ABSTRACT

OBJECTIVE

To understand patients’ narratives about the barriers they faced in the diagnosis and treatment of multidrug-resistant tuberculosis, and their consequences in Rio de Janeiro State, Brazil.

METHODS

This is a qualitative cross-sectional study with non-probabilistic sampling. A theoretical saturation criterion was considered for composing the number of interviewees. Semi-structured interviews were conducted from August to December 2019 with 31 patients undergoing treatment for multidrug-resistant tuberculosis at an outpatient referral center in Rio de Janeiro. Data were transcribed and processed with the aid of the NVIVO software. Interviews were evaluated by content analysis, and their themes, cross-referenced with participants’ characterization data.

RESULTS

Our main findings were: a) participants show a high proportion of primary drug resistance, b) patients experience delays in the diagnosis and effective treatment of multidrug-resistant tuberculosis ; c) healthcare providers fail to value or seek the diagnosis of drug-resistant tuberculosis, thus beginning the inadequate treatment for drug-susceptible tuberculosis, d) primary health units show low report rates of active case-finding and contact monitoring, and e) patients show poor knowledge about the disease.

CONCLUSIONS

We need to improve referral systems, and access to the diagnosis and effective treatment of multidrug-resistant tuberculosis; conduct an active investigation of contacts; intensify the training of healthcare providers, in collaboration with medical and nursing schools, in both public and private systems; and promote campaigns to educate the population on tuberculosis signs and symptoms.

Patients; Tuberculosis, Multidrug-Resistant, diagnosis; Barriers to Access of Health Services; Health Knowledge, Attitudes, Practice; Qualitative Research

INTRODUCTION

Brazil appears on the World Health Organization (WHO) list of the 30 countries with the highest burden of tuberculosis and coinfection with the human immunodeficiency virus (HIV) in the world¹1. World Health Organization. Global Tuberculosis Report 2020. Geneva (CH): WHO; 2020 [cited 2020 Nov 13]. Available from: https://www.who.int/publications/i/item/9789240013131
https://www.who.int/publications/i/item/... . Although the country achieved a high level of treatment coverage (> 80%) in 2018, only 69.6% of new cases and 49.3% of retreatment ones were cured²2. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Doenças Condições Crônicas e Infecções Sexualmente Transmissíveis. Tuberculose 2020. Bol Epidemiol. 2020 [cited 2021 Mar 15];Nº Espec:1-39. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-turbeculose-2020
http://www.aids.gov.br/pt-br/pub/2020/bo... . The target is to successfully treat 85% of all tuberculosis cases¹1. World Health Organization. Global Tuberculosis Report 2020. Geneva (CH): WHO; 2020 [cited 2020 Nov 13]. Available from: https://www.who.int/publications/i/item/9789240013131
https://www.who.int/publications/i/item/... .

Rio de Janeiro State (RJ) stands out for having the highest tuberculosis mortality rate in Brazil, 4.3 per 100 thousand inhabitants in 2018²2. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Doenças Condições Crônicas e Infecções Sexualmente Transmissíveis. Tuberculose 2020. Bol Epidemiol. 2020 [cited 2021 Mar 15];Nº Espec:1-39. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-turbeculose-2020
http://www.aids.gov.br/pt-br/pub/2020/bo... , despite being one of its most developed states with a 0.761 HDI, the fourth highest in the country. Moreover, the municipality of Rio de Janeiro, the state capital and the second-most populous city in the country with more than 6.7 million inhabitants³3. Instituto Brasileiro de Geografia e Estatítica. Censo demográfico 2010: Características gerais da população, religião e pessoas com deficiência. Rio de Janeiro: IBGE; 2012 [cited 2021 Mar 10]. Available from: https://biblioteca.ibge.gov.br/visualizacao/periodicos/94/cd_2010_religiao_deficiencia.pdf
https://biblioteca.ibge.gov.br/visualiza... , stands out for having an incidence of 93.7 cases per 100 thousand inhabitants, the second highest among Brazilian capitals²2. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Doenças Condições Crônicas e Infecções Sexualmente Transmissíveis. Tuberculose 2020. Bol Epidemiol. 2020 [cited 2021 Mar 15];Nº Espec:1-39. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-turbeculose-2020
http://www.aids.gov.br/pt-br/pub/2020/bo... . Furthermore, 29% of all drug-resistant tuberculosis in Brazil occurs in Rio de Janeiro⁴4. Rudgard WE, Chagas NS, Gayoso R, Barreto ML, Boccia D, Smeeth L, et al. Uptake of governmental social protection and financial hardship during drug-resistant tuberculosis treatment in Rio de Janeiro, Brazil. Eur Respir J. 2018;51(3):1800274. https://doi.org/10.1183/13993003.00274-2018
https://doi.org/10.1183/13993003.00274-2... .

Despite the Brazilian Ministry of Health suggesting the Xpert MTB RIF (Xpert) test to detect rifampicin resistance in tuberculosis cases, since 2014⁵5. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Vigilância Epidemiológica. Manual de recomendações para o controle da tuberculose no Brasil. 2. ed atual. Brasília, DF; 2019 [cited 2021 Feb15]. Available from: https://bvsms.saude.gov.br/bvs/publicacoes/manual_recomendacoes_controle_tuberculose_brasil_2_ed.pdf
https://bvsms.saude.gov.br/bvs/publicaco... , in Rio de Janeiro, among new cases, only 42.5% had their clinical samples evaluated by the Xpert test²2. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Doenças Condições Crônicas e Infecções Sexualmente Transmissíveis. Tuberculose 2020. Bol Epidemiol. 2020 [cited 2021 Mar 15];Nº Espec:1-39. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-turbeculose-2020
http://www.aids.gov.br/pt-br/pub/2020/bo... . Among retreatment cases, only 56.8% underwent drug-susceptibility testing²2. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Doenças Condições Crônicas e Infecções Sexualmente Transmissíveis. Tuberculose 2020. Bol Epidemiol. 2020 [cited 2021 Mar 15];Nº Espec:1-39. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-turbeculose-2020
http://www.aids.gov.br/pt-br/pub/2020/bo... . These tests are essential for the early diagnosis and initiation of an effective treatment for all patients with drug-resistant tuberculosis and the subsequent prevention of its transmission⁶6. Nathavitharana RR, Lederer P, Tierney DB, Nardell E. Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2019;23(4):396-404. https://doi.org/10.5588/ijtld.18.0276
https://doi.org/10.5588/ijtld.18.0276... .

This scenario of high incidence, combined with a low percentage of cure and identification of drug resistance, contributes to increasing the cases of multidrug-resistant (MDR) tuberculosis (MDR-resistance to, at least, rifampicin and isoniazid). Moreover, delays in initiating the effective treatment of MDR tuberculosis result in the continuous transmission of the disease. The condition is aggravated by its longer, more expensive, more toxic, and less effective treatment than the drug-susceptible tuberculosis one⁷7. WHO consolidated guidelines on drug-resistant tuberculosis treatment. Geneva (CH): World Health Organization; 2019..

To overcome the existing gaps in diagnosis and the rapid initiation of an effective treatment of MDR tuberculosis, we need, first, to understand the barriers imposed to the patients in this process. Thus, understanding how MDR tuberculosis is diagnosed and how its treatment affects patients is essential for the surveillance of the disease and the design of a comprehensive control program⁸8. Shringarpure KS, Isaakidis P, Sagili KD, Baxi RK, Das M, Daftary A. “When treatment is more challenging than the disease”: a qualitative study of MDR-TB Patient Retention. PLoS One. 2016;11(3):e0150849. https://doi.org/10.1371/journal.pone.0150849
https://doi.org/10.1371/journal.pone.015... .

Thus, this study aims to understand patients’ narratives about how they adjusted their practices during treatment of MDR tuberculosis, assess the course they took to diagnosis, and identify the barriers to the diagnosis and treatment of MDR tuberculosis and their consequences in Rio de Janeiro State.

METHOD

This is a qualitative, cross-sectional and descriptive study with a non-probabilistic sampling. We applied The Consolidated Criteria for Qualitative Research Reports to guarantee the rigor of our study⁹9. Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19(6):349-57. https://doi.org/10.1093/intqhc/mzm042
https://doi.org/10.1093/intqhc/mzm042... .

In composing our patient sample, the criteria of relevance and sufficiency were respected to control for possible selection and/or confirmation biases¹⁰10. Shenton, AK. Strategies for ensuring trustworthiness in qualitative research projects. Educ Information. 2004;22(2):63-75. https://doi.org/10.3233/EFI-2004-22201
https://doi.org/10.3233/EFI-2004-22201... . Regarding the criterion of relevance, all patients referred to us after their medical consultations who were aged 18 years or older and under treatment for MDR tuberculosis or other mycobacterioses at an outpatient referral clinic (ORC) in Rio de Janeiro State were included. A patient with cognitive impairment, for whom the research instrument was unviable for the production of data, was excluded.

As for the sufficiency criterion, the sociodemographic profile of the patients was considered. Although the theoretical saturation criterion was applied to end the interviews, we decided to control them by selection bias, so as to achieve discursive diversity and provide opportunities for different voices to participate, based on the characteristics of the studied group (Table).

Our field research was conducted from August to December 2019. The researcher visited the ORC on alternate days to avoid the concentration of participants treated by the same doctor. As for the procedures for producing data, a meeting was scheduled to present the research to the ORC health team. It was previously agreed that, when going to a medical appointment, patients would be informed by their doctor about our study. After their appointments, the patients who were interested in participating were referred to a reserved office, in which they were shown the research and the informed consent form. Semi-structured interviews, lasting approximately one hour, were conducted via a previously tested script (our interview instrument), a digital recorder, and a field diary. The script was composed of questions aimed at characterizing the subjects and contextualizing their history with tuberculosis, their knowledge about the disease, and the experiences they lived during its diagnosis and treatment (Figure 1).

To end the interviews, theoretical saturation was used as a criterion to stop us from making new interviews. Data collection was considered saturated when no new element was found, and the addition of new information failed to change our understanding of the studied phenomenon¹³13. Fontanella BJB, Luchesi BM, Saidel MGB, Ricas J, Turato ER, Melo DG. [Sampling in qualitative research: a proposal for procedures to detect theoretical saturation]. Cad Saude Publica. 2011;27(2):389-94. Portuguese. https://doi.org/10.1590/s0102-311x2011000200020
https://doi.org/10.1590/s0102-311x201100... . During the field research, after conducting 31 interviews, no new thematic categories relevant to the scope of our study were found. The sufficiency criterion was also considered in estimating the total sample¹⁰10. Shenton, AK. Strategies for ensuring trustworthiness in qualitative research projects. Educ Information. 2004;22(2):63-75. https://doi.org/10.3233/EFI-2004-22201
https://doi.org/10.3233/EFI-2004-22201... ,¹²12. Minayo MCS. Análise qualitativa: teoria, passos e fidedignidade. Cienc Saude Coletiva. 2012;17(3):621-6. https://doi.org/10.1590/S1413-81232012000300007
https://doi.org/10.1590/S1413-8123201200... , in which the chance of including participants was considered based on their sociodemographic profile and on variables that would bring possible implications for the analysis of our results, i.e., gender, age group, and educational attainment¹⁴14. Narasimhan P, Wood J, MacIntyre CR, Mathai D. Risk factors for tuberculosis. Pulmonary Med. 2013;2013:828939. https://doi.org/10.1155/2013/828939
https://doi.org/10.1155/2013/828939... .

Appointments were routinely observed for aspects related to their structure and process. The outpatient clinic showed characteristics linked to a structure geared toward health treatment, aiming at the safety of its health team and patients, quality of care, and the guarantee of the functionality of the work: scheduling appointments, available staff, and reserved rooms. As for treatment, teams had doctors, nurses, and social service workers who sought support to help meet patients’ needs so treatment could have follow-ups.

Our analysis was conducted according to Bardin’s thematic content analysis¹⁵15. Bardin L. Análise de conteúdo. Lisboa (PT): Edições 70; 2011. The stages chosen were pre-analysis, exploration, data analysis, and interpretation. The software NVIVO version 12 was used to code the themes.

Due to the nature of the dependent variables, number (frequency) and medians (interquartile range [IQR] 25%–75%) were used to describe patients’ characteristics. For the stages of analysis and interpretation of the results of the narratives¹²12. Minayo MCS. Análise qualitativa: teoria, passos e fidedignidade. Cienc Saude Coletiva. 2012;17(3):621-6. https://doi.org/10.1590/S1413-81232012000300007
https://doi.org/10.1590/S1413-8123201200... ,¹⁶16. Riessman CK. Narrative analysis. London (Uk): Sage; 1993. (Qualitative Research Methods; Vol. 30)., a theoretical framework of reference was used, in which the relevance of starting from the consonant and dissonant trajectories patients experienced was considered to obtain the correct diagnosis of MDR tuberculosis.

To classify cases into primary or acquired resistance, previous treatments were checked in the Sistema de Informação de Tratamentos Especiais da Tuberculose (Site TB - Special Tuberculosis Treatment Information System) and the Sistema de Informação de Agravos de Notificação (Sinan - Notifiable Diseases Information System). Participants had an identification number and, to protect their confidentiality, only one investigator had access to the identified codes, and they prepared the anonymous database used in this study.

Ethical Considerations

The study protocol was approved by the research ethics committee of the Escola Nacional de Saúde Pública Sérgio Arouca - Fundação Oswaldo Cruz (CAAE 10126919.2.3001.5240).

RESULTS

Characteristics of the Participants

In total, 72 patients were in treatment for MDR tuberculosis at the ORC within the period of this study. Overall, we invited 32 of them; of these, 31 (97%) agreed to participate in the interviews, and we excluded one (3%) due to their cognitive limitations. Our sample had 16 (51.6%) males aged from 18 to 65 years old, with a median of 48 [27–56] years old. Regarding ethnicity, 18 (58.1%) declared themselves brown or black. Patients were at different stages of treatment, varying from the 1st to the 21st month of treatment.

Regarding marital status, 12 (38.7%) were single, and 15 (48.4%) lived with up to four people in the same household. In total, nine (29%) patients lived alone, 14 (45.2%) had between 8 and 11 years of schooling, and two, none.

As for employment status, 13 (43.3%) patients were unemployed, and 12 (40%) received some government social benefit. The average household monthly income ranged from USD 150 to USD 1,750 (median USD 317, standard deviation USD 329), and one interviewee had no income. We collected monetary values in Brazilian real (BRL) and converted them to 2019 United States dollar (USD) (BRL 4 = USD 1)¹⁷17. Trading Ecomonics. Brazil - Official Exchange Rate, LCU Per USD, Period Average [cited 2020 Dec 15]. Available from: https://tradingeconomics.com/brazil/official-exchange-rate-lcu-per-usd-period-average-wb-data.html
https://tradingeconomics.com/brazil/offi... .

In total, four (13%) patients worked in health care services (as either pharmacists, hospital assistants or hospital laundry assistants), and nine (29%) reported previous cases of active tuberculosis among household contacts.

Regarding clinical aspects, all cases were pulmonary, two (6.4%) patients had HIV coinfection, and seven (22.6%), diabetes mellitus. As for other comorbidities, 16 (51.6%) reported a history of smoking and 11 (35.5%), of alcohol abuse. Finally, we found a high proportion of primary resistance in our group, 20 (64.5%) (Table).

Thematic Analysis

From the framework of thematic analysis, we used three categories: participants’ course to diagnosis, their previous history with tuberculosis, and their knowledge about the disease (Figure 2).

1) Course to diagnosis

This thematic category encompassed reports on participants’ symptoms and various mishaps experienced until diagnosis. The main problems pointed out were wrong initial diagnoses (i.e., of another disease) and failure to detect MDR tuberculosis, which led patients to undergo treatment with a standard drug-susceptible tuberculosis regimen for several months before starting an effective treatment.

The most common symptoms reported were cough (51.6%), weight loss (41.9%), tiredness or weakness (38.7%), and fever (35.5%). In total, seven patients (22.6%) mentioned an incorrect diagnosis at their first visit to primary care: influenza, cold, pneumonia, or gastric ulcer.

In general, 16 patients (51.6%) reported initiating an incorrect treatment with a drug-susceptible tuberculosis regimen, 12 (64.5%), with a primary drug resistance one, and four (36.4%), with an acquired drug resistance one. Moreover, among them, 12 patients underwent the standard tuberculosis regimen for 6 months or more until a new diagnosis identified a therapeutic failure.

Even patients with previous tuberculosis treatments experienced a delay in initiating an effective one. One patient undergoing their third tuberculosis treatment had already suffered from drug resistance since their second treatment. Even so, healthcare providers prescribed a drug-susceptible tuberculosis treatment.

A patient, even reporting that her mother died of MDR tuberculosis, received treatment for drug-susceptible tuberculosis without performing a drug-susceptibility testing. After 6 months, the treatment was a failure.

In total, seven patients received a MDR tuberculosis diagnosis in a public emergency department, one, in the private sector, and one, in a public research center (Fiocruz) after several visits to private doctors.

2) Patients and their history with tuberculosis

In our sample, 20 (64.5%) patients mentioned primary drug resistance. Among them, 14 (70%) reported knowing someone from their family or work who had already had tuberculosis, and four were household contacts.

Patients who previously were household contacts of active tuberculosis cases mention no active case-finding. One of them, whose mother died of tuberculosis, said that she went to a primary health care unit and, even so, healthcare providers doubted that it could be tuberculosis.

Among 11 participants with acquired drug resistance, three abandoned previous treatment due to its large number of pills and injectable drugs or because they claimed they felt better and needed to go back to work.

Regarding current treatment, 21 (68%) had had injectable drugs applied three times a week at a primary health care unit. After the end of the intensive phase, patients received self-administered medications weekly. Six patients (19%) underwent supervised treatment at a primary health care unit, two (6.5%), at home, and in two (6.5%) cases, health agents left the medication at patients’ houses once a week.

Overall, 14 (70%) patients reported that they were hospitalized during treatment due to the severity of their clinical condition.

3) Knowledge about the disease

In total, 13 patients (41.9%) answered that tuberculosis was a disease transmitted by air or cough, five (16%) said that the MDR tuberculosis treatment was more difficult than the drug-susceptible tuberculosis one, and only two stated that tuberculosis could lead to death.

Another interviewee replied that it was an improperly recovered cold.

Only one patient with higher educational attainment provided a complete answer about the disease and drug resistance.

DISCUSSION

This qualitative study explores the barriers to the diagnosis and treatment of MDR tuberculosis. Our main findings are: a) participants show a high proportion of primary resistance; b) patients experience delays in the diagnosis and treatment of MDR tuberculosis; c) healthcare providers fail to value or seek the diagnosis of drug-resistant tuberculosis, thus beginning the inadequate treatment for drug-susceptible tuberculosis; d) primary health units show low report rates of active case-finding and contact monitoring; and e) patients show poor knowledge about the disease.

We were unconcerned with quantifying the delay in diagnosis, but we could observe, via the narratives, that most patients reported journeys with several comings and goings to primary health units until the beginning of the correct treatment, as described earlier. A study conducted in Rio de Janeiro showed that 79% of the interviewed patients with pulmonary tuberculosis had between two and five medical appointments before receiving the correct tuberculosis diagnosis. The median between symptom onset and diagnosis was 68 days¹⁸18. Machado ACFT, Steffen RE, Oxlade O, Menzies D, Kritski A, Trajman A. Fatores associados ao atraso no diagnóstico da tuberculose pulmonar no Estado do Rio de Janeiro. J Bras Pneumol 2011;37(4):512-20. https://doi.org/10.1590/S1806-37132011000400014
https://doi.org/10.1590/S1806-3713201100... .

Overall, seven patients reported having undergone treatment for other diseases before receiving the correct MDR tuberculosis diagnosis. This initial diagnosis of other diseases may be due to nonspecific symptoms at the time of assessment which could have suggested other conditions at first¹⁹19. Lienhardt C, Rowley J, Manneh K, Lahai G, Needham D, Milligan P, et al. Factors affecting time delay to treatment in a tuberculosis control programme in a sub-Saharan African country: the experience of The Gambia. Int J Tuberc Lung Dis. 2001;5(3):233-9..

In countries with a low tuberculosis burden, even if patients show classic tuberculosis symptoms, healthcare providers often fail to test for the disease at patients’ first visits²⁰20. Storla DG, Yimer S, Bjune GA. A systematic review of delay in the diagnosis and treatment of tuberculosis. BMC Public Health. 2008;8:15. https://doi.org/10.1186/1471-2458-8-15
https://doi.org/10.1186/1471-2458-8-15... . In countries with a high tuberculosis burden, such as Brazil, healthcare teams delaying the tuberculosis diagnosis may reflect poor knowledge of the disease, precarious technical performance, and/or the absence of effective diagnostic tools and follow-up routines, as tuberculosis program managers highlight²¹21. Sá LD; Barrêto AJR, Nogueira JA, Cunha FTS, Palha PF, Villa TCS. The discourse of health managers on aspects related to the delay in tuberculosis diagnosis Rev Esc Enferm USP. 2013;47(5):1170-7. https://doi.org/10.1590/S0080-623420130000500022
https://doi.org/10.1590/S0080-6234201300... . A correct diagnosis requires good training and available diagnostic resources. Once the specific diagnosis is available to the health team, tuberculosis treatment should usually start.

Identifying the sources of this delay is a critical issue for effective MDR tuberculosis control. The delay in diagnosing MDR tuberculosis is associated with a critical clinical presentation, in which diagnosis follows hospitalization due to the severity of the clinical condition, as we observed in seven patients in our study, and others described²²22. Almeida CPB, Skupien EC, Silva DR. Health care seeking behavior and patient delay in tuberculosis diagnosis. Cad Saude Publica. 2015;31(2):321-30. https://doi.org/10.1590/0102-311X00195413
https://doi.org/10.1590/0102-311X0019541... .

Treatment failures are the main hypothesis for the increase in drug-resistant cases but reports show the importance of primary transmission of MDR tuberculosis in recent years²²22. Almeida CPB, Skupien EC, Silva DR. Health care seeking behavior and patient delay in tuberculosis diagnosis. Cad Saude Publica. 2015;31(2):321-30. https://doi.org/10.1590/0102-311X00195413
https://doi.org/10.1590/0102-311X0019541... . The high proportion (64%) of primary MDR tuberculosis we found in our study corroborates this evidence. Even though Brazil is excluded as a high-burden MDR tuberculosis country, a study conducted in Rio de Janeiro State with extensively drug resistant tuberculosis patients reported that, between 2000 and 2016, 29,3% of patients were unable to report previous treatment for drug-resistant tuberculosis, suggesting the possibility of primary transmission²⁶26. Bhering M, Duarte R, Kritski A. Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016. PLoS One. 2019;14(11):e0218299. https://doi.org/10.1371/journal.pone.0218299
https://doi.org/10.1371/journal.pone.021... .

Despite the Ministry of Health recommending, since 2014, the use of Xpert as an initial diagnostic test to expedite the initiation of treatment and the detection of rifampicin resistance²⁷27. Ballestero JGA, Garcia JM, Bollela VR, Ruffino Netto A, Dalcomo MMP, Moncaio ACS, et al. Manejo da tuberculose multirresistente: elementos centrais das recomendações brasileiras. J Bras Pneumol. 2020;46(2):1-9. https://doi.org/10.36416/1806-3756/e20190290
https://doi.org/10.36416/1806-3756/e2019... , only 45% of patients who started tuberculosis treatment in 2019 in Rio de Janeiro had an Xpert laboratory confirmation²2. Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Doenças Condições Crônicas e Infecções Sexualmente Transmissíveis. Tuberculose 2020. Bol Epidemiol. 2020 [cited 2021 Mar 15];Nº Espec:1-39. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-turbeculose-2020
http://www.aids.gov.br/pt-br/pub/2020/bo... . The low coverage of Xpert use among patients diagnosed with tuberculosis may relate to the decision of local program managers to not maintain their equipment (since the federal government does not cover it) or the absence of effective plans to implement the use of Xpert due to three crucial areas: a) pre-analysis (adequate sample collection and transport to the laboratory), b) analysis (quality management in carrying out tests at laboratories), and c) post-analysis (release of results, data insertion in the laboratory system, and flow in obtaining the results by the health team)²⁸28. Albert H, Nathavitharana RR, Isaacs C, Pai M, Denkinger CM, Boehme CC. Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better? Eur Respir J. 2016;48(2):516-25. https://doi.org/10.1183/13993003.00543-2016
https://doi.org/10.1183/13993003.00543-2... .

Although the WHO recommends a ≥ 2-year monitoring of MDR tuberculosis contacts for the development of active tuberculosis, despite prophylaxis²⁹29. World Health Organization (WHO). Latent tuberculosis infection: updated and consolidated guidelines for programmatic management. Geneva (CH): WHO; 2018 [cited 2021 Feb 13]. Available from: https://www.who.int/tb/publications/2018/latent-tuberculosis-infection/en/
https://www.who.int/tb/publications/2018... , none of these patients received a diagnosis by active contact case-finding. A study comparing the prevalence of tuberculin skin test positivity in contacts with MDR- and drug-susceptible tuberculosis patients found that MDR tuberculosis contacts are twice as likely (OR = 2.0; 95%CI: 1, 3–3,2) to show a positive tuberculin test. Such results suggest the importance of at least examining household contacts if index cases show MDR tuberculosis³⁰30. Fox GJ, Anh NT, Nhung NV, Loi NT, Hoa NB, Ngoc Anh LT, et al. Latent tuberculous infection in household contacts of multidrug-resistant and newly diagnosed tuberculosis. Int J Tuberc Lung Dis. 2017;21(3):297-302. https://doi.org/10.5588/ijtld.16.0576
https://doi.org/10.5588/ijtld.16.0576... . Another study, conducted in high tuberculosis-burden countries, found that 12% of new tuberculosis cases were among household contacts of MDR tuberculosis cases. In Brazil, one of the countries enrolled in this research, the percentage was 17.6%³¹31. Gupta A, Swindells S, Kim S, Hughes MD, Naini L, Wu X, et al. Feasibility of identifying household contacts of rifampin-and multidrug-resistant tuberculosis cases at high risk of progression to tuberculosis disease. Clin Infect Dis. 2020;70(3):425-35. https://doi.org/10.1093/cid/ciz235
https://doi.org/10.1093/cid/ciz235... .

In this study, we observed participants’ poor knowledge about tuberculosis, especially regarding its symptoms, mode of transmission, and control. Other studies also report insufficient tuberculosis knowledge in the lay population³²32. Kigozi NG, Heunis JC, Engelbrecht MC, Rensburg APJ, Rensburg HCJD. Tuberculosis knowledge, attitudes and practices of patients at primary health care facilities in a South African metropolitan: research towards improved health education. BMC Public Health. 2017;17(1):795. https://doi.org/10.1186/s12889-017-4825-3
https://doi.org/10.1186/s12889-017-4825-... and its association with delays in tuberculosis diagnosis and treatment³³33. Asres M, Gedefaw M, Kahsay A, Weldu Y. Patients’ delay in seeking health care for tuberculosis diagnosis in East Gojjam Zone, Northwest Ethiopia. Am J Trop Med Hyg. 2017;96(5):1071-5. https://doi.org/10.4269/ajtmh.16-0892
https://doi.org/10.4269/ajtmh.16-0892... . For individuals, in addition to knowledge about the disease, important determinants, such as demographic factors, behaviors, beliefs, perceived barriers, skills, gender, education level, and socioeconomic status are associated with patients’ delay in seeking health care³⁴34. Li Y, Ehiri J, Tang S, Li D, Bian Y, Marshall C, et al. Factors associated with patient, and diagnostic delays in Chinese TB patients: a systematic review and meta-analysis. BMC Med. 2013;11:156. https://doi.org/10.1186/1741-7015-11-156
https://doi.org/10.1186/1741-7015-11-156... .

Poor knowledge about tuberculosis or misunderstandings about its transmission increase individuals’ vulnerability to it. In this scenario, we need to promote communication for the lay population in an attempt to reduce their susceptibility to health problems and adverse circumstances³⁵35. Lacerda SNB, Temoteo RCA, Figueiredo TMRM, Luna FDT, Sousa MAN, Abreu LV, et al. Individual and social vulnerabilities upon acquiring tuberculosis: a literature systematic review. Int Arch Med. 2014;7:35. https://doi.org/10.1186/1755-7682-7-35
https://doi.org/10.1186/1755-7682-7-35... . Tuberculosis programs should invest in broader awareness campaigns, going beyond limited educational practices, adding the distribution of pamphlets, and the setting up of posters and sporadic lectures³⁶36. Sá LD, Gomes ALC, Carmo JB, Souza KMJ, Palha PF, Alves RS, et al. Educação em saúde no controle da tuberculose: perspectiva de profissionais da estratégia Saúde da Família. Rev Eletron Enferm. 2013;15(1):103-11. https://doi.org/10.5216/ree.v15i1.15246
https://doi.org/10.5216/ree.v15i1.15246... .

Another important point is the continuous training of health teams to adopt the most appropriate triage for the diagnosis of MDR tuberculosis. Gaps in healthcare providers’ knowledge about the diagnosis and care of tuberculosis indicate that their continuous training, conducted by medical/nursing schools in collaboration with tuberculosis programs, is crucial to ensure that patients are adequately screened and diagnosed, and receive the correct treatment for tuberculosis, as the End TB Strategy highlights.

One of the limitations of this study is that we only interviewed patients undergoing treatment and, therefore, were unable to collect the opinions of those outside that service. Although our sample is unable to represent the barriers faced by all patients diagnosed and treated in Rio de Janeiro State, it may suggest a starting point for understanding the barriers patients face in accessing the diagnosis and effective treatment of MDR tuberculosis.

FINAL REMARKS

For the diagnosis of active tuberculosis, the public health system offers rapid molecular testing, sputum smear microscopy, culture for mycobacteria, and drug-susceptibility testing. Although the Xpert MTB/RIF molecular test has been available in the Brazilian public health system since 2014 for the diagnosis of active tuberculosis, we found that delays in the diagnosis of MDR tuberculosis was a factor that stood out in patients’ narratives.

The delay in the diagnosis of MDR tuberculosis leads patients to face unnecessary drug regimens which worsen their clinical condition and maintain the chain of transmission of the disease. Although Rio de Janeiro State has a laboratory network capable of diagnosing MDR tuberculosis, this has been insufficient to speed up the beginning of effective treatment. We need to improve referral systems, and access to early diagnosis and treatment; conduct an active search for contacts; intensify the training of healthcare providers, in collaboration with medical and nursing schools, and public and private systems; and promote campaigns on the signs and symptoms of tuberculosis for the lay population.

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