Frailty risk in community-dwelling elderly assisted in Primary Health Care and associated factors

Maria Eduarda Morais Lins Ana Paula de Oliveira Marques Marcia Carrera Campos Leal Renata Laíse de Moura Barros About the authors

ABSTRACT

This is a cross-sectional quantitative study whose objective was to estimate the risk of frailty in community-dwelling elderly and their associated factors. The sample consisted of 179 elderly people enrolled in Family Health Units in Recife (PE). Frailty was evaluated using the Clinical-Functional Vulnerability Index. Sociodemographic data, cognitive evaluation, level of physical activity and nutritional risk/malnutrition corresponded to the independent variables. The prevalence of frailty was equivalent to 13%. The independence test was significant according to gender, age, social security status, and in elderly with impaired cognitive ability and malnutrition. Regarding the development of frailty, people aged 71 to 80 years presented eight times more risk; in the age group of 81 to 90 years, the risk is nine times higher. Elderly people subject to malnutrition have twice the risk, and malnutrition increases by five times the frailty risk. The findings show that some associated factors are immutable, but malnutrition, for example, is susceptible to change, from management in Primary Health Care.

KEYWORDS
Primary Health Care; Frail elderly; Frailty

Introduction

Frailty in the elderly is a clinical state in which individuals present reduced strength, resistance and physiological function, becoming more vulnerable to functional decline, dependence and/or death, when exposed to a stressor11 Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397.. It is characterized by weight loss and sarcopenia, which leads to decreased muscle strength, fatigue, postural instability and reduced gait speed, increasing the risk of unfavorable evolution in the face of external aggressions and acute diseases22 Lana LD, Schneider RH. The frailty syndrome in elderly: a narrative review. Rev. bras. geriatr. gerontol. 2014; 17(3):673-680..

The prevalence of frailty increases with age, ranging from 4% to 59% among communitydwelling elderly33 Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community dwelling older persons: a systematic review. J. am. geriatr. soc. 2012; 60(8):1487-1492.. This condition was the main cause of mortality in this scenario, accounting for 27.9% of all deaths11 Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397.,33 Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community dwelling older persons: a systematic review. J. am. geriatr. soc. 2012; 60(8):1487-1492.. In contrast, it can be prevented and managed through the practice of physical activity, reduction of polypharmacy, caloric and protein support, and vitamin D replacement, interventions that can be performed in primary health care11 Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397..

Considering the definition of frailty and the clinical-functional classification suggested by Moraes et al.44 Moraes EN. Avaliação Multidimensional do Idoso: a consulta do idoso e os instrumentos de rastreio. 4. ed. Belo Horizonte: Folium; 2014., developed for public health purposes, the elderly can be classified into three strata: robust, at risk of fragilization and frail. The frail elder demands great costs for the health system, due to the accomplishment of procedures, not always necessary. At the same time, health promotion strategies and prevention measures require behavioral and lifestyle changes and are not useful for this group, whose components will not have time to benefit from long-term results55 Moraes EN. Idosos frágeis e a gestão integral da saúde centrada no idoso e na família. Rev. bras. geriatr. gerontol. 2017; 20(3):307-308..

Therefore, it is imperative to incorporate the concept of micro and macromanagement of health. The first is fundamental for the maintenance and/or recovery of the independence and autonomy of the elderly, while macromanagement refers to the sustainability of health care systems, public or private55 Moraes EN. Idosos frágeis e a gestão integral da saúde centrada no idoso e na família. Rev. bras. geriatr. gerontol. 2017; 20(3):307-308.. Considering the impacts of frailty occurrence and the potential for primary care intervention in the prevention and management of this condition, the present study aims to estimate the risk of frailty in community-dwelling elderly enrolled in Family Health Units (FHU) and their factors associated.

Material and methods

It is a quantitative, population-based and cross-sectional study. The study population consisted of elderly people enrolled in the FHU of Microregion 4.2 in the city of Recife (PE), with a total of 2,907 individuals.

Due to the variability in the prevalence of frailty evidenced in a systematic review22 Lana LD, Schneider RH. The frailty syndrome in elderly: a narrative review. Rev. bras. geriatr. gerontol. 2014; 17(3):673-680., there was no standardization of the criteria for identifying this condition, and due to the insufficiency of Brazilian studies with strong scientific evidence, carried out with elderly residents in the community, a pilot study was conducted with 30 elderly people to establish sample size. The equation was used to study the proportion in the finite population, considering the 95% confidence level, the expected proportion of 0.10, a margin of error of 0.043 and a total population of 2,907, and a sample equivalent to 179 elderly people was defined.

The inclusion criteria for participation in the study corresponded to the minimum age of 60 years and to be assigned to one of the FHU of the area. The elderly institutionalized at the time of data collection were excluded from the study. The selection of participants was done for convenience until the minimum sample size was reached, maintaining the proportionality criterion in the population of origin, in terms of distribution by sex and the elderly enrolled by FHU.

The dependent variable corresponded to the frailty, which was measured using the Clinical-Functional Vulnerability Index (IVCF-20), a screening instrument that classified the elderly as robust, at risk of frailty and frail, based on the evaluation of the main dimensions predictors: age, self-perception of health, activities of daily life, cognition, mood, mobility, communication and presence of multiple comorbidities66 Moraes EN, Carmo JA, Moraes FL, et al. Índice de Vulnerabilidade Clínico Funcional-20 (IVCF-20): reconhecimento rápido do idoso frágil. Rev. saúde pública. 2016; 50(81):1-9..

The independent variables were composed of socio-demographic data and cognitive impairment screening, evaluated by the Mini Mental State Examination (MMSE) proposed by Folstein et al.77 Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for reading the cognitive state of patients for the clinician. J. psychiatr. res. 1975; 12(3):189-198.; level of physical activity, verified by the short version of the International Physical Activity Questionnaire (IPAQ-version 8), validated for Brazilian elderly by Mazo and Benedetti88 Mazo GZ, Benedetti TRB. Adaptação do questionário internacional de atividade física para idosos. Rev. bras. cineantropom. desempenho hum. 2010; 12(6):480-484.; and nutritional risk/malnutrition, investigated through the Mini Nutritional Assessment (MAN), a reduced version presented by Kaiser et al.99 Kaiser MJ, Bauer JM, Ramsch C, et al. MNA-InternationalGroup. Validationof the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J. nutr. Health aging. 2009; 13(9):782-788..

The data collection was performed in a single stage, during a home visit or at the FHU at the time of service, through a face-to-face interview technique, using a semi-structured road map to record the information. In the presence of cognitive impairment, the caregiver answered the requested information, respecting the ethical precepts.

For analyzing the data, the Statistical Package for Social Science (SPSS) software, version 18, was used. In the evaluation of the socioeconomic and health profiles of the elderly, the percentage frequencies were calculated and the distributions of the evaluated factors were constructed.

The Poisson model with robust variance was applied to evaluate the frailty risk. For the permanence of the factors in the model, the significance level of 5% was considered, and in cases where the assumptions of the chisquare test were not satisfied, Fisher’s exact test was applied. Furthermore, the confidence intervals for the prevalence ratio and the Wald test were calculated in the comparison of the risks between the levels of the variables for the frailty.

The present research complies with the requirements of Resolution nº 466, of December 12, 2012, of the National Health Council, regarding the development of research with human beings, safeguarding the ethical principles of justice, beneficence and non-maleficence, with approval by the Research Ethics Committee of the Health Sciences Center of the Federal University of Pernambuco, opinion nº 1.401.767.

Results

Graph 1 presents the categorization of the elderly for frailty analysis from IVCF-20. Although the robust elderly prevailed around 49%, it is important to highlight that the unfavorable situations (frailty or risk of frailty), when aggregated, represent 51% of the sample.

Graph 1
Prevalence of frailty among the elderly in a microregion of Recife (PE), 2016

The distribution of frailty according to sociodemographic factors is described in table 1. The highest prevalence of frailty was found in the female elderly (17.4%), white (16.3%), aged between 81 to 90 years (47.4%), without partners (17.3%), living in households with five or more people (33.3%) and without schooling (15.4%). With regard to the social security status, it is verified that the highest prevalence of frailty is found among the elderly who accumulate retirement and allowance (33.3%).

Table 1
Distribution of frailty in the elderly, according to sociodemographic factors of a microregion of Recife (PE), 2016

It is observed that, although the group of the elderly between 60 and 70 years represents 63.7% of the sample, of the 24 elderly people considered fragile, only 3 (12.5%) are in this age group. This finding demonstrates the progressive nature of the prevalence of frailty, as the age advances. The independence test was significant for the factors: sex, age and social security status.

In table 2, there is the distribution of the frailty according to the health conditions evaluated. The highest prevalence of frailty was found in the group of elderly individuals with impaired cognitive ability (80%), classified as sedentary by IPAQ (48%), and suffers from malnutrition, according to MAN (66.7%). Furthermore, it is observed that the independence test was significant in all evaluated factors (p-value<0.05), indicating that health conditions are important factors in the determination of frailty.

Table 2
Distribution of frailty in the elderly, according to health conditions of a microregion of Recife (PE), 2016

Although the elderly with cognitive impairment represent only 5.6% of the total sample, 33.3% of those considered fragile are in this group. As for the sedentary, they represent 14% of the total participants, but represent 50% of the fragile elderly. Regarding nutritional assessment, adding the malnourished elderly and those at risk of malnutrition, these correspond to 38.5% of the sample and 75% of the frail elderly.

Table 3 shows the adjustment of the Poisson model for frailty. It can be verified that, according to the socio-demographic variables and health conditions, the age and nutritional classification according to the MAN showed a significant joint influence for frailty.

Table 3
Adjustment of the Poisson model for the frailty in the elderly of a microregion of Recife (PE), 2016

It is observed that the group aged between 71 and 80 years presents almost eight times more risk (OR = 8.88) of showing frailty than the elderly in the age group of 60 to 70 years. Among the elderly, those aged between 81 to 90 years, the chance of developing frailty was almost nine times higher (OR = 9.69) than that of the younger elderly group.

Regarding the nutritional status, the elderly who present risk for malnutrition have almost twice as much (OR = 2.83) for frailty, in relation to the individuals classified as well nourished, according to MAN criteria. In turn, malnutrition increases by almost five times (OR = 5.48) the risk for frailty.

Discussions

In line with data from the national and international literature, the present study has found a statistically significant association between being female and the occurrence of frailty1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.

11 Lenardt MH, Carneiro NHK, Binotto MA, et al. Relação entre fragilidade física e características sociodemográficas e clínicas de idosos. Esc. Anna Nery Rev. Enferm. 2015; 19(4):585-592.
-1212 Santos PHS, Fernandes MH, Casotti CA, et al. Perfil de fragilidade e fatores associados em idosos cadastrados em uma Unidade de Saúde da Família. Ciênc. Saúde Colet. 2015; 20(6):1917-1924.. Intrinsic issues make the woman more exposed to frailty, the main one being the greater propensity for sarcopenia, which is reflected in the loss of lean mass and muscle strength. Such a condition may be justified by lower levels of testosterone compared to men, and abrupt drop in hormone levels due to menopause1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.

11 Lenardt MH, Carneiro NHK, Binotto MA, et al. Relação entre fragilidade física e características sociodemográficas e clínicas de idosos. Esc. Anna Nery Rev. Enferm. 2015; 19(4):585-592.

12 Santos PHS, Fernandes MH, Casotti CA, et al. Perfil de fragilidade e fatores associados em idosos cadastrados em uma Unidade de Saúde da Família. Ciênc. Saúde Colet. 2015; 20(6):1917-1924.
-1313 Duarte MCS, Fernandes MGM, Rodrigues RAP, et al. Prevalência e fatores sociodemográficos associados à fragilidade em mulheres idosas. Rev. bras. enferm. 2013; 66(6):901-906.. In addition, as factors associated with frailty, older women experience a higher prevalence of chronic diseases, poorer nutritional conditions, financial dependence and lower schooling compared to men1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.

11 Lenardt MH, Carneiro NHK, Binotto MA, et al. Relação entre fragilidade física e características sociodemográficas e clínicas de idosos. Esc. Anna Nery Rev. Enferm. 2015; 19(4):585-592.

12 Santos PHS, Fernandes MH, Casotti CA, et al. Perfil de fragilidade e fatores associados em idosos cadastrados em uma Unidade de Saúde da Família. Ciênc. Saúde Colet. 2015; 20(6):1917-1924.
-1313 Duarte MCS, Fernandes MGM, Rodrigues RAP, et al. Prevalência e fatores sociodemográficos associados à fragilidade em mulheres idosas. Rev. bras. enferm. 2013; 66(6):901-906..

An association between the advancing age and the occurrence of frailty has been found, suggesting that this is a progressive condition1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.,1414 Fedarko NS. The biology of aging and frailty. Clin. geriatr. med. 2011; 27(1):27-37.

15 Bouillon K, Kivimaki M, Hamer M, et al. Measures of frailty in population-based studies: an overview. BMC geriatr. 2013; 13(1):13-64.
-1616 Brigola AG, Rossetti ES, Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement. Neuropsychol. 2015; 9(2):110-119.. The cellular oxidative stress accumulated with increasing age is one of the hypotheses that justify the higher prevalence of frailty in the more advanced age groups. Exogenous and endogenous agents can cause damage to DNA, inducing changes in cellular and systemic levels, culminating in several clinical conditions, including frailty1414 Fedarko NS. The biology of aging and frailty. Clin. geriatr. med. 2011; 27(1):27-37.. In addition, the cellular response is dysregulated for apoptosis, senescence and repair, resulting in alterations of the inflammatory system and failure in the repair of specific tissues, propitiating the development of frailty1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.,1414 Fedarko NS. The biology of aging and frailty. Clin. geriatr. med. 2011; 27(1):27-37..

As in the present investigation, an inverse association between cognitive function and frailty was found in a systematic review. The justification pointed out by the authors was the probable difficulty that elderly people with cognitive impairment present to eat, exercise and walk, which can lead to weight loss and impairment of motor functions, besides favoring the onset and progression of the syndrome1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168..

In a systematic review developed by Brigola et al.1616 Brigola AG, Rossetti ES, Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement. Neuropsychol. 2015; 9(2):110-119., frail elderly individuals present a higher prevalence of mild cognitive impairment and dementia. The simultaneous presence of these two conditions greatly increases the risk of mortality1616 Brigola AG, Rossetti ES, Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement. Neuropsychol. 2015; 9(2):110-119..

The literature illustrates an association between low educational level and economic conditions that are unfavorable to the increased occurrence of cognitive impairment. Such scenario may be related to the less obtaining of stimuli, as well as the difficulties of access to health care, to an adequate food consumption and to the practice of physical activity, culminating in a lower preservation of cognition in aging1616 Brigola AG, Rossetti ES, Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement. Neuropsychol. 2015; 9(2):110-119.,1717 Santos AA, Mansano-Schlosser TCS, Ceolim MF, et al. Sono, fragilidade e cognição: estudo multicêntrico com idosos brasileiros. Rev. Bras. Enferm. 2013; 66(3):351-357..

As for nutritional status, the present study found a significant statistical association between malnutrition and frailty, being in line with what is found in other scientific studies. Using MAN, Mello, Engstrom and Alves1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168., there is a 15-fold greater risk of frailty for malnourished elderly people or those at risk of malnutrition when compared to wellnourished elderly individuals11 Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397.,1010 Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.,1212 Santos PHS, Fernandes MH, Casotti CA, et al. Perfil de fragilidade e fatores associados em idosos cadastrados em uma Unidade de Saúde da Família. Ciênc. Saúde Colet. 2015; 20(6):1917-1924.,1616 Brigola AG, Rossetti ES, Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement. Neuropsychol. 2015; 9(2):110-119.,1818 Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype.,1919 Moretto MC, Alves RMA, Neri AL, et al. Relação entre estado nutricional e fragilidade em idosos brasileiros. Rev. Soc. Bras. Clín. Méd. 2012; 10(4):267-271.. Such researches indicate that nutritional extremes can anticipate the development of frailty and vulnerabilities, being considered markers for this clinical condition, since they are associated with loss of muscle mass. In addition, cachexia, dehydration and anorexia can also be attributed to weight loss and reduction of Body Mass Index (BMI).

To treat this condition, Morley et al.11 Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397. point out that nutritional supplementation is effective in reversing weight loss. More specifically, protein supplementation increases the proportion of lean mass and gain of muscle strength, thus, potentiating the effects of resisted physical exercises.

Regarding the practice of physical activity, according to what is stated in the literature, an association between sedentarism and frailty was found. Férrer et al.2020 Ferrer A, Formiga F, Sanz H, et al. Envejecimiento satisfactorio e Indicadores de fragilidad en los mayores de la comunidad. Estudio Octabaix. Aten. Primaria. 2014; 46(9):475-482. point out that the scarce practice of physical activity increases by seven times the risk for frailty. This finding can be explained by the fact that the reduction of the level of physical activity causes a decrease in the grip strength and slowness of gait - criteria for the diagnosis of frailty. At the same time, muscle weakness, fatigue, malnutrition and sarcopenia culminate in the reduction of physical activity practices by the elderly1212 Santos PHS, Fernandes MH, Casotti CA, et al. Perfil de fragilidade e fatores associados em idosos cadastrados em uma Unidade de Saúde da Família. Ciênc. Saúde Colet. 2015; 20(6):1917-1924..

In a study developed by Vieira et al.2121 Vieira RA, Guerra RO, Giacomin KC, et al. Prevalência de fragilidade e fatores associados em idosos comunitários de Belo Horizonte, Minas Gerais, Brasil: dados do estudo FIBRA. Cad. Saúde Pública. 2013; 29(8):1631-1643., the most frequently identified component of the phenotype was the level of reduced physical activity. Morley et al.11 Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397. emphasize that the practice of physical activity can be used to manage the frailty, since it improves several markers of this condition, such as gait speed, balance, stability when sitting up and when going up stairs, decreasing the risk of fall. In a review study, the practice of resistance exercises is related to endocrine and immunological alterations capable of minimizing the effects of sarcopenia, and, consequently, to the improvement of frailty2222 Camara LC, Bastos CC, Volpe EFT. Exercício resistido em idosos frágeis: uma revisão da literatura. Fisioter. mov. 2012; 25(2):435-443..

Taking into account micromanagement of the clinic, primary care represents a favorable scenario for the early identification of frailty, given the longitudinal follow-up of the people enrolled in the FHU. In parallel, it allows the development of health promotion activities, whether individual or collective, capable of acting against the factors associated with frailty, such as: sedentary lifestyle, malnutrition and cognitive impairment.

Such potentiality is due to its capacity for intersectoral articulation and multiprofessional composition of the teams, especially those assisted by the Family Health Support Centers (Nasf ). Articulation with the Health Academy Program, healthy eating groups, nutritional guidelines, collective activities for cognitive stimulation and sociability compose feasible examples, which do not require a large amount of resources.

Regarding the macromanagement aspect, it is recommended to include the frailty approach in the public health agenda, considering the adverse impact of this condition, from a clinical and social point of view, when not adequately treated. For this purpose, one of the paths consists in qualifying the professionals that deal with the elderly population, as well as in strengthening the health network to meet the demands inherent to the older segment.

Because it is a cross-sectional study, it is not feasible to infer a causal relationship. The variability found in the specialized literature, regarding the instrument for screening the condition of frailty in the elderly, suggests implications of comparability with the findings of the present study.

Conclusions

Researches related to the frailty in the elderly are emphasized as this is a growing area that has attracted the attention of several health professionals. The present study identified the prevalence of frailty in the elderly associated with socio-demographic factors, such as: age, sex and social security status, health-sedentary conditions, malnutrition and cognitive impairment.

Understanding the dimension of the elderly person and considering the frailty and its multifactorial aspects is to give visibility to this reality, promoting strategies and actions for promotion, prevention and tracking. IVCF-20 is favorable to the identification of frailty in the elderly, and it is recommended in primary care as a practical and rapid alternative in the context of Comprehensive Geriatric Assessment (AGA).

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References

  • 1
    Morley JE, Vellas B, Kan GAV, et al. Frailty Consensus: a call to action. J. Am. Med. Dir. Assoc. 2013; 14(6):392-397.
  • 2
    Lana LD, Schneider RH. The frailty syndrome in elderly: a narrative review. Rev. bras. geriatr. gerontol. 2014; 17(3):673-680.
  • 3
    Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community dwelling older persons: a systematic review. J. am. geriatr. soc. 2012; 60(8):1487-1492.
  • 4
    Moraes EN. Avaliação Multidimensional do Idoso: a consulta do idoso e os instrumentos de rastreio. 4. ed. Belo Horizonte: Folium; 2014.
  • 5
    Moraes EN. Idosos frágeis e a gestão integral da saúde centrada no idoso e na família. Rev. bras. geriatr. gerontol. 2017; 20(3):307-308.
  • 6
    Moraes EN, Carmo JA, Moraes FL, et al. Índice de Vulnerabilidade Clínico Funcional-20 (IVCF-20): reconhecimento rápido do idoso frágil. Rev. saúde pública. 2016; 50(81):1-9.
  • 7
    Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for reading the cognitive state of patients for the clinician. J. psychiatr. res. 1975; 12(3):189-198.
  • 8
    Mazo GZ, Benedetti TRB. Adaptação do questionário internacional de atividade física para idosos. Rev. bras. cineantropom. desempenho hum. 2010; 12(6):480-484.
  • 9
    Kaiser MJ, Bauer JM, Ramsch C, et al. MNA-InternationalGroup. Validationof the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J. nutr. Health aging. 2009; 13(9):782-788.
  • 10
    Mello AC, Engstrom EM, Alves LC. Fatores sociodemográficos e de saúde associados à fragilidade em idosos: uma revisão sistemática de literatura. Cad. Saúde Pública. 2014; 30(6): 1143-1168.
  • 11
    Lenardt MH, Carneiro NHK, Binotto MA, et al. Relação entre fragilidade física e características sociodemográficas e clínicas de idosos. Esc. Anna Nery Rev. Enferm. 2015; 19(4):585-592.
  • 12
    Santos PHS, Fernandes MH, Casotti CA, et al. Perfil de fragilidade e fatores associados em idosos cadastrados em uma Unidade de Saúde da Família. Ciênc. Saúde Colet. 2015; 20(6):1917-1924.
  • 13
    Duarte MCS, Fernandes MGM, Rodrigues RAP, et al. Prevalência e fatores sociodemográficos associados à fragilidade em mulheres idosas. Rev. bras. enferm. 2013; 66(6):901-906.
  • 14
    Fedarko NS. The biology of aging and frailty. Clin. geriatr. med. 2011; 27(1):27-37.
  • 15
    Bouillon K, Kivimaki M, Hamer M, et al. Measures of frailty in population-based studies: an overview. BMC geriatr. 2013; 13(1):13-64.
  • 16
    Brigola AG, Rossetti ES, Santos BR, et al. Relationship between cognition and frailty in elderly: A systematic review. Dement. Neuropsychol. 2015; 9(2):110-119.
  • 17
    Santos AA, Mansano-Schlosser TCS, Ceolim MF, et al. Sono, fragilidade e cognição: estudo multicêntrico com idosos brasileiros. Rev. Bras. Enferm. 2013; 66(3):351-357.
  • 18
    Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype.
  • 19
    Moretto MC, Alves RMA, Neri AL, et al. Relação entre estado nutricional e fragilidade em idosos brasileiros. Rev. Soc. Bras. Clín. Méd. 2012; 10(4):267-271.
  • 20
    Ferrer A, Formiga F, Sanz H, et al. Envejecimiento satisfactorio e Indicadores de fragilidad en los mayores de la comunidad. Estudio Octabaix. Aten. Primaria. 2014; 46(9):475-482.
  • 21
    Vieira RA, Guerra RO, Giacomin KC, et al. Prevalência de fragilidade e fatores associados em idosos comunitários de Belo Horizonte, Minas Gerais, Brasil: dados do estudo FIBRA. Cad. Saúde Pública. 2013; 29(8):1631-1643.
  • 22
    Camara LC, Bastos CC, Volpe EFT. Exercício resistido em idosos frágeis: uma revisão da literatura. Fisioter. mov. 2012; 25(2):435-443.

History

  • Received
    21 Nov 2018
  • Accepted
    18 Mar 2019
Centro Brasileiro de Estudos de Saúde RJ - Brazil
E-mail: revista@saudeemdebate.org.br