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h
S
119.366 783.333 m
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h
S
125.657 783.18 1.116 4.635 re
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127.889 783.18 m
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S
135.062 783.18 m
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h
S
140.57 783.18 1.152 6.282 re
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144.359 783.18 m
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S
150.38 783.18 m
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h
S
157.697 786.645 m
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159.83 785.187 m
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h
S
161.909 783.18 m
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h
S
166.868 786.645 m
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169.001 785.187 m
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h
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172.106 785.547 m
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171.161 781.47 m
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S
179.261 784.287 m
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176.867 785.898 m
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188.369 785.898 m
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197 787.815 m
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462.408 785.574 m
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464.766 783.18 m
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467.646 785.484 m
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h
S
471.38 783.18 m
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h
S
474.62 783.18 1.116 4.635 re
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S
476.96 783.18 1.116 6.75 re
S
481.64 783.18 m
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482.792 788.58 m
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S
489.704 783.18 m
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h
S
494.816 783.18 1.116 4.635 re
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S
497.021 783.18 m
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S
504.023 783.18 m
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h
S
514.4 784.287 m
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512.006 785.898 m
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h
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515.66 783.18 1.116 6.75 re
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523.58 784.287 m
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h
521.186 785.898 m
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532.661 785.187 m
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h
S
534.848 783.18 1.116 6.75 re
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537.206 783.18 1.08 1.17 re
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( is being considered)Tj
/Span<>> BDC
( )Tj
EMC
10.109 0 Td
[(Capability )100(to )100(resolve )100(indeterminate )100(r)18(apid )100(HIV)47(ab)]TJ
/Span<>> BDC
( )Tj
EMC
19.444 0 Td
[(FBC )100(and )100(differential)]TJ
ET
BT
/T1_1 1 Tf
9 0 0 9 62.3622 691.5479 Tm
(for use\))Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 87.4806 695.5449 Tm
(c)Tj
ET
BT
/T1_1 1 Tf
/Span<>> BDC
9 0 0 9 89.422 685.8879 Tm
( )Tj
EMC
ET
BT
/T1_1 1 Tf
9 0 0 9 224.6929 691.5479 Tm
(test by second serological method)Tj
/Span<>> BDC
12.318 -0.629 Td
( )Tj
EMC
7.127 0 Td
(CD4+ cell coun)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 450.2451 685.8879 Tm
(t)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 453.6471 689.8849 Tm
(d)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 62.3622 675.6786 Tm
(Pregnancy testing)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 120.8075 679.6756 Tm
(e)Tj
ET
BT
/T1_1 1 Tf
/Span<>> BDC
9 0 0 9 123.0427 670.0186 Tm
( )Tj
EMC
ET
BT
/T1_1 1 Tf
9 0 0 9 224.6929 675.6786 Tm
(FB)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 232.8559 675.6786 Tm
(C)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 238.5887 679.6756 Tm
(f)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 239.9476 675.6786 Tm
( and differential)Tj
/Span<>> BDC
5.758 -0.629 Td
( )Tj
EMC
11.992 0 Td
(Full serum chemistries \(including but not)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 531.8739 670.0186 Tm
( )Tj
-52.168 -1.133 Td
[(Referr)18(al for sputum smear for tuberculosis)]TJ
/Span<>> BDC
( )Tj
EMC
18.037 0 Td
(CD4+ cell coun)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 275.2451 659.8186 Tm
(t)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 278.6471 663.8156 Tm
(d)Tj
/Span<>> BDC
9 0 0 9 281.0764 659.8186 Tm
( )Tj
EMC
13.18 0 Td
[(restricted to electrolytes)37(,)37( renal function,)]TJ
ET
BT
/T1_1 1 Tf
9 0 0 9 528.2021 659.8186 Tm
( )Tj
-51.76 -1.133 Td
[(\(if microscopy not av)18(ailable\))]TJ
/Span<>> BDC
( )Tj
EMC
ET
BT
/T1_1 1 Tf
9 0 0 9 224.6929 643.9386 Tm
(AL)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 232.3789 643.9386 Tm
(T)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 237.1129 647.9356 Tm
(g)Tj
/Span<>> BDC
9 0 0 9 239.5422 649.6186 Tm
( )Tj
EMC
17.795 0 Td
[(liver enzymes)37(,)37( lipids\))]TJ
ET
BT
/T1_1 1 Tf
/Span<>> BDC
9 0 0 9 62.3622 633.7493 Tm
( )Tj
EMC
ET
BT
/T1_1 1 Tf
/Span<>> BDC
9 0 0 9 224.6929 633.7493 Tm
( )Tj
EMC
ET
BT
/T1_1 1 Tf
9 0 0 9 399.6929 633.7493 Tm
(Pregnancy testin)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 453.5212 633.7493 Tm
(g)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 458.4082 637.7463 Tm
(e )Tj
ET
BT
/T1_1 1 Tf
/Span<>> BDC
9 0 0 9 62.3622 617.88 Tm
( )Tj
EMC
ET
BT
/T1_1 1 Tf
9 0 0 9 224.6929 627.863 Tm
(Pregnancy testin)Tj
ET
BT
/T1_1 1 Tf
9 0 0 9 278.5212 627.863 Tm
(g)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 283.1382 631.86 Tm
(e)Tj
/Span<>> BDC
9 0 0 9 285.3734 617.88 Tm
( )Tj
EMC
12.702 0 Td
(Sputum smear for tuberculosis)Tj
ET
BT
/T1_1 1 Tf
/Span<>> BDC
9 0 0 9 62.3622 602.2107 Tm
( )Tj
EMC
ET
BT
/T1_1 1 Tf
9 0 0 9 224.6929 612.1037 Tm
(Sputum smear for tuberculosis)Tj
/Span<>> BDC
11.003 -1.099 Td
( )Tj
EMC
8.442 0 Td
[(Vir)18(al load testin)]TJ
ET
BT
/T1_1 1 Tf
9 0 0 9 450.875 602.2107 Tm
(g)Tj
ET
BT
/T1_1 1 Tf
5.247 0 0 5.247 455.492 606.2077 Tm
(h)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 62.3622 583.7068 Tm
[(S)6(o)6(u)6(r)6(c)6(e)6(:)43( )-105(W)24(o)6(r)6(l)6(d)6( )6(H)6(e)6(a)6(l)6(t)6(h)6( )6(O)6(r)6(g)6(a)6(n)6(i)6(z)6(a)6(t)6(i)6(o)6(n)6(.)43( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 165.5849 583.7068 Tm
[(S)6(c)6(a)6(l)6(i)6(n)6(g)6( )6(u)6(p)6( )61(A)6(n)6(t)6(i)6(r)6(e)6(t)6(r)6(o)6(v)6(i)6(r)24(a)6(l)6( )61(T)43(h)6(e)6(r)24(a)6(p)6(y)6( )6(i)6(n)6( )6(R)6(e)6(s)6(o)6(u)6(r)6(c)6(e)6(-)6(L)6(i)6(m)6(i)6(t)6(e)6(d)6( )6(S)6(e)6(t)6(t)6(i)6(n)6(g)6(s)6(:)43( )61(T)80(r)6(e)6(a)6(t)6(m)6(e)6(n)6(t)6( )6(G)6(u)6(i)6(d)6(e)6(l)6(i)6(n)6(e)6(s)6( )6(f)6(o)6(r)6( )6(a)6( )6(P)6(u)6(b)6(l)6(i)6(c)6( )6(H)6(e)6(a)6(l)6(t)6(h)6( )61(A)6(p)6(p)6(r)6(o)6(a)6(c)6(h)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 486.8766 583.7068 Tm
[(.)43( )6(2)6(0)6(0)6(3)6( )6(R)6(e)6(v)6(i)6(s)6(i)6(o)6(n)6(.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 62.3622 573.7068 Tm
[(Genev)18(a:)37( )-55(WHO;)37( 2004.)37( )]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 562.7566 Tm
(a)Tj
8 0 0 8 64.4329 560.0926 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.414 0 Td
[(T)37(his table only considers testing that is desir)18(able for proper monitoring of antiretrovir)18(al to)9(xicity)45(,)37( ef\037cacy and two prominent concomitant conditions \(pregnancy )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 67.748 550.0926 Tm
[(and tuberculosis\).)37( It is not meant to be comprehensive with respect to other diagnostic ca\
pabilities that are important in the comprehensive care of HIV)38(-infected )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 67.748 540.0926 Tm
[(persons)37(.)37( Other resources are av)18(ailable for these consider)18(ations)37(.)]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 531.9062 Tm
(b)Tj
8 0 0 8 64.5216 529.2422 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.403 0 Td
[(ZDV = zidovudine)37(.)]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 521.0558 Tm
(c)Tj
8 0 0 8 64.0878 518.3918 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.458 0 Td
[(In primary health care centers where labor)18(atory facilities are not av)18(ailable or in the absence of labor)18(atory-based haemoglobinometry)45(,)37( the )55(WHO haemoglobin )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 67.748 508.3918 Tm
[(colour scale can be used together with clinical signs to ev)18(aluate anaemia \(more information av)18(ailable from:)37( www)45(.who)37(.int/bct/\).)37( )]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 500.2054 Tm
(d)Tj
8 0 0 8 64.5216 497.5414 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.403 0 Td
[(Scale-up of antiretrovir)18(al treatment under the )37(\2233 by 5\224)37( plan does not require uniform CD4 \(cluster designation 4\) testing av)18(ailability but,)37( because of the v)18(alue of )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 67.748 487.5414 Tm
[(this test in patient monitoring,)37( )55(WHO will work with Member States to mak)37(e this a reality)45(.)]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 479.355 Tm
(e)Tj
8 0 0 8 64.349 476.691 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.425 0 Td
[(EFV = efavirenz.)37( EFV should not be given to women with childbearing potential unless ade\
quate contr)19(aception is assured,)37( nor to women in the \037rst trimester of )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 67.748 466.691 Tm
[(pregnancy)45(.)37( )]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 458.5046 Tm
(f)Tj
8 0 0 8 63.5701 455.8406 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.522 0 Td
(FBC = full blood count.)Tj
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 447.6542 Tm
(g)Tj
8 0 0 8 64.5216 444.9902 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.403 0 Td
[(AL)91(T = amino alanine tr)18(ansfer)18(ase)37(.)]TJ
ET
BT
/T1_1 1 Tf
4.664 0 0 4.664 62.3622 436.8038 Tm
(h)Tj
8 0 0 8 64.5216 434.1398 Tm
( )Tj
/Span<>> BDC
( )Tj
EMC
0.403 0 Td
[(Because of the cost and technical issues associated with vir)18(al load testing,)37( this test is not currently recommended as part of the present treatment\
guidelines)37(.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 67.748 424.1398 Tm
[(H)6(o)6(w)6(e)6(v)6(e)6(r)97(,)43( )6(i)6(t)6( )6(i)6(s)6( )6(h)6(o)6(p)6(e)6(d)6( )6(t)6(h)6(a)6(t)6( )6(m)6(o)6(r)6(e)6( )6(c)6(o)6(s)6(t)6(-)6(e)6(f)6(f)6(e)6(c)6(t)6(i)6(v)6(e)6( )6(t)6(e)6(c)6(h)6(n)6(o)6(l)6(o)6(g)6(i)6(e)6(s)6( )6(w)6(i)6(l)6(l)6( )6(a)6(l)6(l)6(o)6(w)6( )6(r)6(e)6(g)6(i)6(o)6(n)6(a)6(l)6( )6(r)6(e)6(f)6(e)6(r)6(r)24(a)6(l)6( )6(c)6(e)6(n)6(t)6(e)6(r)6(s)6( )6(t)6(o)6( )6(a)6(c)6(q)6(u)6(i)6(r)6(e)6( )6(t)6(h)6(i)6(s)6( )6(c)6(a)6(p)6(a)6(b)6(i)6(l)6(i)6(t)6(y)6( )6(g)6(i)6(v)6(e)6(n)6( )6(i)6(t)6(s)6( )6(u)6(t)6(i)6(l)6(i)6(t)6(y)6( )6(i)6(n)6( )6(a)6(s)6(s)6(e)6(s)6(s)6(i)6(n)6(g)6( )6(t)6(r)6(e)6(a)6(t)6(m)6(e)6(n)6(t)6( )6(f)6(a)6(i)6(l)6(u)6(r)6(e)43(.)]TJ
/T1_2 1 Tf
10 0 0 10 56.6929 394.1927 Tm
[(f)-21(o)-21(r)-21( )-146(a)-21(l)-21(l)-21( )-146(H)-21(I)-21(V)]TJ
/Span<>> BDC
4.746 0 Td
(-)Tj
EMC
0.341 0 Td
[(i)-21(n)-21(f)-21(e)-21(c)-21(t)-21(e)-21(d)-21( )-146(i)-21(n)-21(d)-21(i)-21(v)-21(i)-21(d)-21(u)-21(a)-21(l)-21(s)-21(;)-21( )-146(b)-21(e)]TJ
/Span<>> BDC
9.711 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 394.1927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 382.7927 Tm
[(c)2(a)2(u)2(s)2(e)2( )64(t)2(h)2(e)2( )64(r)12(e)2(l)2(a)2(t)2(i)2(o)2(n)2(s)2(h)2(i)2(p)2( )64(b)2(e)2(t)2(w)8(e)2(e)2(n)2( )64(C)2(D)2(4)2( )64(c)2(e)2(l)2(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 371.3927 Tm
[(c)10(o)10(u)10(n)10(t)10( )36(a)10(n)10(d)10( )36(H)10(I)10(V)10( )36(R)10(N)10(A)10( )36(h)10(a)10(s)10( )36(b)10(e)10(e)10(n)10( )36(s)10(h)10(o)22(w)10(n)10( )36(t)10(o )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 359.9927 Tm
[(r)4(e)-6(\035)-6(e)-6(c)-6(t)-6( )-131(d)-6(i)-6(s)-6(e)-6(a)-6(s)-6(e)-6( )-131(p)-6(ro)-6(g)-6(r)4(e)-6(s)-6(s)-6(i)-6(o)-6(n)-6( )-131(r)-6(a)-6(t)-6(h)-6(e)-6(r)-6( )-131(t)-6(h)-6(a)-6(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 348.5927 Tm
[(test )-79(per)-8(formance,)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 124.4388 351.9227 Tm
(1)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 127.3538 348.5927 Tm
[( )-79(w)6(e )-79(ex)12(cluded )-79(studies )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 337.1927 Tm
[(solely )-44(on )-44(the )-44(association )-44(betw)6(een )-44(these )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 325.7927 Tm
[(two measur)10(es.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 73.7007 314.3927 Tm
[(N)30(either )-92(use )-92(nor )-92(type )-92(of )-92(tr)10(eatment )]TJ
-1.701 -1.14 Td
[(\(e.g. )-72(antir)10(etr)6(o)16(viral )-72(therapy )-72(or )-72(oppor)-8(tu)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 302.9927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 291.5927 Tm
[(nistic )52(infection )52(pr)6(ophylaxis\) )52(was )52(used )52(as )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 280.1927 Tm
[(inclusion or ex)12(clusion criteria.)]TJ
ET
/CS0 cs 1 scn
/GS1 gs
BT
/T1_0 1 Tf
11 0 0 11 56.6929 256.6927 Tm
[(Data extr)10(action)]TJ
ET
0 0 0 1 k
/GS0 gs
BT
/T1_2 1 Tf
10 0 0 10 56.6929 245.1927 Tm
[(T)113(o)-7( )-132(i)-7(n)-7(t)-7(e)-7(g)-7(r)-7(a)-7(t)-7(e)-7( )-133(a)-7(v)-1(a)-7(i)-7(l)-7(a)-7(b)-7(l)-7(e)-7( )-132(i)-7(n)-7(f)-7(o)-7(r)-7(m)-7(a)-7(t)-7(i)-7(o)-7(n)-7( )-132(o)-7(n )]TJ
0 -1.15 TD
[(d)4(i)4(a)4(g)4(n)4(o)4(s)4(t)4(i)4(c)4( )27(t)4(e)4(s)4(t)4(s)4( )27(f)4(o)4(r)4( )27(m)4(o)4(n)4(i)4(t)4(o)4(r)4(i)4(n)4(g)4( )27(H)4(I)4(V)4( )27(p)4(a)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 233.6927 Tm
(-)Tj
-14.798 -1.15 Td
[(tients )-9(into )-10(a )-9(format )-9(useful )-9(for )-10(decision)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 207.874 222.1927 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 210.6927 Tm
[(m)-22(a)-23(k)-22(i)-23(n)-22(g)-23(,)-22( )-148(w)-16(e)-23( )-147(c)-23(l)-22(a)-23(s)-22(s)-23(i)-22(\037)-22(e)-23(d)-22( )-148(d)-22(i)-23(a)-22(g)-22(n)-23(o)-22(s)-23(t)-22(i)-23(c)-22( )-148(t)-22(e)-23(s)-22(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 199.1927 Tm
[(information )-2(fr)6(om )-2(each )-2(study )-2(into )-2(thr)10(ee )]TJ
0 -1.14 TD
[(c)4(a)4(t)4(e)4(g)4(o)4(r)4(i)4(e)4(s)4(:)4( )-64(\()4(1)4(\))4( )-64(c)4(l)4(i)4(n)4(i)4(c)4(a)4(l)4( )-64(i)4(n)4(f)4(o)4(r)4(m)4(a)4(t)4(i)4(o)4(n)4(,)4( )-64(d)4(e)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 187.7927 Tm
(-)Tj
-14.798 -1.14 Td
[(\037)-10(n)-10(e)-10(d)-10( )-135(a)-10(s)-10( )-135(n)-10(o)-10(n)]TJ
/Span<>> BDC
5.075 0 Td
(-)Tj
EMC
0.33 0 Td
[(l)-10(a)-10(b)-10(o)-10(r)-10(a)-10(t)-10(o)-10(r)-28(y)]TJ
/Span<>> BDC
4.054 0 Td
(-)Tj
EMC
0.33 0 Td
[(b)-10(a)-10(s)-10(e)-10(d)-10( )-135(p)-10(a)-10(t)-10(i)-10(e)-10(n)-10(t )]TJ
-9.788 -1.14 Td
[(information )-116(including )-116(physical )-116(exami)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 164.9927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 153.5927 Tm
[(n)-7(a)-7(t)-7(i)-7(o)-7(n)-7(,)-7( )-132(c)-7(l)-7(i)-7(n)-7(i)-7(c)-7(a)-7(l)-7( )-132(s)-7(t)-7(a)-7(g)-7(i)-7(n)-7(g)-7( )-132(s)-7(y)-7(s)-7(t)-7(e)-7(m)-7( )-132(a)-7(n)-7(d)-7(/)-7(o)-7(r )]TJ
T*
[(clinical )21(histor)-18(y; )21(\(2\) )21(immunologic )21(infor)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 142.1927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 130.7927 Tm
[(m)10(a)10(t)10(i)10(o)10(n)10(,)10( )48(d)10(e)10(\037)10(n)10(e)10(d)10( )48(a)10(s)10( )48(i)10(n)10(f)10(o)10(r)10(m)10(a)10(t)10(i)10(o)10(n)10( )48(o)10(b)10(t)10(a)10(i)10(n)10(e)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 119.3927 Tm
[(f)12(r)18(o)12(m)12( )43(d)12(i)12(a)12(g)12(n)12(o)12(s)12(t)12(i)12(c)12( )43(l)12(a)12(b)12(o)12(r)12(a)12(t)12(o)12(r)-6(y)12( )43(t)12(e)12(s)12(t)12(s)12( )43(a)12(s)12(s)12(e)12(s)12(s)12(i)12(n)12(g )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 107.9927 Tm
[(i)8(m)8(m)8(u)8(n)8(o)8(l)8(o)8(g)8(i)8(c)8( )70(f)8(u)8(n)8(c)8(t)8(i)8(o)8(n)8(;)8( )70(a)8(n)8(d)8( )70(\()8(3)8(\))8( )70(v)8(i)8(r)14(o)8(l)8(o)8(g)8(i)8(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 96.5927 Tm
[(i)-26(n)-26(f)-26(o)-26(r)-26(m)-26(a)-26(t)-26(i)-26(o)-26(n)-26(,)-26( )-151(d)-26(e)-26(\037)-26(n)-26(e)-26(d)-26( )-151(a)-26(s)-26( )-151(i)-26(n)-26(f)-26(o)-26(r)-26(m)-26(a)-26(t)-26(i)-26(o)-26(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 85.1927 Tm
[(o)11(b)11(t)11(a)11(i)11(n)11(e)11(d)11( )73(f)11(r)17(o)11(m)11( )73(d)11(i)11(a)11(g)11(n)11(o)11(s)11(t)11(i)11(c)11( )73(l)11(a)11(b)11(o)11(r)11(a)11(t)11(o)11(r)-7(y)11( )73(t)11(e)11(s)11(t)11(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 73.7927 Tm
[(a)5(s)6(s)5(e)5(s)5(s)5(i)6(n)5(g)5( )68(v)6(i)5(r)11(o)5(l)6(o)5(g)5(i)6(c)5( )68(s)5(t)5(a)6(t)5(u)5(s)6(.)5( )83(W)83(e)5( )68(c)6(h)5(o)5(s)5(e)6( )68(t)5(h)5(e)6(s)5(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 62.3927 Tm
[(c)-7(a)-7(t)-7(e)-7(g)-7(o)-7(r)-7(i)-7(e)-7(s)-7( )-132(t)-7(o)-7( )-132(r)3(e)-7(\035)-7(e)-7(c)-7(t)-7( )-132(c)-7(u)-7(r)-7(r)3(e)-7(n)-7(t)-7(,)-7( )-132(c)-7(l)-7(i)-7(n)-7(i)-7(c)-7(a)-7(l)-7(l)-7(y )]TJ
16.535 33.18 Td
[(a)1(n)1(d)1( )64(p)1(o)1(l)1(i)1(c)1(y)1( )64(r)11(e)1(l)1(e)1(v)7(a)1(n)1(t)1( )64(a)1(p)1(p)1(r)7(o)1(a)1(c)1(h)1(e)1(s)1( )64(t)1(o)1( )64(m)1(o)1(n)1(i)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 394.1927 Tm
(-)Tj
-14.798 -1.185 Td
(toring HIV)Tj
/Span<>> BDC
4.363 0 Td
(-)Tj
EMC
(infected individuals.)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 239.0551 370.4927 Tm
[(W)78(e )24(r)10(ecor)14(ded )24(data )24(fr)6(om )24(studies )24(that )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 358.6427 Tm
[(met )-88(the )-89(inclusion )-89(criteria, )-88(but )-88(did )-88(not )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 373.2283 358.6427 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 346.7927 Tm
[(v)-42(i)-42(o)-42(l)-42(a)-42(t)-42(e)-42( )-167(t)-42(h)-42(e)-42( )-167(e)-42(x)-30(c)-42(l)-42(u)-42(s)-42(i)-42(o)-42(n)-42( )-167(c)-42(r)-42(i)-42(t)-42(e)-42(r)-42(i)-42(a)-42(.)-42( )-167(D)-36(a)-42(t)-42(a )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 334.9427 Tm
[(i)-9(n)-9(c)-9(l)-9(u)-9(d)-9(e)-9(d)-9( )-134(n)-9(u)-9(m)-9(b)-9(e)-9(r)-9( )-134(a)-9( )-134(o)-9(f)-9( )-134(s)-9(t)-9(u)-9(d)-9(y)-9( )-134(s)-9(u)-9(b)-9(j)-9(e)-9(c)-9(t)-9(s)-9(, )]TJ
0 -1.185 TD
[(m)4(e)4(a)4(n)4( )-21(a)4(g)4(e)4(,)4( )-21(g)4(e)4(n)4(d)4(e)4(r)4( )-21(d)4(i)4(s)4(t)4(r)4(i)4(b)4(u)4(t)4(i)4(o)4(n)4(,)4( )-21(s)4(e)4(n)4(s)4(i)4(t)4(i)4(v)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 323.0927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 311.2427 Tm
[(ity )24(and/or )24(speci\037city )24(of )24(diagnostic )24(tests, )]TJ
T*
[(c)1(o)1(r)1(r)11(e)1(l)1(a)1(t)1(i)1(o)1(n)1( )-124(m)1(e)1(a)1(s)1(u)1(r)11(e)1(s)1(,)1( )-124(d)1(e)1(m)1(o)1(g)1(r)1(a)1(p)1(h)1(i)1(c)1( )-124(i)1(n)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 299.3926 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 287.5427 Tm
[(formation, )-76(tr)10(eatment )-76(type, )-76(pr)10(esence )-76(of )]TJ
T*
[(c)8(o)]TJ
/Span<>> BDC
0.87 0 Td
(-)Tj
EMC
0.312 0 Td
[(i)8(n)8(f)8(e)8(c)8(t)8(i)8(o)8(n)8(,)8( )45(H)8(I)8(V)]TJ
/Span<>> BDC
5.554 0 Td
(-)Tj
EMC
0.312 0 Td
[(1)8( )45(o)8(r)8( )45(H)8(I)8(V)]TJ
/Span<>> BDC
3.44 0 Td
(-)Tj
EMC
0.312 0 Td
[(2)8( )45(i)8(n)8(f)8(e)8(c)8(t)8(i)8(o)8(n)8(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 263.8427 Tm
[(HIV )-36(subtype, )-36(type )-36(of )-36(diagnostic )-36(test\(s\) )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 251.9927 Tm
[(e)-15(x)-15(a)-15(m)-15(i)-15(n)-15(e)-15(d)-15(,)-15( )-140(a)-15(s)-15(s)-15(a)-15(y)-15( )-140(u)-15(s)-15(e)-15(d)-15( )-140(t)-15(o)-15( )-140(p)-15(e)-15(r)-23(f)-15(o)-15(r)-15(m)-15( )-140(t)-15(h)-15(e )]TJ
T*
[(d)4(i)4(a)4(g)4(n)4(o)4(s)4(t)4(i)4(c)4( )1(t)4(e)4(s)4(t)4( )1(a)4(n)4(d)4( )1(p)4(e)4(r)-4(f)4(o)4(r)4(m)4(a)4(n)4(c)4(e)4( )1(e)4(v)10(a)4(l)4(u)4(a)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 240.1427 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 228.2927 Tm
[(t)4(i)4(o)4(n)4( )66(m)4(e)4(t)4(h)4(o)4(d)4(.)4( )66(G)10(e)4(o)4(g)4(r)4(a)4(p)4(h)4(i)4(c)4( )66(l)4(o)4(c)4(a)4(t)4(i)4(o)4(n)4(s)4( )66(w)10(e)4(r)14(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 216.4427 Tm
[(c)-10(l)-10(a)-10(s)-10(s)-10(i)-10(\037)-10(e)-10(d)-10( )-135(b)-4(y)-10( )-135(re)-10(g)-10(i)-10(o)-10(n)-10(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 301.496 219.7727 Tm
(9)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 304.4693 216.4427 Tm
[( )-135(F)26(o)-10(r)-10( )-135(t)-10(h)-10(e)-10( )-135(p)-10(u)-10(r)-10(p)-10(o)-10(s)-10(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 204.5927 Tm
[(o)-9(f)-9( )-134(t)-9(h)-9(i)-9(s)-9( )-134(r)1(e)-9(v)-9(i)-9(e)-15(w)-9( )-134(w)-3(e)-9( )-134(d)-9(e)-9(\037)-9(n)-9(e)-9(d)-9( )-134(u)-9(r)-9(b)-9(a)-9(n)-9(i)-9(t)-9(y)-9( )-134(a)-9(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 192.7427 Tm
[(a )-125(major )-125(city )-125(and/or )-125(its )-125(outlying )-125(ar)10(eas. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 373.2283 192.7427 Tm
( )Tj
-15.118 -1.185 Td
[(A)-32( )-157(s)-32(e)-32(c)-32(o)-32(n)-32(d)-32( )-157(r)-22(e)-32(v)-32(i)-32(e)-38(w)-26(e)-32(r)-32( )-157(e)-32(x)-32(a)-32(m)-32(i)-32(n)-32(e)-32(d)-32( )-157(a)-32( )-157(s)-32(u)-32(b)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 169.0427 Tm
[(s)10(a)10(m)10(p)10(l)10(e)10( )34(t)10(o)10( )33(e)10(n)10(s)10(u)10(r)20(e)10( )33(i)10(n)10(t)10(e)10(r)10(n)10(a)10(l)10( )33(v)16(a)10(l)10(i)10(d)10(i)10(t)10(y)10( )33(o)10(f)10( )34(d)10(a)10(t)10(a )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 157.1927 Tm
(extraction.)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 239.0551 145.3427 Tm
[(F)7(o)-29(r)-29( )-154(s)-29(t)-29(u)-29(d)-29(i)-29(e)-29(s)-29( )-154(r)-19(e)-29(p)-29(o)-29(r)-37(t)-29(i)-29(n)-29(g)-29( )-154(s)-29(e)-29(n)-29(s)-29(i)-29(t)-29(i)-29(v)-29(i)-29(t)-29(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 133.4926 Tm
[(a)-2(n)-3(d)-2( )-127(s)-2(p)-3(e)-2(c)-2(i)-2(\037)-3(c)-2(i)-2(t)-3(y)83(,)-2( )-128(w)4(e)-2( )-128(c)-2(a)-2(t)-2(e)-3(g)-2(o)-2(r)-2(i)-3(z)4(e)-2(d)-3( )-127(t)-2(e)-3(s)-2(t)-2(s)-2( )-128(a)-2(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 121.6427 Tm
[(e)-7(i)-7(t)-7(h)-7(e)-7(r)-7( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 248.3479 121.6427 Tm
[(r)13(e)-7(f)-7(e)-7(r)13(e)-7(n)-7(c)-7(e)-7( )-132(s)-7(t)-7(a)-7(n)-7(d)-7(a)-7(r)13(d)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 316.7368 121.6427 Tm
[( )-132(o)-7(r)-7( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 332.7143 121.6427 Tm
[(i)-7(n)-7(d)-7(e)-7(x)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 353.2764 121.6427 Tm
[( )-132(t)-7(e)-7(s)-7(t)-7(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 109.7927 Tm
[(\034)-2(e)-2( )-127(r)8(e)-2(f)-2(e)-2(r)8(e)-2(n)-2(c)-2(e)-2( )-127(s)-2(t)-2(a)-2(n)-2(d)-2(a)-2(r)12(d)-2( )-127(w)-2(a)-2(s)-2( )-127(d)-2(e)-2(\037)-2(n)-2(e)-2(d)-2( )-127(a)-2(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 373.2283 109.7927 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 97.9427 Tm
[(the )1(best )1(av)6(ailable )1(diagnostic )1(test, )1(which )]TJ
T*
[(ser)-18(v)6(ed )34(as )34(the )34(comparison )34(for )34(an )34(alterna)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 86.0927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 74.2426 Tm
[(tiv)6(e )-125(test.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 255.5278 77.5726 Tm
(10,11)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 268.6573 74.2426 Tm
[( )-125(S)12(ensitivity )-125(was )-125(de\037ned )-125(as )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 222.0473 62.3927 Tm
[(P)43(r)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 231.5549 62.3927 Tm
(\()Tj
ET
BT
/T1_3 1 Tf
10 0 0 10 234.5636 62.3927 Tm
[(p)19(o)19(s)19(i)19(t)19(i)19(v)25(e)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 260.2542 62.3927 Tm
[( )82(t)19(e)19(s)19(t)19( )82(|)19( )82(d)19(i)19(s)19(e)19(a)19(s)19(e)19( )82(c)19(o)19(n)19(d)19(i)19(t)19(i)19(o)19(n)19( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 343.9779 62.3927 Tm
[(p)19(r)39(e)19(s)19(e)19(n)19(t)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 367.7195 62.3927 Tm
[(\))19(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 394.1927 Tm
[(o)-26(r)-26( )-151(t)-26(h)-26(e)-26( )-151(p)-26(r)-20(o)-26(b)-26(a)-26(b)-26(i)-26(l)-26(i)-26(t)-26(y)-26( )-151(t)-26(h)-26(a)-26(t)-26( )-151(t)-26(h)-26(e)-26( )-151(s)-26(p)-26(e)-26(c)-26(i)-26(\037)-26(e)-26(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 538.5826 394.1927 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 382.3427 Tm
[(v)20(a)14(l)14(u)14(e)14( )50(o)14(r)14( )50(c)14(o)14(n)14(d)14(i)14(t)14(i)14(o)14(n)14( )50(a)14(s)14( )50(m)14(e)14(a)14(s)14(u)14(r)24(e)14(d)14( )50(b)20(y)14( )50(t)14(h)14(e)14( )50(i)14(n)14(-)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 382.3427 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 370.4927 Tm
[(d)-2(e)-2(x)-2( )23(t)-2(e)-2(s)-2(t)-2( )23(r)8(e)-2(\035)-2(e)-2(c)-2(t)-2(e)-2(d)-2( )23(t)-2(h)-2(e)-2( )23(v)4(a)-2(l)-2(u)-2(e)-2( )23(o)-2(r)-2( )23(c)-2(o)-2(n)-2(d)-2(i)-2(t)-2(i)-2(o)-2(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 358.6427 Tm
[(as )-70(measur)10(ed )-70(b)6(y )-70(the )-70(r)10(efer)10(ence )-70(standar)14(d. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 346.7927 Tm
[(S)13(p)-11(e)-11(c)-11(i)-11(\037)-11(c)-11(i)-11(t)-11(y)-11( )-136(w)-11(a)-11(s)-11( )-136(d)-11(e)-11(\037)-11(n)-11(e)-11(d)-11( )-136(a)-11(s)-11( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 494.3738 346.7927 Tm
[(P)13(r)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 504.4857 346.7927 Tm
(\()Tj
ET
BT
/T1_3 1 Tf
10 0 0 10 507.7965 346.7927 Tm
[(n)-11(e)-11(g)-11(a)-11(t)-11(i)-11(v)-5(e)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 538.5826 346.7927 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 334.9427 Tm
[(t)-1(e)-1(s)-1(t)-1( )-126(|)-1( )-126(d)-1(i)-1(s)-1(e)-1(a)-1(s)-1(e)-1( )-126(c)-1(o)-1(n)-1(d)-1(i)-1(t)-1(i)-1(o)-1(n)-1( )]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 481.8954 334.9427 Tm
[(a)-1(b)-1(s)-1(e)-1(n)-1(t)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 504.967 334.9427 Tm
[(\))-1(,)-1( )-126(o)-1(r)-1( )-126(t)-1(h)-1(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 323.0927 Tm
[(pr)6(obability )48(that )48(the )48(absence )47(of )48(the )48(v)6(alue )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 311.2427 Tm
[(or )-67(condition )-67(as )-67(measur)10(ed )-67(b)6(y )-67(the )-67(index )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 299.3926 Tm
[(test )25(r)10(e\035ected )25(the )25(absence )25(of )25(the )25(v)6(alue )25(or )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 287.5427 Tm
[(condition )-29(as )-29(measur)10(ed )-29(b)6(y )-29(the )-29(r)10(efer)10(ence )]TJ
T*
[(s)10(t)10(a)10(n)10(d)10(a)10(r)24(d)10(.)10( )31(I)16(f)10( )31(t)10(w)10(o)10( )31(m)10(e)10(t)10(h)10(o)10(d)10(s)10( )31(o)10(f)10( )32(\035)10(o)22(w)10( )31(c)10(y)10(t)10(o)10(m)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 275.6927 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 263.8427 Tm
[(etr)-18(y )-37(\(the )-37(gold )-37(standar)14(d )-37(in )-37(enumerating )]TJ
T*
[(C)-6(D)-6(4)-6(\))-6( )-131(we)-6(r)4(e)-6( )-131(e)-6(va)-6(l)-6(u)-6(a)-6(t)-6(e)-6(d)-6(,)-6( )-131(s)-6(i)-6(n)-6(g)-6(l)-6(e)]TJ
/Span<>> BDC
11.391 0 Td
(-)Tj
EMC
0.326 0 Td
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100.189 787.694 100.207 787.442 100.207 787.109 c
h
S
110.584 784.337 m
110.377 784.184 110.053 783.977 109.369 783.977 c
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109.918 783.158 110.404 783.356 110.638 783.455 c
h
108.19 785.948 m
108.19 786.56 108.433 787.181 109.018 787.181 c
109.522 787.181 109.792 786.767 109.792 785.948 c
h
S
111.844 783.23 1.116 6.75 re
S
119.764 784.337 m
119.557 784.184 119.233 783.977 118.549 783.977 c
117.685 783.977 117.37 784.454 117.37 785.246 c
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120.052 785.462 l
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116.29 784.229 116.938 783.158 118.432 783.158 c
119.098 783.158 119.584 783.356 119.818 783.455 c
h
117.37 785.948 m
117.37 786.56 117.613 787.181 118.198 787.181 c
118.702 787.181 118.972 786.767 118.972 785.948 c
h
S
121.33 787.865 m
120.592 787.865 l
120.592 787.046 l
121.33 787.046 l
121.33 784.508 l
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123.292 784.058 123.148 784.004 122.95 784.004 c
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122.446 787.046 l
123.373 787.046 l
123.373 787.865 l
122.446 787.865 l
122.446 789.161 l
121.33 788.819 l
h
S
126.712 786.695 m
126.928 786.875 127.423 787.145 127.981 787.145 c
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128.62 786.092 l
127.207 786.092 126.181 785.777 126.181 784.517 c
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129.889 787.235 129.556 787.937 128.116 787.937 c
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h
128.845 785.237 m
128.845 784.409 128.602 783.914 127.936 783.914 c
127.504 783.914 127.225 784.202 127.225 784.625 c
127.225 785.3 127.792 785.498 128.746 785.498 c
128.845 785.498 l
h
S
131.032 783.23 1.116 6.75 re
S
133.39 783.23 1.08 1.17 re
S
396.638 783.23 m
398.276 783.23 l
400.022 783.23 401.282 784.256 401.282 786.371 c
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396.638 789.512 l
h
397.79 788.63 m
398.177 788.63 l
399.473 788.63 400.058 787.748 400.058 786.371 c
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397.79 784.112 l
h
S
402.308 783.23 1.116 4.635 re
402.29 788.738 1.152 1.098 re
S
404.828 786.695 m
405.044 786.875 405.539 787.145 406.097 787.145 c
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405.323 786.092 404.297 785.777 404.297 784.517 c
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408.005 787.235 407.672 787.937 406.232 787.937 c
405.521 787.937 405.08 787.739 404.765 787.595 c
h
406.961 785.237 m
406.961 784.409 406.718 783.914 406.052 783.914 c
405.62 783.914 405.341 784.202 405.341 784.625 c
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406.961 785.498 l
h
S
410.066 785.597 m
410.066 786.542 410.291 787.082 410.876 787.091 c
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410.417 784.049 410.066 784.508 410.066 785.597 c
h
409.121 781.52 m
409.391 781.421 409.976 781.232 410.714 781.232 c
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411.812 787.145 l
411.578 787.55 411.263 787.937 410.588 787.937 c
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411.776 783.572 l
411.776 782.843 411.605 782.114 410.552 782.114 c
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h
S
413.873 783.23 m
414.989 783.23 l
414.989 785.93 l
414.989 786.524 415.196 787.019 415.781 787.019 c
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417.536 783.23 l
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417.536 787.154 417.221 787.937 416.168 787.937 c
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414.917 787.388 414.89 787.631 414.881 787.865 c
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413.864 787.658 413.873 787.388 413.873 787.1 c
h
S
419.57 785.552 m
419.57 786.326 419.741 787.145 420.461 787.145 c
421.181 787.145 421.343 786.326 421.343 785.552 c
421.343 784.778 421.181 783.95 420.461 783.95 c
419.741 783.95 419.57 784.778 419.57 785.552 c
h
418.418 785.552 m
418.418 783.608 419.516 783.158 420.461 783.158 c
421.406 783.158 422.495 783.608 422.495 785.552 c
422.495 787.442 421.406 787.937 420.461 787.937 c
419.516 787.937 418.418 787.442 418.418 785.552 c
h
S
423.197 783.383 m
423.431 783.293 423.908 783.158 424.484 783.158 c
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425.042 784.814 425.132 784.643 425.132 784.463 c
425.132 784.103 424.817 784.004 424.412 784.004 c
423.89 784.004 423.431 784.238 423.251 784.31 c
h
S
427.454 787.865 m
426.716 787.865 l
426.716 787.046 l
427.454 787.046 l
427.454 784.508 l
427.454 783.536 427.922 783.158 428.75 783.158 c
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429.416 784.058 429.272 784.004 429.074 784.004 c
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428.57 787.046 l
429.497 787.046 l
429.497 787.865 l
428.57 787.865 l
428.57 789.161 l
427.454 788.819 l
h
S
430.316 783.23 1.116 4.635 re
430.298 788.738 1.152 1.098 re
S
435.635 784.229 m
435.482 784.13 435.113 784.004 434.843 784.004 c
433.988 784.004 433.574 784.67 433.574 785.534 c
433.574 786.524 433.943 787.091 434.789 787.091 c
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432.422 784.229 433.07 783.158 434.6 783.158 c
435.05 783.158 435.437 783.248 435.698 783.347 c
h
S
439.135 787.865 m
438.397 787.865 l
438.397 787.046 l
439.135 787.046 l
439.135 784.508 l
439.135 783.536 439.603 783.158 440.431 783.158 c
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441.098 784.058 440.954 784.004 440.756 784.004 c
440.431 784.004 440.251 784.148 440.251 784.643 c
440.251 787.046 l
441.178 787.046 l
441.178 787.865 l
440.251 787.865 l
440.251 789.161 l
439.135 788.819 l
h
S
445.237 784.337 m
445.03 784.184 444.706 783.977 444.022 783.977 c
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445.525 785.462 l
445.525 787.352 444.67 787.937 443.671 787.937 c
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444.571 783.158 445.057 783.356 445.291 783.455 c
h
442.843 785.948 m
442.843 786.56 443.086 787.181 443.671 787.181 c
444.175 787.181 444.445 786.767 444.445 785.948 c
h
S
446.209 783.383 m
446.443 783.293 446.92 783.158 447.496 783.158 c
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h
S
450.466 787.865 m
449.728 787.865 l
449.728 787.046 l
450.466 787.046 l
450.466 784.508 l
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451.582 787.046 l
452.509 787.046 l
452.509 787.865 l
451.582 787.865 l
451.582 789.161 l
450.466 788.819 l
h
S
453.04 783.383 m
453.274 783.293 453.751 783.158 454.327 783.158 c
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455.695 787.784 455.236 787.937 454.642 787.937 c
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454.885 784.814 454.975 784.643 454.975 784.463 c
454.975 784.103 454.66 784.004 454.255 784.004 c
453.733 784.004 453.274 784.238 453.094 784.31 c
h
S
459.331 783.23 1.116 4.635 re
459.313 788.738 1.152 1.098 re
S
461.563 783.23 m
462.679 783.23 l
462.679 785.93 l
462.679 786.524 462.886 787.019 463.471 787.019 c
463.93 787.019 464.11 786.722 464.11 786.011 c
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465.226 786.218 l
465.226 787.154 464.911 787.937 463.858 787.937 c
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462.607 787.388 462.58 787.631 462.571 787.865 c
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461.554 787.658 461.563 787.388 461.563 787.1 c
h
S
468.736 783.23 m
469.888 783.23 l
469.888 786.002 l
471.751 786.002 l
471.751 783.23 l
472.903 783.23 l
472.903 789.512 l
471.751 789.512 l
471.751 786.956 l
469.888 786.956 l
469.888 789.512 l
468.736 789.512 l
h
S
474.244 783.23 1.152 6.282 re
S
478.033 783.23 m
479.248 783.23 l
481.165 789.512 l
479.977 789.512 l
478.672 784.67 l
478.654 784.67 l
477.385 789.512 l
476.143 789.512 l
h
S
484.054 783.23 m
485.17 783.23 l
485.17 786.038 l
485.17 786.551 485.431 787.019 485.926 787.019 c
486.34 787.019 486.52 786.731 486.52 786.155 c
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490.102 786.092 l
490.102 787.217 489.778 787.937 488.77 787.937 c
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485.17 787.136 l
485.17 787.379 485.143 787.622 485.134 787.865 c
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484.036 787.694 484.054 787.442 484.054 787.109 c
h
S
491.371 786.695 m
491.587 786.875 492.082 787.145 492.64 787.145 c
493.279 787.145 493.504 786.722 493.504 786.263 c
493.504 786.092 l
493.279 786.092 l
491.866 786.092 490.84 785.777 490.84 784.517 c
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494.584 783.41 494.548 783.716 494.548 784.049 c
494.548 786.074 l
494.548 787.235 494.215 787.937 492.775 787.937 c
492.064 787.937 491.623 787.739 491.308 787.595 c
h
493.504 785.237 m
493.504 784.409 493.261 783.914 492.595 783.914 c
492.163 783.914 491.884 784.202 491.884 784.625 c
491.884 785.3 492.451 785.498 493.405 785.498 c
493.504 785.498 l
h
S
495.583 783.23 m
496.699 783.23 l
496.699 785.93 l
496.699 786.524 496.906 787.019 497.491 787.019 c
497.95 787.019 498.13 786.722 498.13 786.011 c
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499.246 783.23 l
499.246 786.218 l
499.246 787.154 498.931 787.937 497.878 787.937 c
497.122 787.937 496.807 787.433 496.645 787.154 c
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496.627 787.388 496.6 787.631 496.591 787.865 c
495.547 787.865 l
495.574 787.658 495.583 787.388 495.583 787.1 c
h
S
500.542 786.695 m
500.758 786.875 501.253 787.145 501.811 787.145 c
502.45 787.145 502.675 786.722 502.675 786.263 c
502.675 786.092 l
502.45 786.092 l
501.037 786.092 500.011 785.777 500.011 784.517 c
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502.711 783.635 502.72 783.41 502.774 783.23 c
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503.755 783.41 503.719 783.716 503.719 784.049 c
503.719 786.074 l
503.719 787.235 503.386 787.937 501.946 787.937 c
501.235 787.937 500.794 787.739 500.479 787.595 c
h
502.675 785.237 m
502.675 784.409 502.432 783.914 501.766 783.914 c
501.334 783.914 501.055 784.202 501.055 784.625 c
501.055 785.3 501.622 785.498 502.576 785.498 c
502.675 785.498 l
h
S
505.78 785.597 m
505.78 786.542 506.005 787.082 506.59 787.091 c
507.121 787.1 507.49 786.578 507.49 785.606 c
507.49 784.553 507.211 784.049 506.509 784.049 c
506.131 784.049 505.78 784.508 505.78 785.597 c
h
504.835 781.52 m
505.105 781.421 505.69 781.232 506.428 781.232 c
508.129 781.232 508.57 782.267 508.57 783.716 c
508.57 787.136 l
508.57 787.379 508.588 787.622 508.606 787.865 c
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507.589 787.622 507.562 787.388 507.562 787.145 c
507.526 787.145 l
507.292 787.55 506.977 787.937 506.302 787.937 c
505.087 787.937 504.628 786.812 504.628 785.534 c
504.628 783.662 505.6 783.23 506.248 783.23 c
506.977 783.23 507.292 783.653 507.472 784.013 c
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507.49 783.572 l
507.49 782.843 507.319 782.114 506.266 782.114 c
505.681 782.114 505.159 782.366 504.898 782.51 c
h
S
512.935 784.337 m
512.728 784.184 512.404 783.977 511.72 783.977 c
510.856 783.977 510.541 784.454 510.541 785.246 c
513.223 785.246 l
513.223 785.462 l
513.223 787.352 512.368 787.937 511.369 787.937 c
510.19 787.937 509.461 786.866 509.461 785.48 c
509.461 784.229 510.109 783.158 511.603 783.158 c
512.269 783.158 512.755 783.356 512.989 783.455 c
h
510.541 785.948 m
510.541 786.56 510.784 787.181 511.369 787.181 c
511.873 787.181 512.143 786.767 512.143 785.948 c
h
S
514.06 783.23 m
515.176 783.23 l
515.176 786.038 l
515.176 786.551 515.437 787.019 515.932 787.019 c
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517.642 786.038 l
517.642 786.551 517.903 787.019 518.398 787.019 c
518.812 787.019 518.992 786.731 518.992 786.155 c
518.992 783.23 l
520.108 783.23 l
520.108 786.092 l
520.108 787.217 519.784 787.937 518.776 787.937 c
518.092 787.937 517.759 787.523 517.534 787.199 c
517.399 787.451 517.147 787.937 516.364 787.937 c
515.725 787.937 515.365 787.496 515.194 787.136 c
515.176 787.136 l
515.176 787.379 515.149 787.622 515.14 787.865 c
514.024 787.865 l
514.042 787.694 514.06 787.442 514.06 787.109 c
h
S
524.437 784.337 m
524.23 784.184 523.906 783.977 523.222 783.977 c
522.358 783.977 522.043 784.454 522.043 785.246 c
524.725 785.246 l
524.725 785.462 l
524.725 787.352 523.87 787.937 522.871 787.937 c
521.692 787.937 520.963 786.866 520.963 785.48 c
520.963 784.229 521.611 783.158 523.105 783.158 c
523.771 783.158 524.257 783.356 524.491 783.455 c
h
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[(r)14(e)4(s)4(u)4(l)4(t)4(s)4( )-39(f)4(o)4(r)4( )-39(a)4( )-39(t)4(o)4(t)4(a)4(l)4( )-40(o)4(f)4( )-40(1)4(2)4( )-39(e)4(n)4(t)4(r)4(i)4(e)4(s)4( )-39(\()-8(T)114(a)4(b)4(l)4(e)4( )-39(4 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 310.9698 Tm
[(\()10(m)10(e)10(a)10(s)10(u)10(r)20(e)10(s)10( )10(o)10(f)10( )10(a)10(c)10(c)10(u)10(r)10(a)10(c)10(y)10(\))10(;)10( )10(F)44(i)10(g)10(.)10( )10(1)10( )10(a)10(n)10(d)10( )10(F)44(i)10(g)10(.)10( )10(2 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 373.2283 310.9698 Tm
( )Tj
-15.118 -1.13 Td
[(\(m)-1(easu)-1(r)10(es)-1( )-125(of )-126(ass)-1(oci)-1(atio)-1(n\);)-1( )-125(al)-1(l )-125(w)6(e)-1(b )-125(v)5(er)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 299.6698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 288.3698 Tm
[(s)-8(i)-8(o)-8(n)-8( )-133(o)-8(n)-8(l)-8(y)77(,)-8( )-133(a)-8(v)-2(a)-8(i)-8(l)-8(a)-8(b)-8(l)-8(e)-8( )-133(f)-8(r)-2(o)-8(m)-8( )-133(h)-8(t)-8(t)-8(p)-8(:)-8(/)-8(/)-8(w)-8(w)-8(w)67(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 277.0698 Tm
[(who)16(.int/bulletin\). )35(T)120(en )-10(of )-10(the )-10(12 )-10(entries )]TJ
T*
[(e)10(x)10(a)10(m)10(i)10(n)10(e)10(d)10( )45(t)10(h)10(e)10( )45(r)20(e)10(l)10(a)10(t)10(i)10(o)10(n)10(s)10(h)10(i)10(p)10( )45(b)10(e)10(t)10(w)16(e)10(e)10(n)10( )45(c)10(l)10(i)10(n)10(i)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 265.7698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 254.4698 Tm
[(cal )-116(and )-116(immunologic )-116(tests; )-116(\037v)6(e )-116(of )-116(the )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 243.1698 Tm
[(ten )5(ev)6(aluated )5(CD4 )5(or )5(total )5(lymphocyte )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 231.8698 Tm
[(c)-14(o)-14(u)-14(n)-14(t)-14(s)-14( )-139(o)-14(n)-14(l)-14(y)-14( )-139(a)-14(n)-14(d)-14( )-139(a)-14( )-139(c)-14(l)-14(i)-14(n)-14(i)-14(c)-14(a)-14(l)-14( )-139(s)-14(t)-14(a)-14(g)-14(i)-14(n)-14(g)-14( )-139(o)-14(r )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 220.5698 Tm
[(classi\037cation )-86(system )-86(only)85(, )-86(and )-86(thr)10(ee )-86(of )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 209.2698 Tm
[(t)-4(h)-4(e)-4( )-129(t)-4(e)-4(n)-4( )-129(c)-4(o)-4(m)-4(p)-4(a)-4(r)6(e)-4(d)-4( )-129(t)-4(h)-4(e)-4( )-129(p)-4(e)-4(r)-12(f)-4(o)-4(r)-4(m)-4(a)-4(n)-4(c)-4(e)-4( )-129(o)-4(f )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 197.9698 Tm
[(v)-16(a)-22(r)-22(i)-22(o)-22(u)-22(s)-22( )-147(p)-22(e)-22(r)-22(m)-22(u)-22(t)-22(a)-22(t)-22(i)-22(o)-22(n)-22(s)-22( )-147(o)-22(f)-22( )-147(c)-22(l)-22(i)-22(n)-22(i)-22(c)-22(a)-22(l)-22( )-147(a)-22(n)-22(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 186.6698 Tm
[(immunologic )-83(tests. )-83(S)12(ensitivity )-83(of )-83(these )]TJ
T*
[(10 )-81(entries )-81(ranged )-81(fr)6(om )-81(29% )-81(when )-81(us)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 175.3698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 164.0698 Tm
[(ing )1(oral )1(candidiasis )1(to )1(pr)10(edict )1(CD4 )1(cell )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 152.7698 Tm
[(c)-8(o)-8(u)-8(n)-8(t)-8(s)-8( )]TJ
ET
BT
/TT0 1 Tf
10 0 0 10 251.9045 152.7698 Tm
(<)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 255.1789 152.7698 Tm
[(2)-8(0)-8(0)-8( )-133(c)-8(e)-8(l)-8(l)-8(s)-8(/)-8(m)-8(m)-8(\263)-8( )-133(t)-8(o)-8( )-133(9)-8(6)-8(%)-8( )-133(w)-8(h)-8(e)-8(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 141.4698 Tm
[(using )-22(clinical )-22(staging, )-22(total )-22(lymphocyte )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 130.1698 Tm
[(c)-15(o)-15(u)-15(n)-15(t)-15( )-140(a)-15(n)-15(d)-15( )-140(w)-15(h)-15(i)-15(t)-15(e)-15( )-140(b)-15(l)-15(o)-15(o)-15(d)-15( )-140(c)-15(e)-15(l)-15(l)-15( )-140(c)-15(o)-15(u)-15(n)-15(t)-15( )-140(t)-15(o )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 118.8698 Tm
[(pr)10(edict )-102(CD4 )-102(cell )-102(count; )-102(speci\037city )-102(for )]TJ
T*
[(these )62(studies )62(was )62(96% )62(and )62(83%, )62(r)10(espec)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 107.5698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 96.2698 Tm
[(t)10(i)10(v)16(e)10(l)10(y)95(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 243.7069 99.5998 Tm
[(1)10(7)10(,)10(1)10(8)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 256.5329 96.2698 Tm
[( )-3(F)46(o)10(u)10(r)10( )-3(e)10(n)10(t)10(r)10(i)10(e)10(s)10( )-3(c)10(o)10(m)10(p)10(a)10(r)20(e)10(d)10( )-3(c)10(l)10(i)10(n)10(i)10(c)10(a)10(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 84.9698 Tm
[(s)13(t)13(a)13(g)13(i)13(n)13(g)13( )75(t)13(o)13( )75(C)13(D)13(4)13( )75(c)13(e)13(l)13(l)13( )75(c)13(o)13(u)13(n)13(t)13( )75(a)13(s)13( )75(m)13(e)13(a)13(s)13(u)13(r)23(e)13(d)13( )75(b)19(y )]TJ
T*
[(\035)4(o)16(w)4( )26(c)4(y)4(t)4(o)4(m)4(e)4(t)4(r)-14(y)4( )26(a)4(n)4(d)4( )26(o)4(n)4(e)4( )26(e)4(x)4(a)4(m)4(i)4(n)4(e)4(d)4( )26(c)4(l)4(i)4(n)4(i)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 73.6698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 62.3698 Tm
[(c)11(a)11(l)11( )73(s)11(t)11(a)11(g)11(i)11(n)11(g)11( )73(a)11(n)11(d)11( )73(t)11(o)11(t)11(a)11(l)11( )73(l)11(y)11(m)11(p)11(h)11(o)11(c)11(y)11(t)11(e)11( )73(c)11(o)11(u)11(n)11(t)11( )73(a)11(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 425.2698 Tm
[(m)1(e)1(a)1(s)1(u)1(r)11(e)1(d)1( )63(b)7(y)1( )63(h)1(a)1(e)1(m)1(a)1(t)1(o)1(l)1(o)1(g)1(y)1( )63(a)1(n)1(a)1(l)1(y)1(s)1(e)1(r)61(.)1( )108(T)131(w)1(o )]TJ
0 -1.17 TD
[(o)2(f)2( )65(1)2(2)2( )65(e)2(n)2(t)2(r)2(i)2(e)2(s)2( )65(c)2(o)2(m)2(p)2(a)2(r)12(e)2(d)2( )65(c)2(l)2(i)2(n)2(i)2(c)2(a)2(l)2( )65(i)2(n)2(f)2(o)2(r)2(m)2(a)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 413.5698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 401.8698 Tm
[(tion )-2(and )-2(vir)6(ologic )-2(information)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 505.0095 405.1998 Tm
(19)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 510.8395 401.8698 Tm
[( )-2(as )-2(w)6(ell )]TJ
-12.344 -1.17 Td
[(a)-4(s)-3( )-129(c)-4(l)-4(i)-4(n)-3(i)-4(c)-4(a)-3(l)-4( )-129(a)-4(n)-4(d)-3( )-129(i)-4(m)-3(m)-4(u)-4(n)-4(o)-4(l)-3(o)-4(g)-4(i)-4(c)-3( )-129(i)-4(n)-3(f)-4(o)-4(r)-4(m)-3(a)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 390.1698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 378.4698 Tm
[(t)10(i)10(o)10(n)10( )9(a)10(n)10(d)10( )9(v)10(i)10(r)16(o)10(l)10(o)10(g)10(i)10(c)10( )9(i)10(n)10(f)10(o)10(r)10(m)10(a)10(t)10(i)10(o)10(n)10(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 504.3835 381.7998 Tm
[(2)10(0)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 510.0969 378.4698 Tm
[( )54(T)140(w)10(o)10( )9(o)10(f )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 366.7698 Tm
[(12 )-14(entries )-14(ev)6(aluated )-14(per)-8(formance )-14(using )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 355.0698 Tm
[(measur)10(es of association.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 479.0102 358.3998 Tm
(20)Tj
ET
BT
/T1_0 1 Tf
11 0 1.9396 11 387.4016 331.5698 Tm
(Immunologic information)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 319.8698 Tm
[(W)71(e)-7( )-132(c)-7(l)-7(a)-7(s)-7(s)-7(i)-7(\037)-7(e)-7(d)-7( )-132(3)-7(9)-7( )-132(o)-7(f)-7( )-132(5)-7(1)-7( )-132(s)-7(t)-7(u)-7(d)-7(i)-7(e)-7(s)-7( )-132(i)-7(n)-7( )-132(t)-7(h)-7(i)-7(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 538.5827 319.8698 Tm
( )Tj
-15.118 -1.17 Td
[(categor)-18(y)85(, )-43(with )-43(14 )-43(of )-43(39 )-43(r)10(epor)-8(ting )-43(mul)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 308.1698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 296.4698 Tm
[(t)-20(i)-20(p)-20(l)-20(e)-20( )-145(r)-10(e)-20(s)-20(u)-20(l)-20(t)-20(s)-20( )-145(f)-20(o)-20(r)-20( )-145(a)-20( )-145(t)-20(o)-20(t)-20(a)-20(l)-20( )-145(o)-20(f)-20( )-145(8)-20(1)-20( )-145(e)-20(n)-20(t)-20(r)-20(i)-20(e)-20(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 284.7698 Tm
[(\()-12(T)110(able )-52(5 )-52(\(measur)10(es )-52(of )-52(accuracy\); )-52(F)34(ig. )-52(1 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 273.0698 Tm
[(\()-1(m)-1(e)-1(a)-1(s)-1(u)-1(r)9(e)-1(s)-1( )-126(o)-1(f)-1( )-126(a)-1(s)-1(s)-1(o)-1(c)-1(i)-1(a)-1(t)-1(io)-1(n)-1(\))-1(;)-1( )-126(w)5(e)-1(b)-1( )-126(v)5(e)-1(r)-1(s)-1(i)-1(o)-1(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 261.3698 Tm
[(o)-10(n)-10(l)-11(y)75(,)-10( )-135(a)-10(v)-5(a)-10(i)-10(l)-10(a)-10(b)-10(l)-10(e)-11( )-135(f)-10(r)-4(o)-10(m)-10( )-136(h)-10(t)-10(t)-10(p)-10(:)-11(/)-10(/)-10(w)-10(w)-10(w)65(.)-11(w)-10(h)-10(o)6(.)]TJ
T*
[(int/bulletin\). )-125(F)36(or)-8(ty)]TJ
/Span<>> BDC
(-)Tj
EMC
[(thr)10(ee )-125(of )-125(81 )-125(entries )]TJ
T*
[(a)-10(s)-10(s)-10(e)-10(s)-10(s)-10(e)-10(d)-10( )-135(o)-10(n)-10(l)-10(y)-10( )-135(l)-10(y)-10(m)-10(p)-10(h)-10(o)-10(c)-10(y)-10(t)-10(e)-10( )-135(s)-10(u)-10(b)-10(s)-10(e)-10(t)-10(s)-10(,)-10( )-135(i)-10(n)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 237.9698 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 226.2698 Tm
[(cluding )61(CD4, )61(CD8 )61(or )61(CD3 )61(cell )61(counts, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 214.5698 Tm
[(o)10(r)10( )62(C)10(D)10(4)10(%)10(,)10( )62(C)10(D)10(8)10(%)10( )62(o)10(r)10( )62(C)10(D)10(3)10(%)10(.)10( )62(S)22(e)10(v)16(e)10(n)10(t)10(e)10(e)10(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 202.8698 Tm
[(e)-13(n)-13(t)-13(r)-13(i)-13(e)-13(s)-13( )-138(e)-13(v)-7(a)-13(l)-13(u)-13(a)-13(t)-13(e)-13(d)-13( )-138(d)-13(i)-13(\033)-13(e)-13(r)-3(e)-13(n)-13(t)-13( )-138(t)-13(e)-13(c)-13(h)-13(n)-13(i)-13(q)-13(u)-13(e)-13(s )]TJ
T*
[(f)10(o)10(r)10( )-114(m)10(e)10(a)10(s)10(u)10(r)10(i)10(n)10(g)10( )-114(C)10(D)10(4)10( )-114(c)10(e)10(l)10(l)10( )-114(c)10(o)10(u)10(n)10(t)10(,)10( )-114(i)10(n)10(c)10(l)10(u)10(d)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 191.1698 Tm
(-)Tj
-14.798 -1.17 Td
[(i)-45(n)-45(g)-45( )-170(s)-45(i)-45(n)-45(g)-45(l)-45(e)]TJ
/Span<>> BDC
4.244 0 Td
(-)Tj
EMC
0.365 0 Td
[( )-170(a)-45(n)-45(d)-45( )-170(d)-45(u)-45(a)-45(l)]TJ
/Span<>> BDC
4.262 0 Td
(-)Tj
EMC
0.365 0 Td
[(p)-45(l)-45(a)-45(t)-45(f)-45(o)-45(r)-45(m)-45( )-170(\035)-45(o)-33(w )]TJ
-9.236 -1.17 Td
[(cytometr)-18(y)85(, )55(enzyme )55(immunoassay)85(, )55(bead)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 156.0698 Tm
[(b)13(a)13(s)13(e)13(d)13( )76(m)13(a)13(n)13(u)13(a)13(l)13( )76(c)13(o)13(u)13(n)13(t)13(i)13(n)13(g)13(,)13( )76(i)13(m)13(m)13(u)13(n)13(o)13(a)13(l)13(k)13(a)13(l)13(i)13(n)13(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 144.3698 Tm
[(p)12(h)12(o)12(s)12(phatase )-116(and )-117(micr)6(ochip )-117(assay)85(. )-117(F)34(iv)6(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 538.5827 144.3698 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 132.6698 Tm
[(a)-29(s)-29(s)-29(e)-29(s)-29(s)-29(e)-29(d)-29( )-154(d)-29(i)-29(\033)-29(e)-29(r)-19(e)-29(n)-29(t)-29( )-154(a)-29(s)-29(s)-29(a)-29(y)-29(s)-29( )-154(f)-29(o)-29(r)-29( )-154(C)-29(D)-29(4)-29(%)-29(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 120.9698 Tm
[(w)10(h)10(i)10(l)10(e)10( )22(f)10(o)10(u)10(r)10( )22(e)10(n)10(t)10(r)10(i)10(e)10(s)10( )22(a)10(n)10(d)10( )22(o)10(n)10(e)10( )22(e)10(n)10(t)10(r)-8(y)10( )22(a)10(s)10(s)10(e)10(s)10(s)10(e)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 109.2698 Tm
[(di\033er)10(ent )11(assays )11(for )11(CD8% )11(and )11(CD3%, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 97.5698 Tm
[(r)10(espectiv)6(ely)85(. )-62(F)36(our )-62(entries )-61(examined )-61(the )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 85.8698 Tm
[(a)10(s)10(s)10(o)10(c)10(i)10(a)10(t)10(i)10(o)10(n)10( )18(b)10(e)10(t)10(w)16(e)10(e)10(n)10( )18(C)10(D)10(4)10( )18(c)10(e)10(l)10(l)10( )18(c)10(o)10(u)10(n)10(t)10( )18(a)10(n)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 74.1698 Tm
[(CD4%. )-19(S)12(ixteen )-19(of )-19(81 )-19(entries )-19(ev)6(aluated )]TJ
ET
BT
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466.494 787.815 l
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h
467.646 785.484 m
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h
S
471.38 783.18 m
472.496 783.18 l
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h
S
474.62 783.18 1.116 4.635 re
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S
476.96 783.18 1.116 6.75 re
S
481.64 783.18 m
483.278 783.18 l
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h
482.792 788.58 m
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h
S
489.704 783.18 m
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490.883 786.132 l
492.773 783.18 l
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492.674 789.462 l
490.883 786.798 l
490.856 786.798 l
490.856 789.462 l
489.704 789.462 l
h
S
494.816 783.18 1.116 4.635 re
494.798 788.688 1.152 1.098 re
S
497.021 783.18 m
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498.137 785.988 l
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h
S
504.023 783.18 m
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505.139 785.988 l
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h
S
514.4 784.287 m
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h
512.006 785.898 m
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h
S
515.66 783.18 1.116 6.75 re
S
523.58 784.287 m
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h
521.186 785.898 m
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h
S
525.146 787.815 m
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527.189 786.996 l
527.189 787.815 l
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h
S
530.528 786.645 m
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533.768 783.18 l
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h
532.661 785.187 m
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h
S
534.848 783.18 1.116 6.75 re
S
537.206 783.18 1.08 1.17 re
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BT
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(Diagnostic tests in HIV management)Tj
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( )Tj
EMC
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(April D Kimmel et al.)Tj
ET
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538.583 778.68 l
538.583 802.58 l
56.683 802.58 l
h
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222.047 769.998 m
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222.047 736.492 m
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222.047 709.422 m
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0.25 w
222.047 319.904 m
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BT
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[(T)74(able 3.)37( )]TJ
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( )Tj
EMC
ET
BT
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[(Description of included studies for the systematic r)10(eview of diagnostic )]TJ
ET
BT
/T1_0 1 Tf
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ET
BT
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[(V)65(ariable)]TJ
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BT
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EMC
ET
BT
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BT
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ET
BT
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BT
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ET
BT
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BT
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BT
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EMC
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[(T)74(reatment)]TJ
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EMC
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[(Antiretrovir)18(al ther)18(apy)]TJ
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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(12 )Tj
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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EMC
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BT
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EMC
26.315 0 Td
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( )Tj
EMC
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EMC
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( )Tj
EMC
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EMC
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( )Tj
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EMC
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EMC
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BT
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EMC
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[(P)37(ercentages may not total 100% due to rounding.)]TJ
ET
BT
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EMC
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[(Countries )-20(were )-20(assigned )-20(an )-20(income-level )-20(status )-20(\(low)45(,)37( )-20(low-middle)37(,)37( )-20(middle-high,)37( )-20(or )-20(high\) )-20(based )-20(on )-20(gross )]TJ
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BT
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ET
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ET
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( One study)Tj
ET
BT
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ET
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[( w)18(as classi\037ed as both low and low-middle income)37(.)]TJ
ET
BT
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ET
BT
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(d)Tj
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EMC
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ET
BT
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ET
BT
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[( had study subjects who were both on and off antiretrovir)18(al ther)18(apy)45(.)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 763.7737 Tm
[(s)-22(u)-22(b)-22(s)-22(e)-22(t)-22(s)-22( )-147(a)-22(n)-22(d)-22( )-147(t)-22(o)-22(t)-22(a)-22(l)-22( )-147(l)-22(y)-22(m)-22(p)-22(h)-22(o)-22(c)-22(y)-22(t)-22(e)-22( )-147(c)-22(o)-22(u)-22(n)-22(t)-22(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 752.0737 Tm
[(with )-94(14 )-94(of )-94(16 )-94(entries )-94(examining )-94(CD4 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 740.3737 Tm
[(cell )-32(count )-32(and )-32(total )-32(lymphocyte )-31(count. )250( )]TJ
0 -1.17 TD
[(F)36(our )-123(of )-123(81 )-123(entries )-123(compar)10(ed )-123(lympho)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 728.6736 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 716.9736 Tm
[(c)-18(y)-18(t)-18(e)-18( )-143(s)-18(u)-18(b)-18(s)-18(e)-18(t)-18(s)-18( )-143(w)-18(i)-18(t)-18(h)-18( )-143(i)-18(m)-18(m)-18(u)-18(n)-18(e)-18( )-143(a)-18(c)-18(t)-18(i)-18(v)-12(a)-18(t)-18(i)-18(o)-18(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 705.2737 Tm
[(mar)6(kers )-22(\(e.g. )-22(lymphocyte )-22(pr)6(oliferation, )]TJ
T*
[(t)6(u)6(m)6(o)6(u)6(r)6( )43(n)6(e)6(c)6(r)12(o)6(s)6(i)6(s)6( )43(f)6(a)6(c)6(t)6(o)6(r)]TJ
/Span<>> BDC
8.484 0 Td
(-)Tj
EMC
ET
BT
/C2_0 1 Tf
10 0 1.7633 10 144.6745 693.5737 Tm
<0044>Tj
/T1_2 1 Tf
10 0 0 10 150.9231 693.5737 Tm
[( )43(\()-6(T)6(N)6(F)]TJ
/Span<>> BDC
2.496 0 Td
(-)Tj
EMC
ET
BT
/C2_0 1 Tf
10 0 1.7633 10 179.0192 693.5737 Tm
<0044>Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 185.2678 693.5737 Tm
[(\))6(\))6( )43(a)6(n)6(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 681.8737 Tm
[(f)-14(o)-14(u)-14(r)-14( )-139(w)-14(i)-14(t)-14(h)-14( )-139(w)-14(h)-14(i)-14(t)-14(e)-14( )-139(b)-14(l)-14(o)-14(o)-14(d)-14( )-139(c)-14(e)-14(l)-14(l)-14( )-139(c)-14(o)-14(u)-14(n)-14(t)-14(s)-14( )-139(o)-14(r )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 670.1736 Tm
[(associated )-55(di\033er)10(entials. )-55(F)36(our )-55(compar)10(ed )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 658.4736 Tm
[(i)1(m)1(m)1(u)1(n)1(e)1( )63(f)1(u)1(n)1(c)1(t)1(i)1(o)1(n)1( )63(a)1(n)1(d)1( )63(v)1(i)1(r)7(o)1(l)1(o)1(g)1(i)1(c)1( )63(m)1(a)1(r)7(k)1(e)1(r)1(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 646.7737 Tm
[(w)-6(h)-6(i)-6(l)-6(e)-6( )-131(1)-6(0)-6( )-131(i)-6(n)-6(ve)-6(s)-6(t)-6(i)-6(g)-6(a)-6(t)-6(e)-6(d)-6( )-131(t)-6(h)-6(e)-6( )-131(r)4(e)-6(l)-6(a)-6(t)-6(i)-6(o)-6(n)-6(s)-6(h)-6(i)-6(p )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 635.0737 Tm
[(betw)6(een )-51(immune )-51(function )-51(and )-51(clinical )]TJ
T*
[(m)-31(a)-30(r)-25(k)-31(e)-31(r)-30(s)-31(.)-31( )-156(F)3(i)-30(f)-31(t)-31(y)]TJ
/Span<>> BDC
5.899 0 Td
(-)Tj
EMC
0.351 0 Td
[(o)-31(n)-30(e)-31( )-156(o)-31(f)-30( )-156(8)-31(1)-31( )-156(e)-30(n)-31(t)-31(r)-31(i)-30(e)-31(s)-31( )-156(r)-20(e)]TJ
/Span<>> BDC
8.549 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 623.3737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 611.6736 Tm
[(por)-8(ted )-46(only )-46(corr)10(elation )-46(coe\036cients, )-46(17 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 599.9736 Tm
[(r)20(e)10(p)10(o)10(r)2(t)10(e)10(d)10( )-73(o)10(n)10(l)10(y)10( )-73(s)10(e)10(n)10(s)10(i)10(t)10(i)10(v)10(i)10(t)10(y)10(/)10(s)10(p)10(e)10(c)10(i)10(\037)10(c)10(i)10(t)10(y)95(,)10( )-73(a)10(n)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 588.2737 Tm
[(1)8(3)8( )-60(r)18(e)8(p)8(o)8(rt)8(e)8(d)8( )-60(c)8(o)8(r)8(r)18(e)8(l)8(a)8(t)8(i)8(o)8(n)8( )-60(c)8(o)8(e)8(\036)8(c)8(i)8(e)8(n)8(t)8(s)8( )-60(a)8(n)8(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 576.5737 Tm
[(sensitivity/speci\037city)85(.)]TJ
1.701 -1.17 Td
[(W)78(e )58(found )58(that )58(studies )58(assessing )58(dif)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 564.8737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 553.1736 Tm
[(f)16(e)16(r)26(e)16(n)16(t)16( )62(t)16(e)16(c)16(h)16(n)16(i)16(q)16(u)16(e)16(s)16( )62(f)16(o)16(r)16( )62(m)16(e)16(a)16(s)16(u)16(r)16(i)16(n)16(g)16( )62(C)16(D)16(4)16( )62(c)16(e)16(l)16(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 541.4736 Tm
[(c)-2(o)-2(u)-2(n)-2(t)-2( )-127(r)8(e)-2(p)-2(o)-2(r)-9(t)-2(e)-2(d)-2( )-127(c)-2(o)-2(r)-2(r)8(e)-2(l)-2(a)-2(t)-2(i)-2(o)-2(n)-2( )-127(c)-2(o)-2(e)-2(\036)-2(c)-2(i)-2(e)-2(n)-2(t)-2(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 529.7737 Tm
[(r)6(a)6(n)6(g)6(i)6(n)6(g)6( )16(f)6(r)12(o)6(m)6( )16(r)6( )16(=)6( )16(0)6(.)6(5)6(4)6( )16(t)6(o)6( )16(r)6( )16(=)6( )16(0)6(.)6(9)6(9)6(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 184.1437 533.1037 Tm
[(2)6(1)6(,)6(2)6(2)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 197.0862 529.7737 Tm
[( )16(I)18(n )]TJ
-14.039 -1.17 Td
[(the )-18(four )-18(studies )-18(examining )-18(enzyme )-18(im)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 518.0737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 506.3737 Tm
[(munoassay)85(, )-122(corr)10(elations )-122(betw)6(een )-122(CD4 )]TJ
T*
[(c)6(e)6(l)6(l)6( )23(c)6(o)6(u)6(n)6(t)6( )23(a)6(s)6( )23(m)6(e)6(a)6(s)6(u)6(r)16(e)6(d)6( )23(b)12(y)6( )23(d)6(u)6(a)6(l)]TJ
/Span<>> BDC
11.486 0 Td
(-)Tj
EMC
0.314 0 Td
[(p)6(l)6(a)6(t)6(f)6(o)6(r)6(m )]TJ
-11.8 -1.17 Td
[(\035)-1(o)11(w)-1( )-126(c)-1(y)-1(t)-1(o)-1(m)-1(e)-1(t)-1(r)-19(y)-1( )-126(a)-1(n)-1(d)-1( )-126(e)-1(n)-1(z)-1(y)-1(m)-1(e)-1( )-126(i)-1(m)-1(m)-1(u)-1(n)-1(o)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 482.9737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 471.2737 Tm
[(a)-35(s)-35(s)-35(a)-35(y)-35( )-160(w)-29(e)-35(r)-25(e)-35( )-160(a)-35(l)-35(l)-35( )-160(r)]TJ
ET
BT
/TT0 1 Tf
10 0 0 10 123.6894 471.2737 Tm
(<)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 127.1814 471.2737 Tm
[(0)-35(.)-35(7)-35(0)-35(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 148.9462 474.6036 Tm
[(1)-35(2)-35(,)-35(2)-35(1)-35(,)-35(2)-35(3)-35(,)-35(2)-35(4)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 178.9023 471.2737 Tm
[( )-145(W)-35(h)-35(e)-35(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 459.5736 Tm
[(a)-20( )-145(b)-20(l)-20(o)-20(o)-20(d)-20( )-145(\037)-20(x)-20(a)-20(t)-20(i)-20(v)-14(e)-20( )-145(w)-20(a)-20(s)-20( )-145(e)-20(m)-20(p)-20(l)-20(o)-8(y)-14(e)-20(d)-20( )-145(u)-20(s)-20(i)-20(n)-20(g )]TJ
T*
[(d)8(u)8(a)8(l)]TJ
/Span<>> BDC
1.64 0 Td
(-)Tj
EMC
0.312 0 Td
[(p)8(l)8(a)8(t)8(f)8(o)8(r)8(m)8( )9(\035)8(o)20(w)8( )9(c)8(y)8(t)8(o)8(m)8(e)8(t)8(r)-10(y)8( )9(w)8(i)8(t)8(h)8( )9(p)8(a)8(n)]TJ
/Span<>> BDC
12.846 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 447.8737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 436.1736 Tm
[(leucogating, )-71(corr)10(elations )-71(w)6(er)10(e )-71(r )-71(= )-71(0.97 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 424.4737 Tm
[(at )-82(day )-82(0, )-82(r )-82(= )-82(0.98 )-82(betw)6(een )-82(days )-82(0)12( )-70(a)12(n)12(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 412.7737 Tm
[(3)12(,)12( )-32(a)12(n)12(d)12( )-32(r)12( )-32(=)12( )-32(0)12(.)12(9)12(2)12( )-32(b)12(e)12(t)12(w)18(e)12(e)12(n)12( )-32(d)12(a)12(y)12(s)12( )-32(0)12( )-32(a)12(n)12(d)12( )-32(7.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 202.044 416.1036 Tm
(25)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 207.874 412.7737 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 401.0736 Tm
[(I)12(n )9(our )9(r)10(evie)-6(w)75(, )9(corr)10(elation )9(betw)6(een )9(total )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 389.3737 Tm
[(l)10(y)10(m)10(p)10(h)10(o)10(c)10(y)10(t)10(e)10( )42(a)10(n)10(d)10( )42(C)10(D)10(4)10( )42(c)10(e)10(l)10(l)10( )42(c)10(o)10(u)10(n)10(t)10(s)10( )42(r)10(a)10(n)10(g)10(e)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 377.6736 Tm
[(fr)6(om )33(r )33(= )33(0.23 )33(to )33(r )33(= )33(0.74.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 152.8291 381.0036 Tm
(26,27)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 165.9466 377.6736 Tm
[( )33(S)12(ensitivity )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 207.874 377.6736 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 365.9737 Tm
[(w)10(h)10(e)10(n)10( )27(a)10(s)10(s)10(e)10(s)10(s)10(i)10(n)10(g)10( )27(C)10(D)10(4)10( )27(c)10(e)10(l)10(l)10( )27(c)10(o)10(u)10(n)10(t)10( )27(a)10(n)10(d)10( )27(t)10(o)10(t)10(a)10(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 354.2737 Tm
[(l)-17(y)-17(m)-17(p)-17(h)-17(o)-17(c)-17(y)-17(t)-17(e)-17( )-142(c)-17(o)-17(u)-17(n)-17(t)-17( )-142(r)-17(a)-17(n)-17(g)-17(e)-17(d)-17( )-142(f)-17(r)-11(o)-17(m)-17( )-142(4)-17(3)-17(% )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 342.5736 Tm
[(f)-22(o)-22(r)-22( )-147(a)-22( )-147(t)-22(o)-22(t)-22(a)-22(l)-22( )-147(l)-22(y)-22(m)-22(p)-22(h)-22(o)-22(c)-22(y)-22(t)-22(e)-22( )-147(c)-22(o)-22(u)-22(n)-22(t)-22( )-147(<)-22(1)-22(2)-22(0)-22(0 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 330.8737 Tm
[(cells/mm\263 )-59(to )-59(pr)10(edict )-59(a )-59(CD4 )-59(cell )-59(count )]TJ
T*
[(<200 )28(cells/mm\263 )28(to )28(78% )28(for )28(a )28(total )28(lym)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 319.1736 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 307.4737 Tm
[(phocyte )25(count )25(<1500 )25(cells/mm\263 )25(to )25(pr)10(e-)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 307.4737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 295.7737 Tm
[(dict )-20(a )-20(CD4 )-20(cell )-20(count )-20(<200 )-20(cells/mm\263; )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 284.0736 Tm
[(s)-15(p)-15(e)-15(c)-15(i)-15(\037)-15(c)-15(i)-15(t)-15(y)-15( )-140(f)-15(o)-15(r)-15( )-140(t)-15(h)-15(e)-15(s)-15(e)-15( )-140(s)-15(t)-15(u)-15(d)-15(i)-15(e)-15(s)-15( )-140(w)-15(a)-15(s)-15( )-140(9)-15(8)-15(% )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 272.3737 Tm
[(a)-8(n)-8(d)-8( )-133(8)-8(0)-8(%)-8(,)-8( )-133(r)2(e)-8(s)-8(p)-8(e)-8(c)-8(t)-8(i)-8(v)-2(e)-8(l)-8(y)77(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 147.0856 275.7036 Tm
[(2)-8(8)-8(,)-8(2)-8(9)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 160.4381 272.3737 Tm
[( )-133(F)28(o)-8(r)-8( )-133(t)-8(h)-8(e)-8( )-133(2)-8(2 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 260.6736 Tm
[(entries )-9(in )-9(which )-10(CD4 )-9(cell )-9(count )-10(ser)-18(v)6(ed )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 248.9736 Tm
[(as )-6(the )-6(r)10(efer)10(ence )-6(standar)14(d )-6(and )-6(for )-6(which )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 237.2737 Tm
[(sensitivity/speci\037city )-44(w)6(er)10(e )-44(r)10(epor)-8(ted, )-44(18 )]TJ
T*
[(and )-5(2 )-5(entries )-5(r)10(epor)-8(ted )-5(a )-5(disease)]TJ
/Span<>> BDC
(-)Tj
EMC
[(pr)10(esent )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 213.8737 Tm
[(s)-12(t)-12(a)-12(t)-12(u)-12(s)-12( )-137(o)-12(f)-12( )-137(C)-12(D)-12(4)-12( )-137(c)-12(o)-12(u)-12(n)-12(t)-12( )]TJ
ET
BT
/TT0 1 Tf
10 0 0 10 145.6525 213.8737 Tm
(<)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 148.9563 213.8737 Tm
[(2)-12(0)-12(0)-12( )-137(c)-12(e)-12(l)-12(l)-12(s)-12(/)-12(m)-12(m)-12(\263 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 202.1736 Tm
(and )Tj
ET
BT
/TT0 1 Tf
10 0 0 10 73.5726 202.1736 Tm
(<)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 76.7806 202.1736 Tm
[(350 cells/mm\263, r)10(espectiv)6(ely)85(.)]TJ
ET
BT
/T1_0 1 Tf
11 0 1.9396 11 56.6929 178.6736 Tm
[(Vir)10(ologic information)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 167.0737 Tm
[(W)71(e)-7( )-132(c)-7(l)-7(a)-7(s)-7(s)-7(i)-7(\037)-7(e)-7(d)-7( )-132(1)-7(6)-7( )-132(o)-7(f)-7( )-132(5)-7(1)-7( )-132(s)-7(t)-7(u)-7(d)-7(i)-7(e)-7(s)-7( )-132(i)-7(n)-7( )-132(t)-7(h)-7(i)-7(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 155.4736 Tm
[(categor)-18(y)85(, )-54(with )-54(\037v)6(e )-54(r)10(epor)-8(ting )-54(r)10(esults )-54(for )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 143.8737 Tm
[(m)-11(u)-11(l)-11(t)-11(i)-11(p)-11(l)-11(e)-11( )-136(d)-11(i)-11(a)-11(g)-11(n)-11(o)-11(s)-11(t)-11(i)-11(c)-11( )-136(t)-11(e)-11(s)-11(t)-11(s)-11(,)-11( )-136(r)-1(e)-11(s)-11(u)-11(l)-11(t)-11(i)-11(n)-11(g)-11( )-136(i)-11(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 132.2737 Tm
[(a )-125(total )-125(of )-125(26 )-125(entries )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 140.0996 132.2737 Tm
(\()Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 143.4195 132.2737 Tm
[(T)110(able )-125(4 )-125(pr)10(esents )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 120.6736 Tm
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ET
BT
/T1_2 1 Tf
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[(p)7(r)17(e)7(s)7(e)7(n)7(t)7(s)7( )70(t)7(w)7(o)7( )]TJ
ET
BT
/T1_2 1 Tf
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[(m)7(e)7(a)7(s)7(u)7(r)17(e)7(s)7( )70(o)7(f)7( )70(a)7(c)7(c)7(u)7(r)7(a)7(c)7(y)]TJ
ET
BT
/T1_2 1 Tf
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[(;)7( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 186.7975 109.0737 Tm
[(F)41(i)7(g)7(.)7( )70(2 )]TJ
ET
BT
/T1_2 1 Tf
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[(\()2(m)2(e)2(a)2(s)2(u)2(r)12(e)2(s)2( )64(o)2(f)2( )64(a)2(s)2(s)2(o)2(c)2(i)2(a)2(t)2(i)2(o)2(n)2(\))2( )]TJ
ET
BT
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[(a)2(l)2(l)2( )64(w)8(e)2(b)2( )64(v)8(e)2(r)2(s)2(i)2(o)2(n )]TJ
ET
BT
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ET
BT
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BT
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(-)Tj
ET
BT
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ET
BT
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ET
BT
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[(a)16(c)16(t)16(i)16(v)22(a)16(t)16(i)16(o)16(n)16( )]TJ
ET
BT
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ET
BT
/T1_2 1 Tf
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[(a)15(c)15(t)15(i)15(v)15(i)15(t)15(y)15(;)15( )77(t)15(h)15(e)15( )77(r)25(e)15(m)15(a)15(i)15(n)15(i)15(n)15(g)15( )77(\037)15(v)21(e)15( )77(e)15(v)21(a)15(l)15(u)15(a)15(t)15(e)15(d)15( )77(v)15(i)15(r)15(a)15(l )]TJ
ET
BT
/T1_2 1 Tf
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ET
BT
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ET
BT
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<0045>Tj
ET
BT
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EMC
ET
BT
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(2)Tj
ET
BT
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( )Tj
ET
BT
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T*
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EMC
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ET
BT
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ET
BT
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ET
BT
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ET
BT
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ET
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ET
BT
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ET
BT
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[(w)11(e)5(r)14(e)5( )67(r)15(e)4(p)5(o)5(r)-3(t)5(e)4(d)5( )67(f)5(o)4(r)5( )67(o)5(n)4(l)5(y)5( )67(4)4( )67(e)5(n)4(t)5(r)5(i)5(e)5(s)4(,)]TJ
ET
BT
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[(1)5(9)4(,)5(3)5(0)]TJ
ET
BT
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[( )67(w)4(i)5(t)5(h )]TJ
ET
BT
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ET
BT
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[(i)-32(n)-32(g)-32( )-157(c)-32(o)-32(r)-32(r)-22(e)-32(l)-32(a)-32(t)-32(i)-32(o)-32(n )]TJ
ET
BT
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(coe\036cients.)Tj
18.236 17.49 Td
[(S)8(e)-4(v)2(e)-4(n)-4(t)-4(e)-4(e)-4(n)-4( )-129(e)-4(n)-4(t)-4(r)-4(i)-4(e)-4(s)-4( )-129(c)-4(o)-4(m)-4(p)-4(a)-4(r)6(e)-4(d)-4( )-129(c)-4(o)-4(m)]TJ
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ET
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(-)Tj
ET
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ET
BT
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ET
BT
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ET
BT
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[(b)-49(r)-49(a)-49(n)-49(c)-49(h)-49(e)-49(d)-49( )-174(d)-49(e)-49(o)-43(x)-49(y)-49(r)-49(i)-49(b)-49(o)-49(s)-49(e)-49( )-174(n)-49(u)-49(c)-49(l)-49(e)-49(i)-49(c)-49( )-174(a)-49(c)-49(i)-49(d )]TJ
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ET
BT
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[(both )-50(R)45(T )-50(PCR )-50(and )-50(bDNA )]TJ
ET
BT
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[(tests )-50(r)6(a)6(n)6(g)6(e)6(d )]TJ
ET
BT
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[(f)6(r)12(o)6(m)6( )60(r)6( )60(=)6( )60(0)6(.)6(5)6(4)6( )60(t)6(o)6( )60(r)6( )60(=)6( )60(0)6(.)6(9)6(0)6(.)]TJ
ET
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[( )60(O)12(t)6(h)6(e)6(r)6( )60(vir)6(o)]TJ
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EMC
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BT
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ET
BT
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ET
BT
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[(assay\) )-23(and )-23(r)10(ev)6(erse )-23(transcriptase )-23(activity)85(. )]TJ
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BT
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ET
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ET
BT
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451.604 802.63 m
451.604 796.01 l
451.604 795.64 451.594 795.32 451.565 795.13 c
452.724 795.13 l
452.745 795.28 452.764 795.58 452.764 795.93 c
452.794 795.93 l
452.995 795.49 453.365 795.05 454.164 795.05 c
455.444 795.05 455.974 796.27 455.974 797.7 c
455.974 799.38 455.305 800.36 454.194 800.36 c
453.454 800.36 453.044 799.94 452.865 799.54 c
452.844 799.54 l
452.844 802.63 l
h
452.844 797.72 m
452.844 798.72 453.125 799.45 453.805 799.45 c
454.495 799.45 454.734 798.78 454.734 797.75 c
454.734 796.56 454.544 795.96 453.824 795.96 c
453.094 795.96 452.844 796.75 452.844 797.72 c
h
S
457.074 795.13 1.24 7.5 re
S
459.674 795.13 1.24 5.15 re
459.654 801.25 1.28 1.22 re
S
465.584 796.24 m
465.414 796.13 465.004 795.99 464.704 795.99 c
463.754 795.99 463.294 796.73 463.294 797.69 c
463.294 798.79 463.704 799.42 464.644 799.42 c
464.984 799.42 465.294 799.28 465.514 799.17 c
465.584 800.15 l
465.354 800.24 464.894 800.36 464.504 800.36 c
462.774 800.36 462.014 799.17 462.014 797.7 c
462.014 796.24 462.734 795.05 464.434 795.05 c
464.934 795.05 465.364 795.15 465.654 795.26 c
h
S
469.194 795.13 m
470.474 795.13 l
470.474 798.21 l
472.544 798.21 l
472.544 795.13 l
473.824 795.13 l
473.824 802.11 l
472.544 802.11 l
472.544 799.27 l
470.474 799.27 l
470.474 802.11 l
469.194 802.11 l
h
S
478.844 796.36 m
478.614 796.19 478.254 795.96 477.494 795.96 c
476.534 795.96 476.184 796.49 476.184 797.37 c
479.164 797.37 l
479.164 797.61 l
479.164 799.71 478.214 800.36 477.104 800.36 c
475.794 800.36 474.984 799.17 474.984 797.63 c
474.984 796.24 475.704 795.05 477.364 795.05 c
478.104 795.05 478.644 795.27 478.904 795.38 c
h
476.184 798.15 m
476.184 798.83 476.454 799.52 477.104 799.52 c
477.664 799.52 477.964 799.06 477.964 798.15 c
h
S
480.444 798.98 m
480.684 799.18 481.234 799.48 481.854 799.48 c
482.564 799.48 482.814 799.01 482.814 798.5 c
482.814 798.31 l
482.564 798.31 l
480.994 798.31 479.854 797.96 479.854 796.56 c
479.854 795.6 480.594 795.05 481.394 795.05 c
482.134 795.05 482.524 795.41 482.834 795.83 c
482.854 795.83 l
482.854 795.58 482.864 795.33 482.924 795.13 c
484.044 795.13 l
484.014 795.33 483.974 795.67 483.974 796.04 c
483.974 798.29 l
483.974 799.58 483.604 800.36 482.004 800.36 c
481.214 800.36 480.724 800.14 480.374 799.98 c
h
482.814 797.36 m
482.814 796.44 482.544 795.89 481.804 795.89 c
481.324 795.89 481.014 796.21 481.014 796.68 c
481.014 797.43 481.644 797.65 482.704 797.65 c
482.814 797.65 l
h
S
485.244 795.13 1.24 7.5 re
S
488.184 800.28 m
487.364 800.28 l
487.364 799.37 l
488.184 799.37 l
488.184 796.55 l
488.184 795.47 488.704 795.05 489.624 795.05 c
489.994 795.05 490.264 795.13 490.454 795.22 c
490.454 796.1 l
490.364 796.05 490.204 795.99 489.984 795.99 c
489.624 795.99 489.424 796.15 489.424 796.7 c
489.424 799.37 l
490.454 799.37 l
490.454 800.28 l
489.424 800.28 l
489.424 801.72 l
488.184 801.34 l
h
S
491.244 795.13 m
492.484 795.13 l
492.484 798.13 l
492.484 798.79 492.714 799.34 493.364 799.34 c
493.874 799.34 494.074 799.01 494.074 798.22 c
494.074 795.13 l
495.314 795.13 l
495.314 798.45 l
495.314 799.49 494.964 800.36 493.794 800.36 c
493.024 800.36 492.734 799.94 492.514 799.62 c
492.484 799.62 l
492.484 802.63 l
491.244 802.63 l
h
S
499.154 795.13 m
500.434 795.13 l
500.434 798.13 l
500.724 798.13 l
501.194 798.13 501.524 797.95 501.694 797.4 c
502.384 795.13 l
503.744 795.13 l
502.834 797.79 l
502.614 798.44 502.324 798.56 502.064 798.6 c
502.064 798.63 l
502.844 798.75 503.414 799.36 503.414 800.27 c
503.414 801.55 502.574 802.11 501.334 802.11 c
499.154 802.11 l
h
500.434 799.07 m
500.434 801.13 l
500.954 801.13 l
501.674 801.13 502.094 800.93 502.094 800.13 c
502.094 799.42 501.634 799.07 500.954 799.07 c
h
S
508.314 796.36 m
508.084 796.19 507.724 795.96 506.964 795.96 c
506.004 795.96 505.654 796.49 505.654 797.37 c
508.634 797.37 l
508.634 797.61 l
508.634 799.71 507.684 800.36 506.574 800.36 c
505.264 800.36 504.454 799.17 504.454 797.63 c
504.454 796.24 505.174 795.05 506.834 795.05 c
507.574 795.05 508.114 795.27 508.374 795.38 c
h
505.654 798.15 m
505.654 798.83 505.924 799.52 506.574 799.52 c
507.134 799.52 507.434 799.06 507.434 798.15 c
h
S
510.704 795.13 m
512.164 795.13 l
513.744 800.28 l
512.544 800.28 l
511.484 796.31 l
511.464 796.31 l
510.414 800.28 l
509.134 800.28 l
h
S
514.524 795.13 1.24 5.15 re
514.504 801.25 1.28 1.22 re
S
520.724 796.36 m
520.494 796.19 520.134 795.96 519.374 795.96 c
518.414 795.96 518.064 796.49 518.064 797.37 c
521.044 797.37 l
521.044 797.61 l
521.044 799.71 520.094 800.36 518.984 800.36 c
517.674 800.36 516.864 799.17 516.864 797.63 c
516.864 796.24 517.584 795.05 519.244 795.05 c
519.984 795.05 520.524 795.27 520.784 795.38 c
h
518.064 798.15 m
518.064 798.83 518.334 799.52 518.984 799.52 c
519.544 799.52 519.844 799.06 519.844 798.15 c
h
S
526.084 795.13 m
527.434 795.13 l
528.804 800.28 l
527.604 800.28 l
526.774 796.27 l
526.754 796.27 l
525.904 800.28 l
524.494 800.28 l
523.624 796.27 l
523.604 796.27 l
522.774 800.28 l
521.494 800.28 l
522.884 795.13 l
524.244 795.13 l
525.144 799.14 l
525.164 799.14 l
h
S
529.214 795.3 m
529.474 795.2 530.004 795.05 530.644 795.05 c
531.764 795.05 532.564 795.62 532.564 796.57 c
532.564 797.17 532.244 797.46 531.604 797.87 c
530.994 798.26 l
530.634 798.49 530.414 798.64 530.414 798.92 c
530.414 799.23 530.624 799.42 531.124 799.42 c
531.574 799.42 531.904 799.31 532.214 799.19 c
532.284 800.15 l
532.164 800.19 531.654 800.36 530.994 800.36 c
529.904 800.36 529.214 799.61 529.214 798.9 c
529.214 798.09 529.784 797.76 530.304 797.45 c
530.814 797.15 l
531.264 796.89 531.364 796.7 531.364 796.5 c
531.364 796.1 531.014 795.99 530.564 795.99 c
529.984 795.99 529.474 796.25 529.274 796.33 c
h
S
/GS0 gs
BT
/T1_0 1 Tf
10 0 0 10 440.6446 795.1299 Tm
(Public Health Reviews)Tj
ET
/GS1 gs
58.592 785.624 m
59.456 788.558 l
59.474 788.558 l
60.266 785.624 l
h
60.95 783.23 m
62.138 783.23 l
60.113 789.512 l
58.853 789.512 l
56.747 783.23 l
57.899 783.23 l
58.349 784.742 l
60.509 784.742 l
h
S
62.714 781.286 m
63.83 781.286 l
63.83 783.896 l
63.848 783.896 l
64.01 783.536 64.379 783.158 65.045 783.158 c
66.044 783.158 66.647 784.04 66.647 785.552 c
66.647 786.839 66.17 787.937 65.018 787.937 c
64.298 787.937 63.965 787.541 63.785 787.145 c
63.758 787.145 l
63.758 787.46 63.74 787.73 63.722 787.865 c
62.678 787.865 l
62.705 787.694 62.714 787.406 62.714 787.073 c
h
63.83 785.534 m
63.83 786.407 64.055 787.118 64.712 787.118 c
65.36 787.118 65.531 786.578 65.531 785.507 c
65.531 784.58 65.315 783.977 64.694 783.977 c
64.082 783.977 63.83 784.634 63.83 785.534 c
h
S
67.565 783.23 m
68.681 783.23 l
68.681 785.768 l
68.681 786.632 69.185 786.911 69.644 786.911 c
69.761 786.911 69.86 786.893 69.959 786.866 c
69.959 787.91 l
69.896 787.919 69.842 787.937 69.77 787.937 c
69.077 787.937 68.726 787.379 68.591 787.019 c
68.573 787.019 l
68.573 787.298 68.546 787.586 68.537 787.865 c
67.529 787.865 l
67.556 787.658 67.565 787.388 67.565 787.1 c
h
S
70.805 783.23 1.116 4.635 re
70.787 788.738 1.152 1.098 re
S
73.145 783.23 1.116 6.75 re
S
77.824 783.23 m
79.462 783.23 l
81.208 783.23 82.469 784.256 82.469 786.371 c
82.469 788.45 81.424 789.512 79.462 789.512 c
77.824 789.512 l
h
78.976 788.63 m
79.363 788.63 l
80.66 788.63 81.245 787.748 81.245 786.371 c
81.245 784.994 80.66 784.112 79.363 784.112 c
78.976 784.112 l
h
S
85.888 783.23 m
87.04 783.23 l
87.04 786.182 l
87.067 786.182 l
88.957 783.23 l
90.352 783.23 l
88.048 786.551 l
90.181 789.512 l
88.858 789.512 l
87.067 786.848 l
87.04 786.848 l
87.04 789.512 l
85.888 789.512 l
h
S
91 783.23 1.116 4.635 re
90.982 788.738 1.152 1.098 re
S
93.205 783.23 m
94.321 783.23 l
94.321 786.038 l
94.321 786.551 94.582 787.019 95.077 787.019 c
95.491 787.019 95.671 786.731 95.671 786.155 c
95.671 783.23 l
96.787 783.23 l
96.787 786.038 l
96.787 786.551 97.048 787.019 97.543 787.019 c
97.957 787.019 98.137 786.731 98.137 786.155 c
98.137 783.23 l
99.253 783.23 l
99.253 786.092 l
99.253 787.217 98.929 787.937 97.921 787.937 c
97.237 787.937 96.904 787.523 96.679 787.199 c
96.544 787.451 96.292 787.937 95.509 787.937 c
94.87 787.937 94.51 787.496 94.339 787.136 c
94.321 787.136 l
94.321 787.379 94.294 787.622 94.285 787.865 c
93.169 787.865 l
93.187 787.694 93.205 787.442 93.205 787.109 c
h
S
100.207 783.23 m
101.323 783.23 l
101.323 786.038 l
101.323 786.551 101.584 787.019 102.079 787.019 c
102.493 787.019 102.673 786.731 102.673 786.155 c
102.673 783.23 l
103.789 783.23 l
103.789 786.038 l
103.789 786.551 104.05 787.019 104.545 787.019 c
104.959 787.019 105.139 786.731 105.139 786.155 c
105.139 783.23 l
106.255 783.23 l
106.255 786.092 l
106.255 787.217 105.931 787.937 104.923 787.937 c
104.239 787.937 103.906 787.523 103.681 787.199 c
103.546 787.451 103.294 787.937 102.511 787.937 c
101.872 787.937 101.512 787.496 101.341 787.136 c
101.323 787.136 l
101.323 787.379 101.296 787.622 101.287 787.865 c
100.171 787.865 l
100.189 787.694 100.207 787.442 100.207 787.109 c
h
S
110.584 784.337 m
110.377 784.184 110.053 783.977 109.369 783.977 c
108.505 783.977 108.19 784.454 108.19 785.246 c
110.872 785.246 l
110.872 785.462 l
110.872 787.352 110.017 787.937 109.018 787.937 c
107.839 787.937 107.11 786.866 107.11 785.48 c
107.11 784.229 107.758 783.158 109.252 783.158 c
109.918 783.158 110.404 783.356 110.638 783.455 c
h
108.19 785.948 m
108.19 786.56 108.433 787.181 109.018 787.181 c
109.522 787.181 109.792 786.767 109.792 785.948 c
h
S
111.844 783.23 1.116 6.75 re
S
119.764 784.337 m
119.557 784.184 119.233 783.977 118.549 783.977 c
117.685 783.977 117.37 784.454 117.37 785.246 c
120.052 785.246 l
120.052 785.462 l
120.052 787.352 119.197 787.937 118.198 787.937 c
117.019 787.937 116.29 786.866 116.29 785.48 c
116.29 784.229 116.938 783.158 118.432 783.158 c
119.098 783.158 119.584 783.356 119.818 783.455 c
h
117.37 785.948 m
117.37 786.56 117.613 787.181 118.198 787.181 c
118.702 787.181 118.972 786.767 118.972 785.948 c
h
S
121.33 787.865 m
120.592 787.865 l
120.592 787.046 l
121.33 787.046 l
121.33 784.508 l
121.33 783.536 121.798 783.158 122.626 783.158 c
122.959 783.158 123.202 783.23 123.373 783.311 c
123.373 784.103 l
123.292 784.058 123.148 784.004 122.95 784.004 c
122.626 784.004 122.446 784.148 122.446 784.643 c
122.446 787.046 l
123.373 787.046 l
123.373 787.865 l
122.446 787.865 l
122.446 789.161 l
121.33 788.819 l
h
S
126.712 786.695 m
126.928 786.875 127.423 787.145 127.981 787.145 c
128.62 787.145 128.845 786.722 128.845 786.263 c
128.845 786.092 l
128.62 786.092 l
127.207 786.092 126.181 785.777 126.181 784.517 c
126.181 783.653 126.847 783.158 127.567 783.158 c
128.233 783.158 128.584 783.482 128.863 783.86 c
128.881 783.86 l
128.881 783.635 128.89 783.41 128.944 783.23 c
129.952 783.23 l
129.925 783.41 129.889 783.716 129.889 784.049 c
129.889 786.074 l
129.889 787.235 129.556 787.937 128.116 787.937 c
127.405 787.937 126.964 787.739 126.649 787.595 c
h
128.845 785.237 m
128.845 784.409 128.602 783.914 127.936 783.914 c
127.504 783.914 127.225 784.202 127.225 784.625 c
127.225 785.3 127.792 785.498 128.746 785.498 c
128.845 785.498 l
h
S
131.032 783.23 1.116 6.75 re
S
133.39 783.23 1.08 1.17 re
S
396.638 783.23 m
398.276 783.23 l
400.022 783.23 401.282 784.256 401.282 786.371 c
401.282 788.45 400.238 789.512 398.276 789.512 c
396.638 789.512 l
h
397.79 788.63 m
398.177 788.63 l
399.473 788.63 400.058 787.748 400.058 786.371 c
400.058 784.994 399.473 784.112 398.177 784.112 c
397.79 784.112 l
h
S
402.308 783.23 1.116 4.635 re
402.29 788.738 1.152 1.098 re
S
404.828 786.695 m
405.044 786.875 405.539 787.145 406.097 787.145 c
406.736 787.145 406.961 786.722 406.961 786.263 c
406.961 786.092 l
406.736 786.092 l
405.323 786.092 404.297 785.777 404.297 784.517 c
404.297 783.653 404.963 783.158 405.683 783.158 c
406.349 783.158 406.7 783.482 406.979 783.86 c
406.997 783.86 l
406.997 783.635 407.006 783.41 407.06 783.23 c
408.068 783.23 l
408.041 783.41 408.005 783.716 408.005 784.049 c
408.005 786.074 l
408.005 787.235 407.672 787.937 406.232 787.937 c
405.521 787.937 405.08 787.739 404.765 787.595 c
h
406.961 785.237 m
406.961 784.409 406.718 783.914 406.052 783.914 c
405.62 783.914 405.341 784.202 405.341 784.625 c
405.341 785.3 405.908 785.498 406.862 785.498 c
406.961 785.498 l
h
S
410.066 785.597 m
410.066 786.542 410.291 787.082 410.876 787.091 c
411.407 787.1 411.776 786.578 411.776 785.606 c
411.776 784.553 411.497 784.049 410.795 784.049 c
410.417 784.049 410.066 784.508 410.066 785.597 c
h
409.121 781.52 m
409.391 781.421 409.976 781.232 410.714 781.232 c
412.415 781.232 412.856 782.267 412.856 783.716 c
412.856 787.136 l
412.856 787.379 412.874 787.622 412.892 787.865 c
411.884 787.865 l
411.875 787.622 411.848 787.388 411.848 787.145 c
411.812 787.145 l
411.578 787.55 411.263 787.937 410.588 787.937 c
409.373 787.937 408.914 786.812 408.914 785.534 c
408.914 783.662 409.886 783.23 410.534 783.23 c
411.263 783.23 411.578 783.653 411.758 784.013 c
411.776 784.013 l
411.776 783.572 l
411.776 782.843 411.605 782.114 410.552 782.114 c
409.967 782.114 409.445 782.366 409.184 782.51 c
h
S
413.873 783.23 m
414.989 783.23 l
414.989 785.93 l
414.989 786.524 415.196 787.019 415.781 787.019 c
416.24 787.019 416.42 786.722 416.42 786.011 c
416.42 783.23 l
417.536 783.23 l
417.536 786.218 l
417.536 787.154 417.221 787.937 416.168 787.937 c
415.412 787.937 415.097 787.433 414.935 787.154 c
414.917 787.154 l
414.917 787.388 414.89 787.631 414.881 787.865 c
413.837 787.865 l
413.864 787.658 413.873 787.388 413.873 787.1 c
h
S
419.57 785.552 m
419.57 786.326 419.741 787.145 420.461 787.145 c
421.181 787.145 421.343 786.326 421.343 785.552 c
421.343 784.778 421.181 783.95 420.461 783.95 c
419.741 783.95 419.57 784.778 419.57 785.552 c
h
418.418 785.552 m
418.418 783.608 419.516 783.158 420.461 783.158 c
421.406 783.158 422.495 783.608 422.495 785.552 c
422.495 787.442 421.406 787.937 420.461 787.937 c
419.516 787.937 418.418 787.442 418.418 785.552 c
h
S
423.197 783.383 m
423.431 783.293 423.908 783.158 424.484 783.158 c
425.492 783.158 426.212 783.671 426.212 784.526 c
426.212 785.066 425.924 785.327 425.348 785.696 c
424.799 786.047 l
424.475 786.254 424.277 786.389 424.277 786.641 c
424.277 786.92 424.466 787.091 424.916 787.091 c
425.321 787.091 425.618 786.992 425.897 786.884 c
425.96 787.748 l
425.852 787.784 425.393 787.937 424.799 787.937 c
423.818 787.937 423.197 787.262 423.197 786.623 c
423.197 785.894 423.71 785.597 424.178 785.318 c
424.637 785.048 l
425.042 784.814 425.132 784.643 425.132 784.463 c
425.132 784.103 424.817 784.004 424.412 784.004 c
423.89 784.004 423.431 784.238 423.251 784.31 c
h
S
427.454 787.865 m
426.716 787.865 l
426.716 787.046 l
427.454 787.046 l
427.454 784.508 l
427.454 783.536 427.922 783.158 428.75 783.158 c
429.083 783.158 429.326 783.23 429.497 783.311 c
429.497 784.103 l
429.416 784.058 429.272 784.004 429.074 784.004 c
428.75 784.004 428.57 784.148 428.57 784.643 c
428.57 787.046 l
429.497 787.046 l
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h
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h
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h
S
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S
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h
S
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S
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h
S
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S
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h
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h
S
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h
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h
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h
S
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h
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h
510.541 785.948 m
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h
S
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h
S
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h
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h
S
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h
S
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h
S
/CS0 cs 1 scn
BT
/T1_0 1 Tf
9 0 0 9 56.6929 783.2299 Tm
(April D Kimmel et al.)Tj
/Span<>> BDC
8.675 0 Td
( )Tj
EMC
28.769 0 Td
( Diagnostic tests in HIV management)Tj
ET
0 w
56.693 802.63 m
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538.593 802.63 l
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h
S
/CS0 CS 1 SCN
1 w
538.093 783.118 m
538.093 802.63 l
S
Q
0 0 0 1 k
0 i
/RelativeColorimetric ri
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 10 0 0 10 56.6929 763.7737 Tm
[(R)-17(N)-17(A)-17( )-142(<)-17(4)-17(0)-17(0)-17( )-142(c)-17(o)-17(p)-17(i)-17(e)-17(s)-17(/)-17(m)-17(l)-17( )-142(w)-17(h)-17(e)-17(n)-17( )-142(c)-17(o)-17(m)-17(p)-17(a)-17(r)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 763.7737 Tm
(-)Tj
-14.798 -1.15 Td
[(i)-15(n)-15(g)-15( )-140(H)-15(I)-15(V)]TJ
/Span<>> BDC
3.466 0 Td
(-)Tj
EMC
0.335 0 Td
[(1)-15( )-140(R)-15(N)-15(A)-15( )-140(a)-15(s)-15( )-140(m)-15(e)-15(a)-15(s)-15(u)-15(r)-5(e)-15(d)-15( )-140(b)-9(y)-15( )-140(R)30(T )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 740.7737 Tm
[(P)-3(C)-3(R)-3( )-128(a)-3(n)-3(d)-3( )-128(v)-3(i)-3(r)-3(a)-3(l)-3( )-128(a)-3(c)-3(t)-3(i)-3(v)3(a)-3(t)-3(i)-3(o)-3(n)-3( )-128(a)-3(s)-3( )-128(m)-3(e)-3(a)-3(s)-3(u)-3(r)7(e)-3(d )]TJ
0 -1.15 TD
[(b)6(y )-89(heat)]TJ
/Span<>> BDC
(-)Tj
EMC
[(denatur)10(ed )-89(p24 )-89(antigen )-89(assay)85(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 202.044 732.6037 Tm
(30)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 207.874 729.2737 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 717.7737 Tm
[(F)40(o)4(u)4(r)4( )67(e)4(n)4(t)4(r)4(i)4(e)4(s)4( )67(e)4(v)10(a)4(l)4(u)4(a)4(t)4(e)4(d)4( )67(i)4(m)4(m)4(u)4(n)4(e)4( )67(a)4(n)4(d)4( )67(v)4(i)4(r)4(a)4(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 706.2737 Tm
[(a)-12(c)-12(t)-12(i)-12(v)-6(a)-12(t)-12(i)-12(o)-12(n)-12( )-137(m)-12(a)-12(r)-6(k)-12(e)-12(r)-12(s)-12(.)-12( )-137(O)-6(n)-12(e)-12( )-137(s)-12(t)-12(u)-12(d)-12(y)-12( )-137(f)-12(o)-12(u)-12(n)-12(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 694.7737 Tm
[(d)5(e)5(t)5(e)5(c)5(t)5(a)5(b)5(l)5(e)5( )68(p)5(2)5(4)5( )68(a)5(n)5(t)5(i)5(g)5(e)5(n)5( )68(7)5(2)5(%)5( )68(s)5(e)5(n)5(s)5(i)5(t)5(i)5(v)11(e)5( )68(f)5(o)5(r )]TJ
ET
BT
/C2_0 1 Tf
10 0 1.7633 10 56.6929 683.2737 Tm
<0045>Tj
ET
BT
/T1_2 1 Tf
6.413 0 1.1308 6.413 62.5738 682.6107 Tm
(2)Tj
/Span<>> BDC
10 0 0 10 66.481 683.2737 Tm
(-)Tj
EMC
0.309 0 Td
[(m)11(i)11(c)11(r)17(o)11(g)11(l)11(o)11(b)11(u)11(l)11(i)11(n)11( )73(c)11(o)11(n)11(c)11(e)11(n)11(t)11(r)11(a)11(t)11(i)11(o)11(n)11( )73(>)11(5)11( )73(m)11(g)11(/)11(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 671.7737 Tm
[(as w)6(ell as 72% sensitiv)6(e for CD4 count )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 660.1736 Tm
[(<200 )-41(cells/mm\263, )-41(the )-41(same )-41(study )-41(found )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 648.5737 Tm
[(d)10(e)10(t)10(e)10(c)10(t)10(a)10(b)10(l)10(e)10( )37(p)10(2)10(4)10( )37(a)10(n)10(t)10(i)10(g)10(e)10(n)10( )37(8)10(6)10(%)10( )37(s)10(e)10(n)10(s)10(i)10(t)10(i)10(v)16(e)10( )37(f)10(o)10(r )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 636.9736 Tm
[(WHO )-97(clinical )-97(stage )-97(4.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 146.3554 640.3036 Tm
(19)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 152.1854 636.9736 Tm
[( )-97(H)18(o)12(w)6(ev)6(er)60(, )-97(the )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 625.3737 Tm
[(c)-14(o)-14(r)-14(r)-4(e)-14(l)-14(a)-14(t)-14(i)-14(o)-14(n)-14( )-139(b)-14(e)-14(t)-14(w)-8(e)-14(e)-14(n)-14( )-139(p)-14(2)-14(4)-14( )-139(a)-14(n)-14(t)-14(i)-14(g)-14(e)-14(n)-14( )-139(a)-14(n)-14(d )]TJ
0 -1.16 TD
[(C)4(D)4(4)4( )20(c)4(e)4(l)4(l)4( )21(c)4(o)4(u)4(n)4(t)4(/)4(C)4(D)4(C)4( )20(c)4(l)4(i)4(n)4(i)4(c)4(a)4(l)4( )20(c)4(l)4(a)4(s)4(s)4(i)4(\037)4(c)4(a)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 613.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 602.1736 Tm
[(tion system was lo)12(w \()]TJ
ET
BT
/T1_3 1 Tf
10 0 0 10 139.0617 602.1736 Tm
(r )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 144.9716 602.1736 Tm
(= 0.23\).)Tj
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 175.6715 605.5037 Tm
(20)Tj
ET
BT
/T1_0 1 Tf
13 0 0 13 56.6929 575.6736 Tm
(Discussion)Tj
/T1_2 1 Tf
10 0 0 10 56.6929 561.239 Tm
[(\034r)6(ough )-94(a )-94(systematic )-94(r)10(evie)-6(w)75(, )-94(w)6(e )-94(iden)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 561.239 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 549.639 Tm
[(t)-2(i)-2(\037)-2(e)-2(d)-2(,)-2( )-127(s)-2(e)-2(l)-2(e)-2(c)-2(t)-2(e)-2(d)-2( )-127(a)-2(n)-2(d)-2( )-127(c)-2(r)-2(i)-2(t)-2(i)-2(c)-2(a)-2(l)-2(l)-2(y)-2( )-127(e)-2(v)4(a)-2(l)-2(u)-2(a)-2(t)-2(e)-2(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 538.039 Tm
[(5)-24(1)-24( )-149(s)-24(t)-24(u)-24(d)-24(i)-24(e)-24(s)-24( )-149(o)-24(n)-24( )-149(c)-24(l)-24(i)-24(n)-24(i)-24(c)-24(a)-24(l)-24(,)-24( )-149(i)-24(m)-24(m)-24(u)-24(n)-24(o)-24(l)-24(o)-24(g)-24(i)-24(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 526.439 Tm
[(and )-84(vir)6(ologic )-84(strategies )-84(for )-84(monitoring )]TJ
T*
(HIV)Tj
/Span<>> BDC
1.76 0 Td
(-)Tj
EMC
[(infected individuals in dev)6(eloping )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 503.239 Tm
[(c)-2(o)-2(u)-2(n)-2(t)-2(r)-2(i)-2(e)-2(s)-2(.)-2( )-127(I)10(n)-2( )-127(t)-2(h)-2(e)-2( )-127(s)-2(t)-2(u)-2(d)-2(i)-2(e)-2(s)-2( )-127(w)4(e)-2( )-127(r)8(e)-2(v)-2(i)-2(e)-8(w)4(e)-2(d)-2(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 491.639 Tm
[(o)26(v)16(e)10(r)10( )67(9)10(0)10(%)10( )67(w)16(e)10(r)20(e)10( )67(p)10(e)10(r)2(f)10(o)10(r)10(m)10(e)10(d)10( )67(i)10(n)10( )67(A)10(f)10(r)10(i)10(c)10(a)10(n)10( )67(a)10(n)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 480.039 Tm
[(A)10(s)10(i)10(a)10(n)10( )41(l)10(o)22(w)16(e)10(r)10( )41(i)10(n)10(c)10(o)10(m)10(e)10( )41(c)10(o)10(u)10(n)10(t)10(r)10(i)10(e)10(s)10( )41(a)10(n)10(d)10( )41(n)10(e)10(a)10(r)10(l)10(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 468.439 Tm
[(8)-13(0)-13(%)-13( )-138(w)-7(e)-13(r)-3(e)-13( )-138(c)-13(o)-13(n)-13(d)-13(u)-13(c)-13(t)-13(e)-13(d)-13( )-138(i)-13(n)-13( )-138(u)-13(r)-13(b)-13(a)-13(n)-13( )-138(a)-13(r)-3(e)-13(a)-13(s)-13(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 456.839 Tm
[(M)36(o)12(n)12(i)12(t)12(o)12(r)12(i)12(n)12(g)12( )74(s)12(t)12(r)12(a)12(t)12(e)12(g)12(i)12(e)12(s)12( )74(w)18(e)12(r)22(e)12( )74(a)12(s)12(s)12(e)12(s)12(s)12(e)12(d)12( )74(u)12(s)12(i)12(n)12(g )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 445.239 Tm
[(a )-12(br)6(oad )-13(range )-12(of )-12(diagnostic )-12(tests, )-12(assays )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 433.639 Tm
(or staging systems.)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 73.7008 422.039 Tm
[(O)6(ur )-91(r)10(evie)-6(w )-91(r)10(ev)6(ealed )-91(that )-91(methods )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 410.439 Tm
[(o)6(f)6( )28(p)6(e)6(r)-2(f)6(o)6(r)6(m)6(a)6(n)6(c)6(e)6( )28(e)6(v)12(a)6(l)6(u)6(a)6(t)6(i)6(o)6(n)6( )28(v)12(a)6(r)6(i)6(e)6(d)6( )28(w)6(i)6(d)6(e)6(l)6(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 398.839 Tm
[(acr)6(oss )-88(all )-88(thr)10(ee )-88(types )-88(of )-88(diagnostic )-88(test )]TJ
T*
[(i)-25(n)-26(f)-25(o)-25(r)-26(m)-25(a)-25(t)-25(i)-26(o)-25(n)-25( )-151(c)-25(a)-25(t)-25(e)-26(g)-25(o)-25(r)-26(i)-25(e)-25(s)-26( )-150(\()-26(c)-25(l)-25(i)-25(n)-26(i)-25(c)-25(a)-26(l)-25(,)-25( )-151(i)-25(m)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 387.239 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 375.639 Tm
[(m)-28(u)-28(n)-28(o)-28(l)-28(o)-28(g)-28(i)-28(c)-28(,)-28( )-153(v)-28(i)-28(r)-22(o)-28(l)-28(o)-28(g)-28(i)-28(c)-28(\))-28(.)-28( )-153(F)8(o)-28(r)-28( )-153(e)-28(x)-28(a)-28(m)-28(p)-28(l)-28(e)-28(, )]TJ
T*
[(per)-8(formance )-123(measur)10(es )-123(for )-123(\223)50(clinical )-123(in)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 364.039 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 352.439 Tm
[(f)-2(o)-3(r)-2(m)-2(a)-3(t)-2(i)-2(o)-2(n)67(\224)-2( )-128(w)4(e)-2(r)8(e)-3( )-127(r)7(e)-2(p)-2(o)-2(r)-11(t)-2(e)-2(d)-2( )-128(p)-2(r)-2(i)-3(m)-2(a)-2(r)-3(i)-2(l)-2(y)-2( )-128(a)-2(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 340.839 Tm
[(sensitivity )-87(and )-87(speci\037city)85(. )-87(As )-87(expected, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 329.239 Tm
[(m)-31(o)-31(s)-31(t)-31( )-156(s)-31(t)-31(u)-31(d)-31(i)-31(e)-31(s)-31( )-156(r)-21(e)-31(p)-31(o)-31(r)-39(t)-31(i)-31(n)-31(g)-31( )-156(p)-31(e)-31(r)-39(f)-31(o)-31(r)-31(m)-31(a)-31(n)-31(c)-31(e )]TJ
T*
[(m)4(e)4(a)4(s)4(u)4(r)14(e)4(s)4( )-13(o)4(f)4( )-13(a)4( )-13(p)4(a)4(t)4(i)4(e)4(n)4(t)22(\222)84(s)4( )-13(c)4(l)4(i)4(n)4(i)4(c)4(a)4(l)4( )-13(i)4(n)4(f)4(o)4(r)4(m)4(a)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 317.639 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 306.039 Tm
[(t)10(i)10(o)10(n)10( )46(f)10(o)10(c)10(u)10(s)10(e)10(d)10( )46(o)10(n)10( )46(t)10(h)10(e)10( )46(r)20(e)10(l)10(a)10(t)10(i)10(o)10(n)10(s)10(h)10(i)10(p)10( )46(b)10(e)10(t)10(w)16(e)10(e)10(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 294.439 Tm
[(a)4( )17(c)4(l)4(i)4(n)4(i)4(c)4(a)4(l)4( )17(s)4(t)4(a)4(g)4(i)4(n)4(g)4( )17(o)4(r)4( )17(c)4(l)4(a)4(s)4(s)4(i)4(\037)4(c)4(a)4(t)4(i)4(o)4(n)4( )17(s)4(y)4(s)4(t)4(e)4(m )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 282.839 Tm
[(a)4(n)4(d)4( )66(l)4(y)4(m)4(p)4(h)4(o)4(c)4(y)4(t)4(e)4( )66(s)4(u)4(b)4(s)4(e)4(t)4(s)4( )66(\()4(p)4(r)4(i)4(m)4(a)4(r)4(i)4(l)4(y)4( )66(C)4(D)4(4 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 271.239 Tm
(count )Tj
ET
BT
/TT0 1 Tf
10 0 0 10 82.0035 271.239 Tm
(<)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 85.2115 271.239 Tm
[(200 )-51(cells/mm\263\). )-36(W)78(e )-51(found )-51(that )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 259.639 Tm
[(t)10(h)10(e)10( )57(s)10(e)10(n)10(s)10(i)10(t)10(i)10(v)10(i)10(t)10(y)10( )57(o)10(f)10( )57(d)10(i)10(\033)10(e)10(r)20(e)10(n)10(t)10( )57(c)10(l)10(i)10(n)10(i)10(c)10(a)10(l)10( )57(s)10(t)10(a)10(g)10(i)10(n)10(g )]TJ
T*
[(s)5(y)5(s)5(t)5(e)5(m)5(s)5( )68(f)5(o)5(r)5( )68(C)5(D)5(4)5( )68(c)5(e)5(l)5(l)5( )68(c)5(o)5(u)5(n)5(t)5( )68(v)11(a)5(r)5(i)5(e)5(d)5( )68(e)5(x)5(t)5(e)5(n)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 248.039 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 236.439 Tm
[(s)2(i)2(v)7(e)2(l)2(y)2( )64(\()2(F)36(i)2(g)1(.)2( )64(3)1(,)2( )64(w)7(e)2(b)2( )64(v)7(e)2(r)2(s)2(i)1(o)2(n)2( )64(o)1(n)2(l)2(y)87(,)1( )64(a)2(v)7(a)2(i)2(l)2(a)1(b)2(l)2(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 224.839 Tm
[(fr)6(om: http://www)75(.who)16(.int/bulletin\).)]TJ
1.701 -1.16 Td
[(I)30(n)18( )30(c)18(o)18(n)18(t)18(r)18(a)18(s)18(t)18(,)18( )30(p)18(e)18(r)10(f)18(o)18(r)18(m)18(a)18(n)18(c)18(e)18( )30(o)18(f)18( )30(d)18(i)18(a)18(g)18(n)18(o)18(s)]TJ
/Span<>> BDC
13.097 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 213.239 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 201.639 Tm
[(tic )32(tests )32(using )32(immunologic )32(or )32(vir)6(ologic )]TJ
T*
[(status )-16(was )-16(r)10(epor)-8(ted )-16(mainly )-16(as )-16(a )-16(corr)10(ela)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 190.039 Tm
(-)Tj
-14.798 -1.16 Td
[(tion )-12(coe\036cient. )3(W)78(e )-12(found )-12(that )-12(corr)10(ela)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 178.439 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 166.839 Tm
[(tion )-61(coe\036cients )-61(ranged )-61(fr)6(om )-61(r)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 177.0288 170.169 Tm
(2 )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 181.7596 166.839 Tm
[(=)-50( )-61(0.29 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 155.239 Tm
[(to )-71(r)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 72.152 158.569 Tm
(2 )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 76.9381 155.239 Tm
[(=)-50( )-71(0.97 )-71(when )-71(comparing )-71(di\033er)10(ent )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 143.639 Tm
[(t)-7(e)-7(c)-7(h)-7(n)-7(i)-7(q)-7(u)-7(e)-7(s)-7( )-132(f)-7(o)-7(r)-7( )-132(e)-7(n)-7(u)-7(m)-7(e)-7(r)-7(a)-7(t)-7(i)-7(n)-7(g)-7( )-132(C)-7(D)-7(4)-7( )-132(c)-7(e)-7(l)-7(l )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 132.039 Tm
[(c)10(o)10(u)10(n)10(t)10(,)10( )72(s)10(u)10(g)10(g)10(e)10(s)10(t)10(i)10(n)10(g)10( )72(r)20(e)10(l)10(a)10(t)10(i)10(v)16(e)10(l)10(y)10( )72(r)16(o)10(b)10(u)10(s)10(t)10( )72(r)20(e)10(s)10(u)10(l)10(t)10(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 120.439 Tm
[(a)-33(m)-32(o)-33(n)-33(g)-32( )-158(w)-33(i)-33(d)-32(e)-33(l)-33(y)-32( )-158(d)-33(i)-32(\033)-33(e)-33(r)-32(i)-33(n)-33(g)-33( )-157(C)-33(D)-33(4)-33( )-157(c)-33(o)-33(u)-33(n)-32(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 108.839 Tm
[(e)8(n)8(u)8(m)8(e)8(r)8(a)8(t)8(i)8(o)8(n)8( )20(t)8(e)8(c)8(h)8(n)8(o)8(l)8(o)8(g)8(i)8(e)8(s)8(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 156.6857 112.169 Tm
[(2)8(1)8(,)8(2)8(2)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 169.57 108.839 Tm
[( )20(H)26(o)20(w)14(e)8(v)14(e)8(r)68(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 97.239 Tm
[(w)4(h)4(e)4(n)4( )25(a)4(s)4(s)4(e)4(s)4(s)4(i)4(n)4(g)4( )25(t)4(h)4(e)4( )25(r)14(e)4(l)4(a)4(t)4(i)4(o)4(n)4(s)4(h)4(i)4(p)4( )25(b)4(e)4(t)4(w)10(e)4(e)4(n )]TJ
T*
[(CD4 )-33(and )-33(total )-33(lymphocyte )-33(count, )-33(cor)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 204.6741 85.639 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 74.039 Tm
[(r)27(e)17(l)17(a)17(t)17(i)17(o)17(n)17( )80(c)17(o)17(e)17(\036)17(c)17(i)17(e)17(n)17(t)17(s)17( )80(r)17(a)17(n)17(g)17(e)17(d)17( )80(f)17(r)23(o)17(m)17( )80(r)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 180.0567 77.369 Tm
[(2)17( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 183.8633 74.039 Tm
[(=)-33( )80(0)17(.)17(0)17(5 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 62.439 Tm
[(to )-113(r)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 72.5729 65.769 Tm
(2 )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 77.6044 62.439 Tm
[(=)-50( )-113(0.55, )-113(indicating )-113(less )-113(consistent )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 763.7737 Tm
[(\037ndings )-99(and )-100(gr)10(eater )-99(v)6(ariation )-100(betw)6(een )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 752.2737 Tm
[(t)-6(h)-6(e)-6(s)-6(e)-6( )-131(t)-6(w)-6(o)-6( )-131(t)-6(e)-6(s)-6(t)-6(s)-6(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 283.4277 755.6037 Tm
[(2)-6(6)-6(,)-6(2)-6(7)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 296.713 752.2737 Tm
[( )-131(I)6(n)-6( )-131(t)-6(h)-6(e)-6( )-131(f)-6(e)-12(w)-6( )-131(s)-6(t)-6(u)-6(d)-6(i)-6(e)-6(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 740.7737 Tm
[(r)10(epor)-8(ting )-91(the )-91(sensitivity )-91(of )-91(a )-91(CD4 )-91(cell )]TJ
0 -1.15 TD
[(c)2(o)2(u)2(n)2(t)2( )3(e)2(n)2(u)2(m)2(e)2(r)2(a)2(t)2(i)2(o)2(n)2( )3(t)2(e)2(c)2(h)2(n)2(o)2(l)2(o)2(g)2(y)87(,)2( )3(t)2(h)2(e)2( )3(d)2(i)2(s)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 729.2737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 717.7737 Tm
[(ease )-13(condition )-13(primarily )-13(was )-13(de\037ned )-13(as )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 706.2737 Tm
[(C)-9(D)-9(4)-9( )-134(c)-9(o)-9(u)-9(n)-9(t)-9( )]TJ
ET
BT
/TT0 1 Tf
10 0 0 10 272.5349 706.2737 Tm
(<)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 275.8176 706.2737 Tm
[(2)-9(0)-9(0)-9( )-134(c)-9(e)-9(l)-9(l)-9(s)-9(/)-9(m)-9(m)-9(\263)-9(.)-9( )-134(I)3(n)-9( )-134(t)-9(h)-9(e)-9(s)-9(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 694.7737 Tm
[(s)2(t)2(u)2(d)2(i)2(e)2(s)2(,)2( )-19(s)2(e)2(n)2(s)2(i)2(t)2(i)2(v)2(i)2(t)2(y)2( )-19(r)2(a)2(n)2(g)2(e)2(d)2( )-19(f)2(r)8(o)2(m)2( )-19(2)2(9)2(%)2( )-19(t)2(o )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 683.2737 Tm
[(9)-10(6)-10(%)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 240.7847 686.6037 Tm
[(1)-10(7)-10(,)-10(1)-10(8)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 254.1914 683.2737 Tm
[( )-135(a)-10(n)-10(d)-10( )-135(s)-10(p)-10(e)-10(c)-10(i)-10(\037)-10(c)-10(i)-10(t)-10(y)-10( )-135(f)-10(r)-4(o)-10(m)-10( )-135(5)-10(5)-10(%)-10( )-135(t)-10(o )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 671.7737 Tm
(98%.)Tj
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 242.9872 675.1037 Tm
(28,33)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 239.0551 660.2737 Tm
[(\034)-8(e)-8( )-133(p)-8(e)-8(r)-16(f)-8(o)-8(r)-8(m)-8(a)-8(n)-8(c)-8(e)-8( )-133(o)-8(f)-8( )-133(t)-8(e)-8(s)-8(t)-8(s)-8( )-133(u)-8(s)-8(e)-8(d)-8( )-133(t)-8(o )]TJ
-1.701 -1.15 Td
[(a)8(s)8(c)8(e)8(rt)8(a)8(i)8(n)8( )-5(v)8(i)8(r)14(o)8(l)8(o)8(g)8(i)8(c)8( )-5(s)8(t)8(a)8(t)8(u)8(s)8( )-5(a)8(l)8(s)8(o)8( )-5(w)8(a)8(s)8( )-5(g)8(e)8(n)8(e)8(r)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0284 648.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 637.2737 Tm
[(a)8(l)8(l)8(y)8( )-10(r)18(e)8(p)8(o)8(rt)8(e)8(d)8( )-10(a)8(s)8( )-10(a)8( )-10(c)8(o)8(r)8(r)18(e)8(l)8(a)8(t)8(i)8(o)8(n)8( )-10(c)8(o)8(e)8(\036)8(c)8(i)8(e)8(n)8(t)8(. )250( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 625.7737 Tm
[(C)-23(o)-23(r)-23(r)-13(e)-23(l)-23(a)-23(t)-23(i)-23(o)-23(n)-23( )-148(c)-23(o)-23(e)-23(\036)-23(c)-23(i)-23(e)-23(n)-23(t)-23(s)-23( )-148(r)-23(a)-23(n)-23(g)-23(e)-23(d)-23( )-148(f)-23(r)-17(o)-23(m )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 373.2284 625.7737 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 614.2737 Tm
(r)Tj
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 226.3093 617.6037 Tm
[(2)6( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 230.2501 614.2737 Tm
[(=)-44( )68(0)6(.)6(2)6(9)6( )68(t)6(o)6( )68(r)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 270.4894 617.6037 Tm
[(2)6( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 274.4302 614.2737 Tm
[(=)-44( )68(0)6(.)6(8)6(1)6( )68(w)6(h)6(e)6(n)6( )68(w)12(e)6( )68(c)6(o)6(m)6(p)6(a)6(r)16(e)6(d )]TJ
-5.238 -1.15 Td
[(c)-37(o)-37(m)-37(m)-37(o)-37(n)-37(l)-37(y)-37( )-162(u)-37(s)-37(e)-37(d)-37( )-162(H)-37(I)-37(V)-37( )-162(R)-37(N)-37(A)-37( )-162(q)-37(u)-37(a)-37(n)-37(t)-37(i)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 602.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 591.2737 Tm
[(\037)-29(c)-29(a)-29(t)-29(i)-29(o)-29(n)-29( )-154(t)-29(e)-29(c)-29(h)-29(n)-29(i)-29(q)-29(u)-29(e)-29(s)-29(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 304.1691 594.6037 Tm
[(3)-29(1)-29(,)-29(3)-29(2)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 318.1432 591.2737 Tm
[( )-154(C)-29(o)-29(r)-29(r)-19(e)-29(l)-29(a)-29(t)-29(i)-29(o)-29(n)-29(s )]TJ
-9.61 -1.15 Td
[(betw)6(een )-115(di\033er)10(ent )-115(HIV )-115(RNA )-115(quanti\037)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 579.7737 Tm
(-)Tj
-14.798 -1.15 Td
[(c)-7(a)-7(t)-7(i)-7(o)-7(n)-7( )-132(t)-7(e)-7(c)-7(h)-7(n)-7(i)-7(q)-7(u)-7(e)-7(s)-7( )-132(f)-7(o)-7(r)-7( )-132(n)-7(o)-7(n)]TJ
/Span<>> BDC
10.445 0 Td
(-)Tj
EMC
0.327 0 Td
[(B)-7( )-132(s)-7(u)-7(b)-7(t)-7(y)-7(p)-7(e)-7(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 556.7737 Tm
[(r)-4(a)-4(n)-3(g)-4(e)-4(d)-4( )-129(m)-4(a)-4(i)-4(n)-3(l)-4(y)-4( )-129(b)-4(e)-4(t)-4(w)2(e)-3(e)-4(n)-4( )-129(r)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 322.8822 560.1037 Tm
[(2)-4( )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 328.0253 556.7737 Tm
[(=)-54( )-129(0)-4(.)-4(4)-4(9)-4( )-128(a)-4(n)-4(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 545.2737 Tm
(r)Tj
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 226.3672 548.6037 Tm
(2 )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 231.4625 545.2737 Tm
[(= )-124(0.72.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 260.2025 548.6037 Tm
(34,35)Tj
10 0 0 10 273.3199 545.2737 Tm
[( )-124(\034ese )-124(r)10(esults )-124(suggest )-124(r)6(o)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 545.2737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 533.7737 Tm
[(bust )-107(r)10(esults )-107(among )-107(v)6(arious )-107(HIV )-107(RNA )]TJ
T*
[(quanti\037cation )-73(techniques )-73(for )-74(HIV)]TJ
/Span<>> BDC
13.37 0 Td
(-)Tj
EMC
[(1 )-74(B )]TJ
-13.37 -1.15 Td
[(and )-109(non)]TJ
/Span<>> BDC
(-)Tj
EMC
[(B )-109(subtypes. )-109(H)18(o)12(w)6(ev)6(er)60(, )-109(due )-109(to )]TJ
T*
[(lack )-41(of )-40(information )-40(on )-41(HIV)]TJ
/Span<>> BDC
10.898 0 Td
(-)Tj
EMC
(2)Tj
/Span<>> BDC
(-)Tj
EMC
(infected )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 487.7737 Tm
[(subjects, )-31(the )-31(per)-8(formance )-31(of )-31(these )-31(tests )]TJ
T*
[(in )-43(such )-43(patients )-43(is )-43(unkno)12(wn. )-28(W)78(e )-43(iden)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 476.2737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 464.7737 Tm
[(t)-25(i)-25(\037)-25(e)-25(d)-25( )-150(o)-25(n)-25(l)-25(y)-25( )-150(o)-25(n)-25(e)-25( )-150(s)-25(t)-25(u)-25(d)-25(y)-25( )-150(e)-25(x)-25(a)-25(m)-25(i)-25(n)-25(i)-25(n)-25(g)-25( )-150(t)-25(h)-25(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 453.2737 Tm
[(accuracy )-40(of )-40(viral )-40(activ)6(ation )-40(mar)6(kers )-40(for )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 441.7737 Tm
(HIV RNA.)Tj
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 265.7569 445.1036 Tm
(30)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 239.0552 430.2737 Tm
[(O)14(u)8(r)8( )-49(r)18(e)8(v)8(i)8(e)2(w)8( )-49(h)8(a)8(d)8( )-49(s)8(e)8(v)14(e)8(r)8(a)8(l)8( )-49(l)8(i)8(m)8(i)8(t)8(a)8(t)8(i)8(o)8(n)8(s)8(. )]TJ
-1.701 -1.15 Td
[(W)78(e )33(con\037ned )33(our )33(study )33(selection )33(to )33(ar)-8(ti)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 418.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 407.2737 Tm
[(c)6(l)6(e)6(s)6( )52(a)6(n)6(d)6( )52(c)6(o)6(n)6(f)6(e)6(r)16(e)6(n)6(c)6(e)6(s)6( )52(t)6(h)6(a)6(t)6( )52(w)12(e)6(r)16(e)6( )52(p)6(u)6(b)6(l)6(i)6(s)6(h)6(e)6(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 395.7737 Tm
[(a)-12(n)-12(d)-12(/)-12(o)-12(r)-12( )-137(e)-12(l)-12(e)-12(c)-12(t)-12(r)-6(o)-12(n)-12(i)-12(c)-12(a)-12(l)-12(l)-12(y)-12( )-137(a)-12(v)-6(a)-12(i)-12(l)-12(a)-12(b)-12(l)-12(e)-12(,)-12( )-137(w)-12(h)-12(i)-12(c)-12(h )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 384.2737 Tm
[(likely )32(limited )32(incorporation )32(of )32(the )32(most )]TJ
T*
[(u)-5(p)]TJ
/Span<>> BDC
1.029 0 Td
(-)Tj
EMC
0.325 0 Td
[(t)-5(o)]TJ
/Span<>> BDC
0.803 0 Td
(-)Tj
EMC
0.325 0 Td
[(d)-5(a)-5(t)-5(e)-5( )-130(d)-5(a)-5(t)-5(a)-5(.)-5( )-115(W)73(e)-5( )-130(a)-5(l)-5(s)-5(o)-5( )-130(e)-5(n)-5(c)-5(o)-5(u)-5(n)-5(t)-5(e)-5(r)5(e)-5(d )]TJ
-2.483 -1.15 Td
[(a )-49(number )-49(of )-49(speci\037c )-49(challenges )-49(in )-49(syn)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 361.2737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 349.7737 Tm
[(thesizing )-26(this )-26(body )-26(of )-26(information. )-25(F)36(or )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 338.2737 Tm
[(example, )43(no )43(univ)6(ersal )43(gold )43(standar)14(d )43(has )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 326.7737 Tm
[(been )-110(explicitly )-110(de\037ned )-110(for )-110(monitoring )]TJ
T*
[(H)4(I)4(V)]TJ
/Span<>> BDC
1.748 0 Td
(-)Tj
EMC
0.316 0 Td
[(i)4(n)4(f)4(e)4(c)4(t)4(e)4(d)4( i)4(n)4(d)4(i)4(v)4(i)4(d)4(u)4(a)4(l)4(s)4(,)4( t)4(h)4(e)4(r)14(e)4(b)10(y)4( m)4(a)4(k)]TJ
/Span<>> BDC
12.734 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 315.2737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 303.7737 Tm
[(ing )-101(identi\037cation )-101(of )-101(the )-101(gold )-101(standar)14(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 292.2737 Tm
[(o)-22(r)-22( )-147(r)-12(e)-22(f)-22(e)-22(r)-12(e)-22(n)-22(c)-22(e)-22( )-147(s)-22(t)-22(a)-22(n)-22(d)-22(a)-22(r)-8(d)-22( )-147(f)-22(o)-22(r)-22( )-147(e)-22(a)-22(c)-22(h)-22( )-147(s)-22(t)-22(u)-22(d)-22(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 280.7737 Tm
[(uncer)-8(tain. )23(\034e )23(de\037nition )23(of )23(disease )23(and )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 269.2737 Tm
[(t)-4(h)-5(e)-4( )-129(m)-5(e)-4(t)-4(h)-5(o)-4(d)-4(s)-4( )-130(u)-4(s)-4(e)-5(d)-4( )-129(t)-5(o)-4( )-129(a)-5(s)-4(s)-4(e)-5(s)-4(s)-4( )-130(d)-4(i)-4(a)-4(g)-5(n)-4(o)-4(s)-5(t)-4(i)-4(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 257.7737 Tm
[(t)-14(e)-14(s)-14(t)-14( )-139(p)-14(e)-14(r)-22(f)-14(o)-14(r)-14(m)-14(a)-14(n)-14(c)-14(e)-14( )-139(w)-8(e)-14(r)-4(e)-14( )-139(n)-14(o)-14(t)-14( )-139(c)-14(o)-14(n)-14(s)-14(i)-14(s)-14(t)-14(e)-14(n)-14(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 246.2737 Tm
[(a)-15(c)-15(r)-9(o)-15(s)-15(s)-15( )-140(s)-15(t)-15(u)-15(d)-15(i)-15(e)-15(s)-15(.)-15( )-140(\034)-15(e)-15(r)-5(e)-15(f)-15(o)-15(r)-5(e)-15(,)-15( )-140(w)-9(e)-15( )-140(d)-15(i)-15(d)-15( )-140(n)-15(o)-15(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 234.7737 Tm
[(e)10(v)16(a)10(l)10(u)10(a)10(t)10(e)10( )22(s)10(t)10(u)10(d)10(y)10( )22(q)10(u)10(a)10(l)10(i)10(t)10(y)10( )22(t)10(o)10( )22(a)10(s)10(s)10(e)10(s)10(s)10( )22(r)20(e)10(l)10(i)10(a)10(b)10(i)10(l)10(i)10(t)10(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 223.2737 Tm
[(and )-47(v)6(alidity )-47(and )-47(could )-47(not )-47(account )-47(for )]TJ
T*
[(b)-7(i)-7(a)-7(s)-7(,)-7( )-132(r)3(e)-7(p)-7(o)-7(r)-15(t)-7(i)-7(n)-7(g)-7( )-132(e)-7(r)-7(r)-1(o)-7(r)-7( )-132(a)-7(n)-7(d)-7( )-132(o)-7(t)-7(h)-7(e)-7(r)-7( )-132(m)-7(e)-7(t)-7(h)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 211.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 200.2737 Tm
[(odological )-22(limitations )-22(of )-23(the )-23(individual )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 373.2285 200.2737 Tm
( )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 188.7737 Tm
[(s)12(t)12(u)12(d)12(i)12(e)12(s)12(.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 249.8569 192.1037 Tm
[(1)12(1)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 255.547 188.7737 Tm
[( W)12(h)12(i)12(l)12(e)12( )-15(m)12(e)12(a)12(s)12(u)12(r)22(e)12(s)12( )-15(o)12(f)12( )-15(a)12(s)12(s)12(o)12(c)12(i)12(a)12(t)12(i)12(o)12(n)12(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 177.2737 Tm
[(such )-13(as )-13(corr)10(elation )-13(coe\036cients, )-13(pr)6(o)16(vide )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 165.7737 Tm
[(r)-6(e)-16(s)-16(e)-16(a)-16(r)-10(c)-16(h)-16(e)-28(r)-28(s)-28( )-153(w)-28(i)-28(t)-28(h)-28( )-153(i)-28(n)-28(f)-28(o)-28(r)-28(m)-28(a)-28(t)-28(i)-28(o)-28(n)-28( )-153(o)-28(n)-28( )-153(t)-28(h)-28(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 154.2737 Tm
[(str)10(ength )-75(of )-75(a )-75(r)10(elationship )-75(betw)6(een )-75(two )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 142.7737 Tm
[(d)-15(i)-15(a)-15(g)-15(n)-15(o)-15(s)-15(t)-15(i)-15(c)-15( )-140(t)-15(e)-15(s)-15(t)-15(s)-15(,)-15( )-140(t)-15(h)-15(e)-15(y)-15( )-140(d)-15(o)-15( )-140(n)-15(o)-15(t)-15( )-140(p)-15(r)-9(o)1(v)-15(i)-15(d)-15(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 131.2737 Tm
[(i)-23(n)-23(f)-23(o)-23(r)-23(m)-23(a)-23(t)-23(i)-23(o)-23(n)-23( )-148(t)-23(h)-23(a)-23(t)-23( )-148(c)-23(a)-23(n)-23( )-148(m)-23(o)-23(r)-13(e)-23( )-148(e)-23(a)-23(s)-23(i)-23(l)-23(y)-23( )-148(b)-23(e )]TJ
T*
[(translated )24(into )24(clinical )24(decision)]TJ
/Span<>> BDC
(-)Tj
EMC
(making )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 108.2737 Tm
[(as )8(with )8(measur)10(es )8(such )8(as )8(sensitivity )8(and )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 96.7737 Tm
[(speci\037city)85(. )-125(\034is )-125(is )-125(par)-8(ticularly )-125(r)10(elev)6(ant )]TJ
T*
[(f)12(o)12(r)12( )54(H)12(I)12(V)12( )54(m)12(a)12(r)18(k)12(e)12(r)12(s)12( )54(e)12(v)18(a)12(l)12(u)12(a)12(t)12(e)12(d)12( )54(o)12(n)12( )54(a)12( )54(c)12(o)12(n)12(t)12(i)12(n)12(u)]TJ
/Span<>> BDC
14.798 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 370.0285 85.2737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 73.8737 Tm
[(o)20(u)20(s)20( )18(s)20(c)20(a)20(l)20(e)20(,)20( )18(w)20(h)20(e)20(r)30(e)20( )18(s)20(e)20(n)20(s)20(i)20(t)20(i)20(v)20(i)20(t)20(y)20( )18(a)20(n)20(d)20( )18(s)20(p)20(e)20(c)20(i)20(\037)20(c)20(i)20(t)20(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0473 62.4236 Tm
[(can )-90(be )-90(used )-90(to )-90(identify )-90(critical )-90(clinical )]TJ
16.535 70.135 Td
[(thr)10(esholds )-92(when )-92(pr)6(o)16(viding )-92(antir)10(etr)6(o)16(vi)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 763.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 752.3737 Tm
[(r)-7(a)-7(l)-7( )-132(t)-7(h)-7(e)-7(r)-7(a)-7(p)-7(y)-7( )-132(o)-7(r)-7( )-132(o)-7(p)-7(p)-7(o)-7(r)-15(t)-7(u)-7(n)-7(i)-7(s)-7(t)-7(i)-7(c)-7( )-132(i)-7(n)-7(f)-7(e)-7(c)-7(t)-7(i)-7(o)-7(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 740.9736 Tm
[(pr)6(ophylaxis. )20(Lastly)85(, )20(w)6(e )20(did )20(not )20(examine )]TJ
0 -1.14 TD
[(r)10(epor)-8(ted )-48(assay)85(, )-48(instr)-8(ument )-48(and )-48(person)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 729.5737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 718.1736 Tm
[(nel )-102(costs )-102(or )-102(include )-102(other )-102(biochemical )]TJ
T*
[(parameters )-67(impor)-8(tant )-67(in )-67(the )-67(follo)12(w)]TJ
/Span<>> BDC
(-)Tj
EMC
(up )Tj
T*
[(o)-11(f)-11( )-136(H)-11(I)-11(V)]TJ
/Span<>> BDC
2.977 0 Td
(-)Tj
EMC
0.331 0 Td
[(i)-11(n)-11(f)-11(e)-11(c)-11(t)-11(e)-11(d)-11( )-136(i)-11(n)-11(d)-11(i)-11(v)-11(i)-11(d)-11(u)-11(a)-11(l)-11(s)-11( )-136(r)-1(e)-11(c)-11(e)-11(i)-11(v)-11(i)-11(n)-11(g )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 683.9736 Tm
[(t)-13(r)-3(e)-13(a)-13(t)-13(m)-13(e)-13(n)-13(t)-13(,)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 428.7054 687.3036 Tm
[(3)-13(6)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 434.6864 683.9736 Tm
[( )-138(a)-13(s)-13( )-138(t)-13(h)-13(e)-13(y)-13( )-138(w)-7(e)-13(r)-3(e)-13( )-138(b)-13(e)-13(y)-7(o)-13(n)-13(d)-13( )-138(t)-13(h)-13(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 672.5737 Tm
[(scope of this study)85(.)]TJ
1.701 -1.14 Td
[(W)10(h)10(i)10(l)10(e)10( )-20(H)10(I)10(V)10( )-20(c)10(a)10(r)20(e)10( )-20(p)10(r)16(o)26(v)10(i)10(d)10(e)10(r)10(s)10( )-20(i)10(n)10( )-20(d)10(e)10(v)16(e)10(l)]TJ
/Span<>> BDC
13.097 0 Td
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 661.1736 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 649.7737 Tm
[(o)10(p)10(i)10(n)10(g)10( )-33(c)10(o)10(u)10(n)10(t)10(r)10(i)10(e)10(s)10( )-33(a)10(r)20(e)10( )-33(w)10(o)10(r)16(k)10(i)10(n)10(g)10( )-33(t)10(o)10( )-33(i)10(m)10(p)10(r)16(o)26(v)16(e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 638.3737 Tm
[(l)4(a)4(b)4(o)4(r)4(a)4(t)4(o)4(r)-14(y)4( )-121(c)4(a)4(p)4(a)4(c)4(i)4(t)4(y)89(,)4( )-121(k)4(e)4(y)4( )-121(i)4(s)4(s)4(u)4(e)4(s)4(,)4( )-121(s)4(u)4(c)4(h)4( )-121(a)4(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 626.9736 Tm
[(w)14(h)14(e)14(r)24(e)14( )35(f)14(u)14(t)14(u)14(r)24(e)14( )35(s)14(t)14(u)14(d)14(i)14(e)14(s)14( )35(m)14(i)14(g)14(h)14(t)14( )35(b)14(e)14( )35(c)14(o)14(n)14(d)14(u)14(c)14(t)14(e)14(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 615.5737 Tm
[(\(e.g. )-113(urban )-113(v)6(ersus )-113(r)-8(ural )-113(locales\) )-113(or )-113(the )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 604.1736 Tm
[(m)-22(e)-22(t)-22(h)-22(o)-22(d)-22(s)-22( )-147(u)-22(s)-22(e)-22(d)-22( )-147(t)-22(o)-22( )-147(e)-22(v)-16(a)-22(l)-22(u)-22(a)-22(t)-22(e)-22( )-147(d)-22(i)-22(a)-22(g)-22(n)-22(o)-22(s)-22(t)-22(i)-22(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 592.7737 Tm
[(t)-20(e)-20(s)-20(t)-20( )-145(p)-20(e)-20(r)-28(f)-20(o)-20(r)-20(m)-20(a)-20(n)-20(c)-20(e)-20(,)-20( )-145(h)-20(a)-20(v)-14(e)-20( )-145(n)-20(o)-20(t)-20( )-145(b)-20(e)-20(e)-20(n)-20( )-145(a)-20(d)-20(-)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 592.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 581.3737 Tm
[(dr)10(essed.)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 417.6812 584.7037 Tm
(37\22640)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 432.2562 581.3737 Tm
[( )21(I)12(n )21(par)-8(ticular)60(, )21(complete )21(and )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 569.9736 Tm
[(t)14(r)14(a)14(n)14(s)14(p)14(a)14(r)24(e)14(n)14(t)14( )46(r)24(e)14(p)14(o)14(r)6(t)14(i)14(n)14(g)14( )46(o)14(f)14( )46(p)14(a)14(r)6(t)14(i)14(c)14(i)14(p)14(a)14(n)14(t)14(s)14(,)14( )46(t)14(e)14(s)14(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 558.5737 Tm
[(m)8(e)8(t)8(h)8(o)8(d)8(s)8(,)8( )8(s)8(t)8(a)8(t)8(i)8(s)8(t)8(i)8(c)8(a)8(l)8( )8(m)8(e)8(t)8(h)8(o)8(d)8(s)8(,)8( )8(t)8(e)8(s)8(t)8( )8(r)18(e)8(s)8(u)8(l)8(t)8(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 547.1736 Tm
[(and )16(test )16(estimates )16(\227 )16(as )16(outlined )16(in )16(\034e )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 535.7737 Tm
[(S)24(tandar)14(ds )-100(for )-100(R)12(epor)-8(ting )-100(of )-100(D)12(iagnostic )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 524.3737 Tm
[(A)12(ccuracy )-86(\(ST)65(ARD\) )-86(I)12(nitiativ)6(e)]TJ
ET
BT
/T1_2 1 Tf
5.83 0 0 5.83 501.9265 527.7037 Tm
(11)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 507.7564 524.3737 Tm
[( )-86(\227 )-86(will )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 512.9736 Tm
[(p)-22(l)-22(a)-22(y)-22( )-147(a)-21( )-147(m)-22(a)-22(j)-22(o)-22(r)-22( )-147(r)-16(o)-22(l)-22(e)-22( )-147(i)-22(n)-22( )-147(i)-22(m)-22(p)-22(r)-16(o)-6(v)-22(i)-22(n)-22(g)-22( )-147(h)-22(o)-10(w )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 501.5736 Tm
[(d)-11(i)-11(a)-11(g)-11(n)-11(o)-11(s)-11(t)-11(i)-11(c)-11( )-136(t)-11(e)-11(s)-11(t)-11( )-136(d)-11(a)-11(t)-11(a)-11( )-136(a)-11(r)-1(e)-11( )-136(c)-11(o)-11(l)-11(l)-11(e)-11(c)-11(t)-11(e)-11(d)-11( )-136(a)-11(n)-11(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 490.1736 Tm
[(r)-3(e)-13(p)-13(o)-13(r)-21(t)-13(e)-13(d)-13(.)-13( )-138(A)-1(d)-13(d)-13(r)-3(e)-13(s)-13(s)-13(i)-13(n)-13(g)-13( )-138(t)-13(h)-13(e)-13(s)-13(e)-13( )-138(i)-13(s)-13(s)-13(u)-13(e)-13(s)-13( )-138(c)-13(a)-13(n )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 478.7737 Tm
[(p)10(r)16(o)26(v)10(i)10(d)10(e)10( )-10(i)10(m)10(p)10(o)10(r)2(t)10(a)10(n)10(t)10( )-10(i)10(n)10(f)10(o)10(r)10(m)10(a)10(t)10(i)10(o)10(n)10( )-10(t)10(h)10(a)10(t)10( )-10(w)10(i)10(l)10(l )]TJ
T*
[(assist )-90(pr)6(ogramme )-90(planners )-89(and )-90(policy)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 455.9737 Tm
[(m)-20(a)-20(k)-20(e)-20(r)-20(s)-20( )-145(i)-20(n)-20( )-145(b)-20(e)-20(t)-20(t)-20(e)-20(r)-20( )-145(u)-20(n)-20(d)-20(e)-20(r)-20(s)-20(t)-20(a)-20(n)-20(d)-20(i)-20(n)-20(g)-20( )-145(h)-20(o)-8(w )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 444.5736 Tm
[(d)-5(i)-5(a)-5(g)-5(n)-5(o)-5(s)-5(t)-5(i)-5(c)-5( )-130(t)-5(e)-5(s)-5(t)-5(s)-5( )-130(c)-5(a)-5(n)-5( )-130(b)-5(e)-5( )-130(u)-5(s)-5(e)-5(d)-5( )-130(t)-5(o)-5( )-130(a)-5(s)-5(s)-5(e)-5(s)-5(s)-5(, )]TJ
T*
[(for )26(example, )26(population)]TJ
/Span<>> BDC
(-)Tj
EMC
[(lev)6(el )26(antir)10(etr)6(o)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 433.1736 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 421.7737 Tm
[(viral )-27(r)10(esistance )-27(patterns )-27(and )-27(HIV )-27(RNA )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 410.3737 Tm
[(d)-10(i)-10(s)-10(t)-10(r)-10(i)-10(b)-10(u)-10(t)-10(i)-10(o)-10(n)-10(s)-10(.)-10( )-135(O)-4(n)-10( )-135(a)-10(n)-10( )-135(i)-10(n)-10(d)-10(i)-10(v)-10(i)-10(d)-10(u)-10(a)-10(l)-10( )-135(l)-10(e)-10(v)-4(e)-10(l)-10(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 398.9737 Tm
[(this )42(information )42(can )42(aid )42(in )42(determining )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 387.5736 Tm
[(not )-69(only )-69(which )-69(diagnostic )-69(tests )-69(should )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 376.1736 Tm
[(b)-6(e)-6( )-131(u)-6(s)-6(e)-6(d)-6( )-131(t)-6(o)-6( )-131(m)-6(o)-6(n)-6(i)-6(t)-6(o)-6(r)-6( )-131(p)-6(a)-6(t)-6(i)-6(e)-6(n)-6(t)-6(s)-6(,)-6( )-131(b)-6(u)-6(t)-6( )-131(a)-6(l)-6(s)-6(o )]TJ
T*
[(which )-38(tests )-38(should )-38(be )-38(emplo)12(y)6(ed )-38(to )-38(ini)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 364.7737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 353.3737 Tm
[(t)-6(i)-6(a)-6(t)-6(e)-6( )-131(H)-6(I)-6(V)-6( )-131(m)-6(a)-6(n)-6(a)-6(g)-6(e)-6(m)-6(e)-6(n)-6(t)-6( )-131(i)-6(n)-6(t)-6(e)-6(r)-24(ve)-6(n)-6(t)-6(i)-6(o)-6(n)-6(s)-6(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 341.9737 Tm
[(F)36(or )59(example, )59(whether )59(a )59(patient)18(\222)80(s )59(clinical )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 330.5736 Tm
[(i)4(n)4(f)4(o)4(r)4(m)4(a)4(t)4(i)4(o)4(n)4( )66(i)4(s)4( )66(a)4(n)4( )66(a)4(p)4(p)4(r)10(o)4(p)4(r)4(i)4(a)4(t)4(e)4( )66(d)4(i)4(a)4(g)4(n)4(o)4(s)4(t)4(i)4(c )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 319.1736 Tm
[(tool )-108(to )-108(initiate )-108(oppor)-8(tunistic )-108(infection )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 307.7737 Tm
[(p)9(r)15(o)9(p)9(h)9(y)9(l)9(a)9(x)9(i)9(s)9( )71(a)9(n)9(d)9(/)9(o)9(r)9( )71(a)9(n)9(t)9(i)9(r)19(e)9(t)9(r)15(o)25(v)9(i)9(r)9(a)9(l)9( )71(t)9(h)9(e)9(r)9(a)9(p)9(y )]TJ
T*
[(will )63(depend )63(on )63(formal )63(analysis )63(that )63(con)]TJ
/Span<>> BDC
(-)Tj
EMC
ET
BT
/T1_2 1 Tf
10 0 0 10 535.3828 296.3737 Tm
(-)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 284.9737 Tm
[(s)-4(i)-4(d)-4(e)-4(r)-4(s)-4( )-129(t)-4(h)-4(e)-4( )-129(b)-4(e)-4(n)-4(e)-4(\037)-4(t)-4(s)-4( )-129(o)-4(f)-4( )-129(t)-4(r)6(e)-4(a)-4(t)-4(i)-4(n)-4(g)-4( )-129(p)-4(a)-4(t)-4(i)-4(e)-4(n)-4(t)-4(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 273.5736 Tm
[(with )-67(tr)-8(ue )-67(positiv)6(e )-67(r)10(esults )-67(as )-67(w)6(ell )-67(as )-67(the )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 262.1736 Tm
[(c)-10(o)-10(n)-10(s)-10(e)-10(q)-10(u)-10(e)-10(n)-10(c)-10(e)-10(s)-10( )-135(o)-10(f)-10( )-135(n)-10(o)-10(t)-10( )-135(t)-10(re)-10(a)-10(t)-10(i)-10(n)-10(g)-10( )-135(p)-10(a)-10(t)-10(i)-10(e)-10(n)-10(t)-10(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 250.7737 Tm
[(w)-17(h)-17(o)-17( )-142(n)-17(e)-17(e)-17(d)-17( )-142(t)-17(r)-7(e)-17(a)-17(t)-17(m)-17(e)-17(n)-17(t)-17( )-142(\()-17(f)-17(a)-17(l)-17(s)-17(e)-17( )-142(n)-17(e)-17(g)-17(a)-17(t)-17(i)-17(v)-11(e)-17(s)-17(\) )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 239.3737 Tm
[(and )-65(tr)10(eating )-65(patients )-65(who )-65(do )-65(not )-65(need )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 227.9736 Tm
[(tr)10(eatment \(false positiv)6(es\).)]TJ
ET
BT
/T1_0 1 Tf
13 0 0 13 387.4016 201.4736 Tm
(Conclusion)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 187.239 Tm
[(W)70(e)-8( )-133(c)-8(o)-8(n)-8(c)-8(l)-8(u)-8(d)-8(e)-8( )-133(t)-8(h)-8(a)-8(t)-8( )-133(t)-8(h)-8(e)-8( )-133(b)-8(r)-2(o)-8(a)-8(d)-8( )-133(r)-8(a)-8(n)-8(g)-8(e)-8( )-133(o)-8(f )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 175.839 Tm
[(d)-15(i)-15(a)-15(g)-15(n)-15(o)-15(s)-15(t)-15(i)-15(c)-15( )-140(t)-15(e)-15(s)-15(t)-15(s)-15(,)-15( )-140(t)-15(h)-15(e)-15( )-140(i)-15(n)-15(s)-15(t)-15(r)-23(u)-15(m)-15(e)-15(n)-15(t)-15(s)-15( )-140(a)-15(n)-15(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 164.439 Tm
[(t)-9(e)-9(c)-9(h)-9(n)-9(i)-9(q)-9(u)-9(e)-9(s)-9( )-134(u)-9(s)-9(e)-9(d)-9( )-134(t)-9(o)-9( )-134(c)-9(o)-9(n)-9(d)-9(u)-9(c)-9(t)-9( )-134(t)-9(h)-9(e)-9( )-134(t)-9(e)-9(s)-9(t)-9(s)-9(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 153.039 Tm
[(and )-35(the )-35(heter)6(ogeneity )-35(of )-35(their )-35(r)10(epor)-8(ted )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 141.639 Tm
[(p)14(e)14(r)6(f)14(o)14(r)14(m)14(a)14(n)14(c)14(e)14( )84(s)14(u)14(g)14(g)14(e)14(s)14(t)14( )84(a)14( )84(n)14(e)14(e)14(d)14( )84(f)14(o)14(r)14( )84(c)14(o)14(n)14(s)14(e)14(n)14(s)14(u)14(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 130.239 Tm
[(among )48(the )48(r)10(esear)6(ch )48(community )48(on )48(ho)12(w )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 118.939 Tm
[(to )37(design )38(studies, )37(and )38(collect )38(and )37(r)10(epor)-8(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 107.639 Tm
[(data )-37(in )-37(a )-37(format )-37(that )-37(is )-37(most )-37(useful )-37(for )]TJ
0 -1.13 TD
[(d)10(e)10(c)11(i)10(s)10(i)10(o)11(n)]TJ
/Span<>> BDC
3.07 0 Td
(-)Tj
EMC
0.31 0 Td
[(m)10(a)10(k)11(e)10(r)10(s)10( )73(i)11(n)10( )73(d)10(e)10(v)17(e)10(l)10(o)10(p)10(i)11(n)10(g)10( )73(c)10(o)10(u)11(n)10(t)10(r)11(i)10(e)10(s)10(. )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 85.039 Tm
[(W)73(e)-5( )-130(r)5(e)-5(c)-5(o)-5(m)-5(m)-5(e)-5(n)-5(d)-5( )-130(t)-5(h)-5(e)-5( )-130(f)-5(o)-5(l)-5(l)-5(o)7(w)-5(i)-5(n)-5(g)-5( )-130(a)-5(c)-5(t)-5(i)-5(o)-5(n)-5(s )]TJ
ET
BT
/T1_2 1 Tf
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461.715 783.18 l
462.165 784.692 l
464.325 784.692 l
h
S
466.53 781.236 m
467.646 781.236 l
467.646 783.846 l
467.664 783.846 l
467.826 783.486 468.195 783.108 468.861 783.108 c
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470.463 786.789 469.986 787.887 468.834 787.887 c
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467.574 787.095 l
467.574 787.41 467.556 787.68 467.538 787.815 c
466.494 787.815 l
466.521 787.644 466.53 787.356 466.53 787.023 c
h
467.646 785.484 m
467.646 786.357 467.871 787.068 468.528 787.068 c
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469.347 784.53 469.131 783.927 468.51 783.927 c
467.898 783.927 467.646 784.584 467.646 785.484 c
h
S
471.38 783.18 m
472.496 783.18 l
472.496 785.718 l
472.496 786.582 473 786.861 473.459 786.861 c
473.576 786.861 473.675 786.843 473.774 786.816 c
473.774 787.86 l
473.711 787.869 473.657 787.887 473.585 787.887 c
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472.388 787.248 472.361 787.536 472.352 787.815 c
471.344 787.815 l
471.371 787.608 471.38 787.338 471.38 787.05 c
h
S
474.62 783.18 1.116 4.635 re
474.602 788.688 1.152 1.098 re
S
476.96 783.18 1.116 6.75 re
S
481.64 783.18 m
483.278 783.18 l
485.024 783.18 486.284 784.206 486.284 786.321 c
486.284 788.4 485.24 789.462 483.278 789.462 c
481.64 789.462 l
h
482.792 788.58 m
483.179 788.58 l
484.475 788.58 485.06 787.698 485.06 786.321 c
485.06 784.944 484.475 784.062 483.179 784.062 c
482.792 784.062 l
h
S
489.704 783.18 m
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490.856 786.132 l
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492.773 783.18 l
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491.864 786.501 l
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492.674 789.462 l
490.883 786.798 l
490.856 786.798 l
490.856 789.462 l
489.704 789.462 l
h
S
494.816 783.18 1.116 4.635 re
494.798 788.688 1.152 1.098 re
S
497.021 783.18 m
498.137 783.18 l
498.137 785.988 l
498.137 786.501 498.398 786.969 498.893 786.969 c
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500.603 783.18 l
500.603 785.988 l
500.603 786.501 500.864 786.969 501.359 786.969 c
501.773 786.969 501.953 786.681 501.953 786.105 c
501.953 783.18 l
503.069 783.18 l
503.069 786.042 l
503.069 787.167 502.745 787.887 501.737 787.887 c
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500.36 787.401 500.108 787.887 499.325 787.887 c
498.686 787.887 498.326 787.446 498.155 787.086 c
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498.137 787.329 498.11 787.572 498.101 787.815 c
496.985 787.815 l
497.003 787.644 497.021 787.392 497.021 787.059 c
h
S
504.023 783.18 m
505.139 783.18 l
505.139 785.988 l
505.139 786.501 505.4 786.969 505.895 786.969 c
506.309 786.969 506.489 786.681 506.489 786.105 c
506.489 783.18 l
507.605 783.18 l
507.605 785.988 l
507.605 786.501 507.866 786.969 508.361 786.969 c
508.775 786.969 508.955 786.681 508.955 786.105 c
508.955 783.18 l
510.071 783.18 l
510.071 786.042 l
510.071 787.167 509.747 787.887 508.739 787.887 c
508.055 787.887 507.722 787.473 507.497 787.149 c
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505.688 787.887 505.328 787.446 505.157 787.086 c
505.139 787.086 l
505.139 787.329 505.112 787.572 505.103 787.815 c
503.987 787.815 l
504.005 787.644 504.023 787.392 504.023 787.059 c
h
S
514.4 784.287 m
514.193 784.134 513.869 783.927 513.185 783.927 c
512.321 783.927 512.006 784.404 512.006 785.196 c
514.688 785.196 l
514.688 785.412 l
514.688 787.302 513.833 787.887 512.834 787.887 c
511.655 787.887 510.926 786.816 510.926 785.43 c
510.926 784.179 511.574 783.108 513.068 783.108 c
513.734 783.108 514.22 783.306 514.454 783.405 c
h
512.006 785.898 m
512.006 786.51 512.249 787.131 512.834 787.131 c
513.338 787.131 513.608 786.717 513.608 785.898 c
h
S
515.66 783.18 1.116 6.75 re
S
523.58 784.287 m
523.373 784.134 523.049 783.927 522.365 783.927 c
521.501 783.927 521.186 784.404 521.186 785.196 c
523.868 785.196 l
523.868 785.412 l
523.868 787.302 523.013 787.887 522.014 787.887 c
520.835 787.887 520.106 786.816 520.106 785.43 c
520.106 784.179 520.754 783.108 522.248 783.108 c
522.914 783.108 523.4 783.306 523.634 783.405 c
h
521.186 785.898 m
521.186 786.51 521.429 787.131 522.014 787.131 c
522.518 787.131 522.788 786.717 522.788 785.898 c
h
S
525.146 787.815 m
524.408 787.815 l
524.408 786.996 l
525.146 786.996 l
525.146 784.458 l
525.146 783.486 525.614 783.108 526.442 783.108 c
526.775 783.108 527.018 783.18 527.189 783.261 c
527.189 784.053 l
527.108 784.008 526.964 783.954 526.766 783.954 c
526.442 783.954 526.262 784.098 526.262 784.593 c
526.262 786.996 l
527.189 786.996 l
527.189 787.815 l
526.262 787.815 l
526.262 789.111 l
525.146 788.769 l
h
S
530.528 786.645 m
530.744 786.825 531.239 787.095 531.797 787.095 c
532.436 787.095 532.661 786.672 532.661 786.213 c
532.661 786.042 l
532.436 786.042 l
531.023 786.042 529.997 785.727 529.997 784.467 c
529.997 783.603 530.663 783.108 531.383 783.108 c
532.049 783.108 532.4 783.432 532.679 783.81 c
532.697 783.81 l
532.697 783.585 532.706 783.36 532.76 783.18 c
533.768 783.18 l
533.741 783.36 533.705 783.666 533.705 783.999 c
533.705 786.024 l
533.705 787.185 533.372 787.887 531.932 787.887 c
531.221 787.887 530.78 787.689 530.465 787.545 c
h
532.661 785.187 m
532.661 784.359 532.418 783.864 531.752 783.864 c
531.32 783.864 531.041 784.152 531.041 784.575 c
531.041 785.25 531.608 785.448 532.562 785.448 c
532.661 785.448 l
h
S
534.848 783.18 1.116 6.75 re
S
537.206 783.18 1.08 1.17 re
S
/CS0 cs 1 scn
BT
/T1_0 1 Tf
9 0 0 9 62.352 783.1801 Tm
(Diagnostic tests in HIV management)Tj
/Span<>> BDC
( )Tj
EMC
44.24 0 Td
(April D Kimmel et al.)Tj
ET
0 w
56.683 802.58 m
56.683 778.68 l
538.583 778.68 l
538.583 802.58 l
56.683 802.58 l
h
S
/CS0 CS 1 SCN
1 w
57.183 782.73 m
57.183 802.63 l
S
Q
0 0 0 1 k
0 i
/RelativeColorimetric ri
/GS0 gs
BT
/T1_2 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 10 0 0 10 56.6929 763.7739 Tm
[(in )-76(dev)6(eloping )-76(countries: )-76(\(1\) )-76(classifying )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 752.2739 Tm
[(i)-38(n)-38(f)-38(o)-38(r)-38(m)-38(a)-38(t)-38(i)-38(o)-38(n)-38( )-163(i)-38(n)-38(t)-38(o)-38( )-163(c)-38(l)-38(i)-38(n)-38(i)-38(c)-38(a)-38(l)-38(l)-38(y)-38( )-163(r)-28(e)-38(l)-38(e)-38(v)-32(a)-38(n)-38(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 740.7739 Tm
[(c)-57(a)-57(t)-57(e)-57(g)-57(o)-57(r)-57(i)-57(e)-57(s)-57( )-182(\()-57(c)-57(l)-57(i)-57(n)-57(i)-57(c)-57(a)-57(l)-57(,)-57( )-182(i)-57(m)-57(m)-57(u)-57(n)-57(o)-57(l)-57(o)-57(g)-57(i)-57(c)-57(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 729.2739 Tm
[(o)-29(r)-29( )-154(v)-29(i)-29(r)-23(o)-29(l)-29(o)-29(g)-29(i)-29(c)-29(\))-29(;)-29( )-154(\()-29(2)-29(\))-29( )-155(u)-29(s)-29(i)-29(n)-29(g)-29( )-154(a)-29( )-154(c)-29(o)-29(n)-29(s)-29(i)-29(s)-29(t)-29(e)-29(n)-29(t )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 717.7739 Tm
[(d)-37(e)-37(\037)-37(n)-37(i)-37(t)-37(i)-37(o)-37(n)-37( )-162(o)-37(f)-37( )-162(d)-37(i)-37(s)-37(e)-37(a)-37(s)-37(e)-37( )-162(a)-37(c)-37(r)-31(o)-37(s)-37(s)-37( )-162(s)-37(t)-37(u)-37(d)-37(i)-37(e)-37(s)-37(; )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 706.2739 Tm
[(a)-31(n)-31(d)-31( )-156(\()-31(3)-31(\))-31( )-156(r)-21(e)-31(p)-31(o)-31(r)-39(t)-31(i)-31(n)-31(g)-31( )-156(b)-31(o)-31(t)-31(h)-31( )-156(m)-31(e)-31(a)-31(s)-31(u)-31(r)-21(e)-31(s)-31( )-156(o)-31(f )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 694.7739 Tm
[(a)1(s)1(s)1(o)1(c)1(i)1(a)1(t)1(i)1(o)1(n)1( )64(\()1(e)1(.)1(g)1(.)1( )63(c)1(o)1(r)1(r)11(e)1(l)1(a)1(t)1(i)1(o)1(n)1( )64(c)1(o)1(e)1(\036)1(c)1(i)1(e)1(n)1(t)1(s)1(\) )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 683.2739 Tm
[(a)7(n)7(d)7( )69(m)7(e)7(a)7(s)7(u)7(r)17(e)7(s)7( )69(o)7(f)7( )69(a)7(c)7(c)7(u)7(r)7(a)7(c)7(y)7( )69(\()7(e)7(.)7(g)7(.)7( )69(s)7(e)7(n)7(s)7(i)7(t)7(i)7(v)7(i)7(t)7(y )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 56.6929 671.7739 Tm
(and speci\037city\). )Tj
ET
/CS0 cs 1 scn
/GS1 gs
BT
/TT0 1 Tf
10 0 0 10 122.3417 671.7739 Tm
(O)Tj
ET
0 0 0 1 k
/GS0 gs
BT
/T1_0 1 Tf
10 0 0 10 222.0472 763.5238 Tm
(Acknowledgements)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 752.0238 Tm
[(W)74(e)-4( )-129(g)-4(r)-4(a)-4(t)-4(e)-4(f)-4(u)-4(l)-4(l)-4(y)-4( )-129(a)-4(c)-4(k)-4(n)-4(o)8(w)-4(l)-4(e)-4(d)-4(g)-4(e)-4( )-129(c)-4(o)-4(m)-4(m)-4(e)-4(n)-4(t)-4(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 740.5238 Tm
[(f)12(r)18(o)12(m)12( )50(D)24(r)12( )50(D)18(a)12(v)12(i)12(d)12( )50(E)12( )50(B)24(l)12(o)12(o)12(m)12( )50(o)12(n)12( )50(e)12(a)12(r)12(l)12(i)12(e)12(r)12( )50(d)12(r)12(a)12(f)12(t)12(s )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 729.0238 Tm
[(of this r)10(evie)-6(w)75(.)]TJ
ET
BT
/T1_0 1 Tf
10 0 0 10 222.0472 706.0238 Tm
(Funding:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 258.1868 706.0238 Tm
[( )-93(\034is )-93(study )-93(was )-93(suppor)-8(ted )-93(in )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 694.6238 Tm
[(par)-8(t )40(b)6(y )40(the )40(N)30(ational )40(I)12(nstitute )40(of )40(Allergy )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 683.2238 Tm
[(a)7(n)7(d)7( )70(I)19(n)7(f)7(e)7(c)7(t)7(i)7(o)7(u)7(s)7( )70(D)19(i)7(s)7(e)7(a)7(s)7(e)7(s)7( )70(\()7(R)7(0)7(1)7( )69(A)7(I)7(0)7(5)7(8)7(7)7(3)7(6)7(, )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 222.0472 671.8238 Tm
[(K)-31(2)-31(5)-31( )-156(A)-31(I)-31(5)-31(0)-31(4)-31(3)-31(6)-31(,)-31( )-156(K)-31(2)-31(4)-31( )-156(A)-31(I)-31(0)-31(6)-31(2)-31(4)-31(7)-31(6)-31(,)-31( )-156(a)-31(n)-31(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 763.7739 Tm
[(C)-1(F)35(A)-1(R)-1( )-126(P)-1(3)-1(0)-1( )-126(A)-1(I)-1(4)-1(2)-1(8)-1(5)-1(1)-1(\))-1(,)-1( )-126(t)-1(h)-1(e)-1( )-126(A)-1(g)-1(e)-1(n)-1(c)-1(y)-1( )-126(f)-1(o)-1(r )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 752.2739 Tm
[(H)18(ealthcar)10(e )-40(R)12(esear)6(ch )-41(and )-40(Q)6(uality )-40(\()-12(T32 )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 740.7739 Tm
[(HS00055\), )-124(and )-124(depar)-8(tmental )-124(funding )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 729.2739 Tm
[(f)10(r)16(o)10(m)10( )22(t)10(h)10(e)10( )22(D)16(e)10(p)10(a)10(r)2(t)10(m)10(e)10(n)10(t)10( )22(o)10(f)10( )22(P)64(o)10(p)10(u)10(l)10(a)10(t)10(i)10(o)10(n)10( )22(a)10(n)10(d )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 717.7739 Tm
[(I)17(n)5(t)5(e)5(r)5(n)5(a)5(t)5(i)5(o)5(n)5(a)5(l)5( )68(H)23(e)5(a)5(l)5(t)5(h)5(,)5( )68(H)11(a)5(r)-13(v)11(a)5(r)19(d)5( )68(S)5(c)5(h)5(o)5(o)5(l)5( )68(o)5(f )]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 387.4016 706.2239 Tm
[(P)30(ublic H)18(ealth.)]TJ
ET
BT
/T1_0 1 Tf
10 0 0 10 387.4016 683.2239 Tm
[(Competing inter)10(ests:)]TJ
ET
BT
/T1_2 1 Tf
10 0 0 10 474.7505 683.2239 Tm
[( none declar)10(ed.)]TJ
ET
/CS0 CS 1 SCN
1 w 10 M 0 j 0 J []0 d
/GS1 gs
56.693 648.578 m
538.583 648.578 l
S
/GS0 gs
BT
/T1_0 1 Tf
11.5 0 0 11.5 56.6929 635.8885 Tm
(R\351sum\351)Tj
ET
BT
/T1_0 1 Tf
11 0 0 11 56.6929 618.2192 Tm
[(T)85(ests diagnostiques et prise en char)10(ge des infections \340 )55(VIH :)37( r)10(evue des m\351thodes cliniques et analytiques )]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 56.6929 606.2192 Tm
[(permettant le suivi des per)10(sonnes contamin\351es dans les pays en d\351veloppement)]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 594.1868 Tm
[(N)8(o)8(u)8(s)8( )-13(a)8(v)8(o)8(n)8(s)8( )-13(r)8(\351)8(a)8(l)8(i)8(s)8(\351)8( )-13(u)8(n)8(e)8( )-13(r)8(e)8(v)8(u)8(e)8( )-13(s)8(y)8(s)8(t)8(\351)8(m)8(a)8(t)8(i)8(q)8(u)8(e)8( )-13(d)8(e)8(s)8( )-13(p)8(e)8(r)8(f)8(o)8(r)8(m)8(a)8(n)8(c)8(e)8(s)8( )-13(d)8(e)8(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 582.6868 Tm
[(tests )51(diagnostiques )51(utilis\351s )50(pour )51(le )50(suivi )51(clinique )50(et )51(biologique )51(des )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 571.1868 Tm
[(adultes )-43(contamin\351s )-43(par )-43(le )12(VIH )-43(dans )-43(les )-43(pays )-43(en )-43(d\351veloppement.)37( )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 559.6868 Tm
[(Les )-63(r\351sultats )-63(de )-63(tests )-63(diagnostiques )-63(recueillis )-63(\340 )-63(partir )-63(des )-63(bases )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 548.1868 Tm
[(d)-27(e)-27( )-147(d)-27(o)-27(n)-27(n)-27(\351)-27(e)-27(s)-27( )-147(i)-27(n)-27(f)-27(o)-27(r)-27(m)-27(a)-27(t)-27(i)-27(s)-27(\351)-27(e)-27(s)10(,)10( )-147(l)-27(e)-27(s)-27( )-147(d)-27(o)-27(n)-27(n)-27(\351)-27(e)-27(s)-27( )-147(b)-27(i)-27(b)-27(l)-27(i)-27(o)-27(g)-27(r)-9(a)-27(p)-27(h)-27(i)-27(q)-27(u)-27(e)-27(s)-27( )-147(e)-27(t )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 536.6868 Tm
[(l)-1(e)-1(s)-1( )-121(i)-1(n)-1(f)-1(o)-1(r)-1(m)-1(a)-1(t)-1(i)-1(o)-1(n)-1(s)-1( )-121(o)-1(b)-1(t)-1(e)-1(n)-1(u)-1(e)-1(s)-1( )-121(s)-1(u)-1(r)-1( )-121(I)-1(n)-1(t)-1(e)-1(r)-1(n)-1(e)-1(t)-1( )-121(o)-1(n)-1(t)-1( )-121(\351)-1(t)-1(\351)-1( )-121(c)-1(l)-1(a)-1(s)-1(s)-1(\351)-1(s)-1( )-121(e)-1(n)-1( )-121(t)-1(r)-1(o)-1(i)-1(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 525.1868 Tm
[(cat\351gories )45(:)37( )45(donn\351es )45(cliniques )45(\(informations )45(au )45(sujet )45(des )45(malades )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 513.6868 Tm
[(ne )-25(provenant )-25(pas )-25(des )-25(examens )-25(en )-25(labor)18(atoire\),)37( )-25(immunologiques )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 502.1868 Tm
[(\()10(i)10(n)10(f)10(o)10(r)10(m)10(a)10(t)10(i)10(o)10(n)10(s)10( )52(f)10(o)10(u)10(r)10(n)10(i)10(e)10(s)10( )52(p)10(a)10(r)10( )52(l)10(e)10(s)10( )52(t)10(e)10(s)10(t)10(s)10( )52(i)10(m)10(m)10(u)10(n)10(o)10(l)10(o)10(g)10(i)10(q)10(u)10(e)10(s)10( )52(e)10(n)10( )52(l)10(a)10(b)10(o)10(r)28(a)10(t)10(o)10(i)10(r)10(e)10(\) )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 490.6868 Tm
[(e)6(t)6( )13(v)6(i)6(r)6(o)6(l)6(o)6(g)6(i)6(q)6(u)6(e)6(s)6( )13(\()6(i)6(n)6(f)6(o)6(r)6(m)6(a)6(t)6(i)6(o)6(n)6(s)6( )13(f)6(o)6(u)6(r)6(n)6(i)6(e)6(s)6( )13(p)6(a)6(r)6( )13(l)6(e)6(s)6( )13(t)6(e)6(s)6(t)6(s)6( )13(v)6(i)6(r)6(o)6(l)6(o)6(g)6(i)6(q)6(u)6(e)6(s)6( )13(e)6(n )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 479.1868 Tm
[(labor)18(atoire\).)37( )-19(P)37(armi )-18(les )-19(51 )-18(\351tudes )-19(s\351lectionn\351es )-18(pour )-18(la )-19(revue)37(,)37( )-18(28 )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 467.6868 Tm
[(\351v)18(aluaient )-89(des )-89(tests )-89(immunologiques)37(,)37( )-89(12 )-89(des )-89(tests )-89(virologiques )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 456.1868 Tm
[(e)-14(t)-14( )-134(7)-14( )-134(d)-14(e)-14(s)-14( )-134(t)-14(e)-14(s)-14(t)-14(s)-14( )-134(c)-14(l)-14(i)-14(n)-14(i)-14(q)-14(u)-14(e)-14(s)-14( )-134(e)-14(t)-14( )-134(i)-14(m)-14(m)-14(u)-14(n)-14(o)-14(l)-14(o)-14(g)-14(i)-14(q)-14(u)-14(e)-14(s)23(.)23( )-134(L)77(\222)-14(\351)-14(v)4(a)-14(l)-14(u)-14(a)-14(t)-14(i)-14(o)-14(n)-14( )-134(d)-14(e)-14(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 444.6868 Tm
[(performances )-48(m\351thodologiques )-48(se )-48(fondait )-48(principalement )-48(sur )-48(la )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 433.1868 Tm
[(s)4(e)4(n)4(s)4(i)4(b)4(i)4(l)4(i)4(t)4(\351)4( )64(e)4(t)4( )64(l)4(a)4( )64(s)4(p)4(\351)4(c)4(i)4(\037)4(c)4(i)4(t)4(\351)4( )64(p)4(o)4(u)4(r)4( )64(l)4(e)4(s)4( )64(d)4(o)4(n)4(n)4(\351)4(e)4(s)4( )64(d)4(e)4( )64(l)4(a)4( )64(c)4(a)4(t)4(\351)4(g)4(o)4(r)4(i)4(e)4( )64(c)4(l)4(i)4(n)4(i)4(q)4(u)4(e )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 421.6868 Tm
[(et )60(sur )60(les )60(coef\037cients )60(de )60(corr\351lation )60(pour )60(les )60(donn\351es )60(appartenant )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 410.1868 Tm
[(aux )-75(cat\351gories )-75(immunologique )-75(et )-75(virologique)37(.)37( )-75(P)37(our )-75(la )-75(cat\351gorie )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 594.1868 Tm
[(c)10(l)10(i)10(n)10(i)10(q)10(u)10(e)47(,)47( )-1(d)10(\222)10(a)10(p)10(r)10(\350)10(s)10( )-1(l)10(a)10( )-1(m)10(e)10(s)10(u)10(r)10(e)10( )-1(d)10(e)10(s)10( )-1(p)10(e)10(r)10(f)10(o)10(r)10(m)10(a)10(n)10(c)10(e)10(s)47(,)47( )-1(l)10(a)10( )-1(m)10(a)10(j)10(o)10(r)10(i)10(t)10(\351)10( )-1(d)10(e)10(s)10( )-1(t)10(e)10(s)10(t)10(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 582.6868 Tm
[(pr\351sentaient )-68(une )-68(sensibilit\351 )-68(> )-68(70 )-68(% )-68(et )-68(une )-68(sp\351ci\037cit\351 )-68(> )-68(65 )-68(%.)37( )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 571.1868 Tm
[(P)37(our )-62(la )-62(cat\351gorie )-61(immunologique)37(,)37( )-62(les )-62(coef\037cients )-61(de )-62(corr\351lation )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 559.6868 Tm
[(allaient )11(de )11(r )10(= )10(0,54 )11(\340 )11(r )10(= )11(0,99 )10(pour )11(les )11(diff\351rentes )11(techniques )11(de )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 548.1868 Tm
[(num\351r)18(ation )-55(des )-55(CD4,)37( )-55(tandis )-55(qu\222entre )-55(la )-55(num\351r)18(ation )-55(des )-55(CD4 )-55(et )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 536.6868 Tm
[(celle )-80(des )-80(lymphocytes )-80(totaux,)37( )-80(ces )-80(coef\037cients )-80(se )-80(situaient )-80(entre )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 538.5236 536.6868 Tm
( )Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 525.1868 Tm
[(r)10( )-12(=)10( )-12(0)10(,)10(2)10(3)10( )-12(e)10(t)10( )-12(r)10( )-13(=)10( )-13(0)10(,)10(7)10(4)10(.)47( )-13(P)47(o)10(u)10(r)10( )-12(l)10(a)10( )-12(c)10(a)10(t)10(\351)10(g)10(o)10(r)10(i)10(e)10( )-12(v)10(i)10(r)10(o)10(l)10(o)10(g)10(i)10(q)10(u)10(e)47(,)47( )-12(l)10(e)10(s)10( )-12(c)10(o)10(e)10(f)10(\037)10(c)10(i)10(e)10(n)10(t)10(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 513.6868 Tm
[(d)3(e)3( )63(c)3(o)3(r)3(r)3(\351)3(l)3(a)3(t)3(i)3(o)3(n)3( )63(e)3(n)3(t)3(r)3(e)3( )63(l)3(e)3(s)3( )63(d)3(i)3(f)3(f)3(\351)3(r)3(e)3(n)3(t)3(e)3(s)3( )63(t)3(e)3(c)3(h)3(n)3(i)3(q)3(u)3(e)3(s)3( )63(d)3(e)3( )63(q)3(u)3(a)3(n)3(t)3(i)3(\037)3(c)3(a)3(t)3(i)3(o)3(n)3( )63(d)3(e )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 502.1868 Tm
[(l\222ARN )-3(du )52(VIH )-3(allaient )-3(de )-3(r )-3(= )-3(0,54 )-3(\340 )-3(r )-3(= )-3(0,90.)37( )-3(P)37(our )-3(les )-3(tr)18(av)18(aux )-3(de )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 490.6868 Tm
[(recherche )-14(\340 )-14(venir)91(,)37( )-14(il )-14(ser)18(ait )-14(n\351cessaire )-14(de )-14(parvenir )-14(\340 )-14(un )-14(consensus )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 479.1868 Tm
[(sur )-46(les )-46(modalit\351s )-46(de )-46(conception )-46(des )-46(\351tudes )-46(et,)37( )-46(de )-46(collecte )-46(et )-46(de )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 467.6868 Tm
[(r)21(a)3(p)3(p)3(o)3(r)3(t)3( )63(d)3(e)3(s)3( )63(d)3(o)3(n)3(n)3(\351)3(e)3(s)3( )63(u)3(t)3(i)3(l)3(e)3(s)3( )63(a)3(u)3(x)3( )63(d)3(\351)3(c)3(i)3(d)3(e)3(u)3(r)3(s)40(.)40( )63(L)94(\222)3(a)3(r)3(t)3(i)3(c)3(l)3(e)3( )63(r)3(e)3(c)3(o)3(m)3(m)3(a)3(n)3(d)3(e)3( )63(d)3(e )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 456.1868 Tm
[(c)1(l)1(a)1(s)1(s)1(e)1(r)1( )61(l)1(e)1(s)1( )61(i)1(n)1(f)1(o)1(r)1(m)1(a)1(t)1(i)1(o)1(n)1(s)1( )61(s)1(e)1(l)1(o)1(n)1( )61(d)1(e)1(s)1( )61(c)1(a)1(t)1(\351)1(g)1(o)1(r)1(i)1(e)1(s)1( )61(c)1(l)1(i)1(n)1(i)1(q)1(u)1(e)1(s)1( )61(p)1(e)1(r)1(t)1(i)1(n)1(e)1(n)1(t)1(e)1(s)38(,)37( )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 444.6868 Tm
[(e)3(n)3( )63(u)3(t)3(i)3(l)3(i)3(s)3(a)3(n)3(t)3( )63(u)3(n)3(e)3( )63(d)3(\351)3(\037)3(n)3(i)3(t)3(i)3(o)3(n)3( )63(i)3(d)3(e)3(n)3(t)3(i)3(q)3(u)3(e)3( )63(d)3(e)3( )63(l)3(a)3( )63(m)3(a)3(l)3(a)3(d)3(i)3(e)3( )63(d)3(a)3(n)3(s)3( )63(l)3(\222)3(e)3(n)3(s)3(e)3(m)3(b)3(l)3(e )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 433.1868 Tm
[(des )-49(\351tudes )-49(et )-49(en )-49(fournissant )-49(une )-49(\351v)18(aluation )-49(de )-49(la )-49(corr\351lation )-49(et )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 421.6868 Tm
(de la pr\351cision.)Tj
ET
/GS1 gs
56.693 386.992 m
538.583 386.992 l
S
/GS0 gs
BT
/T1_0 1 Tf
11.5 0 0 11.5 56.6929 374.3027 Tm
(Resumen)Tj
ET
BT
/T1_0 1 Tf
11 0 0 11 56.6929 356.6335 Tm
[(Pruebas diagn\363sticas en el manejo de la infecci\363n por )55(VIH:)37( estudio de las estr)10(ategias cl\355nicas y de )]TJ
ET
BT
/T1_0 1 Tf
11 0 0 11 56.6929 344.6335 Tm
[(labor)10(atorio empleadas par)10(a contr)10(olar a las per)10(sonas infectadas por el )55(VIH en los pa\355ses en desarr)10(ollo)]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 332.6293 Tm
[(Realizamos )11(una )11(revisi\363n )10(sistem\341tica )11(de )11(la )10(e\037cacia )11(de )10(las )11(pruebas )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 321.1293 Tm
[(diagn\363sticas )11(como )11(medio )11(de )11(seguimiento )11(cl\355nico )11(y )11(de )11(labor)18(atorio )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 309.6293 Tm
[(d)4(e)5( )64(l)4(a)5(s)4( )64(p)4(e)5(r)4(s)4(o)5(n)4(a)4(s)5( )64(i)4(n)4(f)5(e)4(c)4(t)5(a)4(d)4(a)4(s)5( )64(p)4(o)5(r)4( )64(e)5(l)4( )119(V)4(I)5(H)4( )64(e)4(n)5( )64(l)4(o)5(s)4( )64(p)5(a)4(\355)4(s)5(e)4(s)4( )64(e)5(n)4( )64(d)4(e)5(s)4(a)4(r)5(r)4(o)4(l)4(l)5(o)41(.)41( )65(L)4(a )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 298.1293 Tm
[(informaci\363n )33(sobre )33(pruebas )33(diagn\363sticas )33(reunida )33(a )33(partir )33(de )33(bases )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 286.6293 Tm
[(de )15(datos )15(computadorizadas)37(,)37( )15(de )15(las )15(publicaciones )15(y )15(de )15(Internet )15(se )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 275.1293 Tm
[(c)-1(l)-1(a)-1(s)-1(i)-1(\037)-1(c)-1(\363)-1( )-121(c)-1(o)-1(m)-1(o)-1( )-121(c)-1(l)-1(\355)-1(n)-1(i)-1(c)-1(a)-1( )-121(\()-1(i)-1(n)-1(f)-1(o)-1(r)-1(m)-1(a)-1(c)-1(i)-1(\363)-1(n)-1( )-121(s)-1(o)-1(b)-1(r)-1(e)-1( )-121(l)-1(o)-1(s)-1( )-121(p)-1(a)-1(c)-1(i)-1(e)-1(n)-1(t)-1(e)-1(s)-1( )-121(d)-1(i)-1(s)-1(t)-1(i)-1(n)-1(t)-1(a )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 263.6293 Tm
[(d)-3(e)-3( )-123(l)-3(o)-3(s)-3( )-123(d)-3(a)-3(t)-3(o)-3(s)-3( )-123(d)-3(e)-3( )-123(l)-3(a)-3(b)-3(o)-3(r)15(a)-3(t)-3(o)-3(r)-3(i)-3(o)-3(\))-3(,)34( )-123(i)-3(n)-3(m)-3(u)-3(n)-3(o)-3(l)-3(\363)-3(g)-3(i)-3(c)-3(a)-3( )-123(\()-3(i)-3(n)-3(f)-3(o)-3(r)-3(m)-3(a)-3(c)-3(i)-3(\363)-3(n)-3( )-123(s)-3(o)-3(b)-3(r)-3(e )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 252.1293 Tm
[(pruebas )-29(inmunol\363gicas\) )-29(o )-29(virol\363gica )-29(\(informaci\363n )-29(sobre )-29(pruebas )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 240.6293 Tm
[(virol\363gicas\).)37( )-120(De )-120(los )-120(51 )-120(estudios )-120(seleccionados )-119(par)18(a )-120(la )-120(revisi\363n,)37( )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 229.1293 Tm
[(28 )7(ev)18(aluaron )7(pruebas )7(inmunol\363gicas)37(,)37( )7(12 )7(pruebas )7(virol\363gicas)37(,)37( )7(y )7(7 )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 217.6293 Tm
[(p)2(r)2(u)2(e)2(b)2(a)2(s)2( )62(c)2(l)2(\355)2(n)2(i)2(c)2(a)2(s)2( )62(e)2( )62(i)2(n)2(m)2(u)2(n)2(o)2(l)2(\363)2(g)2(i)2(c)2(a)2(s)39(.)39( )62(L)2(o)2(s)2( )62(m)2(\351)2(t)2(o)2(d)2(o)2(s)2( )62(d)2(e)2( )62(e)2(v)20(a)2(l)2(u)2(a)2(c)2(i)2(\363)2(n)2( )62(d)16(e)16( )76(l)16(a )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 206.1293 Tm
[(e)14(\037)14(c)14(a)14(c)14(i)14(a)14( )58(f)14(u)14(e)14(r)14(o)14(n)14( )58(p)14(r)14(i)14(n)14(c)14(i)14(p)14(a)14(l)14(m)14(e)14(n)14(t)14(e)14( )58(l)14(a)14( )58(s)14(e)14(n)14(s)14(i)14(b)14(i)14(l)14(i)14(d)14(a)14(d)14( )58(y)14( )58(l)14(a)14( )59(e)14(s)14(p)14(e)14(c)14(i)14(\037)14(c)14(i)14(d)14(a)14(d)14( )59(en )44(el )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 194.6293 Tm
[(caso )41(de )40(las )41(pruebas )41(cl\355nicas)37(,)37( )41(y )40(los )41(coe\037cientes )41(de )40(correlaci\363n )41(en )41(el )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 183.1293 Tm
[(c)6(a)6(s)6(o)6( )66(d)6(e)6( )66(l)6(a)6(s)6( )66(p)6(r)6(u)6(e)6(b)6(a)6(s)6( )66(i)6(n)6(m)6(u)6(n)6(o)6(l)6(\363)6(g)6(i)6(c)6(a)6(s)6( )66(y)6( )66(v)6(i)6(r)6(o)6(l)6(\363)6(g)6(i)6(c)6(a)6(s)43(.)43( )66(E)6(n)6(t)6(r)6(e)6( )66(l)6(a)6(s)6( )66(p)6(r)6(i)6(m)6(e)6(r)24(a)6(s)43(,)37( )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 56.6929 171.6293 Tm
[(la )-76(mayor\355a )-76(de )-76(las )-76(medidas )-76(de )-76(e\037cacia )-76(de )-76(las )-76(pruebas )-76(revelaron )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 332.6293 Tm
[(una )-33(sensibilidad )-33(superior )-33(al )-33(70% )-33(y )-33(una )-33(especi\037cidad )-33(superior )-33(al )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 321.1293 Tm
[(65%.)37( )-13(En )-13(la )-13(categor\355a )-13(de )-13(pruebas )-13(inmunol\363gicas)37(,)37( )-13(los )-13(coe\037cientes )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 309.6293 Tm
[(d)1(e )61(co)1(rr)1(el)1(a)1(ci)1(\363n)1( )60(o)1(s)1(ci)1(la)1(ro)1(n )61(e)1(nt)1(re)1( )60(0)1(,5)1(4 )61(y)1( )60(0)1(,9)1(9 )61(pa)1(r)18(a)1( )61(di)1(fe)1(re)1(nt)1(e)1(s )61(t\351)1(cn)1(ic)1(a)1(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 298.1293 Tm
[(d)-6(e)-6( )-126(r)-6(e)-6(c)-6(u)-6(e)-6(n)-6(t)-6(o)-6( )-126(d)-6(e)-6( )-126(C)-6(D)-6(4)-6(,)31( )-126(m)-6(i)-6(e)-6(n)-6(t)-6(r)12(a)-6(s)-6( )-126(q)-6(u)-6(e)-6( )-126(l)-6(a)-6( )-126(c)-6(o)-6(r)-6(r)-6(e)-6(l)-6(a)-6(c)-6(i)-6(\363)-6(n)-6( )-126(\()2(r)2(\))2( )-118(e)2(n)1(t)2(r)2(e)2( )-118(l)2(o)2(s )]TJ
ET
BT
/T1_1 1 Tf
10 0 0 10 304.7141 286.6293 Tm
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121.33 788.819 l
h
S
126.712 786.695 m
126.928 786.875 127.423 787.145 127.981 787.145 c
128.62 787.145 128.845 786.722 128.845 786.263 c
128.845 786.092 l
128.62 786.092 l
127.207 786.092 126.181 785.777 126.181 784.517 c
126.181 783.653 126.847 783.158 127.567 783.158 c
128.233 783.158 128.584 783.482 128.863 783.86 c
128.881 783.86 l
128.881 783.635 128.89 783.41 128.944 783.23 c
129.952 783.23 l
129.925 783.41 129.889 783.716 129.889 784.049 c
129.889 786.074 l
129.889 787.235 129.556 787.937 128.116 787.937 c
127.405 787.937 126.964 787.739 126.649 787.595 c
h
128.845 785.237 m
128.845 784.409 128.602 783.914 127.936 783.914 c
127.504 783.914 127.225 784.202 127.225 784.625 c
127.225 785.3 127.792 785.498 128.746 785.498 c
128.845 785.498 l
h
S
131.032 783.23 1.116 6.75 re
S
133.39 783.23 1.08 1.17 re
S
396.638 783.23 m
398.276 783.23 l
400.022 783.23 401.282 784.256 401.282 786.371 c
401.282 788.45 400.238 789.512 398.276 789.512 c
396.638 789.512 l
h
397.79 788.63 m
398.177 788.63 l
399.473 788.63 400.058 787.748 400.058 786.371 c
400.058 784.994 399.473 784.112 398.177 784.112 c
397.79 784.112 l
h
S
402.308 783.23 1.116 4.635 re
402.29 788.738 1.152 1.098 re
S
404.828 786.695 m
405.044 786.875 405.539 787.145 406.097 787.145 c
406.736 787.145 406.961 786.722 406.961 786.263 c
406.961 786.092 l
406.736 786.092 l
405.323 786.092 404.297 785.777 404.297 784.517 c
404.297 783.653 404.963 783.158 405.683 783.158 c
406.349 783.158 406.7 783.482 406.979 783.86 c
406.997 783.86 l
406.997 783.635 407.006 783.41 407.06 783.23 c
408.068 783.23 l
408.041 783.41 408.005 783.716 408.005 784.049 c
408.005 786.074 l
408.005 787.235 407.672 787.937 406.232 787.937 c
405.521 787.937 405.08 787.739 404.765 787.595 c
h
406.961 785.237 m
406.961 784.409 406.718 783.914 406.052 783.914 c
405.62 783.914 405.341 784.202 405.341 784.625 c
405.341 785.3 405.908 785.498 406.862 785.498 c
406.961 785.498 l
h
S
410.066 785.597 m
410.066 786.542 410.291 787.082 410.876 787.091 c
411.407 787.1 411.776 786.578 411.776 785.606 c
411.776 784.553 411.497 784.049 410.795 784.049 c
410.417 784.049 410.066 784.508 410.066 785.597 c
h
409.121 781.52 m
409.391 781.421 409.976 781.232 410.714 781.232 c
412.415 781.232 412.856 782.267 412.856 783.716 c
412.856 787.136 l
412.856 787.379 412.874 787.622 412.892 787.865 c
411.884 787.865 l
411.875 787.622 411.848 787.388 411.848 787.145 c
411.812 787.145 l
411.578 787.55 411.263 787.937 410.588 787.937 c
409.373 787.937 408.914 786.812 408.914 785.534 c
408.914 783.662 409.886 783.23 410.534 783.23 c
411.263 783.23 411.578 783.653 411.758 784.013 c
411.776 784.013 l
411.776 783.572 l
411.776 782.843 411.605 782.114 410.552 782.114 c
409.967 782.114 409.445 782.366 409.184 782.51 c
h
S
413.873 783.23 m
414.989 783.23 l
414.989 785.93 l
414.989 786.524 415.196 787.019 415.781 787.019 c
416.24 787.019 416.42 786.722 416.42 786.011 c
416.42 783.23 l
417.536 783.23 l
417.536 786.218 l
417.536 787.154 417.221 787.937 416.168 787.937 c
415.412 787.937 415.097 787.433 414.935 787.154 c
414.917 787.154 l
414.917 787.388 414.89 787.631 414.881 787.865 c
413.837 787.865 l
413.864 787.658 413.873 787.388 413.873 787.1 c
h
S
419.57 785.552 m
419.57 786.326 419.741 787.145 420.461 787.145 c
421.181 787.145 421.343 786.326 421.343 785.552 c
421.343 784.778 421.181 783.95 420.461 783.95 c
419.741 783.95 419.57 784.778 419.57 785.552 c
h
418.418 785.552 m
418.418 783.608 419.516 783.158 420.461 783.158 c
421.406 783.158 422.495 783.608 422.495 785.552 c
422.495 787.442 421.406 787.937 420.461 787.937 c
419.516 787.937 418.418 787.442 418.418 785.552 c
h
S
423.197 783.383 m
423.431 783.293 423.908 783.158 424.484 783.158 c
425.492 783.158 426.212 783.671 426.212 784.526 c
426.212 785.066 425.924 785.327 425.348 785.696 c
424.799 786.047 l
424.475 786.254 424.277 786.389 424.277 786.641 c
424.277 786.92 424.466 787.091 424.916 787.091 c
425.321 787.091 425.618 786.992 425.897 786.884 c
425.96 787.748 l
425.852 787.784 425.393 787.937 424.799 787.937 c
423.818 787.937 423.197 787.262 423.197 786.623 c
423.197 785.894 423.71 785.597 424.178 785.318 c
424.637 785.048 l
425.042 784.814 425.132 784.643 425.132 784.463 c
425.132 784.103 424.817 784.004 424.412 784.004 c
423.89 784.004 423.431 784.238 423.251 784.31 c
h
S
427.454 787.865 m
426.716 787.865 l
426.716 787.046 l
427.454 787.046 l
427.454 784.508 l
427.454 783.536 427.922 783.158 428.75 783.158 c
429.083 783.158 429.326 783.23 429.497 783.311 c
429.497 784.103 l
429.416 784.058 429.272 784.004 429.074 784.004 c
428.75 784.004 428.57 784.148 428.57 784.643 c
428.57 787.046 l
429.497 787.046 l
429.497 787.865 l
428.57 787.865 l
428.57 789.161 l
427.454 788.819 l
h
S
430.316 783.23 1.116 4.635 re
430.298 788.738 1.152 1.098 re
S
435.635 784.229 m
435.482 784.13 435.113 784.004 434.843 784.004 c
433.988 784.004 433.574 784.67 433.574 785.534 c
433.574 786.524 433.943 787.091 434.789 787.091 c
435.095 787.091 435.374 786.965 435.572 786.866 c
435.635 787.748 l
435.428 787.829 435.014 787.937 434.663 787.937 c
433.106 787.937 432.422 786.866 432.422 785.543 c
432.422 784.229 433.07 783.158 434.6 783.158 c
435.05 783.158 435.437 783.248 435.698 783.347 c
h
S
439.135 787.865 m
438.397 787.865 l
438.397 787.046 l
439.135 787.046 l
439.135 784.508 l
439.135 783.536 439.603 783.158 440.431 783.158 c
440.764 783.158 441.008 783.23 441.178 783.311 c
441.178 784.103 l
441.098 784.058 440.954 784.004 440.756 784.004 c
440.431 784.004 440.251 784.148 440.251 784.643 c
440.251 787.046 l
441.178 787.046 l
441.178 787.865 l
440.251 787.865 l
440.251 789.161 l
439.135 788.819 l
h
S
445.237 784.337 m
445.03 784.184 444.706 783.977 444.022 783.977 c
443.158 783.977 442.843 784.454 442.843 785.246 c
445.525 785.246 l
445.525 785.462 l
445.525 787.352 444.67 787.937 443.671 787.937 c
442.492 787.937 441.763 786.866 441.763 785.48 c
441.763 784.229 442.411 783.158 443.905 783.158 c
444.571 783.158 445.057 783.356 445.291 783.455 c
h
442.843 785.948 m
442.843 786.56 443.086 787.181 443.671 787.181 c
444.175 787.181 444.445 786.767 444.445 785.948 c
h
S
446.209 783.383 m
446.443 783.293 446.92 783.158 447.496 783.158 c
448.504 783.158 449.224 783.671 449.224 784.526 c
449.224 785.066 448.936 785.327 448.36 785.696 c
447.811 786.047 l
447.487 786.254 447.289 786.389 447.289 786.641 c
447.289 786.92 447.478 787.091 447.928 787.091 c
448.333 787.091 448.63 786.992 448.909 786.884 c
448.972 787.748 l
448.864 787.784 448.405 787.937 447.811 787.937 c
446.83 787.937 446.209 787.262 446.209 786.623 c
446.209 785.894 446.722 785.597 447.19 785.318 c
447.649 785.048 l
448.054 784.814 448.144 784.643 448.144 784.463 c
448.144 784.103 447.829 784.004 447.424 784.004 c
446.902 784.004 446.443 784.238 446.263 784.31 c
h
S
450.466 787.865 m
449.728 787.865 l
449.728 787.046 l
450.466 787.046 l
450.466 784.508 l
450.466 783.536 450.934 783.158 451.762 783.158 c
452.095 783.158 452.338 783.23 452.509 783.311 c
452.509 784.103 l
452.428 784.058 452.284 784.004 452.086 784.004 c
451.762 784.004 451.582 784.148 451.582 784.643 c
451.582 787.046 l
452.509 787.046 l
452.509 787.865 l
451.582 787.865 l
451.582 789.161 l
450.466 788.819 l
h
S
453.04 783.383 m
453.274 783.293 453.751 783.158 454.327 783.158 c
455.335 783.158 456.055 783.671 456.055 784.526 c
456.055 785.066 455.767 785.327 455.191 785.696 c
454.642 786.047 l
454.318 786.254 454.12 786.389 454.12 786.641 c
454.12 786.92 454.309 787.091 454.759 787.091 c
455.164 787.091 455.461 786.992 455.74 786.884 c
455.803 787.748 l
455.695 787.784 455.236 787.937 454.642 787.937 c
453.661 787.937 453.04 787.262 453.04 786.623 c
453.04 785.894 453.553 785.597 454.021 785.318 c
454.48 785.048 l
454.885 784.814 454.975 784.643 454.975 784.463 c
454.975 784.103 454.66 784.004 454.255 784.004 c
453.733 784.004 453.274 784.238 453.094 784.31 c
h
S
459.331 783.23 1.116 4.635 re
459.313 788.738 1.152 1.098 re
S
461.563 783.23 m
462.679 783.23 l
462.679 785.93 l
462.679 786.524 462.886 787.019 463.471 787.019 c
463.93 787.019 464.11 786.722 464.11 786.011 c
464.11 783.23 l
465.226 783.23 l
465.226 786.218 l
465.226 787.154 464.911 787.937 463.858 787.937 c
463.102 787.937 462.787 787.433 462.625 787.154 c
462.607 787.154 l
462.607 787.388 462.58 787.631 462.571 787.865 c
461.527 787.865 l
461.554 787.658 461.563 787.388 461.563 787.1 c
h
S
468.736 783.23 m
469.888 783.23 l
469.888 786.002 l
471.751 786.002 l
471.751 783.23 l
472.903 783.23 l
472.903 789.512 l
471.751 789.512 l
471.751 786.956 l
469.888 786.956 l
469.888 789.512 l
468.736 789.512 l
h
S
474.244 783.23 1.152 6.282 re
S
478.033 783.23 m
479.248 783.23 l
481.165 789.512 l
479.977 789.512 l
478.672 784.67 l
478.654 784.67 l
477.385 789.512 l
476.143 789.512 l
h
S
484.054 783.23 m
485.17 783.23 l
485.17 786.038 l
485.17 786.551 485.431 787.019 485.926 787.019 c
486.34 787.019 486.52 786.731 486.52 786.155 c
486.52 783.23 l
487.636 783.23 l
487.636 786.038 l
487.636 786.551 487.897 787.019 488.392 787.019 c
488.806 787.019 488.986 786.731 488.986 786.155 c
488.986 783.23 l
490.102 783.23 l
490.102 786.092 l
490.102 787.217 489.778 787.937 488.77 787.937 c
488.086 787.937 487.753 787.523 487.528 787.199 c
487.393 787.451 487.141 787.937 486.358 787.937 c
485.719 787.937 485.359 787.496 485.188 787.136 c
485.17 787.136 l
485.17 787.379 485.143 787.622 485.134 787.865 c
484.018 787.865 l
484.036 787.694 484.054 787.442 484.054 787.109 c
h
S
491.371 786.695 m
491.587 786.875 492.082 787.145 492.64 787.145 c
493.279 787.145 493.504 786.722 493.504 786.263 c
493.504 786.092 l
493.279 786.092 l
491.866 786.092 490.84 785.777 490.84 784.517 c
490.84 783.653 491.506 783.158 492.226 783.158 c
492.892 783.158 493.243 783.482 493.522 783.86 c
493.54 783.86 l
493.54 783.635 493.549 783.41 493.603 783.23 c
494.611 783.23 l
494.584 783.41 494.548 783.716 494.548 784.049 c
494.548 786.074 l
494.548 787.235 494.215 787.937 492.775 787.937 c
492.064 787.937 491.623 787.739 491.308 787.595 c
h
493.504 785.237 m
493.504 784.409 493.261 783.914 492.595 783.914 c
492.163 783.914 491.884 784.202 491.884 784.625 c
491.884 785.3 492.451 785.498 493.405 785.498 c
493.504 785.498 l
h
S
495.583 783.23 m
496.699 783.23 l
496.699 785.93 l
496.699 786.524 496.906 787.019 497.491 787.019 c
497.95 787.019 498.13 786.722 498.13 786.011 c
498.13 783.23 l
499.246 783.23 l
499.246 786.218 l
499.246 787.154 498.931 787.937 497.878 787.937 c
497.122 787.937 496.807 787.433 496.645 787.154 c
496.627 787.154 l
496.627 787.388 496.6 787.631 496.591 787.865 c
495.547 787.865 l
495.574 787.658 495.583 787.388 495.583 787.1 c
h
S
500.542 786.695 m
500.758 786.875 501.253 787.145 501.811 787.145 c
502.45 787.145 502.675 786.722 502.675 786.263 c
502.675 786.092 l
502.45 786.092 l
501.037 786.092 500.011 785.777 500.011 784.517 c
500.011 783.653 500.677 783.158 501.397 783.158 c
502.063 783.158 502.414 783.482 502.693 783.86 c
502.711 783.86 l
502.711 783.635 502.72 783.41 502.774 783.23 c
503.782 783.23 l
503.755 783.41 503.719 783.716 503.719 784.049 c
503.719 786.074 l
503.719 787.235 503.386 787.937 501.946 787.937 c
501.235 787.937 500.794 787.739 500.479 787.595 c
h
502.675 785.237 m
502.675 784.409 502.432 783.914 501.766 783.914 c
501.334 783.914 501.055 784.202 501.055 784.625 c
501.055 785.3 501.622 785.498 502.576 785.498 c
502.675 785.498 l
h
S
505.78 785.597 m
505.78 786.542 506.005 787.082 506.59 787.091 c
507.121 787.1 507.49 786.578 507.49 785.606 c
507.49 784.553 507.211 784.049 506.509 784.049 c
506.131 784.049 505.78 784.508 505.78 785.597 c
h
504.835 781.52 m
505.105 781.421 505.69 781.232 506.428 781.232 c
508.129 781.232 508.57 782.267 508.57 783.716 c
508.57 787.136 l
508.57 787.379 508.588 787.622 508.606 787.865 c
507.598 787.865 l
507.589 787.622 507.562 787.388 507.562 787.145 c
507.526 787.145 l
507.292 787.55 506.977 787.937 506.302 787.937 c
505.087 787.937 504.628 786.812 504.628 785.534 c
504.628 783.662 505.6 783.23 506.248 783.23 c
506.977 783.23 507.292 783.653 507.472 784.013 c
507.49 784.013 l
507.49 783.572 l
507.49 782.843 507.319 782.114 506.266 782.114 c
505.681 782.114 505.159 782.366 504.898 782.51 c
h
S
512.935 784.337 m
512.728 784.184 512.404 783.977 511.72 783.977 c
510.856 783.977 510.541 784.454 510.541 785.246 c
513.223 785.246 l
513.223 785.462 l
513.223 787.352 512.368 787.937 511.369 787.937 c
510.19 787.937 509.461 786.866 509.461 785.48 c
509.461 784.229 510.109 783.158 511.603 783.158 c
512.269 783.158 512.755 783.356 512.989 783.455 c
h
510.541 785.948 m
510.541 786.56 510.784 787.181 511.369 787.181 c
511.873 787.181 512.143 786.767 512.143 785.948 c
h
S
514.06 783.23 m
515.176 783.23 l
515.176 786.038 l
515.176 786.551 515.437 787.019 515.932 787.019 c
516.346 787.019 516.526 786.731 516.526 786.155 c
516.526 783.23 l
517.642 783.23 l
517.642 786.038 l
517.642 786.551 517.903 787.019 518.398 787.019 c
518.812 787.019 518.992 786.731 518.992 786.155 c
518.992 783.23 l
520.108 783.23 l
520.108 786.092 l
520.108 787.217 519.784 787.937 518.776 787.937 c
518.092 787.937 517.759 787.523 517.534 787.199 c
517.399 787.451 517.147 787.937 516.364 787.937 c
515.725 787.937 515.365 787.496 515.194 787.136 c
515.176 787.136 l
515.176 787.379 515.149 787.622 515.14 787.865 c
514.024 787.865 l
514.042 787.694 514.06 787.442 514.06 787.109 c
h
S
524.437 784.337 m
524.23 784.184 523.906 783.977 523.222 783.977 c
522.358 783.977 522.043 784.454 522.043 785.246 c
524.725 785.246 l
524.725 785.462 l
524.725 787.352 523.87 787.937 522.871 787.937 c
521.692 787.937 520.963 786.866 520.963 785.48 c
520.963 784.229 521.611 783.158 523.105 783.158 c
523.771 783.158 524.257 783.356 524.491 783.455 c
h
522.043 785.948 m
522.043 786.56 522.286 787.181 522.871 787.181 c
523.375 787.181 523.645 786.767 523.645 785.948 c
h
S
525.589 783.23 m
526.705 783.23 l
526.705 785.93 l
526.705 786.524 526.912 787.019 527.497 787.019 c
527.956 787.019 528.136 786.722 528.136 786.011 c
528.136 783.23 l
529.252 783.23 l
529.252 786.218 l
529.252 787.154 528.937 787.937 527.884 787.937 c
527.128 787.937 526.813 787.433 526.651 787.154 c
526.633 787.154 l
526.633 787.388 526.606 787.631 526.597 787.865 c
525.553 787.865 l
525.58 787.658 525.589 787.388 525.589 787.1 c
h
S
530.674 787.865 m
529.936 787.865 l
529.936 787.046 l
530.674 787.046 l
530.674 784.508 l
530.674 783.536 531.142 783.158 531.97 783.158 c
532.303 783.158 532.546 783.23 532.717 783.311 c
532.717 784.103 l
532.636 784.058 532.492 784.004 532.294 784.004 c
531.97 784.004 531.79 784.148 531.79 784.643 c
531.79 787.046 l
532.717 787.046 l
532.717 787.865 l
531.79 787.865 l
531.79 789.161 l
530.674 788.819 l
h
S
/CS0 cs 1 scn
BT
/T1_0 1 Tf
9 0 0 9 56.6929 783.2301 Tm
(April D Kimmel et al.)Tj
/Span<>> BDC
8.675 0 Td
( )Tj
EMC
28.769 0 Td
( Diagnostic tests in HIV management)Tj
ET
0 w
56.693 802.63 m
56.693 778.11 l
538.593 778.11 l
538.593 802.63 l
56.693 802.63 l
h
S
/CS0 CS 1 SCN
1 w
538.093 783.118 m
538.093 802.63 l
S
Q
/CS0 CS 1 SCN
0 i 1 w 10 M 0 j 0 J []0 d
/RelativeColorimetric ri
/GS1 gs
56.693 770.521 m
538.583 770.521 l
S
0 0 0 1 k
/GS0 gs
BT
/C0_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 16 0 0 16 510.9967 758.9662 Tm
<003E002900610065>Tj
ET
BT
/C0_0 1 Tf
14 0 0 14 332.4792 743.1663 Tm
[<03670078>74<028100130060000F0001007B004C0010006B02EF000F00010031>-58<0244>72<0073>-85<0244>85<004D0060000F00010033>28<0072>5<02FC0054000102FC0012002C00180001029300010016007A003D007A00290039001800010017000F>56<002F0010001300190028000F>]TJ
ET
BT
/C0_0 1 Tf
14 0 0 14 94.3629 728.2663 Tm
[<0016007A00650010006B0060000F00010069000F002C006100130060000F0001029300010078>74<028100130060000F0001007B004C0010006B02EF000F00010031>14<0073004D0060000F00010033>29<0072>5<02FC005400010074>24<0072002C004D0012000102FE00120010003D02EF000F0001002C003C>87<00300060000100160079026B0019002902EF000F>43<0072000103780016007A005D007A006B007A0061005C>22<029E000F037900010016007900300079027B0060000F000100170010007A0021007A0018000F>58<02700034>68<0299006000010016004D0020000F>69<00300065>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 711.1472 Tm
[<000102FE00120010003D02EF000F>-3<0001002C003C>88<00300060>-1<000100160079026B0019002902EF000F>42<0072>-1<00010016007A003D007A0029003900190060000F>-2<00010017000F>58<002F0010001300190028>49<0298000F>-2<00010002000F002B>58<029C>-1<00010016007A00210070006B0065>-2<00010016004D0020000F>68<0030026C>-1<00010010006B00660058>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 697.0872 Tm
[<00010010006B004D00660020>-24<000103680016007A00650010006B0060000F>-25<00010069000F002C006100130060000F>-25<00010293>-24<000102FE00510060001000130060000F>-24<0001006C0065>-25<00010078>78<028100130060000F>-24<0001007B004C0010006B02EF000F>-25<00010031>14<0073004D0060000F>-24<00010033>34<0072>34<02FC0054>-25<00010074>24<0072002C004D0012>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 683.0272 Tm
[<00010016>-11<0244>11<0013>-122<0244>122<0034>-54<0248>79<0073>-124<0244>124<0025>-114<0245>115<0066023D0060000F>-139<000100170010007A0045004D02EF000F>-140<0001002C004C000F>34<00730058>-139<0001006C0065>-140<00010016007A003D007A0029003900190060000F>-140<00010017000F>58<002F0010001300190028>49<0298000F>-139<0001005F>38<00730024>-138<0001001700100065>24<00730061004D02EF000F>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 668.9672 Tm
[<0001001700100065>24<00730061004D00650379>-159<00010016007900300079027A>-159<00010017000F>58<002F0010001300190028000F>-158<000102F00009>-158<00010010006F0010006B0055006B003C>29<0072>-158<00010345001A006A>73<0270006A>24<029E000F>44<0072>-158<00010017001000130019005D02EF000F>-159<00010033>82<002F001000700054>30<0072>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 654.9072 Tm
[<000103780016007A004C0010006B02EF000F>-147<00010017000F>58<002F0010001300190028>49<0298000F>-146<0001006C0065>-146<0001001700100065>24<00730061004D00650379>-146<00010016007A004C0010006B0065>33<0072>-145<000103450378028E>87<003002EF000F>-146<0001005F>38<00730024>-145<000100160079026B001900290065>-147<000102FC0050>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 640.8472 Tm
[<000100160034000F>58<002F002B>-149<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 328.0725 640.8472 Tm
(51)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 339.4241 640.8472 Tm
[<000102FE0012>-149<0001006C0065>34<0072>-148<0001036803780016007A0020>33<00730060>49<0072>34<02FC00550060000F>-148<00010017000F>58<026B0019002902EF000F>-149<0001006C0065>-149<0001001700100065>24<00730061004D00650379>-149<00010016007A0020>34<00730060>49<0072>34<02FC0054>29<0072>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 626.7872 Tm
[<000100160034000F>58<002F002B0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 326.2124 626.7872 Tm
(12)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 335.7124 626.7872 Tm
[<0072>1<000103450016007A004C0010006B02EF000F>-1<00010017000F>58<002F0010001300190028>49<0298000F>1<00010067007A023D007A005900190060000100160034000F>58<002F002B0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 450.5988 626.7872 Tm
(28)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 460.0902 626.7872 Tm
[<0001001A006A0010005C>1<000103450016004D0020000F>68<0030006600610060>1<00010017>78<02FC00190028000F>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 612.7272 Tm
[<00010016007900300079027B0060000F>-115<00010017000F>58<002F0010001300190028>49<0298000F>-114<00010067007A023D007A005900190060>-114<0001001700100034000F>58<002F002B>-114<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 427.3007 612.7272 Tm
(7)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 432.0507 612.7272 Tm
[<0072>-113<00010016007A0020>34<00730060>49<0072>34<02FC00550060000F>-114<00010017000F>58<002F0010001300190028>49<0298000F>-114<00010067007A023D007A005900190060>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 598.6672 Tm
[<00010016007A004C>9<0073006B0060000F>44<0072>-70<00010016007A00340010003500250060000F>-70<0001027F007A000C>83<002F>-70<00010062005D00390012>-70<0001001A006A0010005D0054>-70<00010002000F002B>58<029C000F>-70<00010067007A023D007A0059>-1<0018>-70<00010057>-12<0245>85<0030>-151<0245>151<0044>-70<000100100065>19<0005>-70<000103680016007A004C0010006B02EF000F>43<0072>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 302.283 584.6072 Tm
[<000100690010005C>-21<0001002C0058>29<0072>-21<00010368>12<0240>-12<0010004D0065>-21<00010016007A004C0010006B02EF000F>42<0072>-21<00010016007A0020>34<00730060>49<0072>34<02FC00550060000F>-22<000100170010000D005500610060>-21<000100460012000F>58<02700060000F>-21<0001006200650010004D0065>34<0072>-21<00010016007900300079027B0060000F>-22<00010016000D005500610060>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 711.1472 Tm
[<000103680016007A004C>9<0073006A>33<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 79.0452 711.1472 Tm
(%65)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 96.1494 711.1472 Tm
[<0001006C004C>24<0072>33<00010016007A0034001000350024>33<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 143.6617 711.1472 Tm
(%70)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 160.7659 711.1472 Tm
[<000102F1004C>32<0001002C007900320018>32<00010017000F>58<002F0010001300190028>49<0298000F>33<00010002000F002B>14<0005>33<00010036007A023D0079001000590065>32<000100670049004D0065>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 697.0872 Tm
[<0001001600130035006B006000100012>-99<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 83.5521 697.0872 Tm
(0.99)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 100.1771 697.0872 Tm
[<0072>-98<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 108.1153 697.0872 Tm
(0.54)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 125.9647 697.0872 Tm
[<000102FE0012>-99<000100460012000F>58<02700060000F>-98<0001006200650010004D0065>-98<00010023>43<0072000F>68<00300018>-99<0001002C00590054>-99<00010016007A004C0010006B02EF000F>-99<00010016000D00550060000F>-99<00010293>-98<000100100065>19<0005>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 683.0272 Tm
[<000102FE0012>-50<000100430010023D00130018>82<002F>15<0298000F>-50<0001006200650010004D0065>-50<00010023>43<0072000F>68<00300018>-50<00010010023D023D0066007A0054>-51<00010345>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 166.1782 683.0272 Tm
(CD4)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 185.5692 683.0272 Tm
[<00010010023D023D0079>38<029900290060000F>-49<0001002B000F002C>-1<004D00190060>-49<0001001600550061001900290065>-50<00010014007A006000100034>74<029C>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 668.9672 Tm
[<00010293>25<0072>19<00010368>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 71.1473 668.9672 Tm
(0.74)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 87.7723 668.9672 Tm
[<0072>19<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 94.2494 668.9672 Tm
(0.23)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 110.6376 668.9672 Tm
[<000102FE0012>18<00010023>43<0072000F>59<02700079>18<000100170010023D0079007200100055006600610060000F>19<0001006200650010005C>19<0001002B000F002C004D0018>38<0072>19<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 227.3858 668.9672 Tm
(CD4)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 245.921 668.9672 Tm
[<000100100079>39<029900290060000F>20<0001002B000F002C023D004D0018>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 654.9072 Tm
[<00010016007A0066005C>-14<000100300079002C005900190060>-14<00010016005500610019002902EF000F>-15<00010014007A006000100034>74<029C000F>-14<00010293>-13<00010043001000130018>82<002F>15<0298000F>-14<0001006200650010004D0065>-14<00010023>43<0072000F>68<00300018>-14<000103450016007A0020>34<00730060>49<0072>34<02FC00550060000F>-14<00010016000D00550060000F>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 640.8472 Tm
[<00010062001300590019003502EF000F>30<00010293>31<000100160020001000250060000F>32<0001>-267<0247>267<00360271>38<0072>31<00010368>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 140.4252 640.8472 Tm
(0.90)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 157.0502 640.8472 Tm
[<0072>31<0001>]TJ
ET
BT
/T1_2 1 Tf
9.5 0 0 9.5 163.376 640.8472 Tm
(0.54)Tj
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 179.613 640.8472 Tm
[<000102FE0012>30<00010078>78<028100130060000F>31<0001007B004C0010006B02EF000F>31<00010031>14<0073004D0060000F>31<00010033>34<0072>34<02FC0054>31<00010010006A>82<002F>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 626.7872 Tm
[<000100100070006B004C>6<0001004F>83<02990012>10<029E000F>44<0072>6<000100170010007A0045004D02EF000F>4<0001004E00660020>34<0072>6<0001001700100034000F>58<002F002C0060000F>6<00010067007A0066003D0018>5<0001005F>38<00730024>6<0001004B>54<02F40020>15<0009>6<000102F00009>6<0001005F>38<0073003C>20<00730060000F>6<000102F00009>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 612.7272 Tm
[<000100170010000D0054>-111<000102F00009>-110<0001001700100065>24<00730061004D02EF000F>-111<00010056007A006B003D00190012>-112<00010010006B007A003C>29<0072>10<0005>44<0072>-110<00010368027E0010007A00350060000F>-110<0001002F000F>68<00300059>-1<0060000F>-110<0001001100100025003C>15<0005>-111<0001002C007A00550079>-112<000102F40065>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 54.2515 598.6672 Tm
[<00010062000C00100034>34<0072>36<000102FC0054>19<00730018>39<0072>36<0001001700100034000F>58<002F002C0060000F>36<0001004E007A00660020>36<00010293>36<0001003F000F>68<00300065>58<029D0060>36<000100160059003500190065>35<000100560079002F0010004D0018>35<00010063000F002C00290019003400100012>35<00010016001300340010006B0065>]TJ
ET
BT
/C0_1 1 Tf
12.5 0 0 12.5 243.3405 584.6072 Tm
[<036800160058002C00610060>49<0072000100460012000F>58<027000610060>]TJ
ET
/GS1 gs
56.683 561.403 m
538.583 561.403 l
S
/GS0 gs
BT
/T1_0 1 Tf
11.5 0 0 11.5 56.6827 547.7216 Tm
[(Refer)10(ences)]TJ
ET
BT
/T1_1 1 Tf
/Span<>> BDC
8 0 0 8 56.6827 532.0632 Tm
( )Tj
EMC
0.557 0 Td
(1.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.531 0 Td
[(Mellors JW)74(,)37( Munoz )55(A,)37( Giorgi JV)128(,)37( Margolick JB)37(,)37( )55(T)74(assoni CJ)37(,)37( Gupta P)128(,)37( et al.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 522.0632 Tm
[(Plasma vir)18(al load and CD4+ lymphocytes as prognostic mark)37(ers of HIV)37(-1 )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 512.0632 Tm
[(infection.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 99.4475 512.0632 Tm
(Ann Intern Med)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 145.2149 512.0632 Tm
( 1997;126:946-54.)Tj
/Span<>> BDC
-11.067 -1.25 Td
( )Tj
EMC
0.557 0 Td
(2.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.531 0 Td
[(Hughes MD)37(,)37( Johnson )55(V)45(A,)37( Hirsch MS)37(,)37( Bremer JW)74(,)37( Elbeik )55(T)111(,)37( Erice )55(A,)37( et al.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 492.0632 Tm
[(Monitoring plasma HIV)37(-1 RNA levels in addition to CD4+ lymphocyte count )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 482.0632 Tm
[(improves assessment of antiretrovir)18(al ther)18(apeutic response)37(.)37( )55(A)18(CTG 241 )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 472.0632 Tm
[(Protocol )55(Virology Substudy )55(T)55(eam.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 168.5266 472.0632 Tm
(Ann Intern Med)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 214.294 472.0632 Tm
( 1997;126:929-38.)Tj
/Span<>> BDC
-19.701 -1.25 Td
( )Tj
EMC
0.557 0 Td
(3.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.531 0 Td
[(Masur H,)37( Ognibene FP)128(,)37( )55(Y)74(archoan R,)37( Shelhamer JH,)37( Baird BF)128(,)37( )55(T)74(r)18(avis )55(W)74(,)37( et al.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 286.3654 462.0632 Tm
( )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 452.0632 Tm
(CD4 counts as predictors of opportunistic pneumonias in human )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 442.0632 Tm
[(immunode\037ciency virus \(HIV\) infection.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 185.3901 442.0632 Tm
(Ann Intern Med)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 231.1575 442.0632 Tm
( 1989;111:223-31.)Tj
/Span<>> BDC
-21.809 -1.25 Td
( )Tj
EMC
0.557 0 Td
(4.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.476 0 Td
[(W)18(orld )60(Health )60(Organization.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 150.0291 432.0632 Tm
[(Safe )60(and )60(effective )60(use )60(of )60(antiretrovir)18(als)37(.)37( )60(Guidance )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 70.8559 422.0632 Tm
[(module 4.)37( Guidance modules on antiretrovir)18(al treatments)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 236.9654 422.0632 Tm
[(.)37( )55(WHO/ASD/98.1;)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 412.0632 Tm
[(UNAIDS/98.7.)37( 1998.)37( )55(Av)18(ailable from:)37( http://whqlibdoc.who)37(.int/hq/1998/)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 402.0632 Tm
(WHO_ASD_98.1_module4.pdf)Tj
/Span<>> BDC
-1.772 -1.25 Td
( )Tj
EMC
0.557 0 Td
(5.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.477 0 Td
[(W)18(orld Health Organization/UNAIDS)37(.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 176.6626 392.0632 Tm
[(Labor)18(atory requirements for the safe )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 70.8559 382.0632 Tm
[(and effective use of antiretrovir)18(als)37(.)37( Guidance module 5.)37( Guidance modules )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 70.8559 372.0632 Tm
[(on antiretrovir)18(al treatments)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 150.3028 372.0632 Tm
[(.)37( )55(WHO/ASD/98.1;)37( UNAIDS/98.7.)37( 1998.)37( )55(Av)18(ailable )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 362.0632 Tm
[(from:)37( http://whqlibdoc.who)37(.int/hq/1998/WHO_ASD_98.1_module5.pdf )]TJ
/Span<>> BDC
-1.772 -1.25 Td
( )Tj
EMC
0.557 0 Td
(6.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.477 0 Td
[(W)18(orld Health Organization.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 151.4709 352.0632 Tm
[(Scaling up antiretrovir)18(al ther)18(apy in resource-)]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 70.8559 342.0632 Tm
[(limited settings:)37( treatment guidelines for a public health approach)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 262.1169 342.0632 Tm
[(.)37( 2003 )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 332.0632 Tm
[(Revision.)37( Genev)18(a:)37( )55(WHO;)37( 2003.)37( )55(Av)18(ailable from:)37( http://whqlibdoc.who)37(.int/)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 279.8773 332.0632 Tm
( )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 322.0632 Tm
(publications/2004/9241591552.pdf )Tj
/Span<>> BDC
-1.772 -1.25 Td
( )Tj
EMC
0.557 0 Td
(7.)Tj
/Span<>> BDC
0.683 0 Td
( )Tj
EMC
0.477 0 Td
[(W)18(orld Health Organization.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 1.4106 8 151.4709 312.0632 Tm
[(T)74(reating 3 million by 2005:)37( Making it happen)]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 282.645 312.0632 Tm
[(.)37( )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 302.0632 Tm
[(T)37(he )55(WHO str)18(ategy:)37( the )55(WHO and UNAIDS global initiative to provide )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 292.0632 Tm
[(antiretrovir)18(al ther)18(apy to 3 million people with HIV/AIDS in developing )]TJ
ET
BT
/T1_1 1 Tf
8 0 0 8 70.8559 282.0632 Tm
[(countries by the end of 2005.)37( Genev)18(a:)37( )55(WHO;)37( 2003.)37( )55(Av)18(ailable from:)37( http://)]TJ
ET
BT
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ET
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)Tj
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414.917 787.388 414.89 787.631 414.881 787.865 c
413.837 787.865 l
413.864 787.658 413.873 787.388 413.873 787.1 c
h
S
419.57 785.552 m
419.57 786.326 419.741 787.145 420.461 787.145 c
421.181 787.145 421.343 786.326 421.343 785.552 c
421.343 784.778 421.181 783.95 420.461 783.95 c
419.741 783.95 419.57 784.778 419.57 785.552 c
h
418.418 785.552 m
418.418 783.608 419.516 783.158 420.461 783.158 c
421.406 783.158 422.495 783.608 422.495 785.552 c
422.495 787.442 421.406 787.937 420.461 787.937 c
419.516 787.937 418.418 787.442 418.418 785.552 c
h
S
423.197 783.383 m
423.431 783.293 423.908 783.158 424.484 783.158 c
425.492 783.158 426.212 783.671 426.212 784.526 c
426.212 785.066 425.924 785.327 425.348 785.696 c
424.799 786.047 l
424.475 786.254 424.277 786.389 424.277 786.641 c
424.277 786.92 424.466 787.091 424.916 787.091 c
425.321 787.091 425.618 786.992 425.897 786.884 c
425.96 787.748 l
425.852 787.784 425.393 787.937 424.799 787.937 c
423.818 787.937 423.197 787.262 423.197 786.623 c
423.197 785.894 423.71 785.597 424.178 785.318 c
424.637 785.048 l
425.042 784.814 425.132 784.643 425.132 784.463 c
425.132 784.103 424.817 784.004 424.412 784.004 c
423.89 784.004 423.431 784.238 423.251 784.31 c
h
S
427.454 787.865 m
426.716 787.865 l
426.716 787.046 l
427.454 787.046 l
427.454 784.508 l
427.454 783.536 427.922 783.158 428.75 783.158 c
429.083 783.158 429.326 783.23 429.497 783.311 c
429.497 784.103 l
429.416 784.058 429.272 784.004 429.074 784.004 c
428.75 784.004 428.57 784.148 428.57 784.643 c
428.57 787.046 l
429.497 787.046 l
429.497 787.865 l
428.57 787.865 l
428.57 789.161 l
427.454 788.819 l
h
S
430.316 783.23 1.116 4.635 re
430.298 788.738 1.152 1.098 re
S
435.635 784.229 m
435.482 784.13 435.113 784.004 434.843 784.004 c
433.988 784.004 433.574 784.67 433.574 785.534 c
433.574 786.524 433.943 787.091 434.789 787.091 c
435.095 787.091 435.374 786.965 435.572 786.866 c
435.635 787.748 l
435.428 787.829 435.014 787.937 434.663 787.937 c
433.106 787.937 432.422 786.866 432.422 785.543 c
432.422 784.229 433.07 783.158 434.6 783.158 c
435.05 783.158 435.437 783.248 435.698 783.347 c
h
S
439.135 787.865 m
438.397 787.865 l
438.397 787.046 l
439.135 787.046 l
439.135 784.508 l
439.135 783.536 439.603 783.158 440.431 783.158 c
440.764 783.158 441.008 783.23 441.178 783.311 c
441.178 784.103 l
441.098 784.058 440.954 784.004 440.756 784.004 c
440.431 784.004 440.251 784.148 440.251 784.643 c
440.251 787.046 l
441.178 787.046 l
441.178 787.865 l
440.251 787.865 l
440.251 789.161 l
439.135 788.819 l
h
S
445.237 784.337 m
445.03 784.184 444.706 783.977 444.022 783.977 c
443.158 783.977 442.843 784.454 442.843 785.246 c
445.525 785.246 l
445.525 785.462 l
445.525 787.352 444.67 787.937 443.671 787.937 c
442.492 787.937 441.763 786.866 441.763 785.48 c
441.763 784.229 442.411 783.158 443.905 783.158 c
444.571 783.158 445.057 783.356 445.291 783.455 c
h
442.843 785.948 m
442.843 786.56 443.086 787.181 443.671 787.181 c
444.175 787.181 444.445 786.767 444.445 785.948 c
h
S
446.209 783.383 m
446.443 783.293 446.92 783.158 447.496 783.158 c
448.504 783.158 449.224 783.671 449.224 784.526 c
449.224 785.066 448.936 785.327 448.36 785.696 c
447.811 786.047 l
447.487 786.254 447.289 786.389 447.289 786.641 c
447.289 786.92 447.478 787.091 447.928 787.091 c
448.333 787.091 448.63 786.992 448.909 786.884 c
448.972 787.748 l
448.864 787.784 448.405 787.937 447.811 787.937 c
446.83 787.937 446.209 787.262 446.209 786.623 c
446.209 785.894 446.722 785.597 447.19 785.318 c
447.649 785.048 l
448.054 784.814 448.144 784.643 448.144 784.463 c
448.144 784.103 447.829 784.004 447.424 784.004 c
446.902 784.004 446.443 784.238 446.263 784.31 c
h
S
450.466 787.865 m
449.728 787.865 l
449.728 787.046 l
450.466 787.046 l
450.466 784.508 l
450.466 783.536 450.934 783.158 451.762 783.158 c
452.095 783.158 452.338 783.23 452.509 783.311 c
452.509 784.103 l
452.428 784.058 452.284 784.004 452.086 784.004 c
451.762 784.004 451.582 784.148 451.582 784.643 c
451.582 787.046 l
452.509 787.046 l
452.509 787.865 l
451.582 787.865 l
451.582 789.161 l
450.466 788.819 l
h
S
453.04 783.383 m
453.274 783.293 453.751 783.158 454.327 783.158 c
455.335 783.158 456.055 783.671 456.055 784.526 c
456.055 785.066 455.767 785.327 455.191 785.696 c
454.642 786.047 l
454.318 786.254 454.12 786.389 454.12 786.641 c
454.12 786.92 454.309 787.091 454.759 787.091 c
455.164 787.091 455.461 786.992 455.74 786.884 c
455.803 787.748 l
455.695 787.784 455.236 787.937 454.642 787.937 c
453.661 787.937 453.04 787.262 453.04 786.623 c
453.04 785.894 453.553 785.597 454.021 785.318 c
454.48 785.048 l
454.885 784.814 454.975 784.643 454.975 784.463 c
454.975 784.103 454.66 784.004 454.255 784.004 c
453.733 784.004 453.274 784.238 453.094 784.31 c
h
S
459.331 783.23 1.116 4.635 re
459.313 788.738 1.152 1.098 re
S
461.563 783.23 m
462.679 783.23 l
462.679 785.93 l
462.679 786.524 462.886 787.019 463.471 787.019 c
463.93 787.019 464.11 786.722 464.11 786.011 c
464.11 783.23 l
465.226 783.23 l
465.226 786.218 l
465.226 787.154 464.911 787.937 463.858 787.937 c
463.102 787.937 462.787 787.433 462.625 787.154 c
462.607 787.154 l
462.607 787.388 462.58 787.631 462.571 787.865 c
461.527 787.865 l
461.554 787.658 461.563 787.388 461.563 787.1 c
h
S
468.736 783.23 m
469.888 783.23 l
469.888 786.002 l
471.751 786.002 l
471.751 783.23 l
472.903 783.23 l
472.903 789.512 l
471.751 789.512 l
471.751 786.956 l
469.888 786.956 l
469.888 789.512 l
468.736 789.512 l
h
S
474.244 783.23 1.152 6.282 re
S
478.033 783.23 m
479.248 783.23 l
481.165 789.512 l
479.977 789.512 l
478.672 784.67 l
478.654 784.67 l
477.385 789.512 l
476.143 789.512 l
h
S
484.054 783.23 m
485.17 783.23 l
485.17 786.038 l
485.17 786.551 485.431 787.019 485.926 787.019 c
486.34 787.019 486.52 786.731 486.52 786.155 c
486.52 783.23 l
487.636 783.23 l
487.636 786.038 l
487.636 786.551 487.897 787.019 488.392 787.019 c
488.806 787.019 488.986 786.731 488.986 786.155 c
488.986 783.23 l
490.102 783.23 l
490.102 786.092 l
490.102 787.217 489.778 787.937 488.77 787.937 c
488.086 787.937 487.753 787.523 487.528 787.199 c
487.393 787.451 487.141 787.937 486.358 787.937 c
485.719 787.937 485.359 787.496 485.188 787.136 c
485.17 787.136 l
485.17 787.379 485.143 787.622 485.134 787.865 c
484.018 787.865 l
484.036 787.694 484.054 787.442 484.054 787.109 c
h
S
491.371 786.695 m
491.587 786.875 492.082 787.145 492.64 787.145 c
493.279 787.145 493.504 786.722 493.504 786.263 c
493.504 786.092 l
493.279 786.092 l
491.866 786.092 490.84 785.777 490.84 784.517 c
490.84 783.653 491.506 783.158 492.226 783.158 c
492.892 783.158 493.243 783.482 493.522 783.86 c
493.54 783.86 l
493.54 783.635 493.549 783.41 493.603 783.23 c
494.611 783.23 l
494.584 783.41 494.548 783.716 494.548 784.049 c
494.548 786.074 l
494.548 787.235 494.215 787.937 492.775 787.937 c
492.064 787.937 491.623 787.739 491.308 787.595 c
h
493.504 785.237 m
493.504 784.409 493.261 783.914 492.595 783.914 c
492.163 783.914 491.884 784.202 491.884 784.625 c
491.884 785.3 492.451 785.498 493.405 785.498 c
493.504 785.498 l
h
S
495.583 783.23 m
496.699 783.23 l
496.699 785.93 l
496.699 786.524 496.906 787.019 497.491 787.019 c
497.95 787.019 498.13 786.722 498.13 786.011 c
498.13 783.23 l
499.246 783.23 l
499.246 786.218 l
499.246 787.154 498.931 787.937 497.878 787.937 c
497.122 787.937 496.807 787.433 496.645 787.154 c
496.627 787.154 l
496.627 787.388 496.6 787.631 496.591 787.865 c
495.547 787.865 l
495.574 787.658 495.583 787.388 495.583 787.1 c
h
S
500.542 786.695 m
500.758 786.875 501.253 787.145 501.811 787.145 c
502.45 787.145 502.675 786.722 502.675 786.263 c
502.675 786.092 l
502.45 786.092 l
501.037 786.092 500.011 785.777 500.011 784.517 c
500.011 783.653 500.677 783.158 501.397 783.158 c
502.063 783.158 502.414 783.482 502.693 783.86 c
502.711 783.86 l
502.711 783.635 502.72 783.41 502.774 783.23 c
503.782 783.23 l
503.755 783.41 503.719 783.716 503.719 784.049 c
503.719 786.074 l
503.719 787.235 503.386 787.937 501.946 787.937 c
501.235 787.937 500.794 787.739 500.479 787.595 c
h
502.675 785.237 m
502.675 784.409 502.432 783.914 501.766 783.914 c
501.334 783.914 501.055 784.202 501.055 784.625 c
501.055 785.3 501.622 785.498 502.576 785.498 c
502.675 785.498 l
h
S
505.78 785.597 m
505.78 786.542 506.005 787.082 506.59 787.091 c
507.121 787.1 507.49 786.578 507.49 785.606 c
507.49 784.553 507.211 784.049 506.509 784.049 c
506.131 784.049 505.78 784.508 505.78 785.597 c
h
504.835 781.52 m
505.105 781.421 505.69 781.232 506.428 781.232 c
508.129 781.232 508.57 782.267 508.57 783.716 c
508.57 787.136 l
508.57 787.379 508.588 787.622 508.606 787.865 c
507.598 787.865 l
507.589 787.622 507.562 787.388 507.562 787.145 c
507.526 787.145 l
507.292 787.55 506.977 787.937 506.302 787.937 c
505.087 787.937 504.628 786.812 504.628 785.534 c
504.628 783.662 505.6 783.23 506.248 783.23 c
506.977 783.23 507.292 783.653 507.472 784.013 c
507.49 784.013 l
507.49 783.572 l
507.49 782.843 507.319 782.114 506.266 782.114 c
505.681 782.114 505.159 782.366 504.898 782.51 c
h
S
512.935 784.337 m
512.728 784.184 512.404 783.977 511.72 783.977 c
510.856 783.977 510.541 784.454 510.541 785.246 c
513.223 785.246 l
513.223 785.462 l
513.223 787.352 512.368 787.937 511.369 787.937 c
510.19 787.937 509.461 786.866 509.461 785.48 c
509.461 784.229 510.109 783.158 511.603 783.158 c
512.269 783.158 512.755 783.356 512.989 783.455 c
h
510.541 785.948 m
510.541 786.56 510.784 787.181 511.369 787.181 c
511.873 787.181 512.143 786.767 512.143 785.948 c
h
S
514.06 783.23 m
515.176 783.23 l
515.176 786.038 l
515.176 786.551 515.437 787.019 515.932 787.019 c
516.346 787.019 516.526 786.731 516.526 786.155 c
516.526 783.23 l
517.642 783.23 l
517.642 786.038 l
517.642 786.551 517.903 787.019 518.398 787.019 c
518.812 787.019 518.992 786.731 518.992 786.155 c
518.992 783.23 l
520.108 783.23 l
520.108 786.092 l
520.108 787.217 519.784 787.937 518.776 787.937 c
518.092 787.937 517.759 787.523 517.534 787.199 c
517.399 787.451 517.147 787.937 516.364 787.937 c
515.725 787.937 515.365 787.496 515.194 787.136 c
515.176 787.136 l
515.176 787.379 515.149 787.622 515.14 787.865 c
514.024 787.865 l
514.042 787.694 514.06 787.442 514.06 787.109 c
h
S
524.437 784.337 m
524.23 784.184 523.906 783.977 523.222 783.977 c
522.358 783.977 522.043 784.454 522.043 785.246 c
524.725 785.246 l
524.725 785.462 l
524.725 787.352 523.87 787.937 522.871 787.937 c
521.692 787.937 520.963 786.866 520.963 785.48 c
520.963 784.229 521.611 783.158 523.105 783.158 c
523.771 783.158 524.257 783.356 524.491 783.455 c
h
522.043 785.948 m
522.043 786.56 522.286 787.181 522.871 787.181 c
523.375 787.181 523.645 786.767 523.645 785.948 c
h
S
525.589 783.23 m
526.705 783.23 l
526.705 785.93 l
526.705 786.524 526.912 787.019 527.497 787.019 c
527.956 787.019 528.136 786.722 528.136 786.011 c
528.136 783.23 l
529.252 783.23 l
529.252 786.218 l
529.252 787.154 528.937 787.937 527.884 787.937 c
527.128 787.937 526.813 787.433 526.651 787.154 c
526.633 787.154 l
526.633 787.388 526.606 787.631 526.597 787.865 c
525.553 787.865 l
525.58 787.658 525.589 787.388 525.589 787.1 c
h
S
530.674 787.865 m
529.936 787.865 l
529.936 787.046 l
530.674 787.046 l
530.674 784.508 l
530.674 783.536 531.142 783.158 531.97 783.158 c
532.303 783.158 532.546 783.23 532.717 783.311 c
532.717 784.103 l
532.636 784.058 532.492 784.004 532.294 784.004 c
531.97 784.004 531.79 784.148 531.79 784.643 c
531.79 787.046 l
532.717 787.046 l
532.717 787.865 l
531.79 787.865 l
531.79 789.161 l
530.674 788.819 l
h
S
/CS0 cs 1 scn
BT
/T1_0 1 Tf
9 0 0 9 56.6929 783.2299 Tm
(April D Kimmel et al.)Tj
/Span<>> BDC
8.675 0 Td
( )Tj
EMC
28.769 0 Td
( Diagnostic tests in HIV management)Tj
ET
0 w
56.693 802.63 m
56.693 778.11 l
538.593 778.11 l
538.593 802.63 l
56.693 802.63 l
h
S
/CS0 CS 1 SCN
1 w
538.093 783.118 m
538.093 802.63 l
S
/PlacedPDF /MC0 BDC
Q
q
55.89 61.024 484 710 re
W n
q
55.89 771.023 484 -701.699 re
W n
q
55.89 771.023 484 -701.699 re
W n
0 1 0 0 k
0 i
/RelativeColorimetric ri
/GS2 gs
426.909 479.84 m
426.909 482.986 429.459 485.537 432.606 485.537 c
435.752 485.537 438.303 482.986 438.303 479.84 c
438.303 479.331 438.236 478.838 438.111 478.368 c
427.101 478.368 l
426.975 478.838 426.909 479.331 426.909 479.84 c
f*
0 0 0 1 K
0.491 w 3.864 M 0 j 0 J []0 d
426.909 479.84 m
426.909 482.986 429.459 485.537 432.606 485.537 c
435.752 485.537 438.303 482.986 438.303 479.84 c
438.303 479.331 438.236 478.838 438.111 478.368 c
427.101 478.368 l
426.975 478.838 426.909 479.331 426.909 479.84 c
h
S
0.26 0 0 0 k
166.679 640.922 m
166.679 644.462 169.548 647.332 173.089 647.332 c
176.629 647.332 179.499 644.462 179.499 640.922 c
179.499 637.382 176.629 634.512 173.089 634.512 c
169.548 634.512 166.679 637.382 166.679 640.922 c
f
166.679 640.922 m
166.679 644.462 169.548 647.332 173.089 647.332 c
176.629 647.332 179.499 644.462 179.499 640.922 c
179.499 637.382 176.629 634.512 173.089 634.512 c
169.548 634.512 166.679 637.382 166.679 640.922 c
h
S
173.635 649.612 m
173.635 658.978 181.227 666.571 190.593 666.571 c
199.959 666.571 207.551 658.978 207.551 649.612 c
207.551 640.247 199.959 632.654 190.593 632.654 c
181.227 632.654 173.635 640.247 173.635 649.612 c
f
173.635 649.612 m
173.635 658.978 181.227 666.571 190.593 666.571 c
199.959 666.571 207.551 658.978 207.551 649.612 c
207.551 640.247 199.959 632.654 190.593 632.654 c
181.227 632.654 173.635 640.247 173.635 649.612 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 8.8337 0 0 8.8337 59.7017 756.5075 Tm
(Fig. 1.)Tj
ET
BT
/T1_0 1 Tf
8.8337 0 0 8.8337 81.9096 756.5075 Tm
[(P)37(erformance of immunologic diagnostic tests for monitoring HIV)75(-infected individuals:)37( measur)10(es of association)]TJ
ET
0.231 0.396 0.114 RG
1.963 w
59.682 767.231 m
533.666 767.231 l
S
BT
/T1_2 1 Tf
4.9076 0 0 4.9076 507.7545 72.1483 Tm
(WHO 06.92)Tj
ET
BT
/T1_0 1 Tf
0 7.8521 -7.8521 0 74.7973 583.3225 Tm
[(Corr)10(elation)]TJ
ET
0 0 0 1 K
0.491 w
101.921 723.62 m
97.316 723.62 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.0543 722.1276 Tm
(1.00)Tj
ET
439.349 478.372 m
99.479 478.372 l
99.479 723.861 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 118.7022 468.5505 Tm
(I)Tj
ET
99.448 474.086 m
99.448 478.256 l
S
99.579 478.476 m
97.316 478.476 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.0739 476.9833 Tm
(0.00)Tj
ET
0 0.46 0 0 k
99.394 710.997 m
99.394 712.49 100.604 713.701 102.098 713.701 c
103.591 713.701 104.802 712.49 104.802 710.997 c
104.802 709.503 103.591 708.293 102.098 708.293 c
100.604 708.293 99.394 709.503 99.394 710.997 c
f
99.394 710.997 m
99.394 712.49 100.604 713.701 102.098 713.701 c
103.591 713.701 104.802 712.49 104.802 710.997 c
104.802 709.503 103.591 708.293 102.098 708.293 c
100.604 708.293 99.394 709.503 99.394 710.997 c
h
S
101.921 698.952 m
97.316 698.952 l
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 697.46 Tm
(0.90)Tj
ET
101.921 674.602 m
97.316 674.602 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 673.1099 Tm
(0.80)Tj
ET
101.921 650.411 m
97.316 650.411 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 648.9184 Tm
(0.70)Tj
ET
101.921 625.352 m
97.316 625.352 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 623.859 Tm
(0.60)Tj
ET
101.921 600.525 m
97.316 600.525 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 599.0328 Tm
(0.50)Tj
ET
101.921 576.493 m
97.316 576.493 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 575.0002 Tm
(0.40)Tj
ET
101.921 551.508 m
97.316 551.508 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 550.0151 Tm
(0.30)Tj
ET
101.921 526.682 m
97.316 526.682 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.1329 525.1889 Tm
(0.20)Tj
ET
101.921 502.49 m
97.316 502.49 l
S
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 82.172 500.9977 Tm
(0.10)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 151.9745 468.5505 Tm
(II)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 189.9528 468.5505 Tm
(III)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 230.1126 468.5505 Tm
(IV)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 264.4572 468.5505 Tm
(V)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 289.6566 468.5505 Tm
(VI)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 315.3801 468.5505 Tm
(VII)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 340.1752 468.5505 Tm
(VIII)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 364.9172 468.5505 Tm
(IX)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 383.4105 468.5505 Tm
(X)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 407.1424 468.5505 Tm
(XI)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 427.4468 468.5505 Tm
(XII)Tj
ET
0 0.18 0.67 0 k
148.22 704.18 m
148.22 707.085 150.574 709.439 153.479 709.439 c
156.384 709.439 158.739 707.085 158.739 704.18 c
158.739 701.275 156.384 698.92 153.479 698.92 c
150.574 698.92 148.22 701.275 148.22 704.18 c
f
148.22 704.18 m
148.22 707.085 150.574 709.439 153.479 709.439 c
156.384 709.439 158.739 707.085 158.739 704.18 c
158.739 701.275 156.384 698.92 153.479 698.92 c
150.574 698.92 148.22 701.275 148.22 704.18 c
h
S
0.51 0 0.66 0 k
225.189 708.737 m
225.189 709.854 226.094 710.76 227.211 710.76 c
228.328 710.76 229.233 709.854 229.233 708.737 c
229.233 707.62 228.328 706.715 227.211 706.715 c
226.094 706.715 225.189 707.62 225.189 708.737 c
f
225.189 708.737 m
225.189 709.854 226.094 710.76 227.211 710.76 c
228.328 710.76 229.233 709.854 229.233 708.737 c
229.233 707.62 228.328 706.715 227.211 706.715 c
226.094 706.715 225.189 707.62 225.189 708.737 c
h
S
0 0 0.59 0 k
249.787 502.448 m
249.787 511.715 257.299 519.227 266.566 519.227 c
275.834 519.227 283.346 511.715 283.346 502.448 c
283.346 493.181 275.834 485.668 266.566 485.668 c
257.299 485.668 249.787 493.181 249.787 502.448 c
f
249.787 502.448 m
249.787 511.715 257.299 519.227 266.566 519.227 c
275.834 519.227 283.346 511.715 283.346 502.448 c
283.346 493.181 275.834 485.668 266.566 485.668 c
257.299 485.668 249.787 493.181 249.787 502.448 c
h
S
0 0.68 0.59 0 k
281.522 716.142 m
281.522 717.892 282.941 719.311 284.691 719.311 c
286.441 719.311 287.86 717.892 287.86 716.142 c
287.86 714.391 286.441 712.972 284.691 712.972 c
282.941 712.972 281.522 714.391 281.522 716.142 c
f
281.522 716.142 m
281.522 717.892 282.941 719.311 284.691 719.311 c
286.441 719.311 287.86 717.892 287.86 716.142 c
287.86 714.391 286.441 712.972 284.691 712.972 c
282.941 712.972 281.522 714.391 281.522 716.142 c
h
S
0.94 0.68 0 0 k
308.885 706.608 m
308.885 708.33 310.281 709.726 312.004 709.726 c
313.726 709.726 315.122 708.33 315.122 706.608 c
315.122 704.885 313.726 703.489 312.004 703.489 c
310.281 703.489 308.885 704.885 308.885 706.608 c
f
308.885 706.608 m
308.885 708.33 310.281 709.726 312.004 709.726 c
313.726 709.726 315.122 708.33 315.122 706.608 c
315.122 704.885 313.726 703.489 312.004 703.489 c
310.281 703.489 308.885 704.885 308.885 706.608 c
h
S
0 0 0 0 k
325.616 650.025 m
325.616 659.324 333.154 666.862 342.453 666.862 c
351.752 666.862 359.29 659.324 359.29 650.025 c
359.29 640.726 351.752 633.188 342.453 633.188 c
333.154 633.188 325.616 640.726 325.616 650.025 c
f
325.616 650.025 m
325.616 659.324 333.154 666.862 342.453 666.862 c
351.752 666.862 359.29 659.324 359.29 650.025 c
359.29 640.726 351.752 633.188 342.453 633.188 c
333.154 633.188 325.616 640.726 325.616 650.025 c
h
S
0.28 0.37 0 0 k
360.72 701.291 m
360.72 703.447 362.467 705.194 364.623 705.194 c
366.778 705.194 368.526 703.447 368.526 701.291 c
368.526 699.136 366.778 697.388 364.623 697.388 c
362.467 697.388 360.72 699.136 360.72 701.291 c
f
360.72 701.291 m
360.72 703.447 362.467 705.194 364.623 705.194 c
366.778 705.194 368.526 703.447 368.526 701.291 c
368.526 699.136 366.778 697.388 364.623 697.388 c
362.467 697.388 360.72 699.136 360.72 701.291 c
h
S
0.28 0.91 0 0 k
379.465 704.268 m
379.465 705.907 380.794 707.236 382.434 707.236 c
384.073 707.236 385.402 705.907 385.402 704.268 c
385.402 702.628 384.073 701.299 382.434 701.299 c
380.794 701.299 379.465 702.628 379.465 704.268 c
f
379.465 704.268 m
379.465 705.907 380.794 707.236 382.434 707.236 c
384.073 707.236 385.402 705.907 385.402 704.268 c
385.402 702.628 384.073 701.299 382.434 701.299 c
380.794 701.299 379.465 702.628 379.465 704.268 c
h
S
0.58 0.59 0.72 0 k
403.891 691.893 m
403.891 693.01 404.796 693.915 405.913 693.915 c
407.03 693.915 407.936 693.01 407.936 691.893 c
407.936 690.776 407.03 689.87 405.913 689.87 c
404.796 689.87 403.891 690.776 403.891 691.893 c
f
403.891 691.893 m
403.891 693.01 404.796 693.915 405.913 693.915 c
407.03 693.915 407.936 693.01 407.936 691.893 c
407.936 690.776 407.03 689.87 405.913 689.87 c
404.796 689.87 403.891 690.776 403.891 691.893 c
h
S
0 1 0 0 k
430.099 534.794 m
430.099 536.119 431.173 537.193 432.498 537.193 c
433.823 537.193 434.898 536.119 434.898 534.794 c
434.898 533.469 433.823 532.395 432.498 532.395 c
431.173 532.395 430.099 533.469 430.099 534.794 c
f
430.099 534.794 m
430.099 536.119 431.173 537.193 432.498 537.193 c
433.823 537.193 434.898 536.119 434.898 534.794 c
434.898 533.469 433.823 532.395 432.498 532.395 c
431.173 532.395 430.099 533.469 430.099 534.794 c
h
S
0 0.46 0 0 k
106.699 718.451 m
106.699 720.265 108.169 721.735 109.983 721.735 c
111.797 721.735 113.267 720.265 113.267 718.451 c
113.267 716.638 111.797 715.168 109.983 715.168 c
108.169 715.168 106.699 716.638 106.699 718.451 c
f
106.699 718.451 m
106.699 720.265 108.169 721.735 109.983 721.735 c
111.797 721.735 113.267 720.265 113.267 718.451 c
113.267 716.638 111.797 715.168 109.983 715.168 c
108.169 715.168 106.699 716.638 106.699 718.451 c
h
S
114.916 716.263 m
114.916 718.077 116.386 719.547 118.2 719.547 c
120.013 719.547 121.484 718.077 121.484 716.263 c
121.484 714.45 120.013 712.979 118.2 712.979 c
116.386 712.979 114.916 714.45 114.916 716.263 c
f
114.916 716.263 m
114.916 718.077 116.386 719.547 118.2 719.547 c
120.013 719.547 121.484 718.077 121.484 716.263 c
121.484 714.45 120.013 712.979 118.2 712.979 c
116.386 712.979 114.916 714.45 114.916 716.263 c
h
S
124.774 711.779 m
124.774 713.344 126.042 714.613 127.607 714.613 c
129.173 714.613 130.441 713.344 130.441 711.779 c
130.441 710.214 129.173 708.945 127.607 708.945 c
126.042 708.945 124.774 710.214 124.774 711.779 c
f
124.774 711.779 m
124.774 713.344 126.042 714.613 127.607 714.613 c
129.173 714.613 130.441 713.344 130.441 711.779 c
130.441 710.214 129.173 708.945 127.607 708.945 c
126.042 708.945 124.774 710.214 124.774 711.779 c
h
S
121.674 721.314 m
121.674 722.393 122.548 723.267 123.627 723.267 c
124.706 723.267 125.58 722.393 125.58 721.314 c
125.58 720.236 124.706 719.361 123.627 719.361 c
122.548 719.361 121.674 720.236 121.674 721.314 c
f
121.674 721.314 m
121.674 722.393 122.548 723.267 123.627 723.267 c
124.706 723.267 125.58 722.393 125.58 721.314 c
125.58 720.236 124.706 719.361 123.627 719.361 c
122.548 719.361 121.674 720.236 121.674 721.314 c
h
S
109.981 696.724 m
109.981 698.944 111.78 700.743 114 700.743 c
116.22 700.743 118.019 698.944 118.019 696.724 c
118.019 694.504 116.22 692.705 114 692.705 c
111.78 692.705 109.981 694.504 109.981 696.724 c
f
109.981 696.724 m
109.981 698.944 111.78 700.743 114 700.743 c
116.22 700.743 118.019 698.944 118.019 696.724 c
118.019 694.504 116.22 692.705 114 692.705 c
111.78 692.705 109.981 694.504 109.981 696.724 c
h
S
119.292 696.664 m
119.292 697.743 120.166 698.617 121.245 698.617 c
122.324 698.617 123.198 697.743 123.198 696.664 c
123.198 695.585 122.324 694.711 121.245 694.711 c
120.166 694.711 119.292 695.585 119.292 696.664 c
f
119.292 696.664 m
119.292 697.743 120.166 698.617 121.245 698.617 c
122.324 698.617 123.198 697.743 123.198 696.664 c
123.198 695.585 122.324 694.711 121.245 694.711 c
120.166 694.711 119.292 695.585 119.292 696.664 c
h
S
124.048 696.996 m
124.048 700.07 126.541 702.563 129.615 702.563 c
132.69 702.563 135.182 700.07 135.182 696.996 c
135.182 693.921 132.69 691.429 129.615 691.429 c
126.541 691.429 124.048 693.921 124.048 696.996 c
f
124.048 696.996 m
124.048 700.07 126.541 702.563 129.615 702.563 c
132.69 702.563 135.182 700.07 135.182 696.996 c
135.182 693.921 132.69 691.429 129.615 691.429 c
126.541 691.429 124.048 693.921 124.048 696.996 c
h
S
106.699 659.967 m
106.699 661.046 107.573 661.921 108.652 661.921 c
109.73 661.921 110.605 661.046 110.605 659.967 c
110.605 658.889 109.73 658.014 108.652 658.014 c
107.573 658.014 106.699 658.889 106.699 659.967 c
f
106.699 659.967 m
106.699 661.046 107.573 661.921 108.652 661.921 c
109.73 661.921 110.605 661.046 110.605 659.967 c
110.605 658.889 109.73 658.014 108.652 658.014 c
107.573 658.014 106.699 658.889 106.699 659.967 c
h
S
130.62 649.927 m
130.62 651.006 131.494 651.88 132.573 651.88 c
133.652 651.88 134.526 651.006 134.526 649.927 c
134.526 648.849 133.652 647.974 132.573 647.974 c
131.494 647.974 130.62 648.849 130.62 649.927 c
f
130.62 649.927 m
130.62 651.006 131.494 651.88 132.573 651.88 c
133.652 651.88 134.526 651.006 134.526 649.927 c
134.526 648.849 133.652 647.974 132.573 647.974 c
131.494 647.974 130.62 648.849 130.62 649.927 c
h
S
124.044 640.423 m
124.044 641.501 124.919 642.376 125.997 642.376 c
127.076 642.376 127.951 641.501 127.951 640.423 c
127.951 639.344 127.076 638.469 125.997 638.469 c
124.919 638.469 124.044 639.344 124.044 640.423 c
f
124.044 640.423 m
124.044 641.501 124.919 642.376 125.997 642.376 c
127.076 642.376 127.951 641.501 127.951 640.423 c
127.951 639.344 127.076 638.469 125.997 638.469 c
124.919 638.469 124.044 639.344 124.044 640.423 c
h
S
116.374 611.031 m
116.374 612.11 117.249 612.984 118.328 612.984 c
119.406 612.984 120.281 612.11 120.281 611.031 c
120.281 609.952 119.406 609.078 118.328 609.078 c
117.249 609.078 116.374 609.952 116.374 611.031 c
f
116.374 611.031 m
116.374 612.11 117.249 612.984 118.328 612.984 c
119.406 612.984 120.281 612.11 120.281 611.031 c
120.281 609.952 119.406 609.078 118.328 609.078 c
117.249 609.078 116.374 609.952 116.374 611.031 c
h
S
106.334 627.841 m
106.334 628.92 107.209 629.794 108.287 629.794 c
109.366 629.794 110.24 628.92 110.24 627.841 c
110.24 626.762 109.366 625.888 108.287 625.888 c
107.209 625.888 106.334 626.762 106.334 627.841 c
f
106.334 627.841 m
106.334 628.92 107.209 629.794 108.287 629.794 c
109.366 629.794 110.24 628.92 110.24 627.841 c
110.24 626.762 109.366 625.888 108.287 625.888 c
107.209 625.888 106.334 626.762 106.334 627.841 c
h
S
113.274 637.924 m
113.274 639.738 114.745 641.208 116.559 641.208 c
118.372 641.208 119.843 639.738 119.843 637.924 c
119.843 636.111 118.372 634.64 116.559 634.64 c
114.745 634.64 113.274 636.111 113.274 637.924 c
f
113.274 637.924 m
113.274 639.738 114.745 641.208 116.559 641.208 c
118.372 641.208 119.843 639.738 119.843 637.924 c
119.843 636.111 118.372 634.64 116.559 634.64 c
114.745 634.64 113.274 636.111 113.274 637.924 c
h
S
0 0.18 0.67 0 k
145.526 682.073 m
145.526 684.564 147.545 686.583 150.035 686.583 c
152.526 686.583 154.545 684.564 154.545 682.073 c
154.545 679.582 152.526 677.563 150.035 677.563 c
147.545 677.563 145.526 679.582 145.526 682.073 c
f
145.526 682.073 m
145.526 684.564 147.545 686.583 150.035 686.583 c
152.526 686.583 154.545 684.564 154.545 682.073 c
154.545 679.582 152.526 677.563 150.035 677.563 c
147.545 677.563 145.526 679.582 145.526 682.073 c
h
S
151.251 679.558 m
151.251 682.887 153.95 685.586 157.28 685.586 c
160.61 685.586 163.309 682.887 163.309 679.558 c
163.309 676.228 160.61 673.529 157.28 673.529 c
153.95 673.529 151.251 676.228 151.251 679.558 c
f
151.251 679.558 m
151.251 682.887 153.95 685.586 157.28 685.586 c
160.61 685.586 163.309 682.887 163.309 679.558 c
163.309 676.228 160.61 673.529 157.28 673.529 c
153.95 673.529 151.251 676.228 151.251 679.558 c
h
S
0.26 0 0 0 k
200.093 659.737 m
200.093 663.278 202.963 666.147 206.503 666.147 c
210.043 666.147 212.913 663.278 212.913 659.737 c
212.913 656.197 210.043 653.328 206.503 653.328 c
202.963 653.328 200.093 656.197 200.093 659.737 c
f
200.093 659.737 m
200.093 663.278 202.963 666.147 206.503 666.147 c
210.043 666.147 212.913 663.278 212.913 659.737 c
212.913 656.197 210.043 653.328 206.503 653.328 c
202.963 653.328 200.093 656.197 200.093 659.737 c
h
S
200.32 628.033 m
200.32 631.007 202.731 633.418 205.705 633.418 c
208.679 633.418 211.09 631.007 211.09 628.033 c
211.09 625.059 208.679 622.648 205.705 622.648 c
202.731 622.648 200.32 625.059 200.32 628.033 c
f
200.32 628.033 m
200.32 631.007 202.731 633.418 205.705 633.418 c
208.679 633.418 211.09 631.007 211.09 628.033 c
211.09 625.059 208.679 622.648 205.705 622.648 c
202.731 622.648 200.32 625.059 200.32 628.033 c
h
S
196.905 607.759 m
196.905 610.431 199.071 612.596 201.743 612.596 c
204.415 612.596 206.581 610.431 206.581 607.759 c
206.581 605.087 204.415 602.921 201.743 602.921 c
199.071 602.921 196.905 605.087 196.905 607.759 c
f
196.905 607.759 m
196.905 610.431 199.071 612.596 201.743 612.596 c
204.415 612.596 206.581 610.431 206.581 607.759 c
206.581 605.087 204.415 602.921 201.743 602.921 c
199.071 602.921 196.905 605.087 196.905 607.759 c
h
S
188.871 615.981 m
188.871 618.247 190.708 620.084 192.973 620.084 c
195.239 620.084 197.076 618.247 197.076 615.981 c
197.076 613.716 195.239 611.879 192.973 611.879 c
190.708 611.879 188.871 613.716 188.871 615.981 c
f
188.871 615.981 m
188.871 618.247 190.708 620.084 192.973 620.084 c
195.239 620.084 197.076 618.247 197.076 615.981 c
197.076 613.716 195.239 611.879 192.973 611.879 c
190.708 611.879 188.871 613.716 188.871 615.981 c
h
S
173.714 630.865 m
173.714 636.007 177.882 640.176 183.025 640.176 c
188.167 640.176 192.335 636.007 192.335 630.865 c
192.335 625.723 188.167 621.554 183.025 621.554 c
177.882 621.554 173.714 625.723 173.714 630.865 c
f
173.714 630.865 m
173.714 636.007 177.882 640.176 183.025 640.176 c
188.167 640.176 192.335 636.007 192.335 630.865 c
192.335 625.723 188.167 621.554 183.025 621.554 c
177.882 621.554 173.714 625.723 173.714 630.865 c
h
S
193.383 649.968 m
193.383 652.234 195.219 654.07 197.485 654.07 c
199.751 654.07 201.588 652.234 201.588 649.968 c
201.588 647.702 199.751 645.865 197.485 645.865 c
195.219 645.865 193.383 647.702 193.383 649.968 c
f
193.383 649.968 m
193.383 652.234 195.219 654.07 197.485 654.07 c
199.751 654.07 201.588 652.234 201.588 649.968 c
201.588 647.702 199.751 645.865 197.485 645.865 c
195.219 645.865 193.383 647.702 193.383 649.968 c
h
S
178.637 622.922 m
178.637 625.188 180.474 627.025 182.74 627.025 c
185.005 627.025 186.842 625.188 186.842 622.922 c
186.842 620.656 185.005 618.819 182.74 618.819 c
180.474 618.819 178.637 620.656 178.637 622.922 c
f
178.637 622.922 m
178.637 625.188 180.474 627.025 182.74 627.025 c
185.005 627.025 186.842 625.188 186.842 622.922 c
186.842 620.656 185.005 618.819 182.74 618.819 c
180.474 618.819 178.637 620.656 178.637 622.922 c
h
S
0 0.46 0 0 k
132.079 699.316 m
132.079 700.809 133.289 702.02 134.783 702.02 c
136.276 702.02 137.487 700.809 137.487 699.316 c
137.487 697.822 136.276 696.611 134.783 696.611 c
133.289 696.611 132.079 697.822 132.079 699.316 c
f
132.079 699.316 m
132.079 700.809 133.289 702.02 134.783 702.02 c
136.276 702.02 137.487 700.809 137.487 699.316 c
137.487 697.822 136.276 696.611 134.783 696.611 c
133.289 696.611 132.079 697.822 132.079 699.316 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 100.5415 715.756 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 108.0363 724.2909 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 114.0681 722.4705 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 121.7753 725.2012 Tm
(k)Tj
ET
0.26 0 0 0 k
175.451 578.767 m
175.451 581.033 177.288 582.87 179.554 582.87 c
181.82 582.87 183.656 581.033 183.656 578.767 c
183.656 576.501 181.82 574.664 179.554 574.664 c
177.288 574.664 175.451 576.501 175.451 578.767 c
f
175.451 578.767 m
175.451 581.033 177.288 582.87 179.554 582.87 c
181.82 582.87 183.656 581.033 183.656 578.767 c
183.656 576.501 181.82 574.664 179.554 574.664 c
177.288 574.664 175.451 576.501 175.451 578.767 c
h
S
183.251 534.502 m
183.251 538.514 186.503 541.766 190.515 541.766 c
194.527 541.766 197.779 538.514 197.779 534.502 c
197.779 530.49 194.527 527.238 190.515 527.238 c
186.503 527.238 183.251 530.49 183.251 534.502 c
f
183.251 534.502 m
183.251 538.514 186.503 541.766 190.515 541.766 c
194.527 541.766 197.779 538.514 197.779 534.502 c
197.779 530.49 194.527 527.238 190.515 527.238 c
186.503 527.238 183.251 530.49 183.251 534.502 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 113.7501 702.0726 Tm
(l)Tj
ET
0.51 0 0.66 0 k
230.747 719.002 m
230.747 720.722 232.141 722.116 233.861 722.116 c
235.58 722.116 236.974 720.722 236.974 719.002 c
236.974 717.283 235.58 715.889 233.861 715.889 c
232.141 715.889 230.747 717.283 230.747 719.002 c
f
230.747 719.002 m
230.747 720.722 232.141 722.116 233.861 722.116 c
235.58 722.116 236.974 720.722 236.974 719.002 c
236.974 717.283 235.58 715.889 233.861 715.889 c
232.141 715.889 230.747 717.283 230.747 719.002 c
h
S
228.524 667.287 m
228.524 668.404 229.43 669.31 230.547 669.31 c
231.664 669.31 232.569 668.404 232.569 667.287 c
232.569 666.17 231.664 665.265 230.547 665.265 c
229.43 665.265 228.524 666.17 228.524 667.287 c
f
228.524 667.287 m
228.524 668.404 229.43 669.31 230.547 669.31 c
231.664 669.31 232.569 668.404 232.569 667.287 c
232.569 666.17 231.664 665.265 230.547 665.265 c
229.43 665.265 228.524 666.17 228.524 667.287 c
h
S
234.917 672.083 m
234.917 673.199 235.823 674.105 236.939 674.105 c
238.056 674.105 238.962 673.199 238.962 672.083 c
238.962 670.966 238.056 670.06 236.939 670.06 c
235.823 670.06 234.917 670.966 234.917 672.083 c
f
234.917 672.083 m
234.917 673.199 235.823 674.105 236.939 674.105 c
238.056 674.105 238.962 673.199 238.962 672.083 c
238.962 670.966 238.056 670.06 236.939 670.06 c
235.823 670.06 234.917 670.966 234.917 672.083 c
h
S
0 0.68 0.59 0 k
289.656 716.142 m
289.656 717.892 291.074 719.311 292.825 719.311 c
294.575 719.311 295.994 717.892 295.994 716.142 c
295.994 714.391 294.575 712.972 292.825 712.972 c
291.074 712.972 289.656 714.391 289.656 716.142 c
f
289.656 716.142 m
289.656 717.892 291.074 719.311 292.825 719.311 c
294.575 719.311 295.994 717.892 295.994 716.142 c
295.994 714.391 294.575 712.972 292.825 712.972 c
291.074 712.972 289.656 714.391 289.656 716.142 c
h
S
282.837 696.624 m
282.837 698.375 284.256 699.793 286.006 699.793 c
287.756 699.793 289.175 698.375 289.175 696.624 c
289.175 694.874 287.756 693.455 286.006 693.455 c
284.256 693.455 282.837 694.874 282.837 696.624 c
f
282.837 696.624 m
282.837 698.375 284.256 699.793 286.006 699.793 c
287.756 699.793 289.175 698.375 289.175 696.624 c
289.175 694.874 287.756 693.455 286.006 693.455 c
284.256 693.455 282.837 694.874 282.837 696.624 c
h
S
287.13 694.787 m
287.13 696.976 288.904 698.75 291.092 698.75 c
293.281 698.75 295.055 696.976 295.055 694.787 c
295.055 692.599 293.281 690.825 291.092 690.825 c
288.904 690.825 287.13 692.599 287.13 694.787 c
f
287.13 694.787 m
287.13 696.976 288.904 698.75 291.092 698.75 c
293.281 698.75 295.055 696.976 295.055 694.787 c
295.055 692.599 293.281 690.825 291.092 690.825 c
288.904 690.825 287.13 692.599 287.13 694.787 c
h
S
0.94 0.68 0 0 k
315.736 689.082 m
315.736 689.924 316.418 690.606 317.26 690.606 c
318.102 690.606 318.784 689.924 318.784 689.082 c
318.784 688.24 318.102 687.558 317.26 687.558 c
316.418 687.558 315.736 688.24 315.736 689.082 c
f
315.736 689.082 m
315.736 689.924 316.418 690.606 317.26 690.606 c
318.102 690.606 318.784 689.924 318.784 689.082 c
318.784 688.24 318.102 687.558 317.26 687.558 c
316.418 687.558 315.736 688.24 315.736 689.082 c
h
S
0 0.68 0.59 0 k
284.81 593.932 m
284.81 595.069 285.731 595.99 286.867 595.99 c
288.003 595.99 288.924 595.069 288.924 593.932 c
288.924 592.796 288.003 591.875 286.867 591.875 c
285.731 591.875 284.81 592.796 284.81 593.932 c
f
284.81 593.932 m
284.81 595.069 285.731 595.99 286.867 595.99 c
288.003 595.99 288.924 595.069 288.924 593.932 c
288.924 592.796 288.003 591.875 286.867 591.875 c
285.731 591.875 284.81 592.796 284.81 593.932 c
h
S
292.454 572.212 m
292.454 573.348 293.376 574.269 294.512 574.269 c
295.648 574.269 296.569 573.348 296.569 572.212 c
296.569 571.076 295.648 570.154 294.512 570.154 c
293.376 570.154 292.454 571.076 292.454 572.212 c
f
292.454 572.212 m
292.454 573.348 293.376 574.269 294.512 574.269 c
295.648 574.269 296.569 573.348 296.569 572.212 c
296.569 571.076 295.648 570.154 294.512 570.154 c
293.376 570.154 292.454 571.076 292.454 572.212 c
h
S
289.581 536.893 m
289.581 538.029 290.502 538.95 291.639 538.95 c
292.775 538.95 293.696 538.029 293.696 536.893 c
293.696 535.757 292.775 534.835 291.639 534.835 c
290.502 534.835 289.581 535.757 289.581 536.893 c
f
289.581 536.893 m
289.581 538.029 290.502 538.95 291.639 538.95 c
292.775 538.95 293.696 538.029 293.696 536.893 c
293.696 535.757 292.775 534.835 291.639 534.835 c
290.502 534.835 289.581 535.757 289.581 536.893 c
h
S
0.94 0.68 0 0 k
311.34 615.77 m
311.34 616.992 312.33 617.983 313.553 617.983 c
314.775 617.983 315.766 616.992 315.766 615.77 c
315.766 614.548 314.775 613.557 313.553 613.557 c
312.33 613.557 311.34 614.548 311.34 615.77 c
f
311.34 615.77 m
311.34 616.992 312.33 617.983 313.553 617.983 c
314.775 617.983 315.766 616.992 315.766 615.77 c
315.766 614.548 314.775 613.557 313.553 613.557 c
312.33 613.557 311.34 614.548 311.34 615.77 c
h
S
316.277 605.844 m
316.277 607.067 317.268 608.057 318.491 608.057 c
319.713 608.057 320.704 607.067 320.704 605.844 c
320.704 604.622 319.713 603.631 318.491 603.631 c
317.268 603.631 316.277 604.622 316.277 605.844 c
f
316.277 605.844 m
316.277 607.067 317.268 608.057 318.491 608.057 c
319.713 608.057 320.704 607.067 320.704 605.844 c
320.704 604.622 319.713 603.631 318.491 603.631 c
317.268 603.631 316.277 604.622 316.277 605.844 c
h
S
0.28 0.37 0 0 k
367.808 674.741 m
367.808 675.784 368.653 676.629 369.697 676.629 c
370.74 676.629 371.585 675.784 371.585 674.741 c
371.585 673.697 370.74 672.852 369.697 672.852 c
368.653 672.852 367.808 673.697 367.808 674.741 c
f
367.808 674.741 m
367.808 675.784 368.653 676.629 369.697 676.629 c
370.74 676.629 371.585 675.784 371.585 674.741 c
371.585 673.697 370.74 672.852 369.697 672.852 c
368.653 672.852 367.808 673.697 367.808 674.741 c
h
S
362.757 667.483 m
362.757 668.526 363.603 669.371 364.646 669.371 c
365.689 669.371 366.535 668.526 366.535 667.483 c
366.535 666.44 365.689 665.594 364.646 665.594 c
363.603 665.594 362.757 666.44 362.757 667.483 c
f
362.757 667.483 m
362.757 668.526 363.603 669.371 364.646 669.371 c
365.689 669.371 366.535 668.526 366.535 667.483 c
366.535 666.44 365.689 665.594 364.646 665.594 c
363.603 665.594 362.757 666.44 362.757 667.483 c
h
S
364.475 623.314 m
364.475 624.357 365.32 625.203 366.364 625.203 c
367.407 625.203 368.252 624.357 368.252 623.314 c
368.252 622.271 367.407 621.426 366.364 621.426 c
365.32 621.426 364.475 622.271 364.475 623.314 c
f
364.475 623.314 m
364.475 624.357 365.32 625.203 366.364 625.203 c
367.407 625.203 368.252 624.357 368.252 623.314 c
368.252 622.271 367.407 621.426 366.364 621.426 c
365.32 621.426 364.475 622.271 364.475 623.314 c
h
S
0.28 0.91 0 0 k
383.415 701.898 m
383.415 703.537 384.744 704.866 386.384 704.866 c
388.023 704.866 389.352 703.537 389.352 701.898 c
389.352 700.258 388.023 698.929 386.384 698.929 c
384.744 698.929 383.415 700.258 383.415 701.898 c
f
383.415 701.898 m
383.415 703.537 384.744 704.866 386.384 704.866 c
388.023 704.866 389.352 703.537 389.352 701.898 c
389.352 700.258 388.023 698.929 386.384 698.929 c
384.744 698.929 383.415 700.258 383.415 701.898 c
h
S
0.58 0.59 0.72 0 k
408.502 652.958 m
408.502 654.342 409.624 655.465 411.009 655.465 c
412.393 655.465 413.516 654.342 413.516 652.958 c
413.516 651.573 412.393 650.451 411.009 650.451 c
409.624 650.451 408.502 651.573 408.502 652.958 c
f
408.502 652.958 m
408.502 654.342 409.624 655.465 411.009 655.465 c
412.393 655.465 413.516 654.342 413.516 652.958 c
413.516 651.573 412.393 650.451 411.009 650.451 c
409.624 650.451 408.502 651.573 408.502 652.958 c
h
S
411.743 596.244 m
411.743 597.629 412.866 598.751 414.25 598.751 c
415.635 598.751 416.757 597.629 416.757 596.244 c
416.757 594.859 415.635 593.737 414.25 593.737 c
412.866 593.737 411.743 594.859 411.743 596.244 c
f
411.743 596.244 m
411.743 597.629 412.866 598.751 414.25 598.751 c
415.635 598.751 416.757 597.629 416.757 596.244 c
416.757 594.859 415.635 593.737 414.25 593.737 c
412.866 593.737 411.743 594.859 411.743 596.244 c
h
S
415.4 584.196 m
415.4 585.581 416.522 586.703 417.907 586.703 c
419.292 586.703 420.414 585.581 420.414 584.196 c
420.414 582.811 419.292 581.689 417.907 581.689 c
416.522 581.689 415.4 582.811 415.4 584.196 c
f
415.4 584.196 m
415.4 585.581 416.522 586.703 417.907 586.703 c
419.292 586.703 420.414 585.581 420.414 584.196 c
420.414 582.811 419.292 581.689 417.907 581.689 c
416.522 581.689 415.4 582.811 415.4 584.196 c
h
S
399.06 586.418 m
399.06 588.942 401.105 590.987 403.629 590.987 c
406.153 590.987 408.199 588.942 408.199 586.418 c
408.199 583.894 406.153 581.848 403.629 581.848 c
401.105 581.848 399.06 583.894 399.06 586.418 c
f
399.06 586.418 m
399.06 588.942 401.105 590.987 403.629 590.987 c
406.153 590.987 408.199 588.942 408.199 586.418 c
408.199 583.894 406.153 581.848 403.629 581.848 c
401.105 581.848 399.06 583.894 399.06 586.418 c
h
S
406.753 578.883 m
406.753 581.407 408.799 583.453 411.322 583.453 c
413.846 583.453 415.892 581.407 415.892 578.883 c
415.892 576.36 413.846 574.314 411.322 574.314 c
408.799 574.314 406.753 576.36 406.753 578.883 c
f
406.753 578.883 m
406.753 581.407 408.799 583.453 411.322 583.453 c
413.846 583.453 415.892 581.407 415.892 578.883 c
415.892 576.36 413.846 574.314 411.322 574.314 c
408.799 574.314 406.753 576.36 406.753 578.883 c
h
S
400.256 546.915 m
400.256 549.439 402.302 551.484 404.826 551.484 c
407.349 551.484 409.395 549.439 409.395 546.915 c
409.395 544.391 407.349 542.345 404.826 542.345 c
402.302 542.345 400.256 544.391 400.256 546.915 c
f
400.256 546.915 m
400.256 549.439 402.302 551.484 404.826 551.484 c
407.349 551.484 409.395 549.439 409.395 546.915 c
409.395 544.391 407.349 542.345 404.826 542.345 c
402.302 542.345 400.256 544.391 400.256 546.915 c
h
S
409.004 551.732 m
409.004 554.683 411.396 557.076 414.348 557.076 c
417.299 557.076 419.691 554.683 419.691 551.732 c
419.691 548.781 417.299 546.389 414.348 546.389 c
411.396 546.389 409.004 548.781 409.004 551.732 c
f
409.004 551.732 m
409.004 554.683 411.396 557.076 414.348 557.076 c
417.299 557.076 419.691 554.683 419.691 551.732 c
419.691 548.781 417.299 546.389 414.348 546.389 c
411.396 546.389 409.004 548.781 409.004 551.732 c
h
S
401.936 527.397 m
401.936 531.836 405.534 535.434 409.973 535.434 c
414.412 535.434 418.011 531.836 418.011 527.397 c
418.011 522.958 414.412 519.36 409.973 519.36 c
405.534 519.36 401.936 522.958 401.936 527.397 c
f
401.936 527.397 m
401.936 531.836 405.534 535.434 409.973 535.434 c
414.412 535.434 418.011 531.836 418.011 527.397 c
418.011 522.958 414.412 519.36 409.973 519.36 c
405.534 519.36 401.936 522.958 401.936 527.397 c
h
S
0 0 0 0 k
464.992 501.816 m
464.992 511.115 472.53 518.653 481.829 518.653 c
491.128 518.653 498.666 511.115 498.666 501.816 c
498.666 492.517 491.128 484.978 481.829 484.978 c
472.53 484.978 464.992 492.517 464.992 501.816 c
f
464.992 501.816 m
464.992 511.115 472.53 518.653 481.829 518.653 c
491.128 518.653 498.666 511.115 498.666 501.816 c
498.666 492.517 491.128 484.978 481.829 484.978 c
472.53 484.978 464.992 492.517 464.992 501.816 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 131.1808 710.7847 Tm
(c)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 119.4706 702.2401 Tm
(g)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 137.8362 697.7056 Tm
(h)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 123.9769 684.9097 Tm
(f)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 151.615 711.465 Tm
(n)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 144.5351 687.6653 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 157.9185 686.6929 Tm
(o)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 109.3634 664.9529 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 131.0747 654.4756 Tm
(e)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 125.0677 644.3137 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 114.5543 643.706 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 106.105 631.4687 Tm
(d)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 119.0389 616.552 Tm
(j)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 189.5479 668.8845 Tm
(t)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 204.1496 669.1009 Tm
(s)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 168.9921 650.2574 Tm
(r)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 176.3854 626.4846 Tm
(u)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 204.8152 634.1202 Tm
(x)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 187.6453 650.4741 Tm
(w)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 193.6725 620.9056 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 199.1848 613.9195 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 178.9939 585.9462 Tm
(p)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 188.4203 545.3359 Tm
(v)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 265.5275 521.559 Tm
(t)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 290.7862 541.4803 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 294.309 576.4543 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 285.1153 598.2279 Tm
(e)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 317.8654 609.9002 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 312.3053 619.6624 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 364.7827 626.7079 Tm
(e)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 230.0155 670.8159 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 235.9619 676.3539 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 224.3443 712.0754 Tm
(k)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 232.4832 723.739 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 281.9166 721.4249 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 290.7217 721.4249 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 284.3997 702.3606 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 291.4333 701.4078 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 309.4535 711.3948 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 315.4823 692.5742 Tm
(k)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 363.6949 672.6835 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 368.2423 678.7862 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 363.5202 708.3688 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 380.9004 708.9856 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 385.566 706.0698 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 405.4463 695.496 Tm
(z)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 409.1351 658.3495 Tm
(y)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 340.2365 670.7394 Tm
(t)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 409.1751 601.7906 Tm
(bb)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 399.4182 593.3553 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 418.2722 587.4473 Tm
(bb)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 409.8962 585.7607 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 403.2103 554.7408 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 411.6517 559.0175 Tm
(n)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 407.9382 537.4183 Tm
(aa)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 432.9779 540.7995 Tm
(y)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 500.3813 Tm
(2777)Tj
ET
0 0 0 0 k
467.375 540.744 m
467.375 548.867 473.96 555.452 482.083 555.452 c
490.206 555.452 496.791 548.867 496.791 540.744 c
496.791 532.62 490.206 526.036 482.083 526.036 c
473.96 526.036 467.375 532.62 467.375 540.744 c
f
467.375 540.744 m
467.375 548.867 473.96 555.452 482.083 555.452 c
490.206 555.452 496.791 548.867 496.791 540.744 c
496.791 532.62 490.206 526.036 482.083 526.036 c
473.96 526.036 467.375 532.62 467.375 540.744 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 538.1624 Tm
(2000)Tj
ET
0 0 0 0 k
469.074 576.634 m
469.074 583.803 474.885 589.614 482.054 589.614 c
489.222 589.614 495.033 583.803 495.033 576.634 c
495.033 569.466 489.222 563.655 482.054 563.655 c
474.885 563.655 469.074 569.466 469.074 576.634 c
f
469.074 576.634 m
469.074 583.803 474.885 589.614 482.054 589.614 c
489.222 589.614 495.033 583.803 495.033 576.634 c
495.033 569.466 489.222 563.655 482.054 563.655 c
474.885 563.655 469.074 569.466 469.074 576.634 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 574.2875 Tm
(1500)Tj
ET
0 0 0 0 k
471.142 605.063 m
471.142 610.609 475.638 615.104 481.184 615.104 c
486.729 615.104 491.225 610.609 491.225 605.063 c
491.225 599.518 486.729 595.022 481.184 595.022 c
475.638 595.022 471.142 599.518 471.142 605.063 c
f
471.142 605.063 m
471.142 610.609 475.638 615.104 481.184 615.104 c
486.729 615.104 491.225 610.609 491.225 605.063 c
491.225 599.518 486.729 595.022 481.184 595.022 c
475.638 595.022 471.142 599.518 471.142 605.063 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 603.47 Tm
(1000)Tj
ET
0 0 0 0 k
473.117 631.336 m
473.117 635.964 476.869 639.716 481.497 639.716 c
486.125 639.716 489.876 635.964 489.876 631.336 c
489.876 626.708 486.125 622.957 481.497 622.957 c
476.869 622.957 473.117 626.708 473.117 631.336 c
f
473.117 631.336 m
473.117 635.964 476.869 639.716 481.497 639.716 c
486.125 639.716 489.876 635.964 489.876 631.336 c
489.876 626.708 486.125 622.957 481.497 622.957 c
476.869 622.957 473.117 626.708 473.117 631.336 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 629.0628 Tm
(750)Tj
ET
0 0 0 0 k
473.937 653.544 m
473.937 657.558 477.191 660.811 481.204 660.811 c
485.217 660.811 488.47 657.558 488.47 653.544 c
488.47 649.531 485.217 646.278 481.204 646.278 c
477.191 646.278 473.937 649.531 473.937 653.544 c
f
473.937 653.544 m
473.937 657.558 477.191 660.811 481.204 660.811 c
485.217 660.811 488.47 657.558 488.47 653.544 c
488.47 649.531 485.217 646.278 481.204 646.278 c
477.191 646.278 473.937 649.531 473.937 653.544 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 651.1393 Tm
(500)Tj
ET
0 0 0 0 k
475.403 669.806 m
475.403 672.735 477.777 675.109 480.706 675.109 c
483.635 675.109 486.009 672.735 486.009 669.806 c
486.009 666.877 483.635 664.503 480.706 664.503 c
477.777 664.503 475.403 666.877 475.403 669.806 c
f*
475.403 669.806 m
475.403 672.735 477.777 675.109 480.706 675.109 c
483.635 675.109 486.009 672.735 486.009 669.806 c
486.009 666.877 483.635 664.503 480.706 664.503 c
477.777 664.503 475.403 666.877 475.403 669.806 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 668.3818 Tm
(250)Tj
ET
0 0 0 0 k
477.011 682.903 m
477.011 684.974 478.69 686.653 480.762 686.653 c
482.833 686.653 484.512 684.974 484.512 682.903 c
484.512 680.831 482.833 679.152 480.762 679.152 c
478.69 679.152 477.011 680.831 477.011 682.903 c
f*
477.011 682.903 m
477.011 684.974 478.69 686.653 480.762 686.653 c
482.833 686.653 484.512 684.974 484.512 682.903 c
484.512 680.831 482.833 679.152 480.762 679.152 c
478.69 679.152 477.011 680.831 477.011 682.903 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 680.9073 Tm
(100)Tj
ET
0 0 0 0 k
478.505 695.75 m
478.505 696.982 479.504 697.981 480.736 697.981 c
481.968 697.981 482.966 696.982 482.966 695.75 c
482.966 694.519 481.968 693.52 480.736 693.52 c
479.504 693.52 478.505 694.519 478.505 695.75 c
f*
478.505 695.75 m
478.505 696.982 479.504 697.981 480.736 697.981 c
481.968 697.981 482.966 696.982 482.966 695.75 c
482.966 694.519 481.968 693.52 480.736 693.52 c
479.504 693.52 478.505 694.519 478.505 695.75 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 694.1984 Tm
(50)Tj
ET
0 0 0 0 k
479.171 706.417 m
479.171 707.243 479.841 707.914 480.668 707.914 c
481.494 707.914 482.164 707.243 482.164 706.417 c
482.164 705.59 481.494 704.92 480.668 704.92 c
479.841 704.92 479.171 705.59 479.171 706.417 c
f*
479.171 706.417 m
479.171 707.243 479.841 707.914 480.668 707.914 c
481.494 707.914 482.164 707.243 482.164 706.417 c
482.164 705.59 481.494 704.92 480.668 704.92 c
479.841 704.92 479.171 705.59 479.171 706.417 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 507.7825 703.7981 Tm
(23)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 496.45 732.2997 Tm
(Associated)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 495.1466 723.4661 Tm
(Sample size)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 469.9504 732.2997 Tm
(Bubble)Tj
ET
BT
/T1_1 1 Tf
7.8521 0 0 7.8521 474.5321 723.4661 Tm
(size)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 445.1075 Tm
(Correlation coefficients \(on the )Tj
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 125.9392 445.1075 Tm
(y)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 128.1181 445.1075 Tm
(-axis\) range from 0 to 1, with performance measures grouped by type of \
diagnostic tests compared. Twelve groups were defined an)Tj
(d represented as I\226XII on the )Tj
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 465.4358 445.1075 Tm
(x)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 467.6147 445.1075 Tm
(-axis, as follows: \(I\) CD4 cell)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 439.2184 Tm
(count versus CD4 cell count; \(II\) CD4 cell count versus CD4%; \(III\) \
CD4 cell count versus total lymphocyte count \(TLC\); \(IV\) CD)Tj
(4% versus CD4%; \(V\) CD4% versus TLC; \(VI\) CD8 cell count versus CD8 \
cell count; \(VII\) CD8%)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 433.3292 Tm
(versus CD8%; \(VIII\) CD8% versus TLC; \(IX\) CD4/CD8 versus CD4/CD8; \(\
X\) CD3 cell count \(CD3%\) versus CD3 cell count \(CD3%\); \(XI\) )Tj
(CD4 cell count versus clinical and/or other immunologic information; and\
\(XII\) immunologic)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 427.4401 Tm
(and/or clinical information versus virologic information. Groups I\226X \
reflect measures of association between different sources )Tj
(of immunologic information only. Group XI reflects measures of associati\
on between immunologic)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 421.551 Tm
(information and clinical and/or immunologic information. Group XII refle\
cts measures of association between immunologic and/or )Tj
(clinical information and virologic information. The area of each bubble \
is proportional to the)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 414.6804 Tm
(sample size of the study from which a correlation was abstracted. The le\
tter\(s\) above each marker denote the associated referen)Tj
(ce of the point estimate.)Tj
ET
BT
/T1_0 1 Tf
5.8891 0 0 5.8891 59.6821 400.9391 Tm
[(Fig)37(.)37( 1 Refer)10(ences)]TJ
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 389.98 Tm
(a)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.7366 387.1979 Tm
[(Urassa WK, Mbena EM, Swai AB, Gaines H, Mhalu FS, Biberfeld G. L)37(ymphocyte subset enumeration in HIV ser)18(onegative and HIV)55(-1 ser)18(opositive adults in Dar es Salaam, T)111(anzania: determination of r)18(efer)18(ence values in males and)]TJ
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 380.3273 Tm
(females and comparison of two flow cytometric methods. )Tj
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 182.1064 380.3273 Tm
(J Immunol Methods )Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 224.9201 380.3273 Tm
(2003;277:65-74.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 376.2387 Tm
(b)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.9563 373.4566 Tm
[(L)37(yamuya EF)129(, Kagoma C, Mbena EC, Urassa WK, Pallangyo K, Mhalu FS, et al. Evaluatio\
n of the F)55(ACScount, TRAx CD4 and Dynabeads methods for CD4 lymphocyte determinatio\
n. )]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 438.4606 373.4566 Tm
(J Immunol Methods )Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 481.2743 373.4566 Tm
(1996;195:103-12.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 369.3681 Tm
(c)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.5166 366.586 Tm
[(T)92(ugume SB, Otim SW)74(, Atwline D, Okir)18(o J, Kityo C, Mugyenyi PN, et al. Inexpensive CD4 lymphocyte subset esti\
mation by dual platform \(dp\) CD45 assisted panleucogati)(ng methoc using af)18(for)18(d monoclonal antibodies [Abstract)]TJ
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 359.7154 Tm
[(B10658]. XIV Inter)-18(national AIDS Confer)18(ence, Bar)18(celona, Spain, 7\22612 July 2002. A)18(vailable fr)18(om: http://www)55(.iasociety)92(.org/abstract/show)55(.asp?abstract_id=9704.)]TJ
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 355.6268 Tm
(d)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.9563 352.8448 Tm
[(Diagbouga S, Durand G, Sanou PT)111(, Dahour)18(ou H, Ledru E. Evaluation of a quantitative determination of CD4 and CD8\
molecules as an alter)-18(native to CD4+ and CD8+ T lymphocyte counts in Africans.)]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 59.6821 345.9741 Tm
(Trop Med Int Health)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 101.9511 345.9741 Tm
( 1999;4:79-84.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 341.8856 Tm
(e)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.6403 339.1035 Tm
[(K)7(a)7(n)7(n)7(a)7(n)7(g)7(a)7(i)7( )13(R)7(,)7( )13(R)7(a)7(m)7(a)7(l)7(i)7(n)7(g)7(a)7(m)7( )13(S)7(,)7( )13(J)7(e)7(s)7(u)7(d)7(a)7(s)7(o)7(n)7( )13(M)7(V)136(,)7( )13(V)1(i)7(j)7(a)7(y)7(a)7(k)7(u)7(m)7(a)7(r)7( )13(T)7(S)7(,)7( )13(A)7(b)7(r)7(a)7(h)7(a)7(m)7( )13(O)7(C)7(,)7( )13(Z)7(a)7(c)7(h)7(a)7(r)7(i)7(a)7(h)7( )13(A)7(,)7( )13(e)7(t)7( )13(a)7(l)7(.)7( )13(C)7(o)7(r)7(r)25(e)7(l)7(a)7(t)7(i)7(o)7(n)7( )13(o)7(f)7( )13(C)7(D)7(4)7(\()7(+)7(\))7( )13(T)136(-)7(C)7(e)7(l)7(l)7( )13(c)7(o)7(u)7(n)7(t)7(s)7( )13(e)7(s)7(t)7(i)7(m)7(a)7(t)7(e)7(d)7( )13(b)7(y)7( )13(a)7(n)7( )13(i)7(m)7(m)7(u)7(n)7(o)7(c)7(a)7(p)7(t)7(u)7(r)25(e)7( )13(t)7(e)7(c)7(h)7(n)7(i)7(q)7(u)7(e)7( )13(\()7(C)7(a)7(p)7(c)7(e)7(l)7(l)7(i)7(a)7(\))7( )13(w)7(i)7(t)7(h)7( )13(v)7(i)7(r)7(a)7(l)7( )13(l)7(o)7(a)7(d)7(s)7( )13(i)7(n)7( )13(h)7(u)6(m)7(a)7(n)7( )13(i)7(m)7(m)7(u)7(n)7(o)7(d)7(e)7(f)7(i)7(c)7(i)7(e)7(n)7(c)7(y)]TJ
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 332.2329 Tm
[(virus-ser)18(opositive individuals. )]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 121.2135 332.2329 Tm
(Clin Diagn Lab Immunol)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 171.3886 332.2329 Tm
( 2001;8:1286-8.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 328.1443 Tm
(f)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.0809 325.3622 Tm
[(Diagbouga S, Chazallon C, Kazatchkine MD, V)55(an de Perr)18(e P)153(, Inwoley A, M'Boup S, et al. Successful implementation of a low-cost me\
thod for enumerating CD4+ T lymphocytes in r)18(esour)18(ce-limited settings:)]TJ
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 318.4916 Tm
[(the ANRS 12-26 study)92(. )]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 108.3262 318.4916 Tm
(AIDS)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 118.4162 318.4916 Tm
( 2003;17:2201-08.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 314.4031 Tm
(g)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.9563 311.621 Tm
[(Landay A, Ho JL, Hom D, Russell T)111(, Zwer)-18(ner R, Minuty JG, et al. A rapid manual method for CD4+ T)129(-cell quantitation for use in developing countries)]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 371.3244 311.621 Tm
(. AIDS)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 384.1431 311.621 Tm
( 1993;7:1565-8.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 307.5324 Tm
(h)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.9563 304.7504 Tm
[(Kar)18(cher H, Downing R, Ali M, Kagwir)18(e F)129(, W)18(eide A, Harms G. Comparison of a manual CD4+ T cell counting method with\
a standar)18(d dual-platform flow cytometry pr)18(otocol in a Ugandan rural HIV tr)18(eatment cohort)]TJ
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 297.8797 Tm
[([Abstract LB46]. The 2nd IAS Confer)18(ence on HIV Pathogenesis and T)92(r)18(eatment, Paris, France, 13\22616 July 2003. A)18(vailable fr)18(om: http://www)55(.iasociety)92(.org/abstract/show)55(.asp?abstract_id=11100.)]TJ
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 293.7912 Tm
(i)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 61.6451 291.0091 Tm
[(Ger)-18(now A, Lisse IM, B\366ttiger B, Christensen L, Brattegaar)18(d K. Determination of CD4+ and CD8+ lymphocytes with the cytospher)18(e assay: a comparative study with flow cytometry and the immunoalkaline \
phosphatase method.)]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 59.6821 284.1385 Tm
(Clin Immunol Immunopathol)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 119.6722 284.1385 Tm
( 1995;76:135-41.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 280.0499 Tm
(j)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 61.6451 277.2679 Tm
[(Mwaba P)153(, Cassol S, Pilon R, Chintu C, Janes M, Nunn A, et al. Use of dried whol\
e blood spots to measur)18(e CD4+ lymphocyte counts in HIV)55(-1-infected patients.)]TJ
ET
BT
/T1_4 1 Tf
4.9076 0 0 4.9076 391.8327 277.2679 Tm
( Lancet)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 406.8253 277.2679 Tm
( 2003;362:1459-60.)Tj
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 273.1793 Tm
(k)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 62.7366 270.3972 Tm
[(Graham S, Rodriguez W)74(, Christodoulides N, Romanovicz D, Dixon M, Goodey A, et al. Field testi\
ng of a portable micr)18(ochip assay for CD4 counts in Bostwana [Abstract 687]. The 2nd IAS Confe\
r)18(ence on HIV Pathogenesis and)]TJ
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 59.6821 263.5266 Tm
[(T)92(r)18(eatment, Paris, France, 13\22616 July 2003. A)18(vailable fr)18(om: http://www)55(.iasociety)92(.org/abstract/show)55(.asp?abstract_id=10372.)]TJ
ET
BT
/T1_3 1 Tf
3.9261 0 0 3.9261 59.6821 259.438 Tm
(l)Tj
ET
BT
/T1_3 1 Tf
4.9076 0 0 4.9076 61.6451 256.656 Tm
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(0;1:125-7.)Tj
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[(Sandstr\366m E, Urassa W)74(, Bakari M, Swai A, Mhalu F)129(, Biberfeld G, et al. Estimation of CD4 T)129(-lymphocyte counts fr)18(om per)18(cent CD4 T)129(-lymphocyte determinations in HIV)55(-1-infected subjects in sub-Saharan Africa.)]TJ
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[(Ledru E, Diagbouga S, Meda N, Sanou PT)111(, Dahour)18(ou H, Ledru S, et al. A pr)18(oposal for basic management of HIV disease in W)18(est Africa: use of clinical staging and haemogram data)]TJ
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( 1998;9:463-70.)Tj
ET
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[(Anglar)18(et X, Diagbouga S, Mortier E, Meda N, V)55(erg\351-V)55(alette V)129(, Sylla-Koko F)129(, et al. CD4+ T)129(-lymphocyte counts in HIV infection: ar)18(e Eur)18(opean standar)18(ds applicable to African patients?)]TJ
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4.9076 0 0 4.9076 439.1325 229.1735 Tm
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4.9076 0 0 4.9076 59.6821 222.3028 Tm
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[(M)3(b)3(a)3(n)3(y)3(a)3( )5(D)3(N)3(,)3( )5(A)3(s)3(s)3(a)3(h)3( )5(F)3(K)3(,)3( )5(K)3(a)3(p)3(t)3(u)3(e)3( )5(L)3(N)3(.)3( )5(C)3(o)3(r)3(r)21(e)3(l)3(a)3(t)3(i)3(o)3(n)3( )5(b)3(e)3(t)3(w)3(e)3(e)3(n)3( )5(t)3(o)3(t)3(a)3(l)3( )5(l)3(y)3(m)3(p)3(h)3(o)3(c)3(y)3(t)3(e)3( )5(c)3(o)3(u)3(n)3(t)3(s)3( )5(a)3(n)3(d)3( )5(C)3(D)3(4)3( )5(c)3(o)3(u)3(n)3(t)3(s)3( )5(i)3(n)3( )5(H)3(I)3(V)58(-)3(1)3( )5(p)3(o)3(s)3(i)3(t)3(i)3(v)3(e)3( )5(a)3(d)3(u)3(l)3(t)3(s)3( )5(i)3(n)3( )5(Y)95(a)3(o)3(u)3(n)3(d)3(e)3( )5([)3(A)3(b)3(s)3(t)3(r)3(a)3(c)3(t)3( )5(M)3(o)3(P)3(e)3(B)3(3)3(0)3(9)3(9)3(])3(.)3( )5(X)3(I)3(V)3( )5(I)3(n)3(t)3(e)3(r)-15(n)3(a)3(t)3(i)3(o)3(n)3(a)3(l)3( )5(A)3(I)3(D)3(S)3( )5(C)3(o)3(n)3(f)3(e)3(r)21(e)3(n)3(c)3(e)3(,)3( )5(B)3(a)3(r)21(c)3(e)3(l)3(o)3(n)3(a)3(,)3( )5(S)3(p)3(a)3(i)3(n)3(,)3( )5(7)3(\226)3(1)3(2)3( )5(J)3(u)3(l)3(y)3( )5(2)3(0)3(0)3(2)3(.)]TJ
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[(Mane A, Patel A, Pujari S, Gupte N, Patel J, Patel K, et al. T)111(otal lymphocyte counts \(TLC\) is a poor surr)18(ogate for CD4 counts amongst asymptomatic HIV infected patients in r)18(esour)18(ce limited settings [Abstract 481]. The 2nd IAS)]TJ
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[(Confer)18(ence on HIV Pathogenesis and T)92(r)18(eatment, Paris, France, 13\22616 July 2003. A)18(vailable fr)18(om: http://www)55(.iasociety)92(.org/abstract/show)55(.asp?abstract_id=10643.)]TJ
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[(Kimani J, Irungu E, Thottingal P)153(, Njeri J, Karirl A, W)37(achihi C, et al. Is a total lymphocyte count a surr)18(ogate marker for absolute CD4+ cells count among HIV)55(-1 infected patients in Nair)18(obi, Kenya [Abstract 139]. The 2nd IAS)]TJ
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[(Confer)18(ence on HIV Pathogenesis and T)92(r)18(eatment, Paris, France, 13\22616 July 2003. A)18(vailable fr)18(om: http://www)55(.iasociety)92(.org/abstract/show)55(.asp?abstract_id=10190.)]TJ
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92.178 787.734 91.719 787.887 91.125 787.887 c
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91.368 784.764 91.458 784.593 91.458 784.413 c
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h
S
93.78 787.815 m
93.042 787.815 l
93.042 786.996 l
93.78 786.996 l
93.78 784.458 l
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95.742 784.008 95.598 783.954 95.4 783.954 c
95.076 783.954 94.896 784.098 94.896 784.593 c
94.896 786.996 l
95.823 786.996 l
95.823 787.815 l
94.896 787.815 l
94.896 789.111 l
93.78 788.769 l
h
S
96.641 783.18 1.116 4.635 re
96.623 788.688 1.152 1.098 re
S
101.96 784.179 m
101.807 784.08 101.438 783.954 101.168 783.954 c
100.313 783.954 99.899 784.62 99.899 785.484 c
99.899 786.474 100.268 787.041 101.114 787.041 c
101.42 787.041 101.699 786.915 101.897 786.816 c
101.96 787.698 l
101.753 787.779 101.339 787.887 100.988 787.887 c
99.431 787.887 98.747 786.816 98.747 785.493 c
98.747 784.179 99.395 783.108 100.925 783.108 c
101.375 783.108 101.762 783.198 102.023 783.297 c
h
S
105.461 787.815 m
104.723 787.815 l
104.723 786.996 l
105.461 786.996 l
105.461 784.458 l
105.461 783.486 105.929 783.108 106.757 783.108 c
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107.423 784.008 107.279 783.954 107.081 783.954 c
106.757 783.954 106.577 784.098 106.577 784.593 c
106.577 786.996 l
107.504 786.996 l
107.504 787.815 l
106.577 787.815 l
106.577 789.111 l
105.461 788.769 l
h
S
111.563 784.287 m
111.356 784.134 111.032 783.927 110.348 783.927 c
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111.851 787.302 110.996 787.887 109.997 787.887 c
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110.897 783.108 111.383 783.306 111.617 783.405 c
h
109.169 785.898 m
109.169 786.51 109.412 787.131 109.997 787.131 c
110.501 787.131 110.771 786.717 110.771 785.898 c
h
S
112.535 783.333 m
112.769 783.243 113.246 783.108 113.822 783.108 c
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114.38 784.764 114.47 784.593 114.47 784.413 c
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113.228 783.954 112.769 784.188 112.589 784.26 c
h
S
116.792 787.815 m
116.054 787.815 l
116.054 786.996 l
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116.792 784.458 l
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117.908 786.996 l
118.835 786.996 l
118.835 787.815 l
117.908 787.815 l
117.908 789.111 l
116.792 788.769 l
h
S
119.366 783.333 m
119.6 783.243 120.077 783.108 120.653 783.108 c
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122.021 787.734 121.562 787.887 120.968 787.887 c
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121.211 784.764 121.301 784.593 121.301 784.413 c
121.301 784.053 120.986 783.954 120.581 783.954 c
120.059 783.954 119.6 784.188 119.42 784.26 c
h
S
125.657 783.18 1.116 4.635 re
125.639 788.688 1.152 1.098 re
S
127.889 783.18 m
129.005 783.18 l
129.005 785.88 l
129.005 786.474 129.212 786.969 129.797 786.969 c
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131.552 786.168 l
131.552 787.104 131.237 787.887 130.184 787.887 c
129.428 787.887 129.113 787.383 128.951 787.104 c
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128.933 787.338 128.906 787.581 128.897 787.815 c
127.853 787.815 l
127.88 787.608 127.889 787.338 127.889 787.05 c
h
S
135.062 783.18 m
136.214 783.18 l
136.214 785.952 l
138.077 785.952 l
138.077 783.18 l
139.229 783.18 l
139.229 789.462 l
138.077 789.462 l
138.077 786.906 l
136.214 786.906 l
136.214 789.462 l
135.062 789.462 l
h
S
140.57 783.18 1.152 6.282 re
S
144.359 783.18 m
145.574 783.18 l
147.491 789.462 l
146.303 789.462 l
144.998 784.62 l
144.98 784.62 l
143.711 789.462 l
142.469 789.462 l
h
S
150.38 783.18 m
151.496 783.18 l
151.496 785.988 l
151.496 786.501 151.757 786.969 152.252 786.969 c
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151.496 787.329 151.469 787.572 151.46 787.815 c
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150.362 787.644 150.38 787.392 150.38 787.059 c
h
S
157.697 786.645 m
157.913 786.825 158.408 787.095 158.966 787.095 c
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159.605 786.042 l
158.192 786.042 157.166 785.727 157.166 784.467 c
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160.874 786.024 l
160.874 787.185 160.541 787.887 159.101 787.887 c
158.39 787.887 157.949 787.689 157.634 787.545 c
h
159.83 785.187 m
159.83 784.359 159.587 783.864 158.921 783.864 c
158.489 783.864 158.21 784.152 158.21 784.575 c
158.21 785.25 158.777 785.448 159.731 785.448 c
159.83 785.448 l
h
S
161.909 783.18 m
163.025 783.18 l
163.025 785.88 l
163.025 786.474 163.232 786.969 163.817 786.969 c
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162.953 787.338 162.926 787.581 162.917 787.815 c
161.873 787.815 l
161.9 787.608 161.909 787.338 161.909 787.05 c
h
S
166.868 786.645 m
167.084 786.825 167.579 787.095 168.137 787.095 c
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170.045 787.185 169.712 787.887 168.272 787.887 c
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h
169.001 785.187 m
169.001 784.359 168.758 783.864 168.092 783.864 c
167.66 783.864 167.381 784.152 167.381 784.575 c
167.381 785.25 167.948 785.448 168.902 785.448 c
169.001 785.448 l
h
S
172.106 785.547 m
172.106 786.492 172.331 787.032 172.916 787.041 c
173.447 787.05 173.816 786.528 173.816 785.556 c
173.816 784.503 173.537 783.999 172.835 783.999 c
172.457 783.999 172.106 784.458 172.106 785.547 c
h
171.161 781.47 m
171.431 781.371 172.016 781.182 172.754 781.182 c
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174.896 787.329 174.914 787.572 174.932 787.815 c
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173.915 787.572 173.888 787.338 173.888 787.095 c
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173.618 787.5 173.303 787.887 172.628 787.887 c
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173.816 782.793 173.645 782.064 172.592 782.064 c
172.007 782.064 171.485 782.316 171.224 782.46 c
h
S
179.261 784.287 m
179.054 784.134 178.73 783.927 178.046 783.927 c
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179.549 787.302 178.694 787.887 177.695 787.887 c
176.516 787.887 175.787 786.816 175.787 785.43 c
175.787 784.179 176.435 783.108 177.929 783.108 c
178.595 783.108 179.081 783.306 179.315 783.405 c
h
176.867 785.898 m
176.867 786.51 177.11 787.131 177.695 787.131 c
178.199 787.131 178.469 786.717 178.469 785.898 c
h
S
180.386 783.18 m
181.502 783.18 l
181.502 785.988 l
181.502 786.501 181.763 786.969 182.258 786.969 c
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183.968 785.988 l
183.968 786.501 184.229 786.969 184.724 786.969 c
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186.434 786.042 l
186.434 787.167 186.11 787.887 185.102 787.887 c
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182.051 787.887 181.691 787.446 181.52 787.086 c
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181.502 787.329 181.475 787.572 181.466 787.815 c
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180.368 787.644 180.386 787.392 180.386 787.059 c
h
S
190.763 784.287 m
190.556 784.134 190.232 783.927 189.548 783.927 c
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191.051 785.412 l
191.051 787.302 190.196 787.887 189.197 787.887 c
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187.289 784.179 187.937 783.108 189.431 783.108 c
190.097 783.108 190.583 783.306 190.817 783.405 c
h
188.369 785.898 m
188.369 786.51 188.612 787.131 189.197 787.131 c
189.701 787.131 189.971 786.717 189.971 785.898 c
h
S
191.915 783.18 m
193.031 783.18 l
193.031 785.88 l
193.031 786.474 193.238 786.969 193.823 786.969 c
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195.578 787.104 195.263 787.887 194.21 787.887 c
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192.959 787.338 192.932 787.581 192.923 787.815 c
191.879 787.815 l
191.906 787.608 191.915 787.338 191.915 787.05 c
h
S
197 787.815 m
196.262 787.815 l
196.262 786.996 l
197 786.996 l
197 784.458 l
197 783.486 197.468 783.108 198.296 783.108 c
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198.116 786.996 l
199.043 786.996 l
199.043 787.815 l
198.116 787.815 l
198.116 789.111 l
197 788.769 l
h
S
462.408 785.574 m
463.272 788.508 l
463.29 788.508 l
464.082 785.574 l
h
464.766 783.18 m
465.954 783.18 l
463.929 789.462 l
462.669 789.462 l
460.563 783.18 l
461.715 783.18 l
462.165 784.692 l
464.325 784.692 l
h
S
466.53 781.236 m
467.646 781.236 l
467.646 783.846 l
467.664 783.846 l
467.826 783.486 468.195 783.108 468.861 783.108 c
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467.574 787.41 467.556 787.68 467.538 787.815 c
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466.521 787.644 466.53 787.356 466.53 787.023 c
h
467.646 785.484 m
467.646 786.357 467.871 787.068 468.528 787.068 c
469.176 787.068 469.347 786.528 469.347 785.457 c
469.347 784.53 469.131 783.927 468.51 783.927 c
467.898 783.927 467.646 784.584 467.646 785.484 c
h
S
471.38 783.18 m
472.496 783.18 l
472.496 785.718 l
472.496 786.582 473 786.861 473.459 786.861 c
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472.388 787.248 472.361 787.536 472.352 787.815 c
471.344 787.815 l
471.371 787.608 471.38 787.338 471.38 787.05 c
h
S
474.62 783.18 1.116 4.635 re
474.602 788.688 1.152 1.098 re
S
476.96 783.18 1.116 6.75 re
S
481.64 783.18 m
483.278 783.18 l
485.024 783.18 486.284 784.206 486.284 786.321 c
486.284 788.4 485.24 789.462 483.278 789.462 c
481.64 789.462 l
h
482.792 788.58 m
483.179 788.58 l
484.475 788.58 485.06 787.698 485.06 786.321 c
485.06 784.944 484.475 784.062 483.179 784.062 c
482.792 784.062 l
h
S
489.704 783.18 m
490.856 783.18 l
490.856 786.132 l
490.883 786.132 l
492.773 783.18 l
494.168 783.18 l
491.864 786.501 l
493.997 789.462 l
492.674 789.462 l
490.883 786.798 l
490.856 786.798 l
490.856 789.462 l
489.704 789.462 l
h
S
494.816 783.18 1.116 4.635 re
494.798 788.688 1.152 1.098 re
S
497.021 783.18 m
498.137 783.18 l
498.137 785.988 l
498.137 786.501 498.398 786.969 498.893 786.969 c
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500.603 785.988 l
500.603 786.501 500.864 786.969 501.359 786.969 c
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503.069 783.18 l
503.069 786.042 l
503.069 787.167 502.745 787.887 501.737 787.887 c
501.053 787.887 500.72 787.473 500.495 787.149 c
500.36 787.401 500.108 787.887 499.325 787.887 c
498.686 787.887 498.326 787.446 498.155 787.086 c
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498.137 787.329 498.11 787.572 498.101 787.815 c
496.985 787.815 l
497.003 787.644 497.021 787.392 497.021 787.059 c
h
S
504.023 783.18 m
505.139 783.18 l
505.139 785.988 l
505.139 786.501 505.4 786.969 505.895 786.969 c
506.309 786.969 506.489 786.681 506.489 786.105 c
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507.605 783.18 l
507.605 785.988 l
507.605 786.501 507.866 786.969 508.361 786.969 c
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510.071 783.18 l
510.071 786.042 l
510.071 787.167 509.747 787.887 508.739 787.887 c
508.055 787.887 507.722 787.473 507.497 787.149 c
507.362 787.401 507.11 787.887 506.327 787.887 c
505.688 787.887 505.328 787.446 505.157 787.086 c
505.139 787.086 l
505.139 787.329 505.112 787.572 505.103 787.815 c
503.987 787.815 l
504.005 787.644 504.023 787.392 504.023 787.059 c
h
S
514.4 784.287 m
514.193 784.134 513.869 783.927 513.185 783.927 c
512.321 783.927 512.006 784.404 512.006 785.196 c
514.688 785.196 l
514.688 785.412 l
514.688 787.302 513.833 787.887 512.834 787.887 c
511.655 787.887 510.926 786.816 510.926 785.43 c
510.926 784.179 511.574 783.108 513.068 783.108 c
513.734 783.108 514.22 783.306 514.454 783.405 c
h
512.006 785.898 m
512.006 786.51 512.249 787.131 512.834 787.131 c
513.338 787.131 513.608 786.717 513.608 785.898 c
h
S
515.66 783.18 1.116 6.75 re
S
523.58 784.287 m
523.373 784.134 523.049 783.927 522.365 783.927 c
521.501 783.927 521.186 784.404 521.186 785.196 c
523.868 785.196 l
523.868 785.412 l
523.868 787.302 523.013 787.887 522.014 787.887 c
520.835 787.887 520.106 786.816 520.106 785.43 c
520.106 784.179 520.754 783.108 522.248 783.108 c
522.914 783.108 523.4 783.306 523.634 783.405 c
h
521.186 785.898 m
521.186 786.51 521.429 787.131 522.014 787.131 c
522.518 787.131 522.788 786.717 522.788 785.898 c
h
S
525.146 787.815 m
524.408 787.815 l
524.408 786.996 l
525.146 786.996 l
525.146 784.458 l
525.146 783.486 525.614 783.108 526.442 783.108 c
526.775 783.108 527.018 783.18 527.189 783.261 c
527.189 784.053 l
527.108 784.008 526.964 783.954 526.766 783.954 c
526.442 783.954 526.262 784.098 526.262 784.593 c
526.262 786.996 l
527.189 786.996 l
527.189 787.815 l
526.262 787.815 l
526.262 789.111 l
525.146 788.769 l
h
S
530.528 786.645 m
530.744 786.825 531.239 787.095 531.797 787.095 c
532.436 787.095 532.661 786.672 532.661 786.213 c
532.661 786.042 l
532.436 786.042 l
531.023 786.042 529.997 785.727 529.997 784.467 c
529.997 783.603 530.663 783.108 531.383 783.108 c
532.049 783.108 532.4 783.432 532.679 783.81 c
532.697 783.81 l
532.697 783.585 532.706 783.36 532.76 783.18 c
533.768 783.18 l
533.741 783.36 533.705 783.666 533.705 783.999 c
533.705 786.024 l
533.705 787.185 533.372 787.887 531.932 787.887 c
531.221 787.887 530.78 787.689 530.465 787.545 c
h
532.661 785.187 m
532.661 784.359 532.418 783.864 531.752 783.864 c
531.32 783.864 531.041 784.152 531.041 784.575 c
531.041 785.25 531.608 785.448 532.562 785.448 c
532.661 785.448 l
h
S
534.848 783.18 1.116 6.75 re
S
537.206 783.18 1.08 1.17 re
S
/CS0 cs 1 scn
BT
/T1_0 1 Tf
9 0 0 9 62.352 783.1798 Tm
(Diagnostic tests in HIV management)Tj
/Span<>> BDC
( )Tj
EMC
44.24 0 Td
(April D Kimmel et al.)Tj
ET
0 w
56.683 802.58 m
56.683 778.68 l
538.583 778.68 l
538.583 802.58 l
56.683 802.58 l
h
S
/CS0 CS 1 SCN
1 w
57.183 782.73 m
57.183 802.63 l
S
/PlacedPDF /MC0 BDC
Q
q
55.89 185.477 484 586 re
W n
q
55.89 771.477 484 -577.648 re
W n
q
55.89 771.477 484 -577.648 re
W n
0.28 0.37 0 0 k
0 i
/RelativeColorimetric ri
/GS2 gs
115.859 481.617 m
115.859 484.751 118.399 487.291 121.533 487.291 c
124.667 487.291 127.207 484.751 127.207 481.617 c
127.207 481.11 127.141 480.619 127.016 480.151 c
116.05 480.151 l
115.926 480.619 115.859 481.11 115.859 481.617 c
f*
0 0 0 1 K
0.489 w 3.864 M 0 j 0 J []0 d
115.859 481.617 m
115.859 484.751 118.399 487.291 121.533 487.291 c
124.667 487.291 127.207 484.751 127.207 481.617 c
127.207 481.11 127.141 480.619 127.016 480.151 c
116.05 480.151 l
115.926 480.619 115.859 481.11 115.859 481.617 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 8.798 0 0 8.798 59.6862 757.0197 Tm
(Fig. 2.)Tj
ET
BT
/T1_0 1 Tf
8.798 0 0 8.798 81.8044 757.0197 Tm
[(P)37(erformance of vir)10(ologic diagnostic tests for monitoring HIV)75(-infected individuals:)37( measur)10(es of association)]TJ
ET
0.231 0.396 0.114 RG
1.955 w
59.667 767.7 m
531.736 767.7 l
S
BT
/T1_2 1 Tf
4.8878 0 0 4.8878 503.2114 197.0072 Tm
(WHO 06.100)Tj
ET
BT
/T1_0 1 Tf
0 7.8204 -7.8204 0 74.7208 584.5342 Tm
[(Corr)10(elation)]TJ
ET
0 0 0 1 K
0.489 w
101.735 724.265 m
97.148 724.265 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 81.9484 722.7786 Tm
(1.00)Tj
ET
451.421 480.008 m
99.303 480.008 l
99.303 724.505 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 115.5157 470.2259 Tm
(I)Tj
ET
99.272 475.739 m
99.272 479.892 l
S
99.402 480.111 m
97.148 480.111 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 81.968 478.6246 Tm
(0.00)Tj
ET
101.735 699.697 m
97.148 699.697 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 698.2106 Tm
(0.90)Tj
ET
101.735 675.445 m
97.148 675.445 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 673.9589 Tm
(0.80)Tj
ET
101.735 651.352 m
97.148 651.352 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 649.8652 Tm
(0.70)Tj
ET
101.735 626.394 m
97.148 626.394 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 624.907 Tm
(0.60)Tj
ET
101.735 601.668 m
97.148 601.668 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 600.1811 Tm
(0.50)Tj
ET
101.735 577.732 m
97.148 577.732 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 576.2456 Tm
(0.40)Tj
ET
101.735 552.848 m
97.148 552.848 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 551.3614 Tm
(0.30)Tj
ET
101.735 528.122 m
97.148 528.122 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0267 526.6355 Tm
(0.20)Tj
ET
101.735 504.028 m
97.148 504.028 l
S
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 82.0657 502.542 Tm
(0.10)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 164.2944 470.2259 Tm
(II)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 249.0419 470.2259 Tm
(III)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 335.7177 470.2259 Tm
(IV)Tj
ET
0.94 0.68 0 0 k
243.627 673.733 m
243.627 675.566 245.113 677.051 246.945 677.051 c
248.777 677.051 250.263 675.566 250.263 673.733 c
250.263 671.901 248.777 670.415 246.945 670.415 c
245.113 670.415 243.627 671.901 243.627 673.733 c
f
243.627 673.733 m
243.627 675.566 245.113 677.051 246.945 677.051 c
248.777 677.051 250.263 675.566 250.263 673.733 c
250.263 671.901 248.777 670.415 246.945 670.415 c
245.113 670.415 243.627 671.901 243.627 673.733 c
h
S
0.28 0.37 0 0 k
104.579 536.602 m
104.579 538.201 105.876 539.498 107.475 539.498 c
109.074 539.498 110.371 538.201 110.371 536.602 c
110.371 535.002 109.074 533.706 107.475 533.706 c
105.876 533.706 104.579 535.002 104.579 536.602 c
f
104.579 536.602 m
104.579 538.201 105.876 539.498 107.475 539.498 c
109.074 539.498 110.371 538.201 110.371 536.602 c
110.371 535.002 109.074 533.706 107.475 533.706 c
105.876 533.706 104.579 535.002 104.579 536.602 c
h
S
0.26 0 0 0 k
332.45 700.877 m
332.45 703.744 334.774 706.067 337.64 706.067 c
340.506 706.067 342.829 703.744 342.829 700.877 c
342.829 698.011 340.506 695.688 337.64 695.688 c
334.774 695.688 332.45 698.011 332.45 700.877 c
f
332.45 700.877 m
332.45 703.744 334.774 706.067 337.64 706.067 c
340.506 706.067 342.829 703.744 342.829 700.877 c
342.829 698.011 340.506 695.688 337.64 695.688 c
334.774 695.688 332.45 698.011 332.45 700.877 c
h
S
0 0.68 0.59 0 k
428.872 674.585 m
428.872 676.328 430.285 677.741 432.028 677.741 c
433.771 677.741 435.185 676.328 435.185 674.585 c
435.185 672.842 433.771 671.429 432.028 671.429 c
430.285 671.429 428.872 672.842 428.872 674.585 c
f
428.872 674.585 m
428.872 676.328 430.285 677.741 432.028 677.741 c
433.771 677.741 435.185 676.328 435.185 674.585 c
435.185 672.842 433.771 671.429 432.028 671.429 c
430.285 671.429 428.872 672.842 428.872 674.585 c
h
S
0.28 0.91 0 0 k
151.232 702.22 m
151.232 704.451 153.041 706.26 155.272 706.26 c
157.503 706.26 159.312 704.451 159.312 702.22 c
159.312 699.989 157.503 698.18 155.272 698.18 c
153.041 698.18 151.232 699.989 151.232 702.22 c
f
151.232 702.22 m
151.232 704.451 153.041 706.26 155.272 706.26 c
157.503 706.26 159.312 704.451 159.312 702.22 c
159.312 699.989 157.503 698.18 155.272 698.18 c
153.041 698.18 151.232 699.989 151.232 702.22 c
h
S
0.58 0.59 0.72 0 k
382.833 691.283 m
382.833 693.31 384.476 694.953 386.503 694.953 c
388.53 694.953 390.173 693.31 390.173 691.283 c
390.173 689.256 388.53 687.613 386.503 687.613 c
384.476 687.613 382.833 689.256 382.833 691.283 c
f
382.833 691.283 m
382.833 693.31 384.476 694.953 386.503 694.953 c
388.53 694.953 390.173 693.31 390.173 691.283 c
390.173 689.256 388.53 687.613 386.503 687.613 c
384.476 687.613 382.833 689.256 382.833 691.283 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 338.1468 707.1874 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 429.9532 680.8245 Tm
(g)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 245.2416 678.2648 Tm
(h)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 105.6818 541.9839 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 153.5517 709.2406 Tm
(c)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 384.7112 698.8792 Tm
(m)Tj
ET
0 0 0 0 k
477.179 564.429 m
477.179 567.346 479.544 569.711 482.461 569.711 c
485.378 569.711 487.742 567.346 487.742 564.429 c
487.742 561.512 485.378 559.148 482.461 559.148 c
479.544 559.148 477.179 561.512 477.179 564.429 c
f*
477.179 564.429 m
477.179 567.346 479.544 569.711 482.461 569.711 c
485.378 569.711 487.742 567.346 487.742 564.429 c
487.742 561.512 485.378 559.148 482.461 559.148 c
479.544 559.148 477.179 561.512 477.179 564.429 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 508.6868 562.4238 Tm
(266)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 499.558 732.9097 Tm
(Associated)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 498.2599 724.1118 Tm
(Sample size)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 472.1879 732.9097 Tm
(Bubble)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 476.7511 724.1118 Tm
(size)Tj
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 59.6666 446.0954 Tm
(Correlation coefficients \(on the )Tj
ET
BT
/T1_3 1 Tf
5.8653 0 0 5.8653 126.6955 446.0954 Tm
(y)Tj
ET
BT
/T1_3 1 Tf
5.3765 0 0 5.3765 129.2996 446.0954 Tm
(-)Tj
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 131.09 446.0954 Tm
(axis\) range from 0 to 1, with performance measures grouped by type of d\
iagnostic tests compared. Six groups were defined and re)Tj
(presented as I\226VI on the )Tj
ET
BT
/T1_3 1 Tf
5.3765 0 0 5.3765 462.4339 446.0954 Tm
(x)Tj
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 464.821 446.0954 Tm
(-axis, as follows: \(I\) Virologic)Tj
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 59.6666 439.2526 Tm
(information compared to clinical and/or immunologic information, \(II\) \
HIV RNA and p24 antigen, \(III\) HIV-1 RNA \(RT-PCR\) versus )Tj
(HIV-1 RNA \(NASBA\), \(IV\) HIV-1 RNA \(RT-PCR\) versus HIV-1 RNA \(bDNA\
\), \(V\) HIV-1 RNA)Tj
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 59.6666 432.4097 Tm
(\(RT-PCR\) versus HIV-1 RNA \(RT-PCR or RT enzyme activity\), and \(VI\)\
HIV-1 RNA \(NASBA\) versus HIV-1 RNA \(bDNA\). Group I reflects)Tj
( measures of association between virologic information and clinical and/\
or immunologic)Tj
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 59.6666 425.5668 Tm
[(i)5(n)5(f)5(o)5(r)5(m)5(a)5(t)5(i)5(o)5(n)5(.)5( )10(G)5(r)5(o)5(u)5(p)5(s)5( )10(I)5(I)5(\226)5(V)5(I)5( )10(r)5(e)5(f)5(l)5(e)5(c)5(t)5( )10(m)5(e)5(a)5(s)5(u)5(r)5(e)5(s)5( )10(o)5(f)5( )10(a)5(s)5(s)5(o)5(c)5(i)5(a)5(t)5(i)5(o)5(n)5( )10(b)5(e)5(t)5(w)5(e)5(e)5(n)5( )10(d)5(i)5(f)5(f)5(e)5(r)5(e)5(n)5(t)5( )10(s)5(o)5(u)5(r)5(c)5(e)5(s)5( )10(o)5(f)5( )10(v)5(i)5(r)5(o)5(l)5(o)5(g)5(i)5(c)5( )10(i)5(n)5(f)5(o)5(r)5(m)5(a)5(t)5(i)5(o)5(n)5( )10(o)5(n)5(l)5(y)5(.)5( )10(T)5(h)5(e)5( )10(a)5(r)5(e)5(a)5( )10(o)5(f)5( )10(e)5(a)5(c)5(h)5( )10(b)5(u)5(b)5(b)5(l)5(e)5( )10(i)5(s)5( )10(p)5(r)5(o)5(p)5(o)5(r)5(t)5(i)5(o)5(n)5(a)5(l)5( )10(t)5(o)5( )10(t)5(h)5(e)5( )10(s)5(a)5(m)5(p)5(l)5(e)5( )10(s)5(i)5(z)5(e)5( )10(o)5(f)5( )10(t)5(h)5(e)5( )10(s)5(t)5(u)5(d)5(y)5( )10(f)5(r)5(o)5(m)5( )10(w)5(h)5(i)5(c)5(h)5( )10(a)5( )10(c)5(o)5(r)5(r)5(e)5(l)5(a)5(t)5(i)5(o)5(n)5( )10(w)5(a)5(s)5( )10(a)5(b)5(s)5(t)5(r)5(a)5(c)5(t)5(e)5(d)5(.)]TJ
ET
BT
/T1_1 1 Tf
5.8653 0 0 5.8653 59.6666 418.7239 Tm
(The letter above each marker denotes the associated reference of the poi\
nt estimate.)Tj
ET
BT
/T1_0 1 Tf
5.8653 0 0 5.8653 59.6666 405.0382 Tm
[(Fig)37(.)37( 2 Refer)10(ences)]TJ
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 393.1458 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.3413 390.3749 Tm
(Sehgal S, Datta U, Mujtaba S, Sood A, Vinayak VK. Cellular and serologic\
al markers of disease activity in Indian patients with )Tj
(HIV/AIDS. )Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 303.9631 390.3749 Tm
(Methods Cell Sci)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 338.4512 390.3749 Tm
( 2002;24:107-14.)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 385.3253 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 63.1027 382.5545 Tm
(Badri M, Wood R. Usefulness of total lymphocyte count in monitoring high\
ly active antiretroviral therapy in resource-limited se)Tj
(ttings. )Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 299.1866 382.5545 Tm
(AIDS)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 309.2359 382.5545 Tm
( 2003;17:541-5.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 377.5049 Tm
(c)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.0518 374.734 Tm
(Kumarasamy N, Chaguturu SK, Balakrishnan P, Mayer KH, Solomon S, Flaniga\
n TP. Low-cost strategies to monitor highly active anti)Tj
(retroviral therapy in resource-limited settings [Abstract 589]. 11th Con\
ference on Retroviruses and Opportunistic Infections,)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 366.9136 Tm
(San Francisco, CA, 8\22611 February 2004. Available from: http://www.ret\
roconference.org/2004/cd/Abstract/589.htm.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 361.864 Tm
(d)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.4155 359.0932 Tm
(Bonard D, Rouet F, Toni TA, Minga A, Huet C, Ekouevi DK, et al. Field ev\
aluation of an improved assay using a heat-dissociated )Tj
(p24 antigen for adults mainly infected with HIV-1 CRF02_AG strains in C\364\
te d\222Ivoire, West Africa.)Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 463.8432 359.0932 Tm
( J Acquir Immune Defic Syndr)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 351.2728 Tm
(2003;34:267-73.)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 346.2232 Tm
(e)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.9218 343.4523 Tm
(Respess R, Cachafeiro A, Fiscus S, Newman D, Branson B, Varnier O, et al\
. Evaluation of a commercially available ultrasensitive)Tj
( p24 antigen viral load assay in samples from patients infected with gen\
etically diverse HIV-1 from different geographic settin)Tj
(gs)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 335.6319 Tm
([Abstract 669]. 10th Conference on Retroviruses and Opportunistic Infect\
ions, Boston, MA, 10\22614 February 2003. Available from:)Tj
( http://www.retroconference.org/2003/cd/Abstract/669.htm.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 330.5823 Tm
(f)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 61.6179 327.8115 Tm
(Nkengasong JN, Bile C, Kalou M, Maurice C, Boateng E, Sassan-Morokro M, \
et al. Quantification of RNA in HIV type 1 subtypes D a)Tj
(nd G by NucliSens and Amplicor assays in Abidjan, Ivory Coast. )Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 408.9236 327.8115 Tm
(AIDS Res Hum Retroviruses)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 465.1427 327.8115 Tm
( 1999;15:495-8.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 322.7619 Tm
(g)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.4155 319.9911 Tm
(Ruxrungtham K, Ubolyam S, Hassink EA, Ungsedhapand C, Kroon E, Duncombe \
C, et al. Significant differences between plasma HIV-1 )Tj
(RNA assays in HIV-1 subtype E infected patients treated with antiretrovi\
ral therapy. )Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 450.4505 319.9911 Tm
(Asian Pac J Allergy Immunol)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 312.1706 Tm
(2002;20:105-11.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 308.6513 Tm
(h)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.362 304.3502 Tm
[(I)4(d)4(i)4(g)4(b)4(e)4( )7(E)4(O)4(,)4( )7(E)4(k)4(o)4(n)4(g)4( )7(E)4(E)4(,)4( )7(S)4(a)4(l)4(u)4( )7(O)4(B)4(,)4( )7(A)4(u)4(d)4(u)4( )7(R)4(A)4(,)4( )7(O)4(n)4(y)4(e)4(w)4(u)4(c)4(h)4(e)4( )7(J)4(,)4( )7(M)4(u)4(s)4(a)4( )7(A)4(Z)4(,)4( )7(e)4(t)4( )7(a)4(l)4(.)4( )7(P)4(r)4(i)4(m)4(a)4(g)4(e)4(n)4( )7(R)4(e)4(t)4(i)4(n)4(a)4(T)4(M)4( )7(R)4(a)4(i)4(n)4(b)4(o)4(w)4( )7(v)4(i)4(r)4(a)4(l)4( )7(l)4(o)4(a)4(d)4( )7(a)4(s)4(s)4(a)4(y)4(:)4( )7(a)4( )7(f)4(e)4(a)4(s)4(i)4(b)4(l)4(e)4( )7(a)4(s)4(s)4(a)4(y)4( )7(f)4(o)4(r)4( )7(r)4(e)4(s)4(o)4(u)4(r)4(c)4(e)4( )7(l)4(i)4(m)4(i)4(t)4(e)4(d)4( )7(s)4(e)4(t)4(t)4(i)4(n)4(g)4(s)4( )7(\226)4( )7(T)4(h)4(e)4( )7(N)4(i)4(g)4(e)4(r)4(i)4(a)4(n)4( )7(e)4(x)4(p)4(e)4(r)4(i)4(e)4(n)4(c)4(e)4( )7([)4(A)4(b)4(s)4(t)4(r)4(a)4(c)4(t)4( )7(L)4(B)4(3)4(8)4(])4(.)4( )7(T)4(h)4(e)4( )7(2)4(n)4(d)4( )7(I)4(A)4(S)4( )7(C)4(o)4(n)4(f)4(e)4(r)4(e)4(n)4(c)4(e)4( )7(o)4(n)4( )7(H)4(I)4(V)4( )7(P)4(a)4(t)4(h)4(o)4(g)4(e)4(n)4(e)4(s)4(i)4(s)4( )7(a)4(n)4(d)4( )7(T)4(r)4(e)4(a)4(t)4(m)4(e)4(n)4(t)4(,)]TJ
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 296.5298 Tm
(Paris, France, 13\22616 July 2003. Available from: http://www.iasociety.\
org/abstract/show.asp?abstract_id=11092.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 291.4802 Tm
(i)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 61.4028 288.7094 Tm
(Nkengasong JN, Kalou M, Maurice C, Bile C, Borget MY, Koblavi S, et al. \
Comparison of NucliSens and Amplicor monitor assays for)Tj
( quantification of human immunodeficiency virus type 1 \(HIV-1\) RNA in \
plasma of persons with HIV-1 subtype A infection in Abidj)Tj
(an,)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 280.8889 Tm
(C\364te d\222Ivoire.)Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 83.4799 280.8889 Tm
( J Clin Microbiol )Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 117.9679 280.8889 Tm
(1998;36:2495-8.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 275.8393 Tm
(j)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 61.4028 273.0685 Tm
(Hodara V, Monticelli A, Pampuro S, Salom\363'97n H, Jauregui Rueda H, Li\
bonatti O. HIV-1 viral load: comparative evaluation of thr)Tj
(ee commercially available assays in Argentina. )Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 373.9219 273.0685 Tm
(Acta Physiol Pharmacol Ther Latinoam )Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 454.5698 273.0685 Tm
(1998;48:107-13.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 268.0189 Tm
(k)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.2709 265.248 Tm
(Rouet F, Bonard D, Toni TA, Montcho C, Minga A, Inwoley A, et al. Field \
validation of quantitation of plasma human immunodefici)Tj
(ency virus type 1 \(HIV-1\) RNA viral load in African adults mainly infe\
cted with CRF02_AG strains [Abstract TuPeC4819].)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 257.4276 Tm
(The XIV International AIDS Conference, Barcelona, Spain, 7\22612 July 20\
02. Available from: http://www.iasociety.org/abstract/show)Tj
(.asp?abstract_id=8219.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 252.3781 Tm
(l)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 61.4028 249.6072 Tm
(Toure-Kane C, Diop-Ndiaye H, Diop A, Diaw PA, Gautron JL, Esnault A, et \
al. Evaluation of LCx HIV RNA Quantitative assay perfor)Tj
(mance on non-B patients treated by HAART: comparison with bDNA in Senega\
l [Abstract 680]. The 2nd IAS Conference on HIV)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 241.7868 Tm
(Pathogenesis and Treatment, Paris, France, 13\22616 July 2003. Available\
from: http://www.iasociety.org/abstract/show.asp?abstract)Tj
(_id=10662.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 236.7372 Tm
(m)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 63.2876 233.9664 Tm
(Rekhviashvili N, Stevens G, Corrigan G, Scott L, Stevens W. A cost effec\
tive alternative viral load assay for Africa: correlati)Tj
(on of Cavidi Exavir Load Quantitative HIV-RT kit with Roche Amplicor Mon\
itor version 1.5 [Abstract 476]. The 2nd IAS Conference)Tj
( on HIV)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 226.1459 Tm
(Pathogenesis and Treatment, Paris, France, 13\22616 July 2003. Available\
from: http://www.iasociety.org/abstract/show.asp?abstract)Tj
(_id=9881.)Tj
ET
BT
/T1_1 1 Tf
3.9102 0 0 3.9102 59.6666 221.0963 Tm
(n)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 62.4155 218.3255 Tm
(Mani I, Cao H, Hom D, Johnson JL, Mugerwa RD, Travers KU, et al. Plasma \
RNA viral load as measured by the branched DNA and nucl)Tj
(eic acid sequence-based amplification assays of HIV-1 subtypes A and D i\
n Uganda.. )Tj
ET
BT
/T1_3 1 Tf
4.8878 0 0 4.8878 451.9615 218.3255 Tm
(J Acquir Immune Defic Syndr)Tj
ET
BT
/T1_1 1 Tf
4.8878 0 0 4.8878 59.6666 210.5051 Tm
(1999;22:208-9.)Tj
ET
0.28 0.91 0 0 k
172.837 678.202 m
172.837 680.433 174.646 682.242 176.877 682.242 c
179.109 682.242 180.917 680.433 180.917 678.202 c
180.917 675.971 179.109 674.162 176.877 674.162 c
174.646 674.162 172.837 675.971 172.837 678.202 c
f
172.837 678.202 m
172.837 680.433 174.646 682.242 176.877 682.242 c
179.109 682.242 180.917 680.433 180.917 678.202 c
180.917 675.971 179.109 674.162 176.877 674.162 c
174.646 674.162 172.837 675.971 172.837 678.202 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 174.7386 685.2225 Tm
(e)Tj
ET
0.94 0.68 0 0 k
217.357 697.802 m
217.357 698.479 217.906 699.028 218.583 699.028 c
219.26 699.028 219.809 698.479 219.809 697.802 c
219.809 697.124 219.26 696.575 218.583 696.575 c
217.906 696.575 217.357 697.124 217.357 697.802 c
f
217.357 697.802 m
217.357 698.479 217.906 699.028 218.583 699.028 c
219.26 699.028 219.809 698.479 219.809 697.802 c
219.809 697.124 219.26 696.575 218.583 696.575 c
217.906 696.575 217.357 697.124 217.357 697.802 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 217.9504 701.4202 Tm
(f)Tj
ET
0.94 0.68 0 0 k
230.087 671.114 m
230.087 672.611 231.301 673.824 232.797 673.824 c
234.294 673.824 235.507 672.611 235.507 671.114 c
235.507 669.617 234.294 668.404 232.797 668.404 c
231.301 668.404 230.087 669.617 230.087 671.114 c
f
230.087 671.114 m
230.087 672.611 231.301 673.824 232.797 673.824 c
234.294 673.824 235.507 672.611 235.507 671.114 c
235.507 669.617 234.294 668.404 232.797 668.404 c
231.301 668.404 230.087 669.617 230.087 671.114 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 231.2764 677.1777 Tm
(g)Tj
ET
0.94 0.68 0 0 k
258.181 666.482 m
258.181 667.979 259.394 669.192 260.891 669.192 c
262.388 669.192 263.601 667.979 263.601 666.482 c
263.601 664.985 262.388 663.772 260.891 663.772 c
259.394 663.772 258.181 664.985 258.181 666.482 c
f
258.181 666.482 m
258.181 667.979 259.394 669.192 260.891 669.192 c
262.388 669.192 263.601 667.979 263.601 666.482 c
263.601 664.985 262.388 663.772 260.891 663.772 c
259.394 663.772 258.181 664.985 258.181 666.482 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 260.227 670.3327 Tm
(i)Tj
ET
0.94 0.68 0 0 k
273.254 654.501 m
273.254 655.421 274 656.167 274.919 656.167 c
275.839 656.167 276.584 655.421 276.584 654.501 c
276.584 653.582 275.839 652.836 274.919 652.836 c
274 652.836 273.254 653.582 273.254 654.501 c
f
273.254 654.501 m
273.254 655.421 274 656.167 274.919 656.167 c
275.839 656.167 276.584 655.421 276.584 654.501 c
276.584 653.582 275.839 652.836 274.919 652.836 c
274 652.836 273.254 653.582 273.254 654.501 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 274.1385 658.9932 Tm
(j)Tj
ET
0.94 0.68 0 0 k
252.237 634.828 m
252.237 635.748 252.982 636.493 253.902 636.493 c
254.822 636.493 255.567 635.748 255.567 634.828 c
255.567 633.909 254.822 633.163 253.902 633.163 c
252.982 633.163 252.237 633.909 252.237 634.828 c
f
252.237 634.828 m
252.237 635.748 252.982 636.493 253.902 636.493 c
254.822 636.493 255.567 635.748 255.567 634.828 c
255.567 633.909 254.822 633.163 253.902 633.163 c
252.982 633.163 252.237 633.909 252.237 634.828 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 252.7106 639.3199 Tm
(f)Tj
ET
0.94 0.68 0 0 k
237.041 627.624 m
237.041 629.121 238.254 630.334 239.751 630.334 c
241.248 630.334 242.461 629.121 242.461 627.624 c
242.461 626.128 241.248 624.914 239.751 624.914 c
238.254 624.914 237.041 626.128 237.041 627.624 c
f
237.041 627.624 m
237.041 629.121 238.254 630.334 239.751 630.334 c
241.248 630.334 242.461 629.121 242.461 627.624 c
242.461 626.128 241.248 624.914 239.751 624.914 c
238.254 624.914 237.041 626.128 237.041 627.624 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 239.0874 631.475 Tm
(i)Tj
ET
0.26 0 0 0 k
320.216 688.903 m
320.216 690.589 321.583 691.956 323.269 691.956 c
324.955 691.956 326.322 690.589 326.322 688.903 c
326.322 687.217 324.955 685.85 323.269 685.85 c
321.583 685.85 320.216 687.217 320.216 688.903 c
f
320.216 688.903 m
320.216 690.589 321.583 691.956 323.269 691.956 c
324.955 691.956 326.322 690.589 326.322 688.903 c
326.322 687.217 324.955 685.85 323.269 685.85 c
321.583 685.85 320.216 687.217 320.216 688.903 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 320.9676 695.0809 Tm
(g)Tj
ET
0.26 0 0 0 k
307.613 685.981 m
307.613 687.216 308.614 688.217 309.849 688.217 c
311.083 688.217 312.084 687.216 312.084 685.981 c
312.084 684.747 311.083 683.746 309.849 683.746 c
308.614 683.746 307.613 684.747 307.613 685.981 c
f
307.613 685.981 m
307.613 687.216 308.614 688.217 309.849 688.217 c
311.083 688.217 312.084 687.216 312.084 685.981 c
312.084 684.747 311.083 683.746 309.849 683.746 c
308.614 683.746 307.613 684.747 307.613 685.981 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 307.7671 692.2479 Tm
(k)Tj
ET
0.26 0 0 0 k
329.118 613.422 m
329.118 614.374 329.89 615.146 330.842 615.146 c
331.794 615.146 332.565 614.374 332.565 613.422 c
332.565 612.47 331.794 611.699 330.842 611.699 c
329.89 611.699 329.118 612.47 329.118 613.422 c
f
329.118 613.422 m
329.118 614.374 329.89 615.146 330.842 615.146 c
331.794 615.146 332.565 614.374 332.565 613.422 c
332.565 612.47 331.794 611.699 330.842 611.699 c
329.89 611.699 329.118 612.47 329.118 613.422 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 330.2958 619.909 Tm
(j)Tj
ET
0.58 0.59 0.72 0 k
371.345 652.458 m
371.345 653.163 371.916 653.734 372.62 653.734 c
373.325 653.734 373.896 653.163 373.896 652.458 c
373.896 651.754 373.325 651.183 372.62 651.183 c
371.916 651.183 371.345 651.754 371.345 652.458 c
f
371.345 652.458 m
371.345 653.163 371.916 653.734 372.62 653.734 c
373.325 653.734 373.896 653.163 373.896 652.458 c
373.896 651.754 373.325 651.183 372.62 651.183 c
371.916 651.183 371.345 651.754 371.345 652.458 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 371.4417 655.6957 Tm
(f)Tj
ET
0.58 0.59 0.72 0 k
390.795 620.754 m
390.795 622.237 391.998 623.44 393.481 623.44 c
394.965 623.44 396.168 622.237 396.168 620.754 c
396.168 619.27 394.965 618.067 393.481 618.067 c
391.998 618.067 390.795 619.27 390.795 620.754 c
f
390.795 620.754 m
390.795 622.237 391.998 623.44 393.481 623.44 c
394.965 623.44 396.168 622.237 396.168 620.754 c
396.168 619.27 394.965 618.067 393.481 618.067 c
391.998 618.067 390.795 619.27 390.795 620.754 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 393.0343 625.4216 Tm
(i)Tj
ET
0 0.68 0.59 0 k
441.038 684.301 m
441.038 685.051 441.646 685.659 442.396 685.659 c
443.146 685.659 443.754 685.051 443.754 684.301 c
443.754 683.551 443.146 682.943 442.396 682.943 c
441.646 682.943 441.038 683.551 441.038 684.301 c
f
441.038 684.301 m
441.038 685.051 441.646 685.659 442.396 685.659 c
443.146 685.659 443.754 685.051 443.754 684.301 c
443.754 683.551 443.146 682.943 442.396 682.943 c
441.646 682.943 441.038 683.551 441.038 684.301 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 442.1014 689.3203 Tm
(j)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 450.73 676.1558 Tm
(n)Tj
ET
0 0.68 0.59 0 k
451.785 669.786 m
451.785 670.536 452.393 671.144 453.143 671.144 c
453.893 671.144 454.502 670.536 454.502 669.786 c
454.502 669.036 453.893 668.428 453.143 668.428 c
452.393 668.428 451.785 669.036 451.785 669.786 c
f
451.785 669.786 m
451.785 670.536 452.393 671.144 453.143 671.144 c
453.893 671.144 454.502 670.536 454.502 669.786 c
454.502 669.036 453.893 668.428 453.143 668.428 c
452.393 668.428 451.785 669.036 451.785 669.786 c
h
S
0.28 0.91 0 0 k
159.135 561.547 m
159.135 563.779 160.944 565.588 163.175 565.588 c
165.407 565.588 167.216 563.779 167.216 561.547 c
167.216 559.316 165.407 557.507 163.175 557.507 c
160.944 557.507 159.135 559.316 159.135 561.547 c
f
159.135 561.547 m
159.135 563.779 160.944 565.588 163.175 565.588 c
165.407 565.588 167.216 563.779 167.216 561.547 c
167.216 559.316 165.407 557.507 163.175 557.507 c
160.944 557.507 159.135 559.316 159.135 561.547 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 160.806 568.7507 Tm
(d)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 119.1191 490.8276 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 392.5603 470.2259 Tm
(V)Tj
ET
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 444.9787 470.2259 Tm
(VI)Tj
ET
0 0 0 0 k
477.179 590.359 m
477.179 593.085 479.389 595.295 482.115 595.295 c
484.841 595.295 487.051 593.085 487.051 590.359 c
487.051 587.633 484.841 585.424 482.115 585.424 c
479.389 585.424 477.179 587.633 477.179 590.359 c
f*
477.179 590.359 m
477.179 593.085 479.389 595.295 482.115 595.295 c
484.841 595.295 487.051 593.085 487.051 590.359 c
487.051 587.633 484.841 585.424 482.115 585.424 c
479.389 585.424 477.179 587.633 477.179 590.359 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 508.6868 588.0087 Tm
(200)Tj
ET
0 0 0 0 k
477.625 611.46 m
477.625 613.963 479.654 615.992 482.157 615.992 c
484.659 615.992 486.688 613.963 486.688 611.46 c
486.688 608.958 484.659 606.929 482.157 606.929 c
479.654 606.929 477.625 608.958 477.625 611.46 c
f*
477.625 611.46 m
477.625 613.963 479.654 615.992 482.157 615.992 c
484.659 615.992 486.688 613.963 486.688 611.46 c
486.688 608.958 484.659 606.929 482.157 606.929 c
479.654 606.929 477.625 608.958 477.625 611.46 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 508.6868 608.7051 Tm
(150)Tj
ET
0 0 0 0 k
477.714 632.967 m
477.714 635.469 479.743 637.498 482.246 637.498 c
484.748 637.498 486.777 635.469 486.777 632.967 c
486.777 630.464 484.748 628.435 482.246 628.435 c
479.743 628.435 477.714 630.464 477.714 632.967 c
f*
477.714 632.967 m
477.714 635.469 479.743 637.498 482.246 637.498 c
484.748 637.498 486.777 635.469 486.777 632.967 c
486.777 630.464 484.748 628.435 482.246 628.435 c
479.743 628.435 477.714 630.464 477.714 632.967 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.8204 0 0 7.8204 508.6868 630.2112 Tm
(125)Tj
ET
0 0 0 0 k
478.783 653.362 m
478.783 655.263 480.324 656.805 482.226 656.805 c
484.128 656.805 485.669 655.263 485.669 653.362 c
485.669 651.46 484.128 649.919 482.226 649.919 c
480.324 649.919 478.783 651.46 478.783 653.362 c
f*
478.783 653.362 m
478.783 655.263 480.324 656.805 482.226 656.805 c
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127.405 787.937 126.964 787.739 126.649 787.595 c
h
128.845 785.237 m
128.845 784.409 128.602 783.914 127.936 783.914 c
127.504 783.914 127.225 784.202 127.225 784.625 c
127.225 785.3 127.792 785.498 128.746 785.498 c
128.845 785.498 l
h
S
131.032 783.23 1.116 6.75 re
S
133.39 783.23 1.08 1.17 re
S
396.638 783.23 m
398.276 783.23 l
400.022 783.23 401.282 784.256 401.282 786.371 c
401.282 788.45 400.238 789.512 398.276 789.512 c
396.638 789.512 l
h
397.79 788.63 m
398.177 788.63 l
399.473 788.63 400.058 787.748 400.058 786.371 c
400.058 784.994 399.473 784.112 398.177 784.112 c
397.79 784.112 l
h
S
402.308 783.23 1.116 4.635 re
402.29 788.738 1.152 1.098 re
S
404.828 786.695 m
405.044 786.875 405.539 787.145 406.097 787.145 c
406.736 787.145 406.961 786.722 406.961 786.263 c
406.961 786.092 l
406.736 786.092 l
405.323 786.092 404.297 785.777 404.297 784.517 c
404.297 783.653 404.963 783.158 405.683 783.158 c
406.349 783.158 406.7 783.482 406.979 783.86 c
406.997 783.86 l
406.997 783.635 407.006 783.41 407.06 783.23 c
408.068 783.23 l
408.041 783.41 408.005 783.716 408.005 784.049 c
408.005 786.074 l
408.005 787.235 407.672 787.937 406.232 787.937 c
405.521 787.937 405.08 787.739 404.765 787.595 c
h
406.961 785.237 m
406.961 784.409 406.718 783.914 406.052 783.914 c
405.62 783.914 405.341 784.202 405.341 784.625 c
405.341 785.3 405.908 785.498 406.862 785.498 c
406.961 785.498 l
h
S
410.066 785.597 m
410.066 786.542 410.291 787.082 410.876 787.091 c
411.407 787.1 411.776 786.578 411.776 785.606 c
411.776 784.553 411.497 784.049 410.795 784.049 c
410.417 784.049 410.066 784.508 410.066 785.597 c
h
409.121 781.52 m
409.391 781.421 409.976 781.232 410.714 781.232 c
412.415 781.232 412.856 782.267 412.856 783.716 c
412.856 787.136 l
412.856 787.379 412.874 787.622 412.892 787.865 c
411.884 787.865 l
411.875 787.622 411.848 787.388 411.848 787.145 c
411.812 787.145 l
411.578 787.55 411.263 787.937 410.588 787.937 c
409.373 787.937 408.914 786.812 408.914 785.534 c
408.914 783.662 409.886 783.23 410.534 783.23 c
411.263 783.23 411.578 783.653 411.758 784.013 c
411.776 784.013 l
411.776 783.572 l
411.776 782.843 411.605 782.114 410.552 782.114 c
409.967 782.114 409.445 782.366 409.184 782.51 c
h
S
413.873 783.23 m
414.989 783.23 l
414.989 785.93 l
414.989 786.524 415.196 787.019 415.781 787.019 c
416.24 787.019 416.42 786.722 416.42 786.011 c
416.42 783.23 l
417.536 783.23 l
417.536 786.218 l
417.536 787.154 417.221 787.937 416.168 787.937 c
415.412 787.937 415.097 787.433 414.935 787.154 c
414.917 787.154 l
414.917 787.388 414.89 787.631 414.881 787.865 c
413.837 787.865 l
413.864 787.658 413.873 787.388 413.873 787.1 c
h
S
419.57 785.552 m
419.57 786.326 419.741 787.145 420.461 787.145 c
421.181 787.145 421.343 786.326 421.343 785.552 c
421.343 784.778 421.181 783.95 420.461 783.95 c
419.741 783.95 419.57 784.778 419.57 785.552 c
h
418.418 785.552 m
418.418 783.608 419.516 783.158 420.461 783.158 c
421.406 783.158 422.495 783.608 422.495 785.552 c
422.495 787.442 421.406 787.937 420.461 787.937 c
419.516 787.937 418.418 787.442 418.418 785.552 c
h
S
423.197 783.383 m
423.431 783.293 423.908 783.158 424.484 783.158 c
425.492 783.158 426.212 783.671 426.212 784.526 c
426.212 785.066 425.924 785.327 425.348 785.696 c
424.799 786.047 l
424.475 786.254 424.277 786.389 424.277 786.641 c
424.277 786.92 424.466 787.091 424.916 787.091 c
425.321 787.091 425.618 786.992 425.897 786.884 c
425.96 787.748 l
425.852 787.784 425.393 787.937 424.799 787.937 c
423.818 787.937 423.197 787.262 423.197 786.623 c
423.197 785.894 423.71 785.597 424.178 785.318 c
424.637 785.048 l
425.042 784.814 425.132 784.643 425.132 784.463 c
425.132 784.103 424.817 784.004 424.412 784.004 c
423.89 784.004 423.431 784.238 423.251 784.31 c
h
S
427.454 787.865 m
426.716 787.865 l
426.716 787.046 l
427.454 787.046 l
427.454 784.508 l
427.454 783.536 427.922 783.158 428.75 783.158 c
429.083 783.158 429.326 783.23 429.497 783.311 c
429.497 784.103 l
429.416 784.058 429.272 784.004 429.074 784.004 c
428.75 784.004 428.57 784.148 428.57 784.643 c
428.57 787.046 l
429.497 787.046 l
429.497 787.865 l
428.57 787.865 l
428.57 789.161 l
427.454 788.819 l
h
S
430.316 783.23 1.116 4.635 re
430.298 788.738 1.152 1.098 re
S
435.635 784.229 m
435.482 784.13 435.113 784.004 434.843 784.004 c
433.988 784.004 433.574 784.67 433.574 785.534 c
433.574 786.524 433.943 787.091 434.789 787.091 c
435.095 787.091 435.374 786.965 435.572 786.866 c
435.635 787.748 l
435.428 787.829 435.014 787.937 434.663 787.937 c
433.106 787.937 432.422 786.866 432.422 785.543 c
432.422 784.229 433.07 783.158 434.6 783.158 c
435.05 783.158 435.437 783.248 435.698 783.347 c
h
S
439.135 787.865 m
438.397 787.865 l
438.397 787.046 l
439.135 787.046 l
439.135 784.508 l
439.135 783.536 439.603 783.158 440.431 783.158 c
440.764 783.158 441.008 783.23 441.178 783.311 c
441.178 784.103 l
441.098 784.058 440.954 784.004 440.756 784.004 c
440.431 784.004 440.251 784.148 440.251 784.643 c
440.251 787.046 l
441.178 787.046 l
441.178 787.865 l
440.251 787.865 l
440.251 789.161 l
439.135 788.819 l
h
S
445.237 784.337 m
445.03 784.184 444.706 783.977 444.022 783.977 c
443.158 783.977 442.843 784.454 442.843 785.246 c
445.525 785.246 l
445.525 785.462 l
445.525 787.352 444.67 787.937 443.671 787.937 c
442.492 787.937 441.763 786.866 441.763 785.48 c
441.763 784.229 442.411 783.158 443.905 783.158 c
444.571 783.158 445.057 783.356 445.291 783.455 c
h
442.843 785.948 m
442.843 786.56 443.086 787.181 443.671 787.181 c
444.175 787.181 444.445 786.767 444.445 785.948 c
h
S
446.209 783.383 m
446.443 783.293 446.92 783.158 447.496 783.158 c
448.504 783.158 449.224 783.671 449.224 784.526 c
449.224 785.066 448.936 785.327 448.36 785.696 c
447.811 786.047 l
447.487 786.254 447.289 786.389 447.289 786.641 c
447.289 786.92 447.478 787.091 447.928 787.091 c
448.333 787.091 448.63 786.992 448.909 786.884 c
448.972 787.748 l
448.864 787.784 448.405 787.937 447.811 787.937 c
446.83 787.937 446.209 787.262 446.209 786.623 c
446.209 785.894 446.722 785.597 447.19 785.318 c
447.649 785.048 l
448.054 784.814 448.144 784.643 448.144 784.463 c
448.144 784.103 447.829 784.004 447.424 784.004 c
446.902 784.004 446.443 784.238 446.263 784.31 c
h
S
450.466 787.865 m
449.728 787.865 l
449.728 787.046 l
450.466 787.046 l
450.466 784.508 l
450.466 783.536 450.934 783.158 451.762 783.158 c
452.095 783.158 452.338 783.23 452.509 783.311 c
452.509 784.103 l
452.428 784.058 452.284 784.004 452.086 784.004 c
451.762 784.004 451.582 784.148 451.582 784.643 c
451.582 787.046 l
452.509 787.046 l
452.509 787.865 l
451.582 787.865 l
451.582 789.161 l
450.466 788.819 l
h
S
453.04 783.383 m
453.274 783.293 453.751 783.158 454.327 783.158 c
455.335 783.158 456.055 783.671 456.055 784.526 c
456.055 785.066 455.767 785.327 455.191 785.696 c
454.642 786.047 l
454.318 786.254 454.12 786.389 454.12 786.641 c
454.12 786.92 454.309 787.091 454.759 787.091 c
455.164 787.091 455.461 786.992 455.74 786.884 c
455.803 787.748 l
455.695 787.784 455.236 787.937 454.642 787.937 c
453.661 787.937 453.04 787.262 453.04 786.623 c
453.04 785.894 453.553 785.597 454.021 785.318 c
454.48 785.048 l
454.885 784.814 454.975 784.643 454.975 784.463 c
454.975 784.103 454.66 784.004 454.255 784.004 c
453.733 784.004 453.274 784.238 453.094 784.31 c
h
S
459.331 783.23 1.116 4.635 re
459.313 788.738 1.152 1.098 re
S
461.563 783.23 m
462.679 783.23 l
462.679 785.93 l
462.679 786.524 462.886 787.019 463.471 787.019 c
463.93 787.019 464.11 786.722 464.11 786.011 c
464.11 783.23 l
465.226 783.23 l
465.226 786.218 l
465.226 787.154 464.911 787.937 463.858 787.937 c
463.102 787.937 462.787 787.433 462.625 787.154 c
462.607 787.154 l
462.607 787.388 462.58 787.631 462.571 787.865 c
461.527 787.865 l
461.554 787.658 461.563 787.388 461.563 787.1 c
h
S
468.736 783.23 m
469.888 783.23 l
469.888 786.002 l
471.751 786.002 l
471.751 783.23 l
472.903 783.23 l
472.903 789.512 l
471.751 789.512 l
471.751 786.956 l
469.888 786.956 l
469.888 789.512 l
468.736 789.512 l
h
S
474.244 783.23 1.152 6.282 re
S
478.033 783.23 m
479.248 783.23 l
481.165 789.512 l
479.977 789.512 l
478.672 784.67 l
478.654 784.67 l
477.385 789.512 l
476.143 789.512 l
h
S
484.054 783.23 m
485.17 783.23 l
485.17 786.038 l
485.17 786.551 485.431 787.019 485.926 787.019 c
486.34 787.019 486.52 786.731 486.52 786.155 c
486.52 783.23 l
487.636 783.23 l
487.636 786.038 l
487.636 786.551 487.897 787.019 488.392 787.019 c
488.806 787.019 488.986 786.731 488.986 786.155 c
488.986 783.23 l
490.102 783.23 l
490.102 786.092 l
490.102 787.217 489.778 787.937 488.77 787.937 c
488.086 787.937 487.753 787.523 487.528 787.199 c
487.393 787.451 487.141 787.937 486.358 787.937 c
485.719 787.937 485.359 787.496 485.188 787.136 c
485.17 787.136 l
485.17 787.379 485.143 787.622 485.134 787.865 c
484.018 787.865 l
484.036 787.694 484.054 787.442 484.054 787.109 c
h
S
491.371 786.695 m
491.587 786.875 492.082 787.145 492.64 787.145 c
493.279 787.145 493.504 786.722 493.504 786.263 c
493.504 786.092 l
493.279 786.092 l
491.866 786.092 490.84 785.777 490.84 784.517 c
490.84 783.653 491.506 783.158 492.226 783.158 c
492.892 783.158 493.243 783.482 493.522 783.86 c
493.54 783.86 l
493.54 783.635 493.549 783.41 493.603 783.23 c
494.611 783.23 l
494.584 783.41 494.548 783.716 494.548 784.049 c
494.548 786.074 l
494.548 787.235 494.215 787.937 492.775 787.937 c
492.064 787.937 491.623 787.739 491.308 787.595 c
h
493.504 785.237 m
493.504 784.409 493.261 783.914 492.595 783.914 c
492.163 783.914 491.884 784.202 491.884 784.625 c
491.884 785.3 492.451 785.498 493.405 785.498 c
493.504 785.498 l
h
S
495.583 783.23 m
496.699 783.23 l
496.699 785.93 l
496.699 786.524 496.906 787.019 497.491 787.019 c
497.95 787.019 498.13 786.722 498.13 786.011 c
498.13 783.23 l
499.246 783.23 l
499.246 786.218 l
499.246 787.154 498.931 787.937 497.878 787.937 c
497.122 787.937 496.807 787.433 496.645 787.154 c
496.627 787.154 l
496.627 787.388 496.6 787.631 496.591 787.865 c
495.547 787.865 l
495.574 787.658 495.583 787.388 495.583 787.1 c
h
S
500.542 786.695 m
500.758 786.875 501.253 787.145 501.811 787.145 c
502.45 787.145 502.675 786.722 502.675 786.263 c
502.675 786.092 l
502.45 786.092 l
501.037 786.092 500.011 785.777 500.011 784.517 c
500.011 783.653 500.677 783.158 501.397 783.158 c
502.063 783.158 502.414 783.482 502.693 783.86 c
502.711 783.86 l
502.711 783.635 502.72 783.41 502.774 783.23 c
503.782 783.23 l
503.755 783.41 503.719 783.716 503.719 784.049 c
503.719 786.074 l
503.719 787.235 503.386 787.937 501.946 787.937 c
501.235 787.937 500.794 787.739 500.479 787.595 c
h
502.675 785.237 m
502.675 784.409 502.432 783.914 501.766 783.914 c
501.334 783.914 501.055 784.202 501.055 784.625 c
501.055 785.3 501.622 785.498 502.576 785.498 c
502.675 785.498 l
h
S
505.78 785.597 m
505.78 786.542 506.005 787.082 506.59 787.091 c
507.121 787.1 507.49 786.578 507.49 785.606 c
507.49 784.553 507.211 784.049 506.509 784.049 c
506.131 784.049 505.78 784.508 505.78 785.597 c
h
504.835 781.52 m
505.105 781.421 505.69 781.232 506.428 781.232 c
508.129 781.232 508.57 782.267 508.57 783.716 c
508.57 787.136 l
508.57 787.379 508.588 787.622 508.606 787.865 c
507.598 787.865 l
507.589 787.622 507.562 787.388 507.562 787.145 c
507.526 787.145 l
507.292 787.55 506.977 787.937 506.302 787.937 c
505.087 787.937 504.628 786.812 504.628 785.534 c
504.628 783.662 505.6 783.23 506.248 783.23 c
506.977 783.23 507.292 783.653 507.472 784.013 c
507.49 784.013 l
507.49 783.572 l
507.49 782.843 507.319 782.114 506.266 782.114 c
505.681 782.114 505.159 782.366 504.898 782.51 c
h
S
512.935 784.337 m
512.728 784.184 512.404 783.977 511.72 783.977 c
510.856 783.977 510.541 784.454 510.541 785.246 c
513.223 785.246 l
513.223 785.462 l
513.223 787.352 512.368 787.937 511.369 787.937 c
510.19 787.937 509.461 786.866 509.461 785.48 c
509.461 784.229 510.109 783.158 511.603 783.158 c
512.269 783.158 512.755 783.356 512.989 783.455 c
h
510.541 785.948 m
510.541 786.56 510.784 787.181 511.369 787.181 c
511.873 787.181 512.143 786.767 512.143 785.948 c
h
S
514.06 783.23 m
515.176 783.23 l
515.176 786.038 l
515.176 786.551 515.437 787.019 515.932 787.019 c
516.346 787.019 516.526 786.731 516.526 786.155 c
516.526 783.23 l
517.642 783.23 l
517.642 786.038 l
517.642 786.551 517.903 787.019 518.398 787.019 c
518.812 787.019 518.992 786.731 518.992 786.155 c
518.992 783.23 l
520.108 783.23 l
520.108 786.092 l
520.108 787.217 519.784 787.937 518.776 787.937 c
518.092 787.937 517.759 787.523 517.534 787.199 c
517.399 787.451 517.147 787.937 516.364 787.937 c
515.725 787.937 515.365 787.496 515.194 787.136 c
515.176 787.136 l
515.176 787.379 515.149 787.622 515.14 787.865 c
514.024 787.865 l
514.042 787.694 514.06 787.442 514.06 787.109 c
h
S
524.437 784.337 m
524.23 784.184 523.906 783.977 523.222 783.977 c
522.358 783.977 522.043 784.454 522.043 785.246 c
524.725 785.246 l
524.725 785.462 l
524.725 787.352 523.87 787.937 522.871 787.937 c
521.692 787.937 520.963 786.866 520.963 785.48 c
520.963 784.229 521.611 783.158 523.105 783.158 c
523.771 783.158 524.257 783.356 524.491 783.455 c
h
522.043 785.948 m
522.043 786.56 522.286 787.181 522.871 787.181 c
523.375 787.181 523.645 786.767 523.645 785.948 c
h
S
525.589 783.23 m
526.705 783.23 l
526.705 785.93 l
526.705 786.524 526.912 787.019 527.497 787.019 c
527.956 787.019 528.136 786.722 528.136 786.011 c
528.136 783.23 l
529.252 783.23 l
529.252 786.218 l
529.252 787.154 528.937 787.937 527.884 787.937 c
527.128 787.937 526.813 787.433 526.651 787.154 c
526.633 787.154 l
526.633 787.388 526.606 787.631 526.597 787.865 c
525.553 787.865 l
525.58 787.658 525.589 787.388 525.589 787.1 c
h
S
530.674 787.865 m
529.936 787.865 l
529.936 787.046 l
530.674 787.046 l
530.674 784.508 l
530.674 783.536 531.142 783.158 531.97 783.158 c
532.303 783.158 532.546 783.23 532.717 783.311 c
532.717 784.103 l
532.636 784.058 532.492 784.004 532.294 784.004 c
531.97 784.004 531.79 784.148 531.79 784.643 c
531.79 787.046 l
532.717 787.046 l
532.717 787.865 l
531.79 787.865 l
531.79 789.161 l
530.674 788.819 l
h
S
/CS0 cs 1 scn
BT
/T1_0 1 Tf
9 0 0 9 56.6929 783.2299 Tm
(April D Kimmel et al.)Tj
/Span<>> BDC
8.675 0 Td
( )Tj
EMC
28.769 0 Td
( Diagnostic tests in HIV management)Tj
ET
0 w
56.693 802.63 m
56.693 778.11 l
538.593 778.11 l
538.593 802.63 l
56.693 802.63 l
h
S
/CS0 CS 1 SCN
1 w
538.093 783.118 m
538.093 802.63 l
S
/PlacedPDF /MC0 BDC
Q
q
56.154 321.26 495.657 449.82 re
W n
q
56.154 771.08 491.639 -449.733 re
W n
q
56.154 771.08 491.639 -449.733 re
W n
0 0 0 1 k
0 i
/RelativeColorimetric ri
/GS2 gs
BT
/T1_1 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 4.9649 0 0 4.9649 59.9909 428.9799 Tm
(a)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 63.3869 426.1653 Tm
(All values are compared to CD4 \(cluster differentiation 4\) count <200 \
cells/mm)Tj
ET
BT
/T1_1 1 Tf
4.4684 0 0 4.4684 234.3008 428.9799 Tm
(3)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 237.518 426.1653 Tm
(unless otherwise specified. The size of each marker is proportional to t\
he sample size of the study.)Tj
ET
BT
/T1_1 1 Tf
4.9649 0 0 4.9649 59.9909 422.029 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 63.4812 419.2144 Tm
(WHO = World Health Organization.)Tj
ET
BT
/T1_1 1 Tf
4.9649 0 0 4.9649 59.9909 415.0782 Tm
(c)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 63.0195 412.2636 Tm
(CDC = Centers for Disease Control and Prevention .)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 405.3127 Tm
(Kassa et al. \(1995\) = Kassa E, Rinke de Wit TF, Hailu E, Girma M, Mess\
ele T, Mariam HG, et al. Evaluation of the World Health )Tj
(Organization staging system for HIV infection and disease in Ethiopia: a\
ssociation between)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 398.3618 Tm
(clinical stages and laboratory markers)Tj
ET
BT
/T1_2 1 Tf
5.9579 0 0 5.9579 141.5244 398.3618 Tm
(.)Tj
ET
BT
/T1_2 1 Tf
5.4614 0 0 5.4614 144.837 398.3618 Tm
(AIDS)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 156.0657 398.3618 Tm
( 1999;13:381-9.)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 391.411 Tm
(French et al. \(1999\) = French N, Mujugira A, Nakiyingi J, Mulder D, Ja\
noff EN, Gilks CF. Immunologic and clinical stages in HIV)Tj
(-1-infected Ugandan adults are comparable and provide no evidence of rap\
id progression but)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 384.4601 Tm
(poor survival with advanced diseas)Tj
ET
BT
/T1_2 1 Tf
5.9579 0 0 5.9579 135.364 384.4601 Tm
(e.)Tj
ET
BT
/T1_2 1 Tf
5.4614 0 0 5.4614 141.6556 384.4601 Tm
(J Acquir Immune Defic Syndr)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 208.7104 384.4601 Tm
( 1999;22:509-16.)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 377.5092 Tm
[(S)2(c)2(h)2(e)2(c)2(h)2(t)2(e)2(r)2( )3(e)2(t)2( )3(a)2(l)2(.)2( )3(\()2(1)2(9)2(9)2(4)2(\))2( )3(=)2( )3(S)2(c)2(h)2(e)2(c)2(h)2(t)2(e)2(r)2( )3(M)2(,)2( )3(Z)2(a)2(j)2(d)2(e)2(n)2(v)2(e)2(r)2(g)2( )3(R)2(,)2( )3(M)2(a)2(c)2(h)2(a)2(d)2(o)2( )3(L)2(L)2(,)2( )3(P)2(i)2(n)2(t)2(o)2( )3(M)2(E)2(,)2( )3(L)2(i)2(m)2(a)2( )3(L)2(A)2(,)2( )3(P)2(e)2(r)2(e)2(z)2( )3(M)2(A)2(.)2( )3(P)2(r)2(e)2(d)2(i)2(c)2(t)2(i)2(n)2(g)2( )3(C)2(D)2(4)2( )3(c)2(o)2(u)2(n)2(t)2(s)2( )3(i)2(n)2( )3(H)2(I)2(V)2(-)2(i)2(n)2(f)2(e)2(c)2(t)2(e)2(d)2( )3(B)2(r)2(a)2(z)2(i)2(l)2(i)2(a)2(n)2( )3(i)2(n)2(d)2(i)2(v)2(i)2(d)2(u)2(a)2(l)2(s)2(:)2( )3(a)2( )3(m)2(o)2(d)2(e)2(l)2( )3(b)2(a)2(s)2(e)2(d)2( )3(o)2(n)2( )3(t)2(h)2(e)2( )3(W)2(o)2(r)2(l)2(d)2( )3(H)2(e)2(a)2(l)2(t)2(h)2( )3(O)2(r)2(g)2(a)2(n)2(i)2(z)2(a)2(t)2(i)2(o)2(n)2( )3(s)2(t)2(a)2(g)2(i)2(n)2(g)2( )3(s)2(y)2(s)2(t)2(e)2(m)]TJ
ET
BT
/T1_2 1 Tf
5.9579 0 0 5.9579 537.8735 377.5092 Tm
(.)Tj
ET
BT
/T1_2 1 Tf
5.4614 0 0 5.4614 59.9909 370.5584 Tm
(J Acquire Immune Defic Syndr)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 129.7764 370.5584 Tm
( 1994;7:163-8.)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 363.6075 Tm
(Adu-Sarkodie et al. \(1998\) = Adu-Sarkodie Y, Sangar\351 A, d\222Almeid\
a OA, Kanmogne GD. Distribution of CD4+ T-lymphocytes levels in)Tj
( patients with clinical symptoms of AIDS in three West African countries\
. )Tj
ET
BT
/T1_2 1 Tf
5.4614 0 0 5.4614 506.9755 363.6075 Tm
(J Clin Virol)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 356.6566 Tm
(1998;11:173-81.)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 349.7057 Tm
(Ledru et al. \(1998\) = Ledru E, Diagbouga S, Meda N, Sanou PT, Dahourou\
H, Ledru S, et al. A proposal for basic management of HI)Tj
(V disease in West Africa: use of clinical staging and haemogram data.)Tj
ET
BT
/T1_2 1 Tf
5.4614 0 0 5.4614 59.9909 342.7549 Tm
(Int J STD AIDS)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 94.421 342.7549 Tm
(1998;9:463-70.)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 335.804 Tm
(Ramalingam et al. \(2001\) = Ramalingam S, Kannangai R, Zachariah A, Mat\
hai D, Abraham C. CD4 counts of normal and HIV-infected s)Tj
(outh Indian adults:)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 59.9909 328.8531 Tm
(do we need a new staging system? )Tj
ET
BT
/T1_2 1 Tf
5.4614 0 0 5.4614 137.5327 328.8531 Tm
(Natl Med J India)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 176.8181 328.8531 Tm
(2001;14:335-9.)Tj
ET
0.28 0.37 0 0 k
427.504 707.13 m
427.504 709.825 429.689 712.01 432.385 712.01 c
435.08 712.01 437.265 709.825 437.265 707.13 c
437.265 704.435 435.08 702.25 432.385 702.25 c
429.689 702.25 427.504 704.435 427.504 707.13 c
f*
0 0 0 1 K
0.496 w 3.864 M 0 j 0 J []0 d
427.504 707.13 m
427.504 709.825 429.689 712.01 432.385 712.01 c
435.08 712.01 437.265 709.825 437.265 707.13 c
437.265 704.435 435.08 702.25 432.385 702.25 c
429.689 702.25 427.504 704.435 427.504 707.13 c
h
S
427.504 673.744 m
427.504 676.439 429.689 678.624 432.385 678.624 c
435.08 678.624 437.265 676.439 437.265 673.744 c
437.265 671.049 435.08 668.864 432.385 668.864 c
429.689 668.864 427.504 671.049 427.504 673.744 c
f*
427.504 673.744 m
427.504 676.439 429.689 678.624 432.385 678.624 c
435.08 678.624 437.265 676.439 437.265 673.744 c
437.265 671.049 435.08 668.864 432.385 668.864 c
429.689 668.864 427.504 671.049 427.504 673.744 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
8.9368 0 0 8.9368 60.0108 756.3947 Tm
(Fig. 3.)Tj
ET
BT
/T1_0 1 Tf
8.9368 0 0 8.9368 82.4781 756.3947 Tm
[(Sensitivity of differ)10(ent clinical staging systems for CD4 cell count)]TJ
ET
BT
/T1_0 1 Tf
5.9579 0 0 5.9579 326.4882 759.7725 Tm
(a)Tj
ET
0.231 0.396 0.114 RG
1.986 w
59.991 767.244 m
539.511 767.244 l
S
BT
/T1_3 1 Tf
4.9649 0 0 4.9649 510.5357 324.5776 Tm
(WHO 06.101)Tj
ET
BT
/T1_0 1 Tf
0 7.9438 -7.9438 0 75.2827 600.0538 Tm
[(Corr)10(elation)]TJ
ET
0 0 0 1 K
0.496 w
463.147 516.716 m
100.253 516.716 l
100.253 718.664 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 104.6582 501.815 Tm
(WHO)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 119.9739 504.6296 Tm
(b)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 122.7323 501.815 Tm
( Stages 2\2264)Tj
ET
100.221 512.38 m
100.221 516.599 l
S
100.354 516.821 m
98.064 516.821 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7236 515.3112 Tm
(0.20)Tj
ET
102.723 718.741 m
98.064 718.741 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7831 717.2309 Tm
(1.00)Tj
ET
102.723 693.151 m
98.064 693.151 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7236 691.6407 Tm
(0.90)Tj
ET
102.723 667.931 m
98.064 667.931 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7236 666.4213 Tm
(0.80)Tj
ET
102.723 642.881 m
98.064 642.881 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7236 641.3713 Tm
(0.70)Tj
ET
102.723 617.507 m
98.064 617.507 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7236 615.9974 Tm
(0.60)Tj
ET
102.723 592.485 m
98.064 592.485 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7236 590.9753 Tm
(0.50)Tj
ET
102.723 566.982 m
98.064 566.982 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.7435 565.4718 Tm
(0.40)Tj
ET
102.723 541.779 m
98.064 541.779 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 82.8229 540.2688 Tm
(0.30)Tj
ET
0.26 0 0 0 k
127.383 693.381 m
127.383 695.242 128.892 696.751 130.753 696.751 c
132.615 696.751 134.124 695.242 134.124 693.381 c
134.124 691.52 132.615 690.011 130.753 690.011 c
128.892 690.011 127.383 691.52 127.383 693.381 c
f*
127.383 693.381 m
127.383 695.242 128.892 696.751 130.753 696.751 c
132.615 696.751 134.124 695.242 134.124 693.381 c
134.124 691.52 132.615 690.011 130.753 690.011 c
128.892 690.011 127.383 691.52 127.383 693.381 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 506.8246 728.6771 Tm
(Associated)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 505.5061 719.7402 Tm
(Sample size)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 477.0367 728.6771 Tm
(Bubble)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 481.6719 719.7402 Tm
(size)Tj
ET
0 0 0 0 k
482.644 640.924 m
482.644 643.619 484.829 645.804 487.524 645.804 c
490.219 645.804 492.404 643.619 492.404 640.924 c
492.404 638.228 490.219 636.044 487.524 636.044 c
484.829 636.044 482.644 638.228 482.644 640.924 c
f*
482.644 640.924 m
482.644 643.619 484.829 645.804 487.524 645.804 c
490.219 645.804 492.404 643.619 492.404 640.924 c
492.404 638.228 490.219 636.044 487.524 636.044 c
484.829 636.044 482.644 638.228 482.644 640.924 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 515.3528 637.5322 Tm
(266)Tj
ET
133.186 709.347 m
128.526 709.347 l
S
130.756 709.264 m
130.756 677.387 l
S
133.186 677.333 m
128.526 677.333 l
S
0.26 0 0 0 k
181.42 675.868 m
181.42 677.729 182.929 679.238 184.79 679.238 c
186.652 679.238 188.161 677.729 188.161 675.868 c
188.161 674.006 186.652 672.497 184.79 672.497 c
182.929 672.497 181.42 674.006 181.42 675.868 c
f*
181.42 675.868 m
181.42 677.729 182.929 679.238 184.79 679.238 c
186.652 679.238 188.161 677.729 188.161 675.868 c
188.161 674.006 186.652 672.497 184.79 672.497 c
182.929 672.497 181.42 674.006 181.42 675.868 c
h
S
187.223 695.942 m
182.563 695.942 l
S
184.793 695.859 m
184.793 656.769 l
S
187.223 656.715 m
182.563 656.715 l
S
0 0.46 0 0 k
194.787 645.736 m
194.787 647.598 196.296 649.107 198.157 649.107 c
200.019 649.107 201.528 647.598 201.528 645.736 c
201.528 643.875 200.019 642.366 198.157 642.366 c
196.296 642.366 194.787 643.875 194.787 645.736 c
f*
194.787 645.736 m
194.787 647.598 196.296 649.107 198.157 649.107 c
200.019 649.107 201.528 647.598 201.528 645.736 c
201.528 643.875 200.019 642.366 198.157 642.366 c
196.296 642.366 194.787 643.875 194.787 645.736 c
h
S
200.59 670.247 m
195.93 670.247 l
S
198.16 670.164 m
198.16 619.132 l
S
200.59 619.078 m
195.93 619.078 l
S
0.51 0 0.66 0 k
250.394 708.054 m
250.394 709.457 251.531 710.594 252.934 710.594 c
254.338 710.594 255.475 709.457 255.475 708.054 c
255.475 706.651 254.338 705.513 252.934 705.513 c
251.531 705.513 250.394 706.651 250.394 708.054 c
f*
0.374 w
250.394 708.054 m
250.394 709.457 251.531 710.594 252.934 710.594 c
254.338 710.594 255.475 709.457 255.475 708.054 c
255.475 706.651 254.338 705.513 252.934 705.513 c
251.531 705.513 250.394 706.651 250.394 708.054 c
h
S
250.394 697.359 m
250.394 698.762 251.531 699.9 252.934 699.9 c
254.338 699.9 255.475 698.762 255.475 697.359 c
255.475 695.956 254.338 694.819 252.934 694.819 c
251.531 694.819 250.394 695.956 250.394 697.359 c
f*
250.394 697.359 m
250.394 698.762 251.531 699.9 252.934 699.9 c
254.338 699.9 255.475 698.762 255.475 697.359 c
255.475 695.956 254.338 694.819 252.934 694.819 c
251.531 694.819 250.394 695.956 250.394 697.359 c
h
S
0 0.18 0.67 0 k
250.394 552.601 m
250.394 554.462 251.903 555.971 253.764 555.971 c
255.626 555.971 257.135 554.462 257.135 552.601 c
257.135 550.74 255.626 549.231 253.764 549.231 c
251.903 549.231 250.394 550.74 250.394 552.601 c
f*
0.496 w
250.394 552.601 m
250.394 554.462 251.903 555.971 253.764 555.971 c
255.626 555.971 257.135 554.462 257.135 552.601 c
257.135 550.74 255.626 549.231 253.764 549.231 c
251.903 549.231 250.394 550.74 250.394 552.601 c
h
S
256.197 571.445 m
251.537 571.445 l
S
253.766 571.362 m
253.766 534.43 l
S
256.197 534.377 m
251.537 534.377 l
S
0.28 0.37 0 0 k
308.418 599.416 m
308.418 601.591 310.182 603.354 312.357 603.354 c
314.532 603.354 316.295 601.591 316.295 599.416 c
316.295 597.241 314.532 595.478 312.357 595.478 c
310.182 595.478 308.418 597.241 308.418 599.416 c
f*
308.418 599.416 m
308.418 601.591 310.182 603.354 312.357 603.354 c
314.532 603.354 316.295 601.591 316.295 599.416 c
316.295 597.241 314.532 595.478 312.357 595.478 c
310.182 595.478 308.418 597.241 308.418 599.416 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 290.8179 583.0567 Tm
(for CD4 <350)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 297.106 572.1339 Tm
(cells/mm)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 322.423 574.3856 Tm
(3)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 351.7606 705.5103 Tm
(for CD4 )Tj
ET
376.479 708.422 m
380.537 706.553 l
380.537 706.986 l
376.976 708.638 l
380.537 710.29 l
380.537 710.723 l
376.479 708.855 l
h
f*
0.446 w
380.037 705.51 m
376.021 707.414 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 380.8845 705.5103 Tm
(500)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 357.6566 694.5875 Tm
(cells/mm)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 382.9735 696.8391 Tm
(3)Tj
ET
0 0 0 0.5 k
368.284 716.992 m
368.284 718.395 369.421 719.532 370.825 719.532 c
372.228 719.532 373.365 718.395 373.365 716.992 c
373.365 715.589 372.228 714.451 370.825 714.451 c
369.421 714.451 368.284 715.589 368.284 716.992 c
f*
0.374 w
368.284 716.992 m
368.284 718.395 369.421 719.532 370.825 719.532 c
372.228 719.532 373.365 718.395 373.365 716.992 c
373.365 715.589 372.228 714.451 370.825 714.451 c
369.421 714.451 368.284 715.589 368.284 716.992 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 351.4389 616.0365 Tm
(for CD4 )Tj
ET
376.157 618.948 m
380.215 617.079 l
380.215 617.512 l
376.654 619.164 l
380.215 620.817 l
380.215 621.25 l
376.157 619.381 l
h
f*
0.445 w
379.715 616.036 m
375.699 617.94 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 380.5628 616.0365 Tm
(300)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 357.6566 605.1137 Tm
(cells/mm)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 382.9735 607.3654 Tm
(3)Tj
ET
0 0 0 0.5 k
368.284 627.518 m
368.284 628.921 369.421 630.059 370.825 630.059 c
372.228 630.059 373.365 628.921 373.365 627.518 c
373.365 626.115 372.228 624.978 370.825 624.978 c
369.421 624.978 368.284 626.115 368.284 627.518 c
f*
0.374 w
368.284 627.518 m
368.284 628.921 369.421 630.059 370.825 630.059 c
372.228 630.059 373.365 628.921 373.365 627.518 c
373.365 626.115 372.228 624.978 370.825 624.978 c
369.421 624.978 368.284 626.115 368.284 627.518 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 412.8997 694.9043 Tm
(for CD4 <350)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 419.1878 684.9745 Tm
(cells/mm)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 444.5049 687.2261 Tm
(3)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 411.9067 659.2816 Tm
(for CD4 <350)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 417.5848 650.3448 Tm
(cells/mm)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 442.902 652.5964 Tm
(3)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 445.7617 650.3448 Tm
(;)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 403.5801 641.408 Tm
(includes TB and TLC)Tj
ET
0 0 0 0 k
483.069 656.424 m
483.069 658.871 485.053 660.855 487.5 660.855 c
489.946 660.855 491.93 658.871 491.93 656.424 c
491.93 653.977 489.946 651.994 487.5 651.994 c
485.053 651.994 483.069 653.977 483.069 656.424 c
f*
0.496 w
483.069 656.424 m
483.069 658.871 485.053 660.855 487.5 660.855 c
489.946 660.855 491.93 658.871 491.93 656.424 c
491.93 653.977 489.946 651.994 487.5 651.994 c
485.053 651.994 483.069 653.977 483.069 656.424 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 515.3528 652.9235 Tm
(250)Tj
ET
0 0 0 0 k
483.196 670.387 m
483.196 672.713 485.081 674.599 487.408 674.599 c
489.734 674.599 491.619 672.713 491.619 670.387 c
491.619 668.061 489.734 666.175 487.408 666.175 c
485.081 666.175 483.196 668.061 483.196 670.387 c
f*
483.196 670.387 m
483.196 672.713 485.081 674.599 487.408 674.599 c
489.734 674.599 491.619 672.713 491.619 670.387 c
491.619 668.061 489.734 666.175 487.408 666.175 c
485.081 666.175 483.196 668.061 483.196 670.387 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 515.3528 667.1052 Tm
(200)Tj
ET
0 0 0 0 k
483.421 683.7 m
483.421 685.846 485.161 687.586 487.308 687.586 c
489.454 687.586 491.194 685.846 491.194 683.7 c
491.194 681.553 489.454 679.813 487.308 679.813 c
485.161 679.813 483.421 681.553 483.421 683.7 c
f*
483.421 683.7 m
483.421 685.846 485.161 687.586 487.308 687.586 c
489.454 687.586 491.194 685.846 491.194 683.7 c
491.194 681.553 489.454 679.813 487.308 679.813 c
485.161 679.813 483.421 681.553 483.421 683.7 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 515.3528 680.0927 Tm
(150)Tj
ET
0 0 0 0 k
484.445 695.498 m
484.445 697.165 485.796 698.516 487.462 698.516 c
489.129 698.516 490.48 697.165 490.48 695.498 c
490.48 693.832 489.129 692.481 487.462 692.481 c
485.796 692.481 484.445 693.832 484.445 695.498 c
f*
484.445 695.498 m
484.445 697.165 485.796 698.516 487.462 698.516 c
489.129 698.516 490.48 697.165 490.48 695.498 c
490.48 693.832 489.129 692.481 487.462 692.481 c
485.796 692.481 484.445 693.832 484.445 695.498 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 515.3528 691.0221 Tm
(100)Tj
ET
0 0 0 0 k
485.127 705.265 m
485.127 706.584 486.196 707.654 487.515 707.654 c
488.835 707.654 489.904 706.584 489.904 705.265 c
489.904 703.946 488.835 702.877 487.515 702.877 c
486.196 702.877 485.127 703.946 485.127 705.265 c
f*
485.127 705.265 m
485.127 706.584 486.196 707.654 487.515 707.654 c
488.835 707.654 489.904 706.584 489.904 705.265 c
489.904 703.946 488.835 702.877 487.515 702.877 c
486.196 702.877 485.127 703.946 485.127 705.265 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 515.3528 702.6339 Tm
(79)Tj
ET
161.417 516.724 m
161.417 512.064 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 166.2532 501.815 Tm
(WHO Stages 3\2264)Tj
ET
221.613 516.724 m
221.613 512.064 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 229.0783 501.815 Tm
(WHO Stage not)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 239.3018 492.8782 Tm
(reported)Tj
ET
281.808 516.724 m
281.808 512.064 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 292.3035 501.815 Tm
(CDC)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 305.252 504.6296 Tm
(c)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 307.4564 501.815 Tm
( Stage C)Tj
ET
342.448 516.724 m
342.448 512.064 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 355.2002 501.815 Tm
(CDC Stages)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 363.0683 492.8782 Tm
(A or B)Tj
ET
402.515 516.724 m
402.515 512.064 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 415.6908 501.815 Tm
(CDC Stages)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 417.1642 492.8782 Tm
(B and/or C)Tj
ET
462.896 516.724 m
462.896 512.064 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 415.0146 559.0751 Tm
(for CD4 )Tj
ET
439.733 561.986 m
443.791 560.118 l
443.791 560.551 l
440.23 562.203 l
443.791 563.855 l
443.791 564.288 l
439.733 562.42 l
h
f*
0.445 w
443.291 559.075 m
439.275 560.979 l
S
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 444.1386 559.0751 Tm
(80)Tj
ET
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 419.0433 548.1523 Tm
(cells/mm)Tj
ET
BT
/T1_1 1 Tf
5.9579 0 0 5.9579 444.3604 550.404 Tm
(3)Tj
ET
0 0 0 0.5 k
430.664 570.557 m
430.664 571.96 431.801 573.097 433.204 573.097 c
434.607 573.097 435.745 571.96 435.745 570.557 c
435.745 569.154 434.607 568.016 433.204 568.016 c
431.801 568.016 430.664 569.154 430.664 570.557 c
f*
0.374 w
430.664 570.557 m
430.664 571.96 431.801 573.097 433.204 573.097 c
434.607 573.097 435.745 571.96 435.745 570.557 c
435.745 569.154 434.607 568.016 433.204 568.016 c
431.801 568.016 430.664 569.154 430.664 570.557 c
h
S
430.664 627.518 m
430.664 628.921 431.801 630.059 433.204 630.059 c
434.607 630.059 435.745 628.921 435.745 627.518 c
435.745 626.115 434.607 624.978 433.204 624.978 c
431.801 624.978 430.664 626.115 430.664 627.518 c
f*
430.664 627.518 m
430.664 628.921 431.801 630.059 433.204 630.059 c
434.607 630.059 435.745 628.921 435.745 627.518 c
435.745 626.115 434.607 624.978 433.204 624.978 c
431.801 624.978 430.664 626.115 430.664 627.518 c
h
S
0.26 0 0 0 k
99.935 462.513 m
99.935 464.374 101.444 465.883 103.306 465.883 c
105.167 465.883 106.676 464.374 106.676 462.513 c
106.676 460.651 105.167 459.142 103.306 459.142 c
101.444 459.142 99.935 460.651 99.935 462.513 c
f*
0.496 w
99.935 462.513 m
99.935 464.374 101.444 465.883 103.306 465.883 c
105.167 465.883 106.676 464.374 106.676 462.513 c
106.676 460.651 105.167 459.142 103.306 459.142 c
101.444 459.142 99.935 460.651 99.935 462.513 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 110.5215 459.4026 Tm
(Kassa et al. \(1995\))Tj
ET
0 0.46 0 0 k
99.935 450.738 m
99.935 452.599 101.444 454.109 103.306 454.109 c
105.167 454.109 106.676 452.599 106.676 450.738 c
106.676 448.877 105.167 447.368 103.306 447.368 c
101.444 447.368 99.935 448.877 99.935 450.738 c
f*
99.935 450.738 m
99.935 452.599 101.444 454.109 103.306 454.109 c
105.167 454.109 106.676 452.599 106.676 450.738 c
106.676 448.877 105.167 447.368 103.306 447.368 c
101.444 447.368 99.935 448.877 99.935 450.738 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 110.5215 447.6279 Tm
(French et al. \(1999\))Tj
ET
0.51 0 0.66 0 k
191.29 462.513 m
191.29 464.374 192.799 465.883 194.66 465.883 c
196.521 465.883 198.03 464.374 198.03 462.513 c
198.03 460.651 196.521 459.142 194.66 459.142 c
192.799 459.142 191.29 460.651 191.29 462.513 c
f*
191.29 462.513 m
191.29 464.374 192.799 465.883 194.66 465.883 c
196.521 465.883 198.03 464.374 198.03 462.513 c
198.03 460.651 196.521 459.142 194.66 459.142 c
192.799 459.142 191.29 460.651 191.29 462.513 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 201.8758 459.4026 Tm
(Schechter et al. \(1994\))Tj
ET
0 0.18 0.67 0 k
191.29 450.738 m
191.29 452.599 192.799 454.109 194.66 454.109 c
196.521 454.109 198.03 452.599 198.03 450.738 c
198.03 448.877 196.521 447.368 194.66 447.368 c
192.799 447.368 191.29 448.877 191.29 450.738 c
f*
191.29 450.738 m
191.29 452.599 192.799 454.109 194.66 454.109 c
196.521 454.109 198.03 452.599 198.03 450.738 c
198.03 448.877 196.521 447.368 194.66 447.368 c
192.799 447.368 191.29 448.877 191.29 450.738 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 201.8758 447.6279 Tm
(Adu-Sarkodie et al. \(1998\))Tj
ET
0.28 0.37 0 0 k
304.489 462.513 m
304.489 464.374 305.998 465.883 307.86 465.883 c
309.721 465.883 311.23 464.374 311.23 462.513 c
311.23 460.651 309.721 459.142 307.86 459.142 c
305.998 459.142 304.489 460.651 304.489 462.513 c
f*
304.489 462.513 m
304.489 464.374 305.998 465.883 307.86 465.883 c
309.721 465.883 311.23 464.374 311.23 462.513 c
311.23 460.651 309.721 459.142 307.86 459.142 c
305.998 459.142 304.489 460.651 304.489 462.513 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 315.0753 459.4026 Tm
(Ledru et al. \(1998\))Tj
ET
0 0 0 0.5 k
304.489 450.738 m
304.489 452.599 305.998 454.109 307.86 454.109 c
309.721 454.109 311.23 452.599 311.23 450.738 c
311.23 448.877 309.721 447.368 307.86 447.368 c
305.998 447.368 304.489 448.877 304.489 450.738 c
f*
304.489 450.738 m
304.489 452.599 305.998 454.109 307.86 454.109 c
309.721 454.109 311.23 452.599 311.23 450.738 c
311.23 448.877 309.721 447.368 307.86 447.368 c
305.998 447.368 304.489 448.877 304.489 450.738 c
h
S
0 0 0 1 k
BT
/T1_1 1 Tf
7.9438 0 0 7.9438 315.0753 447.6279 Tm
(Ramalingam et al. \(2003\))Tj
ET
BT
/T1_0 1 Tf
7.9438 0 0 7.9438 259.6499 480.5677 Tm
(Clinical stage)Tj
ET
EMC
Q
Q
Q
Q
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