INFORME ESPECIAL SPECIAL REPORT
La catarata en América Latina: resultados de nueve encuestas recientes
Hans LimburgI,1; Juan C. SilvaII; Allen FosterI
ILondon School of Hygiene and Tropical Medicine, London, United Kingdom
IIPan American Health Organization, Bogota, DC, Colombia
OBJECTIVES: To review recent data on blindness and low vision due to cataract in Latin America.
METHODS: Presentation of findings from population-based prevalence surveys conducted between 1999 and 2006 in nine Latin American countries covering 30 544 people aged 50 years and older.
RESULTS: Prevalence of cataract blindness in people 50 years and older ranged from 0.5% in Buenos Aires to 2.3% in four provinces of Guatemala. Low vision from cataract ranged from 0.9% in Buenos Aires to 10.7% in Piura and Tumbes Districts in Peru. Cataract surgical coverage (CSC) was good in Campinas, Brazil; low in Paraguay, Peru, and Guatemala; and moderate in the other areas. Good visual outcome after cataract surgery nearly conformed to World Health Organization (WHO) guidelines in Buenos Aires (more than 80% of operated eyes able to see 20/60 or better), but ranged from 60% to 79% in most of the other settings, and was less than 60% in Guatemala and Peru. "Unaware that treatment is possible," "contraindications," "cannot afford," and "fear of operation" were the most common explanations for failure to come forward for surgery.
CONCLUSIONS: In Campinas, Brazil, cataract is fairly well controlled. In Buenos Aires, the visual outcomes after cataract surgery nearly meet WHO standards. In most countries in Latin America, however, cataract intervention needs to be intensified and visual outcome improved. Reducing the costs of cataract surgery and providing effective health education and adequate program management are essential to combat the expected increase in visual impairment due to cataract in the region.
Key words: Cataract, blindness, population surveys, Latin America.
OBJETIVO: Hacer una revisión de los datos recientes sobre ceguera y visión reducida por catarata en América Latina.
MÉTODO: Presentación de los resultados de estudios de prevalencia de base poblacional realizados entre 1999 y 2006 en nueve países latinoamericanos, que abarcaron 30 544 personas de 50 años o más.
RESULTADOS: La prevalencia de ceguera por catarata en personas de 50 años o más estuvo entre 0,5% en Buenos Aires, Argentina, y 2,3% en cuatro provincias de Guatemala. La visión reducida por catarata varió entre 0,9% en Buenos Aires y 10,7% en los distritos de Piura y Tumbes, Perú. La cobertura de cirugía de catarata fue buena en Campinas, Brasil; baja en Paraguay, Perú y Guatemala; y media en el resto de las áreas. Los resultados positivos de la cirugía de catarata estuvieron muy cerca de los estándares de la Organización Mundial de la Salud (OMS) en Buenos Aires (más de 80% de los ojos operados con visión de 20/60 o mejor), pero varió entre 60% y 79% en la mayoría de los otros lugares y fue inferior a 60% en Guatemala y Perú. Las explicaciones expuestas más frecuentemente para no someterse a esta operación fueron "no saber que el tratamiento es posible", "contraindicaciones", "no poder pagarlo" y "temor a la operación".
CONCLUSIONES: En Campinas, la catarata está bastante bien controlada. En Buenos Aires, la visión después de la cirugía de catarata se acerca a los estándares de la OMS. No obstante, en la mayoría de los países de América Latina las intervenciones contra la catarata deben intensificarse y sus resultados deben mejorar. Es esencial reducir el costo de la cirugía de catarata y brindar una educación sanitaria eficaz y programas adecuados para combatir el esperado aumento en los trastornos de la visión por catarata en la Región.
Palabras clave: Catarata, ceguera, encuestas demográficas, América Latina.
The latest global estimates indicate that approximately 1.7 million people are blind and 9.1 million people have low vision in Latin America and the Caribbean, excluding Cuba. Cataract is the major cause of blindness (affecting 0.75 million people or 44.1%) and the major cause of low vision (affecting 4.7 million people or 51.6%) (1).
These estimates are based on eight population-based surveys, four of which were conducted at least 20 years ago. Results are not always comparable because the studies covered different age groups and used different definitions of blindness and low vision (2).
In 1999, the World Health Organization (WHO) and the International Agency for the Prevention of Blindness (IAPB) launched a joint initiative known as "VISION 2020: The Right to Sight," which aims to eliminate avoidable blindness by the year 2020 (3). The VISION 2020 strategy advocates the development of district-level plans to reduce avoidable blindness. Since 1999, population-based surveys were conducted in nine countries in Latin America to provide baseline data on blindness and low vision for these action plans. Findings from eight of the studies were published earlier (4-11); the results from the ninth survey (Nuevo Léon State in Mexico) are presented here. This review presents and compares the recent findings on cataract in Latin America with those from the earlier studies in order to identify trends. The findings from these recent studies may give a better picture of the current situation on cataract blindness in Latin America.
Seven of the nine studies used Rapid Assessment of Cataract Surgical Services (RACSS), a standardized methodology for rapid population-based assessments of blindness and visual impairment with emphasis on cataract (12). The RACSS was based on multistage cluster sampling (with a cluster size between 40 and 60) and covered people aged 50 years or older residing in the cluster. The two most recent studies (conducted in Mexico and Chile) used Rapid Assessment of Avoidable Blindness (RAAB), a recent update of RACSS (13). Data analysis was performed using the automated and standardized modules of the RACSS and RAAB software. Results of both software packages are comparable. Details of the methodology, the selection of the clusters, and the prevalence of blindness and its main causes are published elsewhere (14).
RACSS surveys were carried out in Asia, Africa, Latin America, and the former Soviet republics (15, 16). Since 2005, surveys have been carried out in Kenya, Mexico, Bangladesh, Chile, Philippines, Rwanda, Botswana, Laos, China, Vietnam, Cambodia, The Gambia, and Tanzania, using the updated (RAAB) methodology (17-20).
WHO defines blindness as visual acuity (VA) less than 20/400, severe visual impairment (SVI) as VA less than 20/200 to 20/400, and visual impairment (VI) as VA less than 20/60 to 20/200, based on measurements of the better eye with best correction. SVI and VI may also be grouped together under the broader category of "low vision." The RACSS and RAAB for this study applied the same WHO VA definitions, but also measured the better eye with available correction. Hereby blindness and low vision due to refractive errors were also assessed.
All nine RACSS and RAAB surveys in Latin America were conducted between 1999 and 2006. Selection of the survey area was determined by the local nongovernmental organization (NGO) or university initiating the survey, usually based on a particular research interest in the respective areas. In Paraguay and Venezuela, the survey covered the entire country, whereas surveys in the other countries were limited to one or more provinces, a city, or several districts. Considerable variation exists in socioeconomic conditions and availability and affordability of eye care services across the different study areas (Table 1).
The proportion of the population in the survey area aged 50 years and older ranged from 11.9% (in the four Guatemalan provinces) to 32% (in Havana). In the mainly urban areas of Buenos Aires; Campinas, Brazil; Nuevo Léon, Mexico; and Bio Bio, Chile, this demographic group represented between 14% and 21% of the survey sample, whereas in the rural areas of Peru and Guatemala it represented only about 12%.
The sample size for each survey was calculated based on the expected prevalence of blindness in people aged 50 years and older, allowing for a variation of 20% around this expected prevalence, with a probability of 95%, and using a cluster sampling methodology. All data were analyzed using the built-in report-generating modules of the RACSS and the RAAB software.
The proportion of the population aged 50 years and older in the nine countries studied is expected to increase by 22 to 67% between 2005 and 2025 (21) (Table 2). The growth in this segment of the population will increase the annual incidence of cataract and the subsequent need for cataract surgical services.
Cataract was the main cause of all blindness (47 to 87%) in eight of the nine surveys (Paraguay, Peru, Argentina, Cuba, Venezuela, Guatemala, Mexico, and Chile); in the survey in Campinas, Brazil, cataract caused 41% of all blindness, and posterior segment diseases caused 47%.
Table 3 shows the prevalence of blindness and low vision due to cataract among people aged 50 years and older in the nine survey areas. The prevalence for blindness ranged from 0.5% in Buenos Aires to 2.3% in four provinces of Guatemala. The variations for low vision due to cataract were considerably higher, ranging from 0.9% in Buenos Aires to 10.7% in Piura and Tumbes Districts. In most areas, prevalence was higher among females compared to males, except in Nuevo Léon and Bio Bio. However, the difference was not significant.
The calculation of the 95% confidence interval (CI) uses the sampling error for cluster sampling according to Bennett et al. (22).
Cataract surgical coverage (CSC) is an indicator measuring the proportion of all operable cataract that has been operated upon (23). The CSC (persons) estimates the proportion of people with bilateral operable cataract that have been operated in one or both eyes. The CSC (eyes) estimates the proportion of eyes with operable cataract that have been operated upon at one point in time. Operable cataract is defined at three different levels of visual acuity: less than 20/400, less than 20/200, and less than 20/60, depending on the common threshold for cataract surgery in the country or area under review. The level of VA at the time of operation is not known; therefore, the CSC is an approximation of the actual situation.
The CSC varies considerably, with the lowest coverage among the poor rural populations of Peru, Guatemala, and Paraguay, and higher coverage in the richer urban populations of Brazil, Argentina, and Mexico (Table 4). In Piura and Tumbes Districts, in Peru, for every operated patient there are 3 patients bilaterally blind, 7 patients with VA less than 20/200, and 14 patients with a VA less than 20/60 due to cataract who have not yet been operated, and 1 out of 5 eyes blind due to cataract is treated operatively. In Campinas, Brazil, 9 out of 10 people bilaterally blind due to cataract have been operated in one or both eyes, and 7 in 10 with a VA less than 20/60; visual loss from cataract is fairly well controlled by the current cataract surgical services.
In all operated patients, visual acuity is measured with available correction and with pinhole correction, which is used as a proxy for best correction. In a population-based survey there is usually considerable variation in the surgical technique, skills, and knowledge of the eye surgeon; time passed since surgery; and conditions under which the surgery was performed. Therefore, visual outcome data from surveys usually show worse results than outcome measured in the first year after cataract surgery in the better institutions. To reduce the impact of time after surgery only results in eyes operated 5 years or less before the time of the survey are shown in Table 5.
Table 5 shows that with available correction 8% (in Buenos Aires) to 43% (in four provinces in Guatemala) of the operated eyes cannot see 20/200, and 40% (in Guatemala) to 81% (in Buenos Aires) can see 20/60. The proportion of intraocular lens (IOL) surgery is lowest in Paraguay and Peru and highest in Argentina, Mexico, and Chile. With pinhole correction, the proportion of people not able to see 20/200 dropped by 1-9% and the proportion of people with VA less than 20/60 to 20/200 dropped by 0-15%, whereas the proportion of people able to see 20/60 increased by 5-20%.
Table 6 shows considerable variance across different survey areas in cataract surgery provider. For example, in Cuba all surgeries are carried out in the public sector, whereas in Argentina they are mainly done in the private sector; in Guatemala and Paraguay cataract surgeries are performed by all four sectors. In general, most cataract operations are done in public hospitals (ranging from 100% in Havana to 15% in four provinces of Guatemala). A considerable number of cataract operations are also done in private hospitals. NGO hospitals that perform cataract surgery are less common and are mainly found in Guatemala, Paraguay, and Mexico. Surgeries carried out in improvised settings with services provided by visiting surgeons are mainly done in Guatemala, Paraguay, and Venezuela.
Almost half of the operated patients indicated that they did not pay anything for their cataract operation, while 29% reported paying part of the costs and 22% said they paid the full amount. In Nuevo Léon, Mexico, the question on cost was not included in the survey.
Many patients who are visually impaired due to cataract do not come forward for surgery. To help determine why, those with a pinhole VA less than 20/200 due to cataract in one or both eyes were asked why they had not yet been operated upon. Table 7 shows the most commonly reported barriers (reasons for failure to come forward for surgery) in the nine surveys. The answers of the respondents will help clarify the reasons why people who are blind or severely visually impaired due to cataract have not undergone operative treatment, and may also help service providers implement more accessible program activities.
There was considerable variation in reported barriers to cataract surgery. Lack of awareness that treatment was possible was the most commonly given explanation for failure to come forward for operative treatment, particularly in Guatemala, Mexico, and Cuba. The second most cited barrier was "other disease contraindicating operation," particularly in Paraguay, Brazil, and Cuba. "Cannot afford operation" was a common response in Argentina, Venezuela, and Peru, whereas "fear of operation" was commonly cited in Chile and Peru.
Cataract output is usually measured as the cataract surgical rate (CSR)-the number of cataract operations per million population in a defined area during a particular year. In Table 8, the CSR in these nine countries in 2005 is compared with the number of ophthalmologists conducting cataract surgery per million population. This gives the average number of cataract operations per ophthalmologist in each country.
The CSR is highest in Cuba, Brazil, and Argentina, and lowest in Guatemala. However, the average number of cataract operations per eye surgeon is highest in Guatemala and lowest in Argentina. In 2005, the large majority of surgeries (95-100%) were performed with IOLs (intraocular lenses).
Variations across survey areas
There is great variation in socioeconomic conditions and availability of cataract surgical services in Latin America. This may largely explain the disparity in prevalence of blindness and, even more so, low vision, due to cataract in the nine surveys reviewed here (24). The demand for cataract surgery is expected to be higher among wealthy urban professionals compared to poor rural laborers. Also, the visual acuity threshold for cataract surgery may be higher in rural areas.
Service provider. While the majority of cataract operations reported in these studies were conducted in public and private hospitals, there was wide variation across countries. In Cuba, for example, all surgery was provided by the government, whereas in Guatemala, 1 in 4 surgeries were performed in eye camps under improvised conditions. Close cooperation and collaboration between the different sectors on planning and implementation of cataract intervention activities is required to ensure optimal utilization of all available manpower and resources.
Cataract surgical coverage. CSC is fairly high in Campinas, Brazil (73% for eyes less than 20/200); moderate in Mexico, Chile, Argentina, Venezuela, and Cuba (40-60%); and low in Paraguay, Peru, and Guatemala (less than 30%). There is an urgent need to increase cataract surgical output and thereby increase the CSC to counteract the increase in incidence of cataract that is expected to result from the aging trend in Latin America (shown in Table 2).
Barriers to cataract surgery. Many people with cataract do not come forward for surgery, reporting lack of awareness that treatment is possible, contraindications, cost ("cannot afford operation"), and "fear of operation" as their main barriers (Table 7). By reducing the price of cataract surgery for those who cannot afford it, and improving health education on cataract, the number of cataract operations could be increased considerably. Determining the contraindications specific to cataract surgery may also prove useful. The data on barriers presented in this study come from one question on the RAAB survey form and thus give only a crude impression of the main reasons why people do not take advantage of cataract surgical services. An additional, more comprehensive, qualitative study may better elucidate barriers to cataract surgery and could thus help improve surgical coverage. This type of study may, however, require specially trained interviewers who are not directly involved in the provision of cataract services.
Cataract outcome. According to the survey, cataract surgical services in Buenos Aires nearly meet WHO standards for good visual outcome (more than 80% of operated eyes can see 20/60 or better), with poor visual outcome (less than 20/200) in just 8% of eyes after cataract surgery (25). On the other hand, in Guatemala (43%), Mexico (27%), Peru (23%), and Paraguay (22%), more than 20% of eyes had poor visual outcome. These results are likely to deter patients from coming forward for surgery and thus indicate the need to review current procedures on case selection, surgery, and post-operative care to improve future results.
It should also be noted that in all nine surveys the proportion of eyes achieving good visual outcome increased by 10-20% with pinhole correction, indicating that good-quality post-operative optical services could improve surgery results considerably.
Output. The average number of cataract operations per eye surgeon per year in the nine Latin American countries surveyed ranged from 18 to 65 (less than 1 to 2 per working week). This is low compared to many other regions. The number of available eye surgeons suggests there is sufficient capacity to increase the number of cataract operations per year and thus reduce the prevalence of blindness and low vision caused by cataract.
Acknowledgments. The surveys presented here were conducted with financial support from WHO (Paraguay); Pan American Health Organization/WHO (Argentina, Brazil, Chile, Cuba, Guatemala, Mexico, Paraguay, Peru, and Venezuela); and Christian Blind Mission (CBM) (Argentina, Brazil, Chile, Cuba, Guatemala, Mexico, Peru, and Venezuela).
1. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82(11):844-51.
2. Pascolini D, Mariotti SP, Pokharel GP, Pararajasegaram R, Etya'ale D, Négrel AD, et al. 2002 Global update of available data on visual impairment: a compilation of population-based prevalence studies. Ophthalmic Epidemiol. 2004;11(2):67-115.
3. Global Initiative for the Elimination of Avoidable Blindness. Geneva: World Health Organization; 1997 [cited 2007 Mar 20]. Available from: http://whqlibdoc.who.int/hq/1997/ WHO_PBL_97.61_Rev.1.pdf.
4. Duerksen R, Limburg H, Carron JE, Foster A. Cataract blindness in Paraguay-results of a national survey. Ophthalmic Epidemiol. 2003; 10(5):349-57.
5. Arieta CEL, Delgado AMN, José NK, Temporini ER, Alves MR, Moreira Filho DC. Refractive errors and cataract as causes of visual impairment in Brazil. Ophthalmic Epidemiol. 2003;10(1):15-22.
6. Águila LP, Carrión R, Luna W, Silva JC, Limburg H. Ceguera por catarata en personas mayores de 50 años en una zona semirrural del norte del Perú. Rev Panam Salud Publica. 2005;17(5-6):387-93.
7. Siso F, Esche G, Limburg H; grupo RACSS. Test nacional de catarata y servicios quirurgicos. Rev Oftalmol Venez. 2005;61(2):112-39.
8. Nano ME, Nano HD, Mugica JM, Silva JC, Montaña G, Limburg H. Rapid assessment of visual impairment due to cataract and cataract surgical services in urban Argentina. Ophthalmic Epidemiol. 2006;13(3):191-7.
9. Hernández Silva JR, Torres MR, Padilla González CM. Resultados del RACSS en Ciudad de La Habana, Cuba, 2005. Rev Cubana Oftalmol. 2006 [cited 2008 Dec 28];19(1). Available from: http://scieloprueba.sld.cu/scielo.php?script=sci_arttext &pid=S0864-21762006000100001&lng= &nrm=iso&tlng=.
10. Beltranena F, Casasola K, Silva JC, Limburg H. Cataract blindness in 4 regions in Guatemala: results of a population-based survey. Ophthalmology. 2007;114(8):1558-63.
11. Barría von-Bischhoffshausen F, Silva JC, Limburg H, Muñoz DR. Análisis de la prevalencia de ceguera y sus causas, determinados mediante encuesta rápida de ceguera evitable (RAAB) en la VI región, Chile. Arch Chil Oftalmol. 2007;64:69-77.
12. RACSS: Rapid Assessment of Cataract Surgical Services [software package/documentation on the Internet]. Geneva: World Health Organization; 2001 [cited 2007 Apr 13]. (WHO/ PBL/01.84). Available from:http://www.who.int/ncd/vision2020_actionplan/documents/raccs/installation_racss. htm.
13. Kuper H, Polack S, Limburg H. Rapid assessment of avoidable blindness. Community Eye Health. 2006 [cited 2007 Nov 8];19(60):68-69. Available from: http://www.cehjournal.org/0953-6833/19/jceh_19_60_068.html.
14. Limburg H, Barria von-Bischhoffshausen F, Gomez P, Silva JC, Foster A. Review of recent surveys on blindness and visual impairment in Latin America. Br J Ophthalmol. 2008;92 (3):315-9.
15. Amansakhatov S, Volokhovskaya ZP, Afanasyeva AN, Limburg H. Cataract blindness in Turkmenistan: results of a national survey. Br J Ophthalmol. 2002;86(11):1207-10.
16. Haider S, Hussain A, Limburg H. Cataract blindness in Chakwal District, Pakistan: results of a survey. Ophthalmic Epidemiol. 2003; 10(4):249-58.
17. Mathenge W, Kuper H, Limburg H, Polack S, Onyango O, Nyaga G, et al. Rapid assessment of avoidable blindness in Nakuru District, Kenya. Ophthalmology. 2007;114(3):599-605.
18. Eusebio C, Kuper H, Polack S, Enconado J, Tongson N, Dionio D, et al. Rapid assessment of avoidable blindness in Negros Island and Antique District, Philippines. Br J Ophthalmol. 2007;91(12):1588-92. Epub 2007 Jun 13.
19. Wadud Z, Kuper H, Polack S, Lindfield R, Akm MR, Choudhury KA, et al. Rapid assessment of avoidable blindness and needs assessment of cataract surgical services in Satkhira District, Bangladesh. Br J Ophthalmol. 2006;90(10):1225-9.
20. Mathenge W, Nkurikiye J, Limburg H, Kuper H. Rapid assessment of avoidable blindness in Western Rwanda: blindness in a postconflict setting. PLoS Med. 2007;4(7): e217.
21. International Data Base (IDB). Country summaries [database on the Internet]. Washington: U.S. Census Bureau, Population Division. c2007 - [cited 2007 Dec 3]. Available from: http://www.census.gov/ipc/www/ idb/summaries.html.
22. Bennett S, Woods T, Liyanage WM, Smith DL. A simplified general method for cluster-sample surveys of health in developing countries. World Health Stat Q. 1991;44(3):98-106.
23. Limburg H, Foster A. Cataract Surgical Coverage: an indicator to measure the impact of cataract intervention programmes. Community Eye Health. 1998;11(25):3-6.
24. Dandona R, Dandona L. Socioeconomic status and blindness. Br J Ophthalmol. 2001; 85(12):1484-8.
25. World Health Organization. Informal consultation on analysis of blindness prevention outcomes [meeting proceedings]. Geneva: WHO; 1998. (WHO/PBL/98/68).
Manuscript received on 28 January 2008.
Revised version accepted for publication on 4 August 2008.
1 Send correspondence and reprint requests to: Hans Limburg, International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom; e-mail: email@example.com