ORIGINAL RESEARCH INVESTIGACIÓN ORIGINAL
Technology transfer for the implementation of a clinical trials network on drug abuse and mental health treatment in Mexico
Transferencia de tecnología para la implantación de una red de investigaciones clínicas sobre el tratamiento de la drogadicción y los problemas de salud mental en México
Viviana E. HorigianI; Rodrigo A. Marín-NavarreteII; Rosa E. VerdejaI; Elizabeth AlonsoI; María A. PerezI; José Fernández-MondragónII; Carlos BerlangaII; María Elena Medina-MoraII; José SzapocznikI
IMiller School of Medicine, University of Miami, Department of Public Health Sciences, Miami, Florida, United States of America. Send correspondence to Viviana E. Horigian, email: email@example.com
IIInstituto Nacional de Psiquiatría Ramón de La Fuente, Mexico City, Mexico
Low- and middle-income countries (LMIC) lack the research infrastructure and capacity to conduct rigorous substance abuse and mental health effectiveness clinical trials to guide clinical practice. A partnership between the Florida Node Alliance of the United States National Drug Abuse Treatment Clinical Trials Network and the National Institute of Psychiatry in Mexico was established in 2011 to improve substance abuse practice in Mexico. The purpose of this partnership was to develop a Mexican national clinical trials network of substance abuse researchers and providers capable of implementing effectiveness randomized clinical trials in community-based settings. A technology transfer model was implemented and ran from 2011-2013. The Florida Node Alliance shared the "know how" for the development of the research infrastructure to implement randomized clinical trials in community programs through core and specific training modules, role-specific coaching, pairings, modeling, monitoring, and feedback. The technology transfer process was bi-directional in nature in that it was informed by feedback on feasibility and cultural appropriateness for the context in which practices were implemented. The Institute, in turn, led the effort to create the national network of researchers and practitioners in Mexico and the implementation of the first trial. A collaborative model of technology transfer was useful in creating a Mexican researcher-provider network that is capable of changing national practice in substance abuse research and treatment. Key considerations for transnational technology transfer are presented.
Key words: Technology transfer; clinical trials as topic; evidence-based practice; science and technology information networks; substance-related disorders; mental health; health services research, methods; Mexico.
Los países de ingresos bajos o medios (PIBM) carecen de una infraestructura de investigación y de la capacidad para llevar a cabo investigaciones clínicas rigurosas sobre la eficacia del tratamiento de la drogadicción y los problemas de salud mental que orienten la práctica clínica. Se estableció una asociación entre la Florida Node Alliance de la National Drug Abuse Treatment Clinical Trials Network de los Estados Unidos y el Instituto Nacional de Psiquiatría de México con objeto de mejorar la práctica en materia de tratamiento de la drogadicción en México. La finalidad de esta asociación fue la de crear una red nacional mexicana de investigaciones clínicas constituida por investigadores y proveedores de tratamiento de la drogadicción capaces de ejecutar ensayos clínicos aleatorizados de eficacia en entornos comunitarios. Se implantó un modelo de transferencia de tecnologías. La Florida Node Alliance compartió el el conocimiento y la experiencia para la creación de la infraestructura de investigación con objeto de ejecutar investigaciones clínicas aleatorizadas en programas comunitarios, por medio de módulos de capacitación común y específica, entrenamiento en funciones específicas, emparejamientos, modelado, vigilancia y retroalimentación. El proceso de transferencia de tecnología fue de tipo bidireccional en cuanto se basó en la retroalimentación sobre la viabilidad y la adecuación cultural para el contexto en el que se llevaron a cabo las prácticas. El Instituto, a su vez, lideró la iniciativa para crear la red nacional de investigadores y profesionales de México y llevar a cabo el primer ensayo. Un modelo colaborativo de transferencia de tecnología resultó útil para la creación de una red mexicana de investigadores y proveedores de tratamiento capaz de cambiar las prácticas nacionales de investigación y tratamiento en materia de drogadicción. Se exponen las consideraciones clave para la transferencia transnacional de tecnología.
Palabras clave: Transferencia de tecnología; ensayos clínicos como asunto; práctica clínica basada en la evidencia; redes de información de ciencia y tecnología; trastornos relacionados con sustancias; salud mental; investigación sobre servicios de salud, métodos; México.
Evidence shows that in most fields in medicine, translation from research to practice can take considerable time (1-4). In the United States, this particular disconnect between research and practice in drug abuse treatment (5-10) led to the establishment of the National Institute on Drug Abuse of the National Drug Abuse Treatment Clinical Trials Network (NIDA CTN) in 2000 (11). This network brought together academic researchers and community-based providers to develop and execute rigorous clinical trials of treatment interventions that fulfill the practical needs of community-based drug abuse treatment programs. Engaging substance abuse treatment providers in the research process in the NIDA CTN improved generalizability, acceptability, adoption, and dissemination of research results (12-14).
Adoption and implementation of evidence-based practices for drug abuse in real world treatment settings is a challenge outside of the United States as well. In Mexico, as in other low- and middle-income countries (LMICs), this challenge is heightened by the lack of research infrastructure and limited capacity for conducting rigorous studies to generate evidence on locally-effective substance abuse and mental health treatments that might inform the decisionmaking process in clinical practice (15, 16). The need to bring evidence-based interventions for drug abuse treatment to community centers in Mexico gained urgency when, in 2010, the Government of Mexico began opening 335 new primary care centers for addictive disorders (Unidades de Especiales Medicas - Centros de Atención Primaria para las Adicciones; UNEME- CAPAS). This offered a perfect opportunity to transfer to Mexico the technology of the NIDA CTN (11-14) and create the first national clinical trials network for substance abuse and mental health treatment in Latin America.
To facilitate technology transfer, a partnership was developed between the University of Miami (Miami, Florida, United States; a CTN-participating academic institution) and the National Institute of Psychiatry in the Ministry of Health of Mexico, with the overarching goal of improving substance abuse treatment in Mexico. The goals of the partnership were to develop a national clinical trials network of substance abuse and mental health researchers and providers in Mexico, and to develop and implement the first randomized clinical trial within the newly-created network.
The objectives of this paper were to: (a) describe the methodology for transferring technology from the United States to Mexico to develop a researcher-provider national clinical trials network that would conduct randomized clinical trials of drug abuse and mental health treatments in real-world, community-based settings; (b) present the results of the technology transfer; and (c) provide key considerations as a result of lessons learned in the process.
MATERIALS AND METHODS
The transfer of technology was supported by a bi-national collaborative effort that involved the University of Miami-based Florida Node Alliance of the NIDA CTN, hereafter referred to as "the Node," the National Institute of Psychiatry in Mexico, hereafter referred to as "the Institute," and several key players working within a facilitative context (Table 1).
The adoption of the NIDA CTN model was facilitated through a process referred to as "technology transfer" (17, 18). Technology transfer took place from 2011-2013 in two sequential, yet overlapping processes: the Node shared the "know how" for the development of the research infrastructure necessary to implement randomized clinical trials in community treatment programs and the methodology with which these trials would be implemented. The Institute, in turn, led the national effort to create the network of researchers and practitioners. In collaboration with the Node, the Institute selected and adapted the design of the first trial that was implemented in the network and was responsible, under the Node's mentorship, for leading the implementation of the trial (19). These processes were bi-directional in nature, that is, they were informed by feedback on feasibility and cultural appropriateness for the context in which they were implemented (Figure 1).
The innovation consisted of a set of practices and guidelines, i.e., the "know how" for building and maintaining a network of scientists and treatment providers with the goal of implementing clinical trials for the treatment and prevention of drug abuse and mental health problems in Mexico. These practices and guidelines (Table 2) were gleaned from the Node team's experience over the last 15 years in the US NIDA CTN.
The strategy for technology transfer involved a stage-wise acquisition of knowledge in sequential, overlapping steps and practical testing of the knowledge gained. These steps involved a progression from (a) developing the knowledge needed to create the network infrastructure and building a knowledge base of clinical trial concepts and practices to (b) developing/adapting a research protocol, and (c) subsequently, implementing/managing the protocol at multiple sites within the newly-formed network. The steps were overlapping in that the processes of creating the network and developing and implementing the first trial were intertwined and informed by each other.
The process of technology transfer was supported by a structured communications plan. The Node team and the leadership at the Institute established regular meetings with specific objectives, which allowed the process of technology transfer to unfold over time. Executive calls, operations calls, and site implementation calls occurred weekly, and face-to-face meetings were held periodically. In addition, informal communications between the Node and the Institute occurred daily or as needed via telephone, email, and online audio/video-conferencing. Meetings served as an essential forum for providing recommendations, instruction, coaching, and feedback, as well as an opportunity to monitor the practices and processes set forth. The Node and Institute teams identified implementation challenges in real-time and worked together to develop solutions that were feasible and sustainable.
The phases of implementation
The implementation of the "innovation" progressed through a continuum of phases as illustrated in Figure 2. As described in the implementation science literature, the phases included: exposure, adoption, (trial) implementation, and routine practice (20-24).
Exposure. In the exposure phase, the Director of the Institute explored and evaluated the NIDA CTN as a model for improving substance abuse practices in Mexico.
Adoption. The adoption phase included the laying the groundwork and building capacity and infrastructure at the Institute. The Node and the Institute had collaborated previously in other contexts and were able to build on existing trust to develop a shared vision and objectives for this effort.
Building the infrastructure at the Institute began with the creation of a specialized team, Unidad de Ensayos Clínicos (the Clinical Trials Unit; UEC) composed of six cores: implementation; quality monitoring; intervention supervision and fidelity; data management; statistics; and logistics and coordination. The structure of this Unit mirrored existing operational cores at the Node. The Unit Director and core leaders were each assigned a specific member of the Node's team for ongoing daily mentoring and support in their respective areas of expertise. Role-specific coaching pairings allowed one-on-one specialized attention, supported professional and technical development, facilitated joint problem-solving, and promoted cross cultural understanding.
The next step in the adoption phase included the delivery of core training modules on clinical trial implementation and management to the Institute. The core training modules for the Clinical Trials Unit were delivered in Spanish by the Node team via a series of face-to-face sessions that spanned 3-4 days each. Modules and their corresponding practical assignments were organized around major content areas: methodology and design of randomized clinical trials; Good Clinical Practices (GCP), which included a regulatory component and the importance of informed consent; quality monitoring; and data management.
The instructional content delivered at each step included core concepts and "how to's" followed by relevant activities where new concepts could be immediately applied with real-time feedback and support. The adaptation and conduct of a trial provided a rich and structured opportunity to apply newly learned concepts and practices. A number of different teaching techniques were used with flexibility. These included didactic instruction, experiential learning, modeling, coaching, monitoring and feedback.
Implementation. The implementation phase entailed building the clinical trials network and the implementation of the first trial. The development of the Mexican Clinical Trials Network meant establishing partnerships with other institutions and community treatment centers to build the foundation of the network. This included visits to community treatment programs and involved the assessment of: characteristics of the patient populations served, existing treatment and research capacities, openness to participating in randomized clinical trials, and program needs. These visits helped to consolidate relationships with the Institute's founding partners in the network, the Youth Integration Centers (Mexico City, Mexico), and the National Center for the Prevention and Control of Addictions (Mexico City, Mexico). Visits also helped to identify community treatment programs that could carry out the first trial.
Critical to the technology transfer plan was the selection of a clinical trial that would serve as the "task" around which the network and its procedures would be established and its capabilities built. The goal was to select a trial that had been implemented previously in the NIDA CTN, could be readily adapted for implementation, and that would be relevant to the treatment needs in Mexico. The Motivational Enhancement Therapy for Spanish Speakers -CTN 0021 (MET-S) (25) trial was selected because it met these criteria and addressed the documented clinical problem of poor treatment engagement and retention in outpatient drug abuse treatment centers in Mexico (26, 27).
The central activities of the implementation phase were the adaptation of the MET-S research protocol by the Institute's Clinical Trials Unit, and the implementation of the trial at three community treatment programs within the new network. A multi-site randomized clinical trial allowed the Clinical Trials Unit team to apply their newly acquired knowledge and to test the infrastructure and systems developed. With support and monitoring from the Node, the Clinical Trials Unit led and served as the main coordinating center for the trial. It was responsible for all aspects of trial management, including budget and timeline planning, training of study teams, development of study procedures (Manuals of Operations), performance and quality monitoring, and data management. The Node trained and certified therapists and clinical supervisors at each of the trial sites to build local capacity on Motivational Enhancement Therapy, and thereby facilitate the sustainability of the intervention at sites after trial completion.
Routine practice. The final phase in implementing an innovation, as described in the literature, is routine practice. Routine practice refers to the sustainability of the practices gained, described in the section that follows.
Study procedures were consistent with the ethical standards for protecting human subjects and the Helsinki Declaration of 1975 (28), and were approved by the internal review boards/ethics committees of all participating institutions, where applicable. All trial participants provided written, informed consent. Safety events were identified and monitored for all study participants, according to a study-specific monitoring plan.
The primary objectives of the technology transfer collaboration were met. A Mexican national clinical trials network of substance abuse researchers and providers was established, and the first randomized clinical trial was successfully completed within the new network.
Under the mentorship and coaching of the Node, the Institute adapted and implemented the first trial in the Mexican Clinical Trials network at three outpatient community-based centers. The objective of this trial was to compare the effectiveness of Motivational Enhancement Treatment (MET) versus Counseling as Usual in retaining substance users in treatment and reducing substance use. The design and characteristics of this trial, "Motivational Enhancement Treatment for outpatient treatment seekers in Mexico," can be found in Marin- Navarette (29).
The trial was implemented with outstanding performance, achieving its randomization target of 120 participants across three outpatient sites ahead of schedule, with a treatment exposure rate of 92%, and attendance of 93% and 95%, respectively, at the 2- and 4-month research follow-up visits. The Clinical Trials Unit developed and implemented a study-specific Quality Assurance Plan that included on-site monitoring visits, written reports of findings, systematic identification and reporting of protocol violations, and implementation of corrective and preventive actions to address all findings and violations. Moreover, the trial provided training in research methods, processes, and intervention to more than 143 community treatment professionals (counselors, research assistants, and clinic directors) through 47 training sessions.
As illustrated in Figure 2, the final step in instituting new practices/innovations is moving from trial to routine practice. We defined routine practice as continuously conducting rigorous research based on the infrastructure and practices gained during the technology transfer process. Results of the technology transfer and sustainment of the practices gained are presented in Table 3 and are summarized below.
Expansion of the Mexican Clinical Trials Network
The Clinical Trials Unit has developed new partnerships using the infrastructure created and the methodology acquired, and has now expanded to include an additional institution, the National University in Mexico, as well as participating centers (i.e., centers overseen by state councils and non-governmental organizations) with both outpatient and residential settings. This expansion was intended to broaden the network's reach to a wider population with substance abuse and mental health problems.
New research projects
The new partnerships have allowed the implementation of research projects, beyond the initial three treatment centers of the trial, to 45 additional centers. This new network has completed a second randomized clinical trial, an online intervention, and a clinical measures validation study-both within the expanded network-and a study examining the process of technology transfer.
Research trainings and protocol specific trainings, including the use clinical research methodology and procedures, standardized measures, good clinical practice, and ethics in research were delivered to sites of the expanded network. In addition, specialized training and certification on three evidence-based interventions (EBIs) were delivered for professionals at participating treatment centers.
Scientific findings of the Mexican Clinical Trials network have also been disseminated through several venues. In collaboration with its partners, the Network has presented its work at national and international conferences (30-38), in peer-reviewed journals (19, 39-41), and a book chapter (15).
Keys to transnational technology transfer
There are key considerations for successful transnational technology transfer. First, is the development of mutually agreed-upon goals and a work plan to guide the collaboration and ensure active investment and accountability by both parties. Second, a detailed needs-assessment is critical to identifying existing local infrastructure (personnel, systems, and expertise) on which to build, as well as areas that will require full development. Third, a local team capable of leading the adoption and implementation of the innovation and sustaining it into the future must be established. Fourth, the mentor team must be culturally informed, able to communicate effectively with the local team in a common language, and have protected time for ongoing support for the duration of the project. Fifth, role-specific coaching pairings allow for efficient and specialized mentoring and facilitate the use of modeling and observation as learning strategies. Sixth, vital for the survival of the project is the identification of invested leaders at all levels of the mentee's country/institution: Ministry of Health, at the participating institutions, and at the community/clinic level. Seventh, the implementation of randomized clinical trials demands careful evaluation of the local regulatory and ethical guidelines, administrative processes, and approvals needed in order to ensure local compliance, as well as plan timelines accordingly. Eighth, partners must allot time and resources to the cultural adaptation of all research interventions, measures, and procedures prior to implementation. For example, adaptations need to be considered when deciding on participant reimbursement and staff compensation structure for research.
Although in the United States participants are reimbursed for time spent on research, this might not be standard practice elsewhere. The adaptation process should involve consideration and discussion of the intended purpose of the practice, and how its implications or consequences may vary once implemented in a different country. Similarly, though a standard practice in the United States, in other countries it may be difficult or impossible to directly cover time spent by staff on research activities with research funds. However, partners can come up with alternative ways to compensate staff for time devoted to the research project, thus rewarding their dedication and ensuring accountability.
Additionally, particular attention needs to be given to the cultural norms of communication. While much of the communication can occur online or by phone, some cultures place a high value on face-to-face contact. This should be considered when planning critical collaborative and problem-solving activities, as well as when celebrating successes and accomplishments. Finally, trust, patience, humility, and flexibility are key ingredients for a true working collaboration.
This paper presents a technology transfer collaboration for the development of research infrastructure to support the rigorous testing and implementation of evidence-based practices, testifying to its successes and providing key considerations for transnational technology transfer. A recent systematic review of implementation frameworks conducted by Moullin (24) acknowledges the multiple existing models for technology transfer and explains that not all models include the full range of concepts involved in implementation. Ward and colleagues (42) summarize common elements of 28 models of knowledge transfer, but argue that studies on the topic have focused narrowly on deterministic approaches instead of on the broad explanations of the journey from knowledge to action. Literature (43) has also described the components for capacity building and sustainable transfer of technology to developing countries.
The work presented here shows how some of these frameworks' core concepts were applied to a methodology for developing research infrastructure for addiction and mental health treatment lacking in LMIC. While the concepts described in our methods have been presented in the literature, the novel contribution of this paper is its application. Our work initiated the first research-to-practice network implementing clinical trials for mental health and drug abuse treatment in Latin America.
The strategy and process of developing the Mexican Clinical Trials network encompasses several distinct components. First, the shared vision for the technology transfer was developed jointly and collaboratively, rather than promoted primarily by either the user or the knowledge broker. Second, in addition to a coaching team, each member of the team had an assigned mentee, which allowed for specialized coaching on practice-based projects over time. Finally, the technology transfer process was culturally informed, reaching beyond typical adaptations for EBIs (44, 45) by acknowledging and addressing the contextual and cultural appropriateness of each practice adopted.
The research-to-practice network created, and most importantly, the local team that led the network to develop and implement rigorous clinical trials in real world settings, are capable of generating evidence for treatments that are effective and culturally relevant among the populations they serve. The culture of quality and quality monitoring that was prompted by the technology transfer process has impacted practices at the Institute and the treatment centers. In addition, some of the solutions generated by network participation and collaboration have included strategies to improve outreach to the population in need. The newly- established research infrastructure can serve as a wide dissemination platform for evidence-based practices, thus advancing the quality of care for substance abuse and mental health in Mexico. All of these accomplishments translate into gains for the population.
Organizational readiness for change has been defined as the extent to which organizational members are psychologically and behaviorally prepared to implement organizational change (46-48). In this case the Node, the Institute, and the participating sites were motivated and open to change; the context of the newly created centers generated the opportunity for an improvement in practice; funding was readily available; and skilled staff were ready to take on this initiative. It is possible that this readiness facilitated and sustained the practices gained.
A limitation of this project was that, even though it could be clearly shown that the technology transfer goals were achieved, we did not take baseline measurements of organizational readiness for change or key theoretical or empirical mediators of the change process. A second limitation was that although training and capacity building are essential to the technology transfer process, they do not guarantee that the innovation will be sustained for the long-term. A lack of funding, of incentives, or of knowledge when facing new practices, among other possible factors, could undermine the project's long-term impact.
The partnership between the Florida Node Alliance of the NIDA CTN and Mexico's National Institute of Psychiatry, through its collaborative technology transfer, created the Mexican national clinical trials network to generate local evidence on effective treatments. The Clinical Trials Unit, the coordinating center for the network, with its multifaceted infrastructure is making contributions to both science and practice in the field. The Unit, besides adopting systems and methods for implementing and overseeing clinical trials in real world settings, has developed the capacity to serve as trainers in core research assessment measures, to conduct quality and intervention fidelity monitoring, and to train and supervise clinicians in the interventions tested. Its versatile structure can disseminate evidence-based practices to community treatment centers and can be used to evaluate current treatment programs. By building this network, conducting the first trial, and applying practices to new projects, a bridge between science and practice has been erected that has the potential to reach farther into the future.
As the Institute moves into the sustained practice of implementing new randomized clinical trials on evidence- based models, it might also serve as a consultant for other countries in Latin America aspiring to do the same. Furthermore, the Mexican Clinical Trials Network could act as a foundation for multinational collaboration among substance-abuse researchers and practitioners throughout Latin America.
Finally, implementation research calls for subsequent efficacy and effectiveness research to confirm that outcomes were indeed improved by this method of technology transfer. In the case of the Node-Institute collaboration, this follow- up research should be done with these objectives: first, to examine the process of the transfer of the "know how" from the Node to the National Institute of Psychiatry; and second, to examine the adoption and implementation of the evidence- based practices that the Mexican Clinical Trials Network tests. Such studies are currently underway to better understand whether we were able to change practice. Subsequent studies could examine whether changes in practice translate into improved patient outcomes.
Acknowledgements. The authors wish to thank the on-site principal researchers of the first trial by the Mexican Clinical Trials Network: Ricardo Sánchez Huesca, Carlos Lima Rodriguez Rodríguez, and Ana De la Fuente Martín. We also appreciate the participation of the following institutions: Centros de Integración Juvenil (Mexico City, Mexico); Centro "Nueva Vida" de Atención Primaria para las Adicciones, Puebla-Sur (Puebla, Mexico); Centro de Trastornos Adictivos, Instituto Nacional de Psiquiatría Ramón de la Fuente (Mexico City, Mexico); Centro Nacional Para la Prevención de las Adicciones; and Comisión Nacional Contra las Adicciones (Mexico City, Mexico). A special acknowledgment is also given to Christiane Farentinos and Thelma Vega who provided intervention training and coaching on the clinical trial; to Manuel Paris and Luis Anez who trained intervention raters; and to the Caribbean Basin and Hispanic Addiction Technology Transfer Center, which provided training on the Addiction Severity Index. Finally, special thanks to Kathy Carroll and her team at Yale University (New Haven, Connecticut, United States), whose Motivational Enhancement Therapy for Spanish Speakers served as the basis for the clinical trial.
Financing. This work was funded by the United States Department of State (grants SINLEC11GR0015 and S-INLEC11GR020) awarded to the Instituto Nacional de Psiquiatría Ramon de la Fuente (Mexico City, Mexico) and the University of Miami (Miami, Florida, United States), respectively. Support for this work was also provided by the National Drug Abuse Treatment Clinical Trials Network (grant U10DA13720) and by the National Center for the Advancement of Translational Sciences (grant 1UL1TR000460) both awarded to the University of Miami. The opinions, findings and conclusions stated herein are those of the authors and do not necessarily reflect those of the funding organizations.
Conflicts of interest. The spouse of a study team member is an employee of INFOTECHSoft, Incorporated (Miami, Florida, United States), a subcontractor on this study.
Disclaimer. Authors hold sole responsibility for the views expressed in the manuscript, which may not necessarily reflect the opinion or policy of the RPSP/PAJPH and/or PAHO.
1. Balas EA, Boren SA. Managing clinical knowledge for health care improvement. Yearbook of medical informatics 2000: patient-centered systems. Stuttgart, Germany: Schattauer; 2000. Pp. 65-70.
2. Green LW, Ottson JM, Garcia C, Hiatt RA. Diffusion theory and knowledge dissemination, utilization, and integration in public health. Ann Rev Public Health. 2009;30:151-74.
3. Hanney SR, Castle-Clarke S, Grant J, Guthrie S, Henshall C, Mestre-Ferrandiz J, et al. How long does biomedical research take? Studying the time taken between biomedical and health research and its translation into products, policy, and practice. Health Res Policy Syst. 2015;13:1. doi: 10.1186/1478-4505-13-1 .
4. Morris ZS, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med. 2011;104(12):510-20. doi:10.1258/jrsm.2011.110180.
5. Carroll KM, Rounsaville BJ. Bridging the gap: a hybrid model to link efficacy and effectiveness research in substance abuse treatment. Psychiatr Serv. 2003;54(3):333-9.
6. Miller WR, Sorensen JL, Selzer JA, Brigham GS. Disseminating evidence-based practices in substance abuse treatment: a review with suggestions. J Subst Abuse Treat. 2006;31:25-39. doi: 10.1016/j.jsat.2006.03.005 .
7. Abraham AJ, Ducharme LJ, Roman PM. Counselor attitudes toward pharmacotherapies for alcohol dependence. J Stud Alcohol Drugs. 2009;70(4):628-35.
8. Abraham AJ, Knudsen HK, Roman PM. The relationship between Clinical Trial Network protocol involvement and quality of substance use disorder (SUD) treatment. J Subst Abuse Treat. 2014;46(2):10. doi:10.1016/j.jsat.2013.08.021.
9. Roll JM, Madden GJ, Rawson R, Petry NM. Facilitating the adoption of contingency management for the treatment of substance use disorders. Behav Anal Pract. 2009;2(1):4-13.
10. Perl HI, Elcano J. Bridging the gap between research and practice: The National Drug Abuse Treatment Clinical Trials Network. APS Obs. 2011;24(10).
11. Tai B, Straus MM, Liu D, Sparenborg S, Jackson R, McCarty D. The first decade of the National Drug Abuse Treatment Clinical Trials Network: Bridging the gap between research and practice to improve drug abuse treatment. J Subst Abuse Treat. 2010; 38(suppl 1):S4-13. doi:10.1016/j.jsat.2010.01.011.
12. Martino S, Brigham GS, Higgins C, Gallon S, Freese TE, Albright LM, et al. Partnerships and pathways of dissemination: The NIDA-SAMHSA Blending Initiative in the Clinical Trials Network. J Subst Abuse Treat. 2010;38(suppl 1):S31-43. doi:10.1016/j.jsat.2009.12.013.
13. Roman PM, Abraham AJ, Rothrauff TC, Knudsen HK. A longitudinal study of organizational formation, innovation adoption, and dissemination activities within the National Drug Abuse Treatment Clinical Trials Network. J Subst Abuse Treat. 2010;38S1:S44-52. doi:10.1016/j.jsat.2009.12.008.
14. Carroll KM, Ball SA, Jackson R, Martino S, Petry NM, Stitzer ML, et al. Ten take home lessons from the first ten years of the CTN and ten recommendations for the future. Am J Drug Alcohol Abuse. 2011;37(5):275-82. doi:10.3109/00952990.2011.596978.
15. Medina-Mora ME, Noknoy S, Cherpitel C, Real T, Pérez R, Marín-Navarrete R, et al. Trials of interventions for people with alcohol use disorders. In: Thornicoft G and Patel V, eds. Global Mental Health Trials. Oxford: Oxford University Press; 2014.
16. Rojas E, Real T, García S, Medina-Mora ME. Revisión sistemática sobre tratamiento de adicciones en México. Salud Ment. 2011;34:351-65.
17. Wahab SA, Rose RC, Osman SI. Defining the concepts of technology and technology transfer: A literature analysis. Int Bus Res. 2012:5(1);62-71.
18. Addiction Technology Transfer Center (ATTC) Network Technology Transfer Workgroup. Research to practice in addiction treatment: key terms and a field- driven model of technology transfer. J Subst Abuse Treat. 2011;41(2):169-78. doi: 10.1016/j.jsat.2011.02.006.
19. Marín-Navarrete R, Fernández-Mondragón J, Eliosa-Hernández A, Nuñez LT, Graue- Moreno J, Galván-Sosa D, et al. Methodological and ethical aspects in conducting randomized controlled clinical trials (RTC) for addictive disorder's interventions. Salud Ment. 2013;36(3):221-32.
20. Simpson DD, Flynn PM. Moving innovations into treatment: A stage-based approach to program change. J Subst Abuse Treat. 2007;33(2):111-20. doi: 10.1016/j.jsat.2006.12.023 .
21. Fixsen DL, Blase KA, Naoom SF, Wallace F. Core implementation components. Res Soc Work Pract. 2009;19:531-40. doi: 10.1177/1049731509335549 .
22. Aarons GA, Hurlburt M, Horwitz SM. Advancing a conceptual model of evidence- based practice implementation in public service sectors. Adm Policy Ment Health. 2011;38(1):4-23. doi: 10.1007/s10488-010-0327-7.
23. Lehman WE, Simpson DD, Knight DK, Flynn PM. Integration of treatment innovation planning and implementation: strategic process models and organizational challenges. Psychol Addict Behav. 2011;25(2):252-61. doi: 10.1037/a0022682 .
24. Moullin JC, Sabater-Hernández D, Fernandez-Llimos F, Benrimoj SI. A systematic review of implementation frameworks of innovations in healthcare and resulting generic implementation framework. Health Res Policy Syst. 2015;13:16. doi: 10.1186/s12961-015-0005-z .
25. Carroll KM, Martino S, Ball SA, Nich C, Frankforter T, Anez LM, et al. A multisite randomized effectiveness trial of motivational enhancement therapy for Spanish- speaking substance users. J Consult Clin Psychol. 2009;77(5):993-9. doi: 10.1037/a0016489.
26. Borges G, Wang PS, Medina-Mora ME, Lara C, Chiu WT. Delay of first treatment of mental and substance use disorders in Mexico. Am J Public Health. 2007;97(9):1638-43. doi:10.2105/AJPH.2006.090985.
27. Villatoro J, Medina-Mora ME, Fleiz Bautista C, López MM, Robles NO, Gamiño MB, et al. El consumo de drogas en México: Resultados de la Encuesta Nacional de Adicciones, 2011. Salud Ment. 2012;35:447-57.
28. World Medical Association. World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA. 2013;310(20):2191-4. doi:10.1001/jama.2013. 281053.
29. Marín-Navarrete R, Templos-Nuñez L, Eloisa-Hernáandez A, Villalobos-Gallegos L, Fernández-Mondragón J, Pérez-López A, et al. Characteristics of a treatment- seeking population in outpatient addiction treatment centers in Mexico. Subst Use Misuse. 2014;49(13):1784-94. doi: 10.3109/10826084.2014.931972.
30. Fernández-Mondragón J, Graue-Moreno J, Bucay-Harari L, Horigian VE, Alonso E, Verdeja RE, et al. Safety report and adverse events in a behavioral clinical trial in Mexico. Poster presentation at: 15th International Conference organized by Centros de Integración Juvenil; 2013, Cancun, Mexico.
31. Horigian VE. A decade of experience of the national drug abuse treatment clinical trials network: Bridging the gap between research and practice to improve drug abuse treatment. Results from Behavioral Interventions. Presented at: XXVII Research Annual Meeting of the National Institute of Psychiatry; 2013, Mexico City, Mexico.
32. Horigian VE. Crossing borders and building bridges: Overview of a successful international collaboration to improve substance abuse treatment research and practice in Mexico." Presented at: the panel on Technology Transfer for the Implementation of a Clinical Trials Network on Drug Abuse and Mental Health in Mexico, National Hispanic Science Network; 2013, Bethesda, Maryland.
33. Horigian VE, Marín-Navarrete R, Medina- Mora ME, Verdeja RE, Alonso E, Berlanga C, et al. Development of a clinical trials network to test and disseminate evidence based practices to treat addiction and mental disorders in Mexico. Poster presented at: The College of Problems on Drug Dependence; 2013, San Diego, CA.
34. Marín-Navarrete R, Horigian VE, Fernández- Mondragón J, Verdeja RE, Alonso E, Templos-Nunez L, et al. Motivational Enhancement Therapy to improve retention and treatment outcomes in Mexican substance abuse treatment seekers: Preliminary results. Poster presentation at: 15th International Conference organized by Centros de Integración Juvenil; 2013, Cancun, Mexico.
35. Villalobos-Gallegos L, Eliosa-Hernández A, Pérez-Lopez A, Fernandez-Mondragon J, Templos-Nunez L, Larios-Chávez L, et al. Substance use variables and related consequences: Analyses from a randomized clinical trial implemented in Mexico. Presented as a poster at: 15th International Conference organized by Centros de Integración Juvenil; 2013, Cancun, Mexico.
36. Horigian VE, Espinal PS, Feaster DJ, Alonso E, Verdeja R, Usaga I, et al. Readiness and Barriers to Adopt Evidence-Based Practices for Substance Abuse Treatment in Mexico. Poster presentation at: 16th World Congress of Psychiatry "Focusing on access, quality and humane care"; 2014, Madrid, Spain.
37. Marín-Navarrete R, Horigian, VE, Fernandez-Mondragon J, Verdeja RE, Alonso E, Templos-Nuñez L, et al. A multisite randomized controlled trial of Motivational Enhancement Treatment in outpatient addiction care centers in Mexico. Presented as a poster at: 76th Annual Meeting of The College on Problems on Drug Dependence; 2014, San Juan, Puerto Rico.
38. Horigian VE, Marin-Navarrete RA, Medina-Mora ME, Szapocznik J. Using Clinical Trials to Develop and Implement Evidence Based Interventions in Mexico. Presented as part of the panel on Implementation Science and Evidence Based Treatments in Latin America: International Collaboration Challenges and Opportunities, NIDA International Forum; 2015, Phoenix, Arizona.
39. Horigian VE, Espinal PS, Alonso E, Verdeja R, Marin-Navarrete R, Usaga I, et al. Readiness and barriers to adopt evidence-based practices for substance abuse treatment in Mexico. Subst Use Misuse. [In press]
40. Horigian VE, Espinal PS, Alonso E, Verdeja R, Marín-Navarrete R, Usaga I, et al. Readiness and barriers to adopt evidence-based practices for substance abuse treatment in Mexico [Abstract]. Alcohol Alcohol, 49(suppl1),i44; doi: 10.1093/alcalc/agu053.29.
41. Marín-Navarrete R, Templos-Nunez L, Eliosa-Hernandez A, Villalobos-Gallegos L, Fernandez-Mondragon J, Perez-Lopez A, et al. Characteristics of a treatment-seeking population in outpatient addiction treatment centers in Mexico. Subst Use Misuse. 2014;49(13):1784-94. doi: 10.3109/10826084.2014.931972 PMID: 25014615.
42. Ward V, House A, Hamer S. Developing a framework for transferring knowledge into action: a thematic analysis of the literature. J Health Serv Res Policy. 2009;14(3):156-64. doi:10.1258/jhsrp.2009. 008120.
43. Coloma J, Harris E. Reducing the impact of poverty on health and human development: scientific approaches. Ann N Y Acad Sci. 2008;(1136):358-68.
44. Castro FG, Barrera MJ, Holleran-Steiker LK. Issues and Challenges in the design of culturally adapted evidence-based interventions. Annu Rev Clin Psychol. 2010;6:213-39. doi: 10.1146/annurev-clinpsy- 033109-132032.
45. Kumpfer KL, Pinyuchon M, Teixeira A, Whiteside HO. Cultural adaptation process for international dissemination of the strengthening families program. Eval Health Prof. 2008;31(2):226-39. doi: 10.1177/0163278708315926.
46. Weiner BJ, Amick H, Lee SY. Conceptualization and measurement of organizational readiness for change: a review of the literature in health services research and other fields. Med Care Res Rev. 2008;65(4):379-436. doi: 10.1177/1077558708317802.
47. Williams I. Organizational readiness for innovation in health care: some lessons from the recent literature. Health Serv Manage Res. 2011;24(4):213-8. doi: 10.1258/hsmr.2011.011014.
48. Gagnon MP, Attieh R, Ghandour EK, Légaré F, Ouimet M, Estabrooks CA, et al. A systematic review of instruments to assess organizational readiness for knowledge translation in health care. Jeyaseelan K, ed. PLoS ONE. 2014;9(12):e114338. doi: 10.1371/journal.pone.0114338.
Manuscript received on 2 August 2014.
Revised version accepted for publication on 16 April 2015.