ABSTRACT

OBJECTIVE

To assess longitudinally the change in quality of life in people living with HIV initiating antiretroviral therapy in three public reference services specialized in HIV care in Belo Horizonte, Brazil.

METHODS

Prospective cohort study among people living with HIV, aged 18 years or older, and initiating antiretroviral therapy. We obtained sociodemographic, behavioral, clinical data related to pharmacological treatment and to the service by face-to-face interviews, and supplemented these data with information from clinical records and Information Systems of the Brazilian HIV/AIDS Program. We measured the quality of life using the WHOQOL-HIV bref instrument, with a minimum interval of six months between the baseline and the follow-up interviews. We used paired t-test to assess the mean change in quality of life between the two interviewsand evaluated factors associated with this outcome using multiple linear regression.

RESULTS

The overall quality of life, as well as the physical, psychological, level of independence, environment and spiritual quality of life domains were statistically higher in people living with HIV using antiretroviral therapy at the end of the follow-up. Factors independently associated with the increase in quality of life were having religious belief and living with other people. Having signs or symptoms of anxiety and depression and the number of adverse drug reactions reported were predictors associated with worsening quality of life.

CONCLUSIONS

These results show an improvement in the quality of life over time in people living with HIV on antiretroviral therapy. They also highlight the need to monitor and provide health care support, especially for individuals with signs and symptoms of anxiety and depression and that report adverse reactions to medicines at the beginning of treatment.

Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Quality of Life; WHOQOLHIV-bref; Cohort Studies

INTRODUCTION

In Brazil, in recent years, first-line antiretroviral (ARV) schemes have been modified, following the global trend and recommendations of the World Health Organization (WHO)¹1. World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. 2. ed. Genebra: WHO; 2016 [cited 2018 May 20]. Available from: http://www.who.int/hiv/pub/arv/arv-2016/en/.
http://www.who.int/hiv/pub/arv/arv-2016/... . In 2015, the Protocolo Clínico e Diretrizes Terapêuticas (PCDT – Clinical Protocol and Therapeutic Guidelines) for the management of HIV recommended a fixed-dose combination (FDC) containing the medicines tenofovir (TDF), lamivudine (3TC) and efavirenz (EFV) as a first-line regimen. In 2017, dolutegravir (DTG), an integrase inhibitor, was recommended as the first-line regimen, replacing EFV. This medicine should be taken together with a fixed-dose combination of TDF and 3TC²2. Brasil. Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância, Prevenção e Controle das Infecções Sexualmente Transmissíveis, do HIV/aids e das Hepatites Virais. Protocolo clínico e diretrizes terapêuticas para manejo da infecção pelo HIV em adultos. Brasília; 2017. .

In developing countries, such as Brazil, evidence from longitudinal studies on the determinants of quality of life (QOL) in people living with HIV (PLWH) are scarce. In a literature review, gender, age, family situation, education, employment, income, viral load, TCD4+ lymphocyte count, diagnosis time, presence of symptoms of depression and anxiety, social support, health care, use of licit and illicit drugs, adherence to antiretroviral therapy (ART), lifestyle and sexual behavior were factors directly associated with PLWH QOL³3. Degroote S, Vogelaers D, Vandijck DM. What determines health-related quality of life among people living with HIV: an updated review of the literature. Arch Public Health. 2014;72(1). https://doi.org/10.1186/2049-3258-72-40.
https://doi.org/10.1186/2049-3258-72-40... . Therefore, understanding QOL is essential to analyze the physical and biopsychosocial impact that HIV can cause, enabling greater knowledge of individuals about themselves, their adaptation to the condition of living with HIV and to their treatment. Evidence on the impact of ART initiation on QOL in PLWH is also scarce.

The objective of our study was to evaluate longitudinally the QOL in PLWH initiating ART that attended three public reference services in Belo Horizonte, Brazil. We further evaluated the predictors of change in QOL.

METHODS

This is a cohort study, using data from the Ecoart project, whose details were previously published⁴4. Costa JO, Pearson SA, Acurcio FA, Bonolo PF, Silveira MR, Ceccato MGB. Health-related quality of life among HIV-infected patients initiating treatment in Brazil in the single-tablet regimen era. AIDS Care. 2019;31(5):572-81. https://doi.org/10.1080/09540121.2019.1576841.
https://doi.org/10.1080/09540121.2019.15... , ⁵5. Mendes JC et al. Adverse reactions associated with first-line regimens in patient initiating antiretroviral therapy. European Journal of Clinical Pharmacology. 2018;74(8):1077-88. https://doi.org/10.1007/s00228-018-2472.
https://doi.org/10.1007/s00228-018-2472... .

The sample selection was non-random, and all eligible individuals attending three public specialized HIV care services were invited to participate in the study. These servicesall together dispense ART for approximately 80% of PLWH in the municipality of Belo Horizonte, state of Minas Gerais,Brazil. Participants’ selection took place between September 2015 and October 2017.

We included individuals with up to 180 days of ART usage, who attended one of the services evaluated and who were identified through their registration in the logistic control system of medicines (Siclom), a national system of ART dispensation. The inclusion criteria were the signing of the informed consent form, being 18 years of age or older, autonomy to respond to the interview and having performed the baseline interview and the second follow-up interview.

We obtained data by face-to-face interviews and in secondary databases, using standardized forms that contained the World Health Organization quality of life HIV instrument – in its shortened version (WHOQOLHIV – bref), the Hospital scale of anxiety and depression (HADS) and the Morisky’s therapeutic adherence scale of eight items (MMAS–8), all validated in Brazil⁶6. Zimpel RR, Fleck MP. (2007). Quality of life in HIV-positive Brazilians: application and validation of the WHOQOL-HIV, Brazilian version. AIDS Care. 2007;19(7), 923-30. https://doi.org/10.1080/09540120701213765.
https://doi.org/10.1080/0954012070121376...

7. Botega NJ, Bio MR, Zomignani MA, Garcia Jr. C, Pereira WAB. Transtornos do humor em enfermaria de clínica médica e validação de escala de medida (HADS) de ansiedade e depressão. Rev. Saúde Pública. 1995:29(5):359-63. - ⁸8. Oliveira-Filho AD, Morisky DE, Neves SJ, Costa FA, Junior DPL. The 8-item Morisky Medication Adherence Scale: validation of a Brazilian-Portuguese version in hypertensive adults. Research in Social and Administrative Pharmacy. 2014;10(3):554-61. https://doi.org/10.1016/j.sapharm.2013.10.006.
https://doi.org/10.1016/j.sapharm.2013.1... . It also contained questions regarding sociodemographic, behavioral, clinical, laboratory information, related to pharmacological treatment and to the health care service.

To minimize potential bias, researchers were properly trained and a pilot project was conducted before starting data collection.

Dependent Variable

We assessed QOL using the WHOQOL-HIV bref instrument in two moments: at the baseline interview and at the second follow-up interview six months after the baseline interview. The mean difference in overall QOL between these two moments was the dependent variable of our study. Therefore, we present the results only of those individuals that concluded both interviews. Data on QOL at baseline were published previously⁴4. Costa JO, Pearson SA, Acurcio FA, Bonolo PF, Silveira MR, Ceccato MGB. Health-related quality of life among HIV-infected patients initiating treatment in Brazil in the single-tablet regimen era. AIDS Care. 2019;31(5):572-81. https://doi.org/10.1080/09540121.2019.1576841.
https://doi.org/10.1080/09540121.2019.15... .

The WHOQOL-HIV bref is a specific instrument for assessing QOL in PLWH, which, in 31 questions, evaluates the following domains: physical, psychological, level of independence, social relations, environment and spirituality. Each question has five-point Likert scale answer options, 1 indicating negative perceptions and 5, positive perceptions, except for seven items, in which the scale is reversed. The average of the items within each domain is used to estimate the total score for the domain. The result is multiplied by 4, and thus the scores vary between 4 and 20⁶6. Zimpel RR, Fleck MP. (2007). Quality of life in HIV-positive Brazilians: application and validation of the WHOQOL-HIV, Brazilian version. AIDS Care. 2007;19(7), 923-30. https://doi.org/10.1080/09540120701213765.
https://doi.org/10.1080/0954012070121376... .

The overall QOL component and general health perception was evaluated using the first two questions of the WHOQOL-HIV bref instrument. The mean of the items was multiplied by 4; thus, the scores also ranged from 4 to 20⁶6. Zimpel RR, Fleck MP. (2007). Quality of life in HIV-positive Brazilians: application and validation of the WHOQOL-HIV, Brazilian version. AIDS Care. 2007;19(7), 923-30. https://doi.org/10.1080/09540120701213765.
https://doi.org/10.1080/0954012070121376... .

Independent Variables

We used sociodemographic, behavioral, clinical and laboratory variables related to pharmacological treatment and service to characterize the study population.

The presence of signs or symptoms of anxiety and depression was measured using the HADS, composed of 14 items⁷7. Botega NJ, Bio MR, Zomignani MA, Garcia Jr. C, Pereira WAB. Transtornos do humor em enfermaria de clínica médica e validação de escala de medida (HADS) de ansiedade e depressão. Rev. Saúde Pública. 1995:29(5):359-63. . People that had 8 or more points in each of the conditions were classified with symptoms of anxiety and depression. The individuals were classified according to the presence of signs and symptoms of anxiety or depression in the baseline interview and in the follow-up interview, being categorized as: (I) never – they never presented signs and symptoms of anxiety or depression, (ii) ever – they presented these symptoms in one of the two interviews or (iii) always – they presented these symptoms in both interviews.

MMAS-8 was used to evaluate adherence to ART. The total score of MMAS-8 varies from 0 to 8, and the higher the score, the higher the adhesion⁸8. Oliveira-Filho AD, Morisky DE, Neves SJ, Costa FA, Junior DPL. The 8-item Morisky Medication Adherence Scale: validation of a Brazilian-Portuguese version in hypertensive adults. Research in Social and Administrative Pharmacy. 2014;10(3):554-61. https://doi.org/10.1016/j.sapharm.2013.10.006.
https://doi.org/10.1016/j.sapharm.2013.1... . Individuals that scored 8 points were considered adherents. Adverse drug reactions (ADR) were assessed by self-reporting. Individuals with less than 50 copies per ml were considered with an undetectable viral load.

The variable economic class (socioeconomic status) was evaluated according to Brazilian criteria, such as high (A, B), intermediate (C) and low (D and E), in which individuals are classified by socioeconomic groups by possession of comfort items and level of education of the head of the family⁹9. Associação Brasileira de Empresas de Pesquisa. Critério de classificação econômica. Brasil: Abep; 2008. [cited 2019 Mar 5]. Available from: http://www.abep. org.
http://www.abep. org... .

For the comorbidity variable, it was considered the self-report of any disease diagnosed by a physician, such as arterial hypertension, diabetes, hypercholesterolemia, among others.

Statistical Analysis

We performed adescriptive analysis by frequency distribution for categorical variables and measures of central tendency for quantitative variables.

To evaluate the scores of the WHOQOL-HIV bref instrument, means and standard deviation were presented for each domain, relative to the baseline interview and the second follow-up interview. We then used paired t -test to compare the mean differences in QOL scores between the two interviews.

The univariate analysis of the relationship between independent variables and the change in QOL score was evaluated by the Student t test (comparison of means) and the Mann-Whitney test (comparison of medians).

We analyzed the association between change in QOL and independent variables by adjusting a multiple linear regression model. Variables with a p-value equal to or less than 0.20 were selected to enter the multivariate model. The backward stepwise method was used to obtain the final model. The results of multiple linear regression were demonstrated by regression coefficients, with their respective 95% confidence intervals (95%CI).

We evaluated the adequacy of the model by a set of statistics. The statistics R² and adjusted R² were used to verify the percentage of variance related to the increase in QOL explained by the model. The Durbin-Watson statistic was used to verify the assumption that the residues are not correlated, with values between 0 and 4, and 2 means no correlation between the residues. It was also tested if there was multicolinearity in the final model, using the statistics of tolerance (acceptable > 0.10) and VIF (acceptable < 10)¹⁰10. Field A. Descobrindo a estatística usando o SPSS-2. Porto Alegre: Bookman; 2009. . To evaluate if the residues had normal distribution, the following graphs were performed: standardized regression residues by standardized regression predicted values, histogram of frequencies of standardized regression residues, and a quantiles-quantile graph (QQ plot).

The Statistical Package for the Social Sciences (SPSS) software version 22.0 was used. In all analyses, a 0.05 significance level was considered.

Ethical Aspects

The Ecoart research project was approved by the Research Ethics Committee (COEP) of the Universidade Federal de Minas Gerais (CAAE protocol 31192914.3.3001.5124, opinion CEP 769.085) and the participating services. The research was conducted following the instructions of resolution 466/2012 of the National Health Council.

RESULTS

During the entire recruitment period of the Ecoart project, 1,017 individuals served in the three services were identified. Of these, 468 performed the baseline interview, of which 323 (69.0%) performed the second follow-up interview and were included in our study ( Figure 1).

No statistically significant differences regarding gender, age, marital status and education were found between the group that completed the second follow-up interview with those that did not. There were also no differences regarding general QOL and QOL domains.

Most of the respondents were men (83.0%), unmarried (79.9%), without children (66.9%), between 20 and 34 years old (54.5%), did not have a private health insurance (72.8%) and self-declared as non-white (76.9%). We found that 80.8% of the individuals lived with others, 38.8% had 10 to 12 years of schooling and 59.4% were employed at the time of the interview, with a predominance of Economy Class C (45.7%).

Regarding behavioral characteristics and lifestyle habits, 24.5% reported current tobacco use, 65.8% reported recent alcohol use, and 47.5% reported current or prior use of illicit drugs in their lives. Most reported having some religious belief (79.4%) and 59.6% were men who have sex with other men (MSM).

Regarding clinical characteristics, 7.8% presented coinfection (such as tuberculosis, syphilis, toxoplasmosis and candidiasis), 18.3%, one or more self-reported comorbidities, and 35.9 had signs or symptoms of anxiety and depression. Most individuals presented asymptomatic clinical classification (67.3%) and had less than or equal to six months of diagnosis of HIV infection (61.8 %). Regarding the baseline laboratory characteristics, 23.5% had an initial TCD4+ lymphocytes count less than 200 cells/mm³, 90.1%, detectable viral load, and 26.0%, viral load greater than 100,000 copies/ml.

Regarding pharmacological treatment, 63.2% used TDF/3TC/EFV, and 32.2%, TDF/3TC+DTG. Most (52.3%) had been using ART for 60 days or less, were non-adherent to ART (52.8%), reported at least one ADR (85.9%), and 53.1% reported three or less ADR ( Table 1 ).

In the second follow-up interview, regarding clinical, laboratory and ART-related characteristics, 34.3% of individuals presented signs and symptoms of anxiety and depression, 73.4% undetectable viral load, 59.5% were non-adherent to treatment, and 51.6% reported some ADR, and 79.9% reported three or less ADR ( Table 1 ).

QOL Results

The second follow-up interview occurred on average 9.47 months (median = 8.66; minimum = 3.5; maximum = 23.0; interquartile interval = 19.5, SD = 3.67) after the baseline interview.

Statistically significant improvements were observed over time in the overall QOL and in the physical, psychological, level of independence, environment and spiritual domains in individuals initiating ART. The only domain, in which the mean difference between baseline and follow-up interviews was not significant, was that of social relations.

The QOL domains with the greatest mean differences were physical (5.11; SD = -3.75), spiritual (3.23; SD = 6.20) and psychological (1.32; SD = 2.82) ( Table 2 ).

In the univariate analysis, individuals that reported illicit drug use throughout their lives had a higher mean difference in QOL (1.25; SD = 3.19). Individuals with no symptoms of anxiety and depression had a greater mean difference in QOL (2.78; SD = 3.22). Among the laboratory and ART-related variables, no statistically significant association was observed among VL, ARV scheme (TDF/3TC/EFV; TDF/3TC+DTG and other schemes), treatment duration, adherence to treatment, ADR, number of ADR and change in Mean QOL ( Table 3 ).

In the final multiple linear regression model, individuals with religious belief (0.92; 95%CI 0.20 to 1.64) and those that lived with others (1.00; 95%CI 0.26 to 1.65) showed an increase in QOL. Whereas individuals that reported signs or symptoms of anxiety and depression in life (-0.99; 95%CI -1.89 to -0.10) or always (-2.91; 95%CI -4.11 to -1.70) had a reduction in QOL. With each additional ADR reported at baseline, there was a reduction in the individual’s QOL (-0.09; 95%CI -0.18 to 0.01). Those individuals with higher QOL scores in the baseline interview obtained lower QOL increments at the end of the study, thus showing an inversely proportional Association (-0.60; 95%CI -0.69 to -0.50) ( Table 4 ).

Regarding the adequacy of the multiple linear regression model, the adjusted R² statistic was equal to 0.414, that is, the model explained approximately 41.4% of the variance of the QOL increase. The Durbin-Watson statistic was equal to 2.02, indicating no correlation between the residues. In the collinearity statistics, all predictors had tolerance values above 0.56 and VIF values close to 1 (1.00 to 1.78). The distribution of standardized waste was also verified, and they approached the normal distribution. This assumption was also confirmed by the Q-Q normal residue regression graph. Finally, the dispersion graph between the standardized and predicted residues did not show that they were randomly distributed; therefore, the developed model shows good fit.

DISCUSSION

Individuals initiating ART in this cohort showed an increase in QOL; having a religious belief and living with other people were positively associated with QOL, whereas having signs or symptoms of anxiety and depression, anytime or always, and additional ADR reported were predictors associated with worse QOL.

The characteristics of this population were similar to those of other studies¹¹11. Grangeiro A, Escuder MM, Cassanote AJF, Souza RA, Kalichman AO, Veloso V et al. The HIV-Brazil cohort study: design, methods and participant characteristics. PLoS One. 2014;9(5):e95673. https://doi.org/10.1371/journal.pone.0095673.
https://doi.org/10.1371/journal.pone.009... , ¹²12. Oliveira FBM, Moura MEB, Araújo TME, Andrade EMLR. Qualidade de vida e fatores associados em pessoas vivendo com HIV/aids. Acta paul. enferm. 2015;28(6):510-6. http://dx.doi.org/10.1590/1982-0194201500086.
http://dx.doi.org/10.1590/1982-019420150... and epidemiological bulletins¹³13. Brasil. Ministério da Saúde, Secretaria de Vigilância em Saúde. Boletim epidemiológico de aids e DST. Brasília; 2018. [cited 2019 Feb 3]. Available from: http://www.aids.gov.br/pt-br/pub/2018/boletim-epidemiologico-hivaids-2018.
http://www.aids.gov.br/pt-br/pub/2018/bo... , ¹⁴14. Minas Gerais. Secretaria Estadual de Saúde, Diretoria de Vigilância Epidemiológica, Coordenação de DST, Aids e Hepatites Virais. Boletim epidemiológico mineiro: análise epidemiológica de HIV/aids. Panorama do ano de 2017. Belo Horizonte; 2018. [cited 2019 Feb 5]. Available from: http://www.saude.mg.gov.br/images/noticias_e_eventos/000_2019/jane_fev_mar/BEM%20Mineiro%202018HIV.pdf.
http://www.saude.mg.gov.br/images/notici... , with a predominance of male, young, self-declared non-white skin color and with high schooling.

Our study showed that, over time, individuals in initial use of ART presented an increase in the overall QOL score, consistent with previous research¹⁵15. Bakiono F, Guiguimdé PW, Sanou M, Ouédraogo L, Robert A. Quality of life in persons living with HIV in Burkina Faso: a follow-up over 12 months. BMC Public Health. 2015; 15(1119). http://dx.doi.org/10.1186/s12889-015-2444-4.
http://dx.doi.org/10.1186/s12889-015-244... . The greatest mean difference in QOL observed in the physical domain, in which aspects such as pain, discomfort, energy, sleep and rest are evaluated, may be related to the use of ART. This causes changes in the course of infection, such as slowing the progression of immunodeficiency caused by the HIV virus and restoring the immune response of individuals – consequently, it can positively affect the individual’s life¹⁸18. Greco DB, Pedroso ERP, Westin MR. Síndrome da imunodeficiência adquirida. In: Pedroso ERP. Série medicina interna: doenças infecciosas. Rio de Janeiro: Rubio; 2015. p. 324-73. .

In the social relations domain, in which questions related to acceptance of diagnosis, family support, interpersonal relationship and sexual life were evaluated, a lower mean difference in QOL was observed. The social relationship is a complication for PLWH, since infection with the virus can be a stigmatizing health condition, which involves feelings of discrimination and, consequently, lack of social support and feelings of loneliness. Considering that these factors will hardly be influenced by the use of ART, it is important to emphasize the need to improve personal relationships and social support for these individuals¹⁵15. Bakiono F, Guiguimdé PW, Sanou M, Ouédraogo L, Robert A. Quality of life in persons living with HIV in Burkina Faso: a follow-up over 12 months. BMC Public Health. 2015; 15(1119). http://dx.doi.org/10.1186/s12889-015-2444-4.
http://dx.doi.org/10.1186/s12889-015-244... .

We observed a statistically significant increase in the overall perception component of QOL. The benefits of ART in the QOL can be explained by the reduction of clinical symptoms of infection. That is, this reinforces the need to link and retain individuals to the health care service and maintain adherence to treatment.

Some behavioral, sociodemographic, clinical and ART-related factors showed a relationship with the change in QOL in individuals initiating ART, and these findings are consistent with the scientific literature¹⁵15. Bakiono F, Guiguimdé PW, Sanou M, Ouédraogo L, Robert A. Quality of life in persons living with HIV in Burkina Faso: a follow-up over 12 months. BMC Public Health. 2015; 15(1119). http://dx.doi.org/10.1186/s12889-015-2444-4.
http://dx.doi.org/10.1186/s12889-015-244... .

Feelings of guilt, loneliness and fear of death, commonly reported by PLWH, are related to spiritual practice and having religious beliefs¹²12. Oliveira FBM, Moura MEB, Araújo TME, Andrade EMLR. Qualidade de vida e fatores associados em pessoas vivendo com HIV/aids. Acta paul. enferm. 2015;28(6):510-6. http://dx.doi.org/10.1590/1982-0194201500086.
http://dx.doi.org/10.1590/1982-019420150... , ²¹21. Medeiros B, Saldanha AAW. Religiosidade e qualidade de vida em pessoas com HIV. Estud. psicol. 2012;29(1):53-61. https://dx.doi.org/10.1590/S0103-166X2012000100006.
https://dx.doi.org/10.1590/S0103-166X201... , which contributes to the increase in QOL and health. Faith and religious beliefs are important strategies for coping with health conditions such as HIV, when allied to ART¹¹11. Grangeiro A, Escuder MM, Cassanote AJF, Souza RA, Kalichman AO, Veloso V et al. The HIV-Brazil cohort study: design, methods and participant characteristics. PLoS One. 2014;9(5):e95673. https://doi.org/10.1371/journal.pone.0095673.
https://doi.org/10.1371/journal.pone.009... , ²¹21. Medeiros B, Saldanha AAW. Religiosidade e qualidade de vida em pessoas com HIV. Estud. psicol. 2012;29(1):53-61. https://dx.doi.org/10.1590/S0103-166X2012000100006.
https://dx.doi.org/10.1590/S0103-166X201... .

Our results stresses the importance of family involvement in reducing HIV-related stigma and prejudice. In another study using the same instrument, but with a cross-sectional design²²22. Razera F, Ferreira J, Bonamigo RR. Factors associated with health-related quality-of-life in HIV-infected Brazilians. International Journal of STD & AIDS. 2008;19(8):519-23. https://dx.doi.org/10.1258/ijsa.2008.007289.
https://dx.doi.org/10.1258/ijsa.2008.007... , conducted in the Southern Brazil, individuals that lived alone presented 30% propensity to worse QOL in the social relations domain. Less emotional support during treatment could partially explain the results. Another cross-sectional study, conducted with 100 PLWH in Nepal, using the WHOQOL-bref instrument, demonstrated that good family support has a greater influence on QOL increase, being statistically associated with overall QOL²³23. Baral R, Thapa U, Khatiwada D. Quality of life among people living with human immunodeficiency virus and acquired immune deficiency syndrome in an anti-retroviral therapy clinic. J Nepal Health Res Counc. 2019;16(41):405-9. .

Signs or symptoms of anxiety and depression can impair PLWH QOL²⁴24. Tostes MA, Chalub M, Botega NJ. The quality of life of HIV-infected women is associated with psychiatric morbidity. AIDS Care. 2004;16(2):177-86. https://dx.doi.org/10.1080/09540120410001641020.
https://dx.doi.org/10.1080/0954012041000... . Depression and anxiety are more frequent in PLWH than in the general population²⁵25. Souza Junior PRB, Szwarcwald CL, Castilho EA. Self-rated health by HIV-infected individuals undergoing antiretroviral therapy in Brazil. Cad. Saúde Pública. 2011;27(Suppl 1):s56-s66. http://dx.doi.org/10.1590/S0102-311X2011001300007.
http://dx.doi.org/10.1590/S0102-311X2011... , which can negatively influence the individual’s behavior and contribute treatment-related difficulties and even worse adherence to ART²⁶26. Reis AC, Lencastre L, Guerra MP, Remor E. Relação entre sintomatologia psicopatológica, adesão ao tratamento e qualidade de vida na infecção HIV e AIDS. Psicol. Reflex. Crit. 2010;23(3):420-9. https://dx.doi.org/10.1590/S0102-79722010000300002.
https://dx.doi.org/10.1590/S0102-7972201... . The impact of psychiatric symptoms on PLWH QOL also occurs due to a deterioration of the immune system and consequent increase in disease progression, justified by the increased level of stress and depressive symptoms²⁷27. Leserman J. Role of depression, stress, and trauma in HIV disease progression. Psychosom Med. 2008;70(5):539-45. https://dx.doi.org/10.1097/PSY.0b013e3181777a5f.
https://dx.doi.org/10.1097/PSY.0b013e318... . Although HADS is not used for diagnostic purposes, but to evaluate signs and symptoms of anxiety and depression, an association was observed between these signs and symptoms and the reduction of QOL in PLWH in follow-up interviews. These results emphasize the importance of the follow-up by a health professional (psychologist, psychiatrist, among others) in HIV specialized services. In another cross-sectional study on QOL of the Ecoart group, conducted with 366 individuals in Belo Horizonte, being single (unmarried), having other comorbidities, lower educational level, being smoker, and having signs and symptoms of anxiety and depression was associated with lower QOL⁴4. Costa JO, Pearson SA, Acurcio FA, Bonolo PF, Silveira MR, Ceccato MGB. Health-related quality of life among HIV-infected patients initiating treatment in Brazil in the single-tablet regimen era. AIDS Care. 2019;31(5):572-81. https://doi.org/10.1080/09540121.2019.1576841.
https://doi.org/10.1080/09540121.2019.15... . In another cross-sectional study including 150PLWH conducted in Cambodia, the authors suggest a strong association between the increase in QOL assessed by the overall QOL score and the six domains of WHOQOL-HIV bref and the absence of signs or symptoms of anxiety and depression²⁸28. Yang Y, Thai S, Choi J. An evaluation of quality of life among Cambodian adults living with HIV/AIDS and using antiretroviral therapy: a short report. AIDS Care. 2016;28(12):1546-50. https://doi.org/10.1080/09540121.2016.1192100.
https://doi.org/10.1080/09540121.2016.11... .

In our study, we verified a greater reduction in QOL to each additional ADR reported by subjects in treatment, that is, the greater the number of ADR reported, the greater the reduction in QOL. This result is similar to that of another study conducted in Brazil, which described the lower number of ADR to ART as one of the factors associated with QOL improvement²⁹29. Campos LN, Cesar CC, Guimarães MD. Quality of life among HIV-infected patients in Brazil after initiation of treatment. Clinics. 2009;64(9):867-75. https://dx.doi.org/10.1590/S1807-59322009000900007.
https://dx.doi.org/10.1590/S1807-5932200... . ADR can affect physically and psychologically the performance of professional and personal activities and, consequently, the QOL of individuals under treatment⁵5. Mendes JC et al. Adverse reactions associated with first-line regimens in patient initiating antiretroviral therapy. European Journal of Clinical Pharmacology. 2018;74(8):1077-88. https://doi.org/10.1007/s00228-018-2472.
https://doi.org/10.1007/s00228-018-2472... . Monitoring the use of antiretrovirals is an important tool to assess the safety of these medicines in clinical practice⁵5. Mendes JC et al. Adverse reactions associated with first-line regimens in patient initiating antiretroviral therapy. European Journal of Clinical Pharmacology. 2018;74(8):1077-88. https://doi.org/10.1007/s00228-018-2472.
https://doi.org/10.1007/s00228-018-2472... and ensure better care and satisfaction of individuals with treatment²⁹29. Campos LN, Cesar CC, Guimarães MD. Quality of life among HIV-infected patients in Brazil after initiation of treatment. Clinics. 2009;64(9):867-75. https://dx.doi.org/10.1590/S1807-59322009000900007.
https://dx.doi.org/10.1590/S1807-5932200... .

When comparing individuals using the TDF/3TC + DTG regimen with those using TDF/3TC/EFV or other regimens, no statistically significant differences were observed in the mean difference in overall QOL, which can be explained by the fact that part of the Ecoart study population had initiated ART even asymptomatic, due to the change of the HIV treatment guidelines by the Brazilian Ministry of Health. Therefore, these individuals may not have recognized the improvement in QOL with the use of ART, regardless of the regimen used.

Our study presents as limitation the incompleteness of data from the control system of laboratory tests (Siscel), such as TCD4+ lymphocyte and VL count. To minimize this limitation, we considered the data for the three-month period before and after the second follow-up interview, resulting in a low percentage of missing data. As positive points, we cite the longitudinal design, and that data were collected with methodological rigor and in representative sites of PLWH of Belo Horizonte, the high number of the sample and the robustness of the final model obtained by multivariate analysis. Moreover, the WHOQOL-HIV bref is an instrument that evaluates QOL in the two weeks prior to the interview; thus, potential memory biases were minimized.

New studies in PLWH with longer follow-up time, using the WHOQOL-HIV bref, as well as other instruments, are necessary to measure the changes in QOL of these individuals and contribute to the direction of actions and interventions of health professionals that may contribute to increasing QOL in PLWH.

We concluded that, over time, PLWH initiating ART showed improvement in QOL. There is a need to monitor and provide health care support, especially for individuals with signs and symptoms of anxiety and depression and that report adverse reactions at the beginning of treatment.

Our study can contribute to the planning and direction of public actions and policies, as well as to identify modifiable factors that can increase the QOL of these individuals.

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