ABSTRACT

Despite its low incidence, pediatric cancer makes up a significant portion of childhood illnesses. Yet information on pediatric cancer in Latin America is scarce. Since the early 2000s the World Health Organization (WHO) has been highlighting the role of cancer registries in cancer surveillance and control. This article describes the main aspects of pediatric cancer registration in Latin America, highlighting the successes of Argentina's national pediatric cancer registry, Registro Oncopediátrico Hospitalario Argentino (ROHA), which allows for better health care and contributes to improved outcomes for children with cancer, to provide a rationale for the expansion and enhancement of pediatric cancer registration in other Latin American countries.

Keywords
Child health services; neoplasms; surveillance; Latin America; Argentina

RESUMEN

A pesar de tener una incidencia baja, el cáncer pediátrico representa una proporción significativa de las enfermedades de la niñez. Sin embargo, en América Latina hay poca información al respecto. Desde comienzos del siglo XXI, la Organización Mundial de la Salud (OMS) ha puesto de relieve la función que tienen los registros oncológicos en la vigilancia y el control del cáncer. En este artículo se describen los principales aspectos de los registros de cáncer pediátrico en América Latina y se pone el acento en los éxitos del Registro Oncopediátrico Hospitalario Argentino (ROHA), que permite mejorar la atención de salud y ayuda a obtener mejores resultados en los niños con cáncer, lo cual puede servir de fundamento para la ampliación y el perfeccionamiento de los registros de cáncer pediátrico en otros países latinoamericanos.

Palabras clave
Servicios de salud del niño; neoplasias; vigilancia; América Latina; Argentina

RESUMO

Apesar da incidência baixa, o câncer em crianças representa uma parcela considerável das afecções infantis. Porém, existem poucos dados sobre o câncer em crianças na América Latina. Desde o princípio dos anos 2000, a Organização Mundial da Saúde (OMS) trabalha para reforçar o papel dos registros de câncer no controle e vigilância da doença. Este artigo examina as principais características dos registros do câncer em crianças na América Latina e põe em relevo os bons resultados obtidos com o registro nacional da Argentina (Registro Oncopediátrico Hospitalario Argentino, ROHA), como melhoria da assistência de saúde e dos desfechos aos pacientes pediátricos, servindo de base para a ampliação e o aperfeiçoamento do registro de câncer em crianças em outros países latino-americanos.

Palavras-chave
Serviços de saúde da criança; neoplasias; vigilância; América Latina; Argentina

Pediatric cancer refers to a group of cancers affecting children between 0–14 years of age (or, when adolescents are included in this classification, between 0–19 years old). Current incidence rates are low, ranging from 50 to 200 cases per million per year, depending on the country (¹1. Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104–16. doi: 10.1016/S1470-2045(13)70008-1.
https://doi.org/10.1016/S1470-2045(13)70... ). However, with the advances in the control of communicable diseases, pediatric cancer is gaining importance as a childhood illness. The International Classification of Childhood Cancer (ICCC) (²2. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, third edition. Cancer. 2005;103(7): 1457–67.) lists 12 main categories of cancers. Leukemia and lymphoma are the most common types in the world, followed by brain and other central nervous system tumors (¹1. Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104–16. doi: 10.1016/S1470-2045(13)70008-1.
https://doi.org/10.1016/S1470-2045(13)70... ). In high-income countries (HICs), overall pediatric cancer five-year survival rates are 80% or higher (¹1. Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104–16. doi: 10.1016/S1470-2045(13)70008-1.
https://doi.org/10.1016/S1470-2045(13)70... ). For lymphoblastic leukemia, five-year survival exceeds 90% in countries such as the United States and Germany (³3. Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group. J Clin Oncol. 2012;30(14):1663–9. doi: 10.1200/JCO.2011.37.8018.
https://doi.org/10.1200/JCO.2011.37.8018... , ⁴4. Kaatsch P, Spix C. German Childhood Cancer Registry: annual report 2015 (1980-2014). Mainz: Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz; 2015. Available from: http://www.kinderkrebsregister.de/typo3temp/secure_downloads/29942/0/f474d594c6b5a-8805c4e629db249872e05d69ddb/jb2015_s.pdf
http://www.kinderkrebsregister.de/typo3t... ). These outcomes are the reason why pediatric cancer control in these countries can be considered a “success story” (¹1. Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104–16. doi: 10.1016/S1470-2045(13)70008-1.
https://doi.org/10.1016/S1470-2045(13)70... ) and a marker of their high-quality health services. Survival data for low- and middle-income countries (LMICs) are not widely available, but the estimates suggest more modest results compared to HICs (¹1. Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104–16. doi: 10.1016/S1470-2045(13)70008-1.
https://doi.org/10.1016/S1470-2045(13)70... , ⁵5. Ribeiro RC, Steliarova-Foucher E, Magrath I, Lemerle J, Eden T, Forget C, et al. Baseline status of paediatric oncology in ten low-income or mid-income countries receiving My Child Matters support: a descriptive study. Lancet Oncol. 2008;9(8):721–9.). The results are highly heterogeneous among LMICs, including five-year survival rates that range from 5% to 60% (⁴4. Kaatsch P, Spix C. German Childhood Cancer Registry: annual report 2015 (1980-2014). Mainz: Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz; 2015. Available from: http://www.kinderkrebsregister.de/typo3temp/secure_downloads/29942/0/f474d594c6b5a-8805c4e629db249872e05d69ddb/jb2015_s.pdf
http://www.kinderkrebsregister.de/typo3t... ).

The gap in survival between HICs and LMICs emerges from differences in available treatments; health resources; infrastructure; early detection; clinical support, and follow-up; and coexisting malnutrition and communicable diseases (⁵5. Ribeiro RC, Steliarova-Foucher E, Magrath I, Lemerle J, Eden T, Forget C, et al. Baseline status of paediatric oncology in ten low-income or mid-income countries receiving My Child Matters support: a descriptive study. Lancet Oncol. 2008;9(8):721–9., ⁶6. Rodríguez-Galindo C, Friedrich P, Alcasabas P, Antillon F, Banavali S, Castillo L, et al. Toward the cure of all children with cancer through collaborative efforts: pediatric oncology as a global challenge. J Clin Oncol. 2015;33(27):3065-73. doi: 10.1200/JCO.2014.60.6376.
https://doi.org/10.1200/JCO.2014.60.6376... ). One strategy that LMICs could adopt to deal with some of these issues is to strengthen their pediatric cancer registration mechanisms to cover the totality (or at least a significant percentage) of pediatric cancer cases within their borders. Reports published by the World Health Organization (WHO) in 2002 and 2011 stress that population-based cancer registries are a key feature of national cancer programs (⁷7. World Health Organization. National cancer control programmes: policies and managerial guidelines. 2nd ed. Geneva: WHO; 2002. Available from: http://www.who.int/cancer/media/en/408.pdf
http://www.who.int/cancer/media/en/408.p... , ⁸8. World Health Organization; International Atomic Energy Agency. National cancer control programmes: core capacity self-assessment tool. Geneva: WHO; 2011. Available from: http://apps.who.int/iris/bitstream/10665/44729/1/9789241502382_eng.pdf
http://apps.who.int/iris/bitstream/10665... ). In line with that, the Pan American Health Organization (PAHO) Policy on Research for Health (2009) underscores the need to develop registries in Latin America (⁹9. Pan American Health Organization. Resolution CD49.R10: policy on research for health. Washington: PAHO; 2009. Available from: http://iris.paho.org/xmlui/handle/123456789/390
http://iris.paho.org/xmlui/handle/123456... ). Expanding pediatric cancer registration in Latin America could serve to better inform national policies. It would also allow for more thorough regional and international comparisons, helping to identify unjustified variations in treatment response and survival.

Latin American countries need to strengthen their cancer registration mechanisms to meet good-quality criteria for completeness, coverage, and timeliness of data (¹⁰10. Bray F, Znaor A, Cueva P, Korir A, Swaminathan R, Ullrich A, et al. Planificación y desarrollo de registros de cáncer de base poblacional en los países de ingresos bajos y medios. Lyon: International Agency for Research on Cancer; 2015. Available from: http://www.iarc.fr/en/publications/pdfs-online/treport-pub/treport-pub43/indexsp.php
http://www.iarc.fr/en/publications/pdfs-... –¹³13. Rolfo C, Caglevic C, Bretel D, Hong D, Raez LE, Cardona AF, et al. Cancer clinical research in Latin America: current situation and opportunities. Expert opinion from the first ESMO workshop on clinical trials, Lima, 2015. ESMO Open. 2016;1(4):e000055. doi: 10.1136/esmoopen-2016-000055.
https://doi.org/10.1136/esmoopen-2016-00... ). Cancer registration—for both adult and pediatric cases—does not have a long history in the region. The first good-quality population-based cancer registry in Latin America was created in 1962 in Cali, Colombia (¹⁴14. Mirra AP. Registros de cáncer en América Latina. Rev Bras Cancerologia. 1997;43(1):65–72., ¹⁵15. Cuervo LG, Roca S, Rodríguez MN, Stein J, Izquierdo J, Trujillo A, et al. Evaluation of institutional cancer registries in Colombia. Rev Panam Salud Publica. 1999;6(3):202–6.). Many of the cancer registries created since then have an institutional or local scope rather than national coverage, limiting their potential to inform health public policies. That is the case of local registries in Argentina, Brazil, Chile, Colombia, Ecuador, Honduras, and Peru. Only Argentina and Chile have national pediatric cancer-specific registries (¹⁶16. International Agency for Research on Cancer. International incidence of childhood cancer 3: results—registry-specific tables [Internet]. Lyon: IARC; 2017. Available from: http://iicc.iarc.fr/results/registries.php Accessed on 19 March 2017.
http://iicc.iarc.fr/results/registries.p... ). Argentina's national pediatric cancer registry, the Registro Oncopediátrico Hospitalario Argentino (ROHA) (¹⁷17. Instituto Nacional del Cáncer (AR). Epidemiología y registros: Registro Oncopediátrico Hospitalario Argentino [Internet]. Buenos Aires: INC; 2017. Available from: http://www.msal.gov.ar/inc/epidemiologia-y-registros/roha/ Accessed on 19 March 2017.
http://www.msal.gov.ar/inc/epidemiologia... ), was created in 2000. It was the first Latin American pediatric cancer registry with a national scope. Nowadays, ROHA is expanding its coverage and developing new features, such as real-time online patient registration. In addition, ROHA's staff provides technical cooperation to other countries in the region for the creation or improvement of pediatric cancer registries.^aaPersonal interview with Florencia Moreno (ROHA and Programa Nacional de Cuidado Integral del Niño y Adolescente con Cáncer (PROCUINCA) / INC, Buenos Aires), July–August 2016.

This article describes the main aspects of pediatric cancer in Latin America, highlighting the successes of ROHA, which allows for better health care and contributes to improved outcomes for children with cancer, to provide a rationale for the expansion of pediatric cancer registration in the region.

GENERAL CONSIDERATIONS ABOUT CANCER REGISTRIES

Registries enable the surveillance of cancer through the ongoing, timely, and systematic collection of information on new cancer cases, treatments, and survival and deaths rates (¹⁸18. Brewster DH, Coebergh JW, Storm HH. Population-based cancer registries: the invisible key to cancer control. Lancet Oncol. 2005;6(4):193-5. doi: 10.1016/S1470-2045(05)70071–1.
https://doi.org/10.1016/S1470-2045(05)70... –²⁰20. American Cancer Society. Cancer surveillance programs in the United States [Internet]. Atlanta: ACS; 2014. Available from: http://www.cancer.org/cancer/cancerbasics/cancersurveillance-programs-and-registries-in-the-united-states Accessed on 19 March 2017.
http://www.cancer.org/cancer/cancerbasic... ). The registries allow for better planning of cancer policies and are valuable tools for the monitoring and evaluation of the effectiveness and efficiency of the health system. Cancer registries are usually categorized in two main groups: hospital-based (HB) and population-based (PB). HB registries focus on the patients of a single institution and can provide detailed data to inform administrative decisions as well as clinical epidemiology. PB registries are the gold standard for cancer registration as they cover a well-defined population in a geographic area instead of focusing on one institution. Some of the essential variables of PB registries are sex, date of birth, incidence date, location of the tumor, and tumor morphology. PB registries gather data from multiple sources, including pathology laboratories, death certificates, and autopsy reports (¹⁹19. Valsecchi MG, Steliarova-Foucher E. Cancer registration in developing countries: luxury or necessity? Lancet Oncol. 2008;9(2):159–67. doi: 10.1016/S1470-2045(08)70028–7.
https://doi.org/10.1016/S1470-2045(08)70... ).

Building and running a pediatric cancer registry with a population scope is challenging, especially in limited-resource settings (¹⁹19. Valsecchi MG, Steliarova-Foucher E. Cancer registration in developing countries: luxury or necessity? Lancet Oncol. 2008;9(2):159–67. doi: 10.1016/S1470-2045(08)70028–7.
https://doi.org/10.1016/S1470-2045(08)70... ). Nevertheless, the low volume of pediatric cancer cases makes it possible to create a high-quality national registry, especially in countries where treatment of pediatric cancer is concentrated in specific hospitals. The case of ROHA is a reflection of that.

PEDIATRIC CANCER REGISTRATION IN ARGENTINA: THE CASE OF ROHA

Main features

ROHA was the first nationwide pediatric cancer registry in Latin America. It was created within the framework of the Kaleidos Foundation (²¹21. Fundación Kaleidos. Fundación Kaleidos [Internet]. Buenos Aires: FK; 2017. Available from: http://www.fundacionkaleidos.org/ Accessed on 19 March 2017.
http://www.fundacionkaleidos.org/... ), an Argentine nongovernmental organization, following international standards (²²22. Jensen OM, Parkin DM, MacLennan R, Muir CS, Skeet RG. Cancer registration: principles and methods. Lyon: International Agency for Research on Cancer; 1991. Available from: http://www.iarc.fr/en/publications/pdfs-online/epi/sp95/index.php
http://www.iarc.fr/en/publications/pdfs-... ) and the example of well-established pediatric cancer registries such as the German Childhood Cancer Registry (GCCR) (²³23. German Childhood Cancer Registry. Overview [Internet]. Mainz: Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz; 2017. Available from: http://www.kinderkrebsregister.de/dkkr-gb/about-us/overview.html?L=1 Accessed on 19 March 2017.
http://www.kinderkrebsregister.de/dkkr-g... ). In 2010, the National Cancer Institute of Argentina (Instituto Nacional del Cáncer, INC) was created, and ROHA began operating as part of the institute. The Argentine government now provides funding and an institutional framework to ROHA. Since its inception, ROHA has been gathering information from all institutions where children with cancer are cared for, thus offering national coverage of pediatric cancer cases (23 provinces and the capital district). The estimated coverage of ROHA is 90% (with the remaining 10% corresponding to data losses) (²⁴24. Moreno F. Registro Oncopediátrico Hospitalario Argentino: incidencia 2000–2013, tendencia temporal de incidencia 2000-2013, sobrevida 2000–2009. Buenos Aires: Instituto Nacional del Cáncer; 2015. Available from: http://www.msal.gob.ar/images/stories/bes/graficos/0000000730cnt-62-publicacionroha.pdf
http://www.msal.gob.ar/images/stories/be... ).

One salient feature of ROHA is that it combines the characteristics of PB and HB registries in order to ensure national coverage. As the treatment of pediatric cancer is concentrated in highly specialized facilities in Argentina, it is possible to use hospitals as the basic unit of the registry. ROHA complements the information that hospitals provide with other relevant sources, such as private clinics, local population registries, death certificates, pathology laboratories, and radiotherapy centers. The doctors treating pediatric cancer patients are usually in charge of the registration, but specially trained administrative personnel can also fulfill this task. ROHA coordinates the network, provides support, and compiles the data. Its permanent staff includes a director, an epidemiologist, a systems analyst, and two coders trained to codify cases according to the ICCC. As of 2015, the network included 88 institutions (²⁴24. Moreno F. Registro Oncopediátrico Hospitalario Argentino: incidencia 2000–2013, tendencia temporal de incidencia 2000-2013, sobrevida 2000–2009. Buenos Aires: Instituto Nacional del Cáncer; 2015. Available from: http://www.msal.gob.ar/images/stories/bes/graficos/0000000730cnt-62-publicacionroha.pdf
http://www.msal.gob.ar/images/stories/be... ).

ROHA's database contains information about type of tumor, incidence, place/s of treatment, survival, and mortality (²⁴24. Moreno F. Registro Oncopediátrico Hospitalario Argentino: incidencia 2000–2013, tendencia temporal de incidencia 2000-2013, sobrevida 2000–2009. Buenos Aires: Instituto Nacional del Cáncer; 2015. Available from: http://www.msal.gob.ar/images/stories/bes/graficos/0000000730cnt-62-publicacionroha.pdf
http://www.msal.gob.ar/images/stories/be... ). The National Identification Number (Documento Nacional de Identidad, DNI), a unique number assigned by the Argentine government to citizens and residents, serves to identify patients. The DNI and other personal data of the patients are treated as confidential by ROHA. Data can be aggregated at different levels: national, provincial, departmental, and hospital. ROHA reports its data on average every two years in publications that can be accessed free of charge either online or in print. Stakeholders can request data that are available but unpublished. ROHA provides more detailed pediatric cancer information than most registries in Latin America, which typically only include data about incidence, lack a national scope, and rely on projections.

The relevance of ROHA for decision-making

ROHA provides crucial data for the identification and development of lines of action for public policies on pediatric cancer in Argentina. The availability of high-quality data is important for developing, implementing, and assessing pediatric cancer strategies. The recently published guideline “Pediatric Central Nervous System (CNS) Tumors” (²⁵25. Fischman M, Ismael J, Pesce P, Rufach D. Tumores pediátricos del sistema nervioso central. Buenos Aires: Instituto Nacional del Cáncer; 2015. Available from: http://docplayer.es/18773349-Presidente-de-la-nacioning-mauricio-macri-ministro-desalud-de-la-nacion-dr-jorge-daniellemus.html
http://docplayer.es/18773349-Presidente-... ) and the promotion of early diagnosis of pediatric cancer in Argentina are two examples of public policies informed by ROHA's data.

Pediatric CNS tumor guidelines

ROHA's data on CNS tumors highlighted the need for pediatric CNS tumor guidelines by identifying unjustified variations in survival outcomes across different provinces and an average national survival rate considerably lower than those observed in other HICs (Table 1). The INC developed the guidelines (²⁵25. Fischman M, Ismael J, Pesce P, Rufach D. Tumores pediátricos del sistema nervioso central. Buenos Aires: Instituto Nacional del Cáncer; 2015. Available from: http://docplayer.es/18773349-Presidente-de-la-nacioning-mauricio-macri-ministro-desalud-de-la-nacion-dr-jorge-daniellemus.html
http://docplayer.es/18773349-Presidente-... ) to standardize pediatric CNS tumor management, promote best practices, and create an environment where departures from standard treatment require a substantiated motive. Based on both evidence and expert consensus, the guidelines provide a rationale for centralizing surgical interventions in hospitals with greater levels of expertise and more skilled teams.

Promotion of early diagnosis

ROHA's information illustrated that many cases of pediatric cancer were being reported at late stages. This triggered an initiative to train primary care providers in the early signs and symptoms of childhood cancer in order to reduce these delays in diagnosis. Trained staff members from the INC regularly travel to Argentine provinces to conduct early diagnosis workshops and to learn from the situation in the field (²⁶26. Instituto Nacional del Cáncer (AR). Programa Nacional de Cuidado Integral del Niño y Adolescente con Cáncer [Internet]. Buenos Aires: INC; 2017. Available from: http://www.msal.gov.ar/inc/el-inc-y-sus-programas/programa-nacional-decuidado-integral-del-nino-y-adolescente-con-cancer-2/ Accessed on 19 March 2017.
http://www.msal.gov.ar/inc/el-inc-y-sus-... ). The staff members train medical personnel and trainers so that the workshops can be replicated throughout the provinces. In 2016, workshops were held in seven provinces in different regions of Argentina.^bbPersonal interview with Florencia Moreno (ROHA and Programa Nacional de Cuidado Integral del Niño y Adolescente con Cáncer (PROCUINCA) / INC, Buenos Aires), July–August 2016. ROHA's data informed the selection of provinces, with priority given to those with greater pediatric cancer incidence rates and/or more advanced stages of cancer at diagnosis.

The future of pediatric cancer registration in Argentina and across Latin America

For the past two years, ROHA has been using online registration to collect real-time information on patients. The development of the open code online registration software cost US$ 15,000.^bbPersonal interview with Florencia Moreno (ROHA and Programa Nacional de Cuidado Integral del Niño y Adolescente con Cáncer (PROCUINCA) / INC, Buenos Aires), July–August 2016. Since its implementation, 71% of patients have been registered online. ROHA's goal is to achieve a 100% online registration by the end of 2017. It also aims to expand the network of hospitals that provide information to the registry, thereby increasing the national population coverage beyond the current 90%.

In the Americas region, technical cooperation between countries with similar challenges and resources could be strategic in boosting good-quality cancer registration. Countries could learn and build upon existing experiences while using some of the capacities and tools already developed. The International Agency for Research on Cancer (IARC) (Lyon, France) has created a cancer registry training hub at the INC to stimulate collaboration and improve cancer registries in the region. Within this context, registries like ROHA could be developed and adapted to local conditions to expand the number of pediatric cancer registries in Latin America. Florencia Moreno, director of ROHA and member of the IARC's “International Incidence of Childhood Cancer” editorial board (²⁷27. International Agency for Research on Cancer. International incidence of childhood cancer 3: about IICC-3—editorial board [Internet]. Lyon: IARC; 2017. Available from: http://iicc.iarc.fr/about/iicc3_editors.php Accessed on 19 March 2017.
http://iicc.iarc.fr/about/iicc3_editors.... ), stated that this could be an auspicious moment for the promotion and expansion of pediatric cancer registration in Latin America.^ccPersonal interview, July–August 2016. She highlighted the ongoing collaboration between ROHA and teams in Paraguay and Peru to help the two countries develop their own registries. While these and other projects continue to grow, it is equally important to continue developing the cancer registries that already exist and increase their visibility and use. For instance, ROHA could have a website offering access to its datasets so that users could conduct their own analysis of the information. It would also be useful to provide information about the registries’ cost-effectiveness; registries like ROHA could, for example, maintain records of the policies they have contributed to and report the information to the public.

CONCLUSIONS

Pediatric cancer registries with population coverage are essential tools for monitoring and evaluating the performance of cancer treatments and health systems, tracking progress, and providing evidence for timely corrective actions. In Latin America, cancer registration in general, and pediatric cancer registration in particular, are still in the development stage and could benefit from lessons learned and benchmarks drawn from innovative registries like ROHA. The ongoing technical cooperation between Latin American countries allows for optimism regarding the future of pediatric cancer registration in the region. However, a long-term commitment from each Latin American country will be necessary for these initiatives to thrive.

Acknowledgments

Florencia Moreno (Registro Oncopediátrico Hospitalario Argentino (ROHA) / Instituto Nacional del Cáncer (INC)) provided key inputs for this article through several interview sessions. Louisa Stüwe and Ana Cristina Castro (PAHO/WHO) and Nicole Corea (American University) reviewed the article and contributed valuable suggestions.

REFERENCES

Publication Dates

History