be included in the sample according to a stratified multi-stage cluster design. In the first stage of sampling, the 63 provinces were stratified across the eight socioeconomic regions of Viet Nam. Next, 16 provinces were selected proportionate to the size of their populations, and 12 communes were then selected from each of the 16 provinces proportionate to the number of households in each commune. In total, the sample consisted of 192 communes, 668 142 households and 2 616 056 people (approximately 3% of the national population).

Data collection

A network of five medical universities coordinated the field operations, and data were compiled for calendar years 2008 and 2009. Extensive capacity building was undertaken to train staff at the provincial, district and commune levels in data collection, management and quality control. In this manuscript, we report on deaths that had occurred in 2009. As ascertained from previous research, Viet Nam has two parallel official reporting systems for vital events at the commune level: the Justice Department and the Commune Health Centre (CHC). ⁵ In addition, the Commune Population and Family Planning Committee (CPFPC) also maintains registers of vital events at the local level, although in most instances the records are regularly matched with and updated from CHC records.

Initially, trained commune health staff compiled a list of deaths for the reference period from each of the main sources of death data at the commune level. These sources were later collated into a single list of unique records for the reference period. The variables used to determine matched or unique records were name(s), sex, age and month of death. A range of 5 years was allowed for matching age at death and a range of 1 month for matching date of death. The correct age at death as verified at the verbal autopsy interview was used for all further analysis. At the first stage of collation, death records from the CHC and CPFPC were merged into a single list because these sources are not independent (i.e. reporting in one source influences reporting in the other). Records from the Justice Department were treated as an independent source and were matched with the CHC/CPFPC records. In the second stage of collation, the records from the Justice Department and the CHC/CPFPC data source were merged to create a single list of unique reconciled death records. This reconciled list showed the deceased individuals' age, sex and address, as well as the source(s) of each record.

In certain rural communes, farmers', women's or senior citizens' unions constitute additional sources of death records. Hence, in the third stage of collation we drew from these additional sources any deaths not identified during the second stage, and this yielded a list of all deaths for the reference calendar year.

For each death on the final list, a household interview was conducted and the Vietnamese version of the verbal autopsy questionnaire was used to explore in detail the symptoms and clinical events that preceded the death, as witnessed by the respondent. ⁶ The detailed verbal autopsy protocols are described in an earlier manuscript. ⁷ Briefly, household interviews were conducted by trained paramedical staff from local commune health stations. Completed questionnaires were subsequently reviewed by trained physicians who assigned the cause(s) of death using the standard International Medical Certificate of Cause of Death, as recommended by the World Health Organization (WHO). ^{8, 9} Physician reviewers were guided by a manual describing key aspects of cause-of-death assignment from verbal autopsy. ¹⁰ Subsequently, a team of physicians trained in applying the coding rules in the International statistical classification of diseases and health-related problems, 10th revision (ICD-10) selected an underlying cause for each death following prescribed international guidelines. ⁸ Causes were aggregated to the ICD-10's Mortality tabulation list 1 for descriptive analysis. ¹¹

Data analysis

We assessed the completeness of death reporting by applying the two-source capture-recapture method proposed by Chandrasekar and Deming in 1949 ¹² to the two sources analysed at the second stage of collation (i.e. to the list derived by reconciling the Justice Department list and the combined CHC/CPFPC list). The probability of reporting a death to the Justice Department is independent of the probability of the death being recorded in the CHC/CPFPC list, and this administrative independence of the systems is a necessary condition for applying the capture-recapture method to estimate data completeness. Capture-recapture analysis was undertaken with the full set of data, and subgroup analyses were performed with the same data broken down by sex and into four age groups: 0-14, 15-59, 60-74 and 75+ years. Based on these analyses, we estimated the deaths missed by both sources in each age and sex group and summed them to the rest of the deaths to obtain the overall estimated number of deaths in the sample population. Data completeness was estimated as the proportion of all estimated deaths derived from the reconciled list.

The 95% confidence intervals (CIs) of completeness estimates were derived using the bootstrapping method in the SAS analytical software version 9.3 (SAS Institute, Cary, United States of America). The reciprocals of these measures of completeness were used to adjust the numbers of deaths from the reconciled list, and these numbers were then used to compute age-specific death rates and develop life tables for the sample population. Age- and sex-specific population counts for the sample communes were obtained from the 2009 census.

During our analyses, we noted that the deaths in the reconciled list for the 0-4 year age group were so few that they would yield implausibly low mortality rates. On closer review of the data we found that all sources were equally deficient in recording early childhood deaths (data not shown). Hence, in generating Vietnamese life tables we used WHO's 2009 national under-five mortality estimates for Viet Nam (24.6 and 22.6 deaths per 1000 for males and females, respectively). ¹³ We calculated the CIs for life expectancy at birth using the Chiang Silcocks method, ¹⁴ and we constructed logarithmic plots to assess the plausibility of the age-specific death rates. ¹⁵

Summary mortality measures derived from the routine continuous data collection process described above were compared with those from adjusted life tables developed with population data from the 2009 Vietnamese census, which employed 12-month annual recall of household deaths to estimate mortality. Census data were adjusted for data completeness using the Preston-Coale method, ¹⁶ an indirect demographic technique previously used to estimate census-based mortality for Viet Nam. ¹⁷ Our mortality results were also compared with modelled mortality estimates published by WHO for 2009 ¹³ and by the United Nations Population Division (UNPD) for 2005-2010. ¹⁸ Finally, we used descriptive analysis of leading causes of death to develop tables of the leading causes of death, by sex, for three broad age groups: 0-14, 15-59 and 60+ years. Causes of deaths identified from additional sources were included in these tables.

Results

Fig. 1 shows the geographical distribution of the communes representing the sample population. Fig. 2 shows the age and sex structure of the national population and the study population. The study population had a higher proportion of people, especially females, in the 20-34 year age category than the national population. The population aged 15 years or less was slightly under-represented in the sample. More detailed analysis showed that the sample population was slightly more urban than the national population (39% versus 30%, urban communes, respectively). This may explain the differences in age structure.

Table 1 shows the distribution of observed and estimated deaths from each source by age and sex. In 2009, 9921 deaths were observed in the sample population, as compared to the estimated total of 11 719 deaths from the two-source capture recapture analysis, yielding an overall completeness of 81.3% (95% CI: 74.4 to 87.1) for the reconciled list. Analyses of subgroups by sex and age showed that completeness varied very little for ages 15 and above (range: 80-83%). Completeness was only marginally different in urban and rural communes: 81.9% and 81.1%, respectively.

The completeness estimates obtained with the Preston-Coale indirect demographics method were 65.6% for males and 57.8% for females (Table 2), both higher than estimates from the 1989 Vietnamese census (55% for males and 47% for females) ¹⁷ but markedly lower than our direct estimates of completeness based on capture-recapture analysis.

Logarithmic plots of age- and sex-specific mortality rates for both unadjusted and adjusted local data demonstrated a smooth exponential increase in groups older than 15 years, which suggests that stated age was accurate and that sample size was adequate (Fig. 3). Table 2 presents the summary mortality measures for Viet Nam derived from different sources. The adjusted life expectancy at birth for males as calculated from our data fell within the range of the estimates derived from Vietnamese census data and WHO/UNPD model life tables. However, life expectancy at birth for females as calculated from our data was substantially higher than UNPD model life table estimates because in our data the observed risk of death for adult females was lower. There are two possible reasons for this difference. First, WHO/UNPD model life tables are based on historical data sets whose corresponding female adult mortality rates may have been higher than current rates as estimated from the local data presented here. On the other hand, our sample population, which was more urban than the national population, may have had lower female adult mortality. These differences between adjusted local data and model life tables data merit future reappraisal using improved data from nationally representative samples.

Table 3 shows the leading causes of death in 2009. Stroke was the leading cause in both males and females, as observed in other Asian countries, notably China, Indonesia and Thailand. ^19-22 In males, transport accidents, infectious diseases (particularly HIV infection and tuberculosis), and tobacco- and alcohol-related conditions (especially lung cancer, chronic obstructive pulmonary disease and liver diseases) were among the leading causes. In women, diseases of the circulatory system accounted for four of the five leading causes of death. In women, diseases of the circulatory system account for four of the five leading causes of death. Of these, stroke and ischaemic heart disease are specific conditions, but the categories ranking third and fifth (i.e. hypertensive disease and "other heart disease", which includes cardiac arrest and heart failure) are relatively non-specific. In addition, one quarter of all female deaths were assigned to ill-defined causes. However, in terms of age distribution, only 5.5% of deaths among females aged 15 to 59 years were assigned to ill-defined causes, in contrast to 31% of the deaths among women aged 60 years or older (data not shown). This illustrates the poor quality of cause-of-death attribution among elderly females.

Discussion

The mortality patterns reported here for Viet Nam are based on empirical observations. The life tables were derived from observed age-specific mortality rates adjusted for completeness, unlike previous model life tables, which were derived from summary input parameters. Furthermore, verbal autopsies yielded individual causes of death that were summed to derive mortality ranks by cause at the population level. In a broader context, these local data conform to the standard international indicators used to measure and compare mortality patterns. In addition, local data are necessary to understand prevailing epidemiological conditions and are politically relevant for public health policy as well as clinical intervention programmes. This is particularly relevant because previous cause-specific mortality estimates for Viet Nam were based on models derived from a combination of Chinese, Indian and Thai data. ²³ This sample-based passive mortality surveillance system using routine local data sources in a national set of population clusters provides a basis for the continued availability of international standard mortality measures for Viet Nam.

The adjusted life expectancies at birth and risks of death in adults, together with mortality rates in children less than 5 years of age (from the Demographic and Health Survey), suggest that Viet Nam has lower mortality rates than other developing countries in south-eastern Asia. ¹³ Also, non-communicable diseases account for a large proportion of the deaths, as reported in Table 3. However, communicable diseases continue to cause considerable mortality in Viet Nam, but largely among adults; populations in earlier stages of epidemiological transition have high mortality from childhood infectious diseases. Furthermore, although liver cancer is a leading cause of death in both males and females, chronic hepatitis B among adults probably accounts for a large proportion of liver cancers in Viet Nam. ²⁴ Although these mortality indicators suggest that Viet Nam is experiencing an epidemiological transition, the country's current mixed burden of communicable and non-communicable diseases, as well as injuries, illustrates that the country's health sector priorities cover a broad range.

The absence of maternal conditions among the leading causes of death among women 15 to 59 years of age (data not shown) probably stems from Viet Nam's very low fertility rate, measured at 2.03 from the 2009 census. ²⁵ However, we may have failed to adequately capture rural maternal deaths in our data set because of the relatively large proportion of urban communes in our sample. As mentioned, stroke was the leading cause of death in both males and females, and mortality from cardiovascular disease was high in women. Research has indicated that deaths attributed to non-specific cardiovascular categories, such as hypertensive disease, heart failure and cardiac arrest, could in reality be misclassified deaths from ischaemic heart disease. ^{26, 27} However, from a more general perspective, attribution to such non-specific categories limits the public health utility of cause-of-death data. ²⁸ More efforts to assess the validity and reliability of cause-of-death attribution in Viet Nam are needed. A national non-communicable-disease surveillance framework has been developed in Viet Nam, ²⁹ and a routine mortality data programme with suitable data quality control mechanisms, such as the one reported here, is needed in the country to provide important information on chronic disease outcomes.

The data presented here have several limitations, as does the operation of the surveillance system. First, reporting practices for all three sources vary widely in different parts of the country. For example, in Thai Nguyen province, the CHC and the Justice Department sources capture 85% and 15% of the deaths, respectively, in the reconciled list, whereas in Ho Chi Minh, the CHC captures only 17% of the deaths and the Justice Department captures 76%. Hence, reconciling the data across sources was necessary to estimate total mortality in the population. Given the need to closely monitor and follow up the deaths recorded in different sources, our mortality statistical compilation process from routine data sources may be described as passive surveillance, as distinct from the active and more costly door-to-door surveillance operations in demographic data collection programmes.

We have shown that the reconciled list captured 80% of deaths in the sample population, more than any individual source. Higher completeness could thus be achieved through stronger local collaboration between different recording systems at the point of registration. However, such collaboration would make routine application of capture-recapture methods to assess completeness impossible, since the different data sources would no longer be independent of each other. Although indirect demographic techniques (such as the Preston-Coale method) could also be used to estimate completeness, such techniques have limitations ³⁰ that make direct measurement of completeness using the capture-recapture method, as reported here, the recommended approach. In such a situation, periodic sample household surveys could provide an additional set of independent data with which to assess completeness using the capture-recapture method, as previously used elsewhere in Asia. ^31-33

Data recorded in local maternal and child health registers in Viet Nam and in routine reproductive health statistical returns are potentially useful supplementary data sources for improving data completeness. ^{34, 35} However, health facilities, especially in urban areas, need to make birth and death records available to improve measures of infant mortality.

The sample population resembles the national population in terms of age structure, but the group composed of females aged 20-34 years was an exception, perhaps because we selected the sample from a pre-census mapping list of households in communes, rather than actual population data. The fact that, as a result, the sample population had a higher fraction of urban communes than the country as a whole could have led to an underestimation of national mortality rates, since urban communities in Viet Nam probably enjoy better health care and health status than rural ones. The sample size, on the other hand, appears adequate for measuring mortality at the national level but would need to be increased to achieve representativeness at the regional level. Any future enlargement of the surveillance sample should take into account the country's urban-rural ratio and the age and sex composition of the population.

Concerning cause-of-death ascertainment, household enquiries have resulted in more detailed diagnoses than those afforded by the rudimentary four-category classification used for statistical compilation in Viet Nam's routine death registration system: disease or old age; accident, suicide and "other". ³ Nevertheless, the high proportions of deaths classified to non-specific causes among the elderly and in women signals the need for improvement. For deaths in 2009, verbal autopsy recall periods ranged from 8 to 18 months, which could have undermined the accuracy of questionnaire responses, particularly with respect to symptoms and clinical events among the elderly. The choice of respondents in terms of education and closeness to the deceased during the terminal illness could also affect the quality of verbal autopsy interviews and limit the information physician reviewers have to draw on to formulate specific diagnoses. To counter this, the household enquiry process should be conducted closer to the date on which the death is notified, while allowing enough time for bereavement, ³⁶ and training on choosing respondents should be intensified.

The inherent weaknesses of verbal autopsy led us to realize that it is essential to establish medical certification of causes for deaths occurring in health facilities in Viet Nam. We therefore used balance funds from the main project to develop medical death certification protocols for institutional deaths, and we conducted a pilot study in five hospitals in 2010 (unpublished report). This experience demonstrated the feasibility of implementing medical death certification in hospitals in Viet Nam, and efforts to broaden coverage beyond those facilities are under way. Verification of the occurrence of death and its cause through local disease-specific programme data would enhance the completeness and quality of sample mortality surveillance data. Maintenance of medical records in commune and district-level health facilities would also improve access to more reliable medical inputs for ascertaining the cause of death.

Conclusion

The epidemiological findings from this research suggest a mixed mortality burden from both communicable and non-communicable diseases and from road traffic accidents in Viet Nam, and they illustrate the complex epidemiological transition currently taking place in the country. Such data provide baseline evidence for designing public health interventions and programmes. Sustained follow-up activities are required to maintain this data collection platform, as well as to conduct additional research to assess and improve data quality for monitoring mortality indicators. Given the size and distribution of the population in Viet Nam, the surveillance system must enlarge its sample. Sample mortality surveillance in a developing country like Viet Nam is beneficial provided appropriate attention is paid to design and operations.

Acknowledgements

This research was partially supported by a grant from the Atlantic Philanthropies. We acknowledge the guidance provided by Gail Williams at the School of Population Health, University of Queensland, in conducting the bootstrap analysis to derive uncertainty bounds for the completeness estimates.

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Submitted: 1 December 2011
Revised version received: 22 June 2012
Accepted: 11 July 2012
Published online: 20 August 2012
Competing interests: None declared.

* Correspondence to Chalapati Rao (e-mail: c.rao@sph.uq.edu.au).