Abstract

Objective:

To characterize the sociodemographic profile of beneficiaries of Brazilian social welfare affected by Chagas disease and identify factors associated with the granting of assistance benefits, 2004 to 2016.

Methods:

Cross-sectional study based on secondary data from the Ministry of Labor and Social Security. Logistical regression was performed to estimate crude and adjusted odds ratios (OR) and 95% confidence intervals (95%CI).

Results:

36,023 benefits were granted; 62.5% were to male; 67.0% to residents of urban areas; 46.7% to residents of Southeast region; 56.7% to people with chronic cardiac form; and 42.7% to the 50-59 age group. Residents of urban areas (OR = 134.9; 95%CI 78.0;233.2), Northeast macro-region (OR = 2.9; 95%CI 2.5;3.1), female (OR = 2.0; 95%CI 1.8;2.1) and age group 60 years or older (OR = 1.6; 95%CI 1,3;1,7) were factors associated with assistance benefits.

Conclusion:

Factors related to the area of residence, macro-region, sex and age group increased the chance of granting assistance benefits.

Keywords:
Chagas Disease; Social Support; Social Security; Social Welfare; Cross-Sectional Studies

INTRODUCTION

Up until the 1990s, Chagas’ disease was considered the parasitic disease with the greatest socioeconomic impact in Latin America. The burden of the disease, as measured by the “Disability-Adjusted Life Years” (DALY) indicator, was greater than that of all other parasitic diseases combined.¹1. Dias JCP, Silveira AC, Schofield CJ. The impact of Chagas disease control in Latin America: a review. Mem Inst Oswaldo Cruz. 2002;97(5):603-612. doi: 10.1590/S0074-02762002000500002
https://doi.org/10.1590/S0074-0276200200... DALY simultaneously measures the effects of mortality and health problems that affect people’s quality of life.²2. GBD 2016 Brazil Collaborators. Burden of disease in Brazil, 1990-2016: a systematic subnational analysis for the global burden of disease study 2016. Lancet. 2018;392(10149):760-75. doi: 10.1016/S0140-6736(18)31221-2
https://doi.org/10.1016/S0140-6736(18)31... According to the World Health Organization (WHO), approximately 8 million people are currently infected with Trypanosoma cruzi worldwide, mainly in Latin America.³3. World Health Organization. Chagas disease (American trypanosomiasis) [Internet]. Geneva: WHO; 2020 [cited 2021 july 4]. Available from: https://www.who.int/health-topics/chagas-disease
https://www.who.int/health-topics/chagas...

Although a large number of infections are asymptomatic, up to 30% of chronically infected people develop cardiac abnormalities and up to 10% develop digestive, neurological or mixed abnormalities, requiring specific treatment. In order to achieve complete cure, treatment must begin in the early stages of infection.⁴4. Ministério da Saúde (BR). Guia de Vigilância em Saúde: volume único [Internet]. 3. ed. Brasília: Ministério da Saúde; 2019 [citado 2021 Jul 4]. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_3ed.pdf
https://bvsms.saude.gov.br/bvs/publicaco...

Chagas’ disease causes great biopsychosocial impact on affected individuals, in addition to high costs for health systems, due to the high demand for care and demand for tests, medications, surgical interventions and procedures.⁵5. Pérez-Molina JA, Molina I. Chagas disease. Lancet. 2018;391(10115):82-94. doi: 10.1016/S0140-6736(17)31612-4
https://doi.org/10.1016/S0140-6736(17)31... In addition, there are serious economic consequences generated by loss of skilled labor, labor law costs, absenteeism, reduced productivity and social welfare costs.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600...

Article 194 of the 1988 Federal Constitution defines social welfare as “an integrated set of actions at the initiative of the public authorities and society, aimed at ensuring the right to health, the right to social assistance and the right to social security”.⁷7. Brasil. Constituição 1988. Constituição da República Federativa do Brasil. Brasília (DF): Senado; 1988. It should be noted that the first two rights are of a non-contributory nature, while social security is eminently contributory in nature.⁷7. Brasil. Constituição 1988. Constituição da República Federativa do Brasil. Brasília (DF): Senado; 1988.

In Brazil, health is a fundamental right of all people and a duty of the State, guaranteed through social and economic policies.⁸8. Brasil. Casa Civil. Lei nº 8.080, de 19 de setembro de 1990. Dispõe sobre as condições para a promoção, proteção e recuperação da saúde, a organização e o funcionamento dos serviços correspondentes e dá outras providências. Diário Oficial da União, Brasília (DF),1990 ago 20; Seção 1:18055. Social assistance is the social policy that provides for the fulfillment of basic needs, translated into protection for the family, motherhood, childhood, adolescence, old age and the disabled. The Organic Law of Social assistance (Lei Orgânica da Assistência Social - LOAS), No. 8742/93, provides for the organization of social assistance and determines that it must be carried out in an integrated way with sectoral policies, aiming at fighting poverty, guaranteeing minimum social rights, providing conditions to meet social contingencies and universalizing social rights.⁹9. Brasil. Casa Civil. Lei nº 8.742, de 07 de dezembro de 1993. Dispõe sobre a organização da Assistência Social e dá outras providências. Diário Oficial da União, Brasília (DF), 1993 dez 8; Seção 1:18769. Social security, in turn, has mandatory membership, where membership is understood to be the bond established between people who contribute to social security, from which rights and obligations derive. It is a public service, aimed at supporting its members and dependents in situations of social risks or contingencies provided for by law, by granting benefits.¹⁰10. Brasil. Casa Civil. Decreto nº 3.048, de 06 de maio de 1999. Aprova o Regulamento da Previdência Social, e dá outras providências. Diário Oficial da União, Brasília (DF), 1999 maio 7; Seção 1:50.

Studies on social welfare concerning specific diseases, containing detailed data, are extremely rare, mainly due to difficulty of access to sources of information.¹¹11. Santos KAS, Melo L, Oliveira AMM, Limongi JE. Social welfare related to AIDS in Brazil: factors associated with social assistance and social security, 2004 - 2016. Rev Panam Salud Publica. 2018;42:e73. doi: 10.26633/RPSP.2018.73
https://doi.org/10.26633/RPSP.2018.73... ^,1212. Santos KAR, Oliveira AMM, Bós AMG, Melo L, Limongi JE. Aids e seguridade social brasileira: análise dos benefícios concedidos na previdência e assistência social, 2004-2016. Cien Saude Colet. 2020;25(8):3215-26. doi: 10.1590/1413-81232020258.18282018
https://doi.org/10.1590/1413-81232020258... With regard to Chagas’ disease in particular, we are not aware of the existence of any national study that addresses the situation of this disease in relation to social welfare. Few studies have analyzed this problem - besides being old publications of studies mostly conducted in the 1970s and 1980s, limited to a small number of cases.¹³13. Zicker F, Zicker EMS. Benefícios previdenciários por incapacidade como indicador de morbidade: estudo da doença de Chagas em Goiás. Rev Goiana Med. 1985;31(3/4):125-36.

14. Zicker F. Chagas’ disease and social security. A case-control study in an urban area, Goiás, Brazil. Rev Saude Publica. 1988;22(4):281-87. doi: 10.1590/s0034-89101988000400004
https://doi.org/10.1590/s0034-8910198800... ^-1515. Almeida O, Meirelles P, Laurentys LL. Aspectos previdenciários da doença de Chagas. Rev Bras Saude Ocup. 1983;11(44):70-73.

The number of people with chronic Chagas’ disease is, however, unknown in Brazil. Compulsory notification of these cases has only been established recently, first in the state of Goiás in 2013, followed by Minas Gerais in 2018, and for the entire country in 2020.¹⁶16. Goiás. Secretaria Estadual de Saúde de Goiás. Resolução nº 004, de 06 de maio de 2013. Acrescenta agravos de interesse à saúde no elenco de doenças de notificação compulsória e dá outras providências. Diário Oficial de Goiás, Goiânia (GO), 2013 maio 14; Ano 176. nº 21.588.

17. Minas Gerais. Secretaria de Estado de Saúde. Resolução SES/MG Nº 6.532, DE 05 de dezembro de 2018. Acrescenta Doenças, Agravos e Eventos de Saúde Pública de Interesse Estadual à Lista Nacional de Doenças de Notificação Compulsória e dá outras providências. Diário Oficial de Minas Gerais, Belo Horizonte (MG), 2018 dez 12; Ano 126, nº 229:13^-1818. Brasil. Ministério da Saúde. Portaria nº 264, de 17 de fevereiro de 2020. Altera a Portaria de Consolidação nº 4/GM/MS, de 28 de setembro de 2017, para incluir a doença de Chagas crônica, na Lista Nacional de Notificação Compulsória de doenças, agravos e eventos de saúde pública nos serviços de saúde públicos e privados em todo o território nacional. Diário Oficial da União, Brasília (DF), 2020 fev 19; Seção 1:97. As such, a study of people with Chagas’ disease who are social welfare beneficiaries can contribute to the characterization of the disease in Brazil.

The objective of this study was to characterize the sociodemographic profile of beneficiaries of Brazilian social welfare affected by Chagas’ disease and to identify factors associated with the granting of assistance benefits to them, from 2004 to 2016.

Methods

This was a cross-sectional study based on data from the Ministry of Labor and Social Security’s Unified Benefits Information System (Sistema Único de Informações de Benefícios - SUIBE). Access to the SUIBE is restricted. It holds sociodemographic data on beneficiaries and data related to the granting of benefits. This system was implemented in mid-2003, but only in 2004 did it start to include a larger number of variables, which is why that year was chosen as the start for data collection. Data access occurred after making a request to the central management level of the National Institute of Social Security (Instituto Nacional do Seguro Social - INSS). The data were made available on an Excel® spreadsheet in January 2017.

We included individuals who received social assistance and social security benefits granted by the INSS between 2004 and 2016, arising from health conditions coded as B57, i.e. Chagas disease’ and its health consequences/impairments, defined in the Tenth Revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) as follows: B57 (Chagas’ disease); B57.0 (acute Chagas’ disease with heart involvement); B57.1 (acute Chagas’ disease without heart involvement); B57.2 (Chronic Chagas' disease with heart involvement); B57.3 (Chronic Chagas' disease with digestive system involvement); B57.4 (Chronic Chagas' disease with nervous system involvement); B57.5 (Chronic Chagas' disease with other organ involvement); K23.1 (megaesophagus in Chagas’ disease); and K93.1 (megacolon in Chagas’ disease).

The following variables were analyzed: sex (male; female), age at onset of Chagas’ disease (in years) and age at onset of disability (in years), time elapsed between disease and disability (in years), age group (in years: up to 29; 30-49; 50-59; 60 or over), zone of residence (urban; rural), geographic macro-region of residence (North; Northeast; Southeast, South; Midwest), type of benefit received (social assistance; social security), year the benefit was granted (2004 to 2016), and category of social security membership (self-employed; special insurance; employee; unemployed; other). The ‘sex’ variable adhered to the biological distinction as recommended by the Sex and Gender Equity in Research guidelines.¹⁹19. Heidari S, Babor TF, Castro P, Tort S, Curno M. Equidade de sexo e gênero na pesquisa: fundamentação das diretrizes SAGER e uso recomendado. Epidemiol Serv Saude. 2017;26(3):665-75. doi: 10.5123/S1679-49742017000300025
https://doi.org/10.5123/S1679-4974201700...

Data completeness and consistency analysis was performed before the inferential statistical analysis. The data were assessed descriptively, using percentages (for categorical variables), measures of central tendency and dispersion (for numerical variables). Blank fields or fields with discrepant values were checked: those that could be corrected by analyzing other variables were changed; and the remainder were discarded from the specific analysis.

We used Epi Info 7.2.2 (CDC, Atlanta, USA) to perform statistical analyses. We calculated means and standard deviations (SD) for the continuous variables. The frequencies of social assistance, social security and total benefit grants were adjusted for each 100,000 inhabitants, for the purpose of comparing the mosaic maps of the geographic macro-regions. We used the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística - IBGE) population estimate for the year 2016, applying the following formulae:

SAB = (Total SAB granted in the GM/EP of the GM) x 100,000 inhab.

SSB = (Total SSB granted in the GM/EP of the GM) x 100,000 inhab.

TB = (TB granted in the GM/EP of the GM) x 100,000 inhab.

where: SAB = social assistance benefits; GM = geographic macroregion; EP = estimated population; SSB = social security benefits; TB = total benefits (social assistance and social security).

With regard to data spatialization, we used the QGIS 2.18 Geographic Information System in order to prepare the mosaic maps. The analytical units were the five Brazilian macro-regions.

Association between the independent variables and the type of benefit received was analyzed by logistic regression. Sex, age group, zone of residence and geographic macro-region were used as independent variables, taking the type of benefit received as the dependent variable (social security benefit was used as the reference category). In the crude models, each independent variable was analyzed individually in relation to the dependent variable. The adjusted model included all four independent variables simultaneously. The reference categories for the analyses were those with the lowest frequency of social assistance benefits. The results of the logistic regression are presented as odds ratios (OR) and 95% confidence intervals (95%CI).

The study project was approved by the Universidade Federal de Uberlândia Human Research Ethics Committee, as per Opinion No. 1.560.139, issued on May 17, 2016.

Results

Between 2004 and 2016, 36,023 benefits were granted, mostly to males (22,503; 62.5%) and people residing in urban areas (24,155; 67.0%). The chronic form of Chagas’ disease with heart involvement predominated (20,424; 56.7%) and only 824 (2.3%) grants were due to acute forms of the disease (Figure 1). Most of the benefits were granted to adults in the 30-49 (14,794; 41.1%) and 50-59 (15,400; 42.7%) age groups.

Total granting of benefits was predominant in the Southeast region (16,828; 46.7%). However, analysis of the granting of benefits per 100,000 inhabitants indicated that this indicator was highest in the Midwest region with regard to social security benefits (37.32/100,000 inhabitants) and social assistance benefits (3.80/100,000 inhabitants) (Figure 2).

The most granted benefit was the temporary incapacity benefit (23,417; 65.0%), followed by the permanent incapacity retirement pension (10,116; 28.1%) and the disability benefit (2,367; 6.6%). The average age of the beneficiaries of permanent incapacity retirement pensions was 52 (SD = 9.0) years. Among the forms of social security system membership, special insurance (11,597; 32.2%), employed (8,411; 23.4%), unemployed (7,495; 20.8%) and self-employed (6,147; 17.1%) were the most frequent. Special insurance was the predominant form of membership (11,597; 97.7%) among those living in rural areas.

On average, individuals had been ill for 4.7 (SD = 7.3) years prior to work incapacity. Mean age at onset of Chagas’ disease was 44 (SD = 10) years, while mean age at onset of work incapacity was 49 (SD = 9.2) years.

Females were twice as likely to receive social assistance benefit (OR = 2.0; 95%CI 1.8;2.1) (Table 1). Granting of social assistance benefits was also positively associated with living in urban areas (OR = 134.9; 95%CI 78.0;233.2) compared to rural areas. The odds of social assistance benefits being granted were highest in the ‘up to 29 years’ and the ‘60 years and over’ age groups (OR = 1.5; 95%CI 1.1;1.9 and OR = 1.6; 95%CI 1.3;1.7, respectively), when compared to the 30-39 age group (Table 1). The national macro-regions with the highest odds of granting social assistance benefits were the Northeast (OR = 2.9; 95%CI 2.5;3.1) and the North (OR = 2.8; 95%CI 2.1;3.7) (Table 1).

The greatest number of total benefits was granted in 2004 (5,217; 14.5%), after which it decreased gradually until 2016 (1,415; 3.9%), with the exception of 2013 (Figure 3).

Discussion

The analysis showed that in the period between 2004 and 2016, Brazilian social welfare beneficiaries with Chagas’ disease were mainly male, lived in urban areas, lived in the Southeast region, had the chronic heart involvement form of the disease, and were between 50 and 59 years old. The granting of social assistance benefits was associated with living in urban areas, living in the Northeast macro-region, being female and being 60 years old or over.

Chagas’ disease is widely distributed over the American continent, where the T. cruzi parasite is considered to be endemic.³3. World Health Organization. Chagas disease (American trypanosomiasis) [Internet]. Geneva: WHO; 2020 [cited 2021 july 4]. Available from: https://www.who.int/health-topics/chagas-disease
https://www.who.int/health-topics/chagas... In Brazil, 3,222 cases of Chagas’ disease were confirmed between 2004 and 2016,²⁰20. Ministério da Saúde (BR). Departamento de Informática do Sistema Único de Saúde (DATASUS). Doença de Chagas aguda; 2021 [citado 2021 jun 24]. Disponível em: http://tabnet.datasus.gov.br/cgi/deftohtm.exe?sinannet/cnv/Chagasbr.def
http://tabnet.datasus.gov.br/cgi/deftoht... and during that period, a total of 36,023 benefits related to the disease were granted by the social welfare service. This discrepancy between the number of cases notified and the number of benefits granted can be attributed to two factors. One is that compulsory notification of chronic cases of Chagas’ disease throughout all of Brazil only became mandatory in 2020.¹⁸18. Brasil. Ministério da Saúde. Portaria nº 264, de 17 de fevereiro de 2020. Altera a Portaria de Consolidação nº 4/GM/MS, de 28 de setembro de 2017, para incluir a doença de Chagas crônica, na Lista Nacional de Notificação Compulsória de doenças, agravos e eventos de saúde pública nos serviços de saúde públicos e privados em todo o território nacional. Diário Oficial da União, Brasília (DF), 2020 fev 19; Seção 1:97. As such, cases of the disease reported on the Notifiable Health Conditions Information System (Sistema de Informação de Agravos de Notificação - SINAN) during the study period only accounted for acute Chagas’s disease cases. Moreover, given the slow and progressive evolution of the disease over the years, it is likely that most benefits were granted to individuals who had been infected in the past.²¹21. Lidani KCF, Sandri TL, Castillo-Neyra R, Andrade FA, Guimarães CM, Marques EM, et al. Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil. Rev Soc Bras Med Trop. 2020;53(1):e20200225. doi: 10.1590/0037-8682-0225-2020
https://doi.org/10.1590/0037-8682-0225-2... The low percentage of acute cases corroborated in this study this statement.

Chagas’ disease is mostly diagnosed in its chronic stage,⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... when the severity of its manifestations has a strong impact on the health of the workers, leading to work incapacity and, consequently, to a greater number social security and social assistance benefits being granted. Chronic Chagas’ cardiopathy is of particular relevance because it is the most frequent clinical form of Chagas’ disease and has high potential for causing incapacity.²²22. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Doença de Chagas. 14 de abril / Dia Mundial. Boletim Epidemiológico. 2021;2.

Mean age of Chagas’ disease onset and onset of work incapacity among affected individuals was below 50 years. In a study that used data from the Global Burden of Disease Study 2016 for the period 1990 to 2016, 141,640 DALYs were estimated to have been lost due to Chagas’ disease in 2016, which corresponds to a reduction of 36.7% in DALYs in comparison with the estimates of this indicator for the year 1990.²³23. Martins-Melo FR, Carneiro M, Ribeiro ALP, Bezerra JMT, Werneck GL. Burden of Chagas disease in Brazil, 1990-2016: findings from the Global Burden of Disease Study 2016. Int J Parasitol. 2019;49(3-4):301-10. doi: 10.1016/j.ijpara.2018.11.008
https://doi.org/10.1016/j.ijpara.2018.11... One DALY means one year of healthy life lost, taking into account premature deaths and years lived with incapacity.²2. GBD 2016 Brazil Collaborators. Burden of disease in Brazil, 1990-2016: a systematic subnational analysis for the global burden of disease study 2016. Lancet. 2018;392(10149):760-75. doi: 10.1016/S0140-6736(18)31221-2
https://doi.org/10.1016/S0140-6736(18)31... These data prove that, despite the reduction of cases experienced in recent decades, Chagas’ disease remains an important cause of morbidity, mortality and disability in Brazil.

A higher frequency of benefits (social security and social assistance) was found for males. However, the odds of receiving social assistance benefits were highest among females. Social security coverage for women under the General Brazilian Social Security System, which is the system analyzed in this study, has always been lower than social security coverage for men, even after the changes that took place in the 1990s, when women’s share in the labor market increased significantly, and continued to grow in the 2000s.²⁴24. Barbieri CV. Reflexo da inserção laboral das mulheres sobre sua situação na previdência social. Informe de Previdência Social. 2016;28(6):3-14. Women are the majority among workers without a labor card, unpaid workers, and workers who produce items for their own consumption, these being facts that are reflected in the differences found in this study between the sexes in percentages of social security benefits granted.²⁴24. Barbieri CV. Reflexo da inserção laboral das mulheres sobre sua situação na previdência social. Informe de Previdência Social. 2016;28(6):3-14. However, women are more representative than men among the contributors to Statutory Social Security Systems, since they are the majority among Health and Education employees.²⁵25. Coordenação Geral de Estudos Previdenciários da SPREV/MF. Evolução da proteção previdenciária no Brasil - 2017. Informe de Previdência Social. 2018;30(6):3-14.

In the first half of the 20^th century, in Brazil, most cases of Chagas’ disease were concentrated in rural areas, the natural habitat of the disease vectors. The industrialization of the country, the growth of cities, and the rural exodus caused individuals infected in the past, in rural areas, to migrate to urban areas, leading to a new epidemiological context.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... The greater frequency of social welfare benefits for people with chronic Chagas’ disease living in urban areas reflects this change in the profile of the disease. Furthermore, rural dwellers have less access to social and health services and therefore the reduced number of claims for benefits granted to residents in these areas may be associated with lack of knowledge about their social rights.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600...

The rural population still presents characteristics that differ greatly from the urban population, and the percentage of individuals in the “special insurance” category of the social security system is an example of this. This category accounts for smallholders and artisanal fishermen, who perform their work individually or as family workers, without employees.²⁵25. Coordenação Geral de Estudos Previdenciários da SPREV/MF. Evolução da proteção previdenciária no Brasil - 2017. Informe de Previdência Social. 2018;30(6):3-14. The family economy system is understood to be activities in which the work of the family members is indispensable for their own subsistence and for the socioeconomic development of the family nucleus.²⁵25. Coordenação Geral de Estudos Previdenciários da SPREV/MF. Evolução da proteção previdenciária no Brasil - 2017. Informe de Previdência Social. 2018;30(6):3-14. In this way, social vulnerability (individual and family) is mitigated, which also results in fewer benefits being granted, especially social assistance benefits.

With the decrease in the incidence of Chagas’ disease in recent decades and the aging of the population that has been infected in the past (therefore, with greater chances of developing clinical manifestations), greater occurrence of the disease is expected among adults and the elderly.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... Indeed, most of the beneficiaries were adults aged 30 to 59 years; the elderly accounted for less than 15%. This low frequency among the elderly may be associated with the high mortality of the disease in older age groups. A study conducted in Brazil, with data from 2000 to 2019, showed a direct relationship of the Chagas’ disease mortality rate with increasing age groups, reaching the maximum value among individuals aged 80 years or older (42.3/100,000 inhab.).²⁶26. Martins-Melo FR, Castro MC, Werneck GL. Levels and trends in Chagas disease-related mortality in Brazil, 2000-2019. Acta Trop. 2021;220:105948. doi: 10.1016/j.actatropica.2021.105948
https://doi.org/10.1016/j.actatropica.20...

In the present study, the approach to the granting of social assistance benefits was restricted to social assistance for people with disabilities related to Chagas’ disease, which are more associated with the younger and more elderly age groups. Considering the slow and chronic progression of the disease, incapacity to work among individuals up to 29 years of age draws attention. Those who are eligible for social assistance benefits demonstrate a situation of significant vulnerability, characterized by the inability to have the means to provide for their own maintenance, work incapacity caused by the disease (with greater social impact in the younger age group) and precarious family conditions (income per person in the family group less than 1/4 of the minimum wage). In the older age groups, the chronicity of Chagas’ disease, associated with comorbidities found in the aging process, increases the risks for individuals and the demands on the health system, representing a great challenge for the Brazilian National Health System.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600...

The Southeast region had higher frequencies of benefits granted, both with regard to social security and social assistance benefits. Besides being Brazil’s most populous and urbanized macro-region, it has higher human development indexes, so that its resident population is more able to contribute to social security; and is better informed as to existing and relevant welfare rights.²⁷27. Duarte CMR, Pedroso MM, Bellido JG, Moreira RS, Viacava F. Regionalização e desenvolvimento humano: uma proposta de tipologia de regiões de saúde no Brasil. Cad Saude Publica. 2015;31(6):1163-74. doi: 10.1590/0102-311X00097414
https://doi.org/10.1590/0102-311X0009741... However, when the benefits were analyzed according to population, the Midwest region had the highest number of benefits granted, both with regard to social assistance and social security. This geographical distribution coincides with an area considered to have high endemicity and intense vector transmission in past decades, an example being the state of Goiás, where there has been intense migration of people from endemic rural areas to urban centers, such as the Federal District.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... ^,2626. Martins-Melo FR, Castro MC, Werneck GL. Levels and trends in Chagas disease-related mortality in Brazil, 2000-2019. Acta Trop. 2021;220:105948. doi: 10.1016/j.actatropica.2021.105948
https://doi.org/10.1016/j.actatropica.20... ^,2828. Drumond JAG, Marcopito LF. Migração interna e a distribuição da mortalidade por doença de Chagas, Brasil, 1981/1998. Cad Saude Publica. 2006;22(10):2131-40. doi: 10.1590/S0102-311X2006001000019
https://doi.org/10.1590/S0102-311X200600... Greater odds of social assistance benefits being granted were associated with the North and Northeast macro-regions, suggesting greater social vulnerability of their populations.²⁷27. Duarte CMR, Pedroso MM, Bellido JG, Moreira RS, Viacava F. Regionalização e desenvolvimento humano: uma proposta de tipologia de regiões de saúde no Brasil. Cad Saude Publica. 2015;31(6):1163-74. doi: 10.1590/0102-311X00097414
https://doi.org/10.1590/0102-311X0009741...

Temporary incapacity benefit was the type most frequently granted, followed by permanent incapacity retirement pension. This shows that the majority of beneficiaries with chronic Chagas’ disease contributed to social security and collaborated with country’s labor force until their temporary or permanent work incapacity was recognized. Similar research carried out in Brazil on social welfare and AIDS, for the same period as this study, found that of 99,369 beneficiaries, 26.5% received welfare benefits and 51% were unemployed.¹¹11. Santos KAS, Melo L, Oliveira AMM, Limongi JE. Social welfare related to AIDS in Brazil: factors associated with social assistance and social security, 2004 - 2016. Rev Panam Salud Publica. 2018;42:e73. doi: 10.26633/RPSP.2018.73
https://doi.org/10.26633/RPSP.2018.73... ^,1212. Santos KAR, Oliveira AMM, Bós AMG, Melo L, Limongi JE. Aids e seguridade social brasileira: análise dos benefícios concedidos na previdência e assistência social, 2004-2016. Cien Saude Colet. 2020;25(8):3215-26. doi: 10.1590/1413-81232020258.18282018
https://doi.org/10.1590/1413-81232020258...

There was a progressive reduction in the number of benefits granted to sufferers of chronic Chagas’ disease in Brazil in the period analyzed. This number followed the epidemiological profile of the disease in the national territory. With the control and reduction of intra-household transmission by vectors and the control of transmission by blood transfusion, the incidence of the disease has reduced drastically in recent decades in Brazil.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... The consequences of these actions are evident in the low percentages of benefits granted to younger age groups which, together with Chagas’ disease mortality among individuals aged 50 to 59 years and older, has contributed to the reduction of its impact on the social security and social assistance system.²⁶26. Martins-Melo FR, Castro MC, Werneck GL. Levels and trends in Chagas disease-related mortality in Brazil, 2000-2019. Acta Trop. 2021;220:105948. doi: 10.1016/j.actatropica.2021.105948
https://doi.org/10.1016/j.actatropica.20...

The peak in the number of benefits granted in 2013 is also noteworthy. Outbreaks of acute Chagas disease cannot justify this increase, since in general they do not affect more than a few dozen people, and not all of them are beneficiaries of social welfare or become unable to work.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... Furthermore, most of these outbreaks have developed in the state of Pará, which, in this study, had one of the lowest percentages of benefits granted.⁶6. Dias JCP, Ramos AN Jr, Gontijo ED, Luquetti A, Shikanai-Yasuda MA, Coura JR, et al. II Consenso brasileiro em doença de Chagas, 2015. Epidemiol Serv Saúde. 2016;25(spe):7-86. doi: 10.5123/s1679-49742016000500002
https://doi.org/10.5123/s1679-4974201600... Peaks in the number of benefits granted can also occur as a result of beneficiaries themselves telling other people about their social security and social assistance claims that have been met, or by the work of lawyers who specialize in certain types of social security cases and request them, successively, for a group of people.

The social security reform in 2019 resulted in an important reduction in the amounts to be received for permanent disability retirement benefits and temporary disability aid.²⁹29. Brasil. Casa Civil. Emenda Constitucional nº 103, de 12 de novembro de 2019. Altera o sistema de previdência social e estabelece regras de transição e disposições transitórias. Diário Oficial da União, Brasília (DF), 2019 nov 13; Seção 1:1. Considering that a large number of people with chronic Chagas’ disease are eligible for these benefits, an increase in the social vulnerability of this hard-hit group is expected. Moreover, with the advent of the COVID-19 pandemic, access to social welfare benefits has been hampered by the lack of face-to-face administrative assistance and by the need to use digital technologies to solve pending issues related to applying for benefits, since part of the population does not have internet access and/or mastery of these tools.³⁰30. Medeiros BP, Goldoni LRF, Batista Junior E, Rocha HR. O uso do ciberespaço pela administração pública na pandemia da COVID-19: diagnósticos e vulnerabilidades. Rev Adm Publica. 2020;54(4):650-62. doi: 10.1590/0034-761220200207
https://doi.org/10.1590/0034-76122020020... This reality constitutes an important element of the reduction found in the granting of benefits, and needs to be considered with regard to future cases.

Uncertainty about data reliability - inherent to any study using secondary data - is a limitation to be considered in this study. The lack of previous research on the subject made comparisons impossible and can also be pointed out as a limitation. In addition, our analysis did not include people with Chagas’ disease who were not registered with the social security system and/or those without the basic requirements to be entitled to social assistance benefits. When they work informally, they remain outside the social welfare system, in relation to social security and social assistance, and therefore, this condition can lead to underestimation of the number of workers affected by the disease, constituting another important limitation of our study.

The analysis of the data we collected fills a gap in knowledge about social welfare and Chagas’ disease in the Brazilian context. Despite the reduction in the incidence of the disease in the country, cases infected in the past continue to significantly impact the Brazilian health, social security and social assistance systems, especially among the adult and elderly populations. Public health policies aimed at the chronically ill should be implemented, in order to provide a better quality of life for those who have the disease and contribute to the stabilization, delay or even clinical improvement of cases, and consequently, to reduce the labor impact of Chagas’ disease in Brazil.

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