Disponibilidad, seguridad y calidad de la sangre para transfusión en las Américas
Pan American Health Organization, Laboratory and Blood Services, Washington, D.C., United States of America
OBJECTIVES: This article has two objectives: (1) to present for countries and territories of the Region of the Americas data on the number of blood donations, proportion of voluntary blood donors versus remunerated blood donors, coverage of screening for infectious agents, and separation of donated blood into its components and (2) to explore the relationships of those characteristics with economic and organizational factors in the countries and territories.
METHODS: We carried out comparative analyses using population and health information gathered annually by the Pan American Health Organization (PAHO) from national health officials from the countries in the Americas, as well as economic information (gross national product (GNP) per capita) obtained from publications of the World Bank.
RESULTS: There is a direct correlation between the availability of blood for transfusion and GNP per capita. Seven countries with a GNP per capita above US$ 10 000 per year account for 38% of the Regional population but 68% of the Regional blood donations. Voluntary blood donation is more common in the countries with better blood availability. There is no association between GNP per capita and coverage of screening for infectious agents. Nevertheless, of the six countries with a GNP per capita below US$ 1 000, only one of the six screens all units for human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B surface antigen (HBsAg). Countries with a higher proportion of voluntary blood donors tend to have lower prevalence rates of infectious markers. Separation of blood into its components is also more common in countries with higher blood donation rates.
CONCLUSIONS: The availability, safety, and quality of blood for transfusion in the Americas needs to be improved. As part of that effort, national policies and strategies must be put into place so that the resources already allocated for blood services are better utilized.
Key words: Blood donors, blood transfusion, socioeconomic factors, North America, Latin America, Caribbean.
OBJETIVOS: Este artículo tiene dos objetivos: 1) presentar para los países y territorios americanos datos acerca del número de donaciones de sangre, la proporción de donantes voluntarios y remunerados, la cobertura con pruebas para el tamizaje de agentes infecciosos y la separación de sangre donada en sus diversos componentes, y 2) explorar las relaciones entre estas características y factores económicos y de organización en los países y territorios.
MÉTODOS: Llevamos a cabo análisis comparativos usando información poblacional y sanitaria obtenida anualmente por la Organización Panamericana de la Salud (OPS) de las autoridades de salud de los países de las Américas, así como información económica (producto nacional bruto (PNB) per cápita) sacada de publicaciones del Banco Mundial.
RESULTADOS: Hay una correlación directa entre la disponibilidad de sangre para transfundir y el PNB per cápita. Siete países con un PNB per cápita mayor de US$ 10 000 anuales representan 38% de la población de la Región, pero 68% de las donaciones en esta. La donación voluntaria de sangre es más común en países donde hay más disponibilidad de sangre. No hay ninguna asociación entre el PNB per cápita y la cobertura con pruebas para el tamizaje de agentes infecciosos. No obstante, de los seis países con un PNB per cápita menor de US$ 1 000, solamente uno somete a tamizaje todas las unidades de sangre para la detección del virus de la inmunodeficiencia humana (VIH), el virus de la hepatitis C (HCV), y el antígeno superficial del virus de la hepatitis B (HBsAg). Los países con una mayor proporción de donantes voluntarios suelen tener una menor prevalencia de positividad a marcadores de infección. La separación de la sangre en sus diversos componentes es también más frecuente en países con tasas más elevadas de donación de sangre.
CONCLUSIONES: La disponibilidad, seguridad y calidad de la sangre para transfusión en países de las Américas deben mejorarse. Como parte de una iniciativa de este tipo, hay que poner en marcha políticas y estrategias nacionales a fin de lograr que los recursos ya adjudicados a los servicios de transfusión de sangre sean mejor aprovechados.
The Region of the Americas is comprised of 48 countries and territories that had an estimated total population of 822 429 000 inhabitants in 2002.2
Wide variations exist among the countries in their land area and population. For example, in 2002 Montserrat had 8 000 inhabitants while the United States of America had 288 530 000 (1). There are also differences in the level of economic development (2). There are countries, such as Haiti and Nicaragua, where the gross national product (GNP) per capita is less than US$ 500 per year. In contrast, the GNP per capita for Bermuda, the Cayman Islands, and the United States is above US$ 20 000 annually. Health indicators also vary widely among the countries of the Region (3), with poverty being associated with illness (4). Among the factors that play an important role in this relationship are sanitation conditions and access to health services and drugs (4).
Blood for transfusion should be considered akin to an essential drug. Nevertheless, its availability depends on the proactive role that health systems take in promoting blood donation and on the willingness of the population to donate. The safety of the blood available for transfusion depends on the quality of the donors, in terms of their risk behaviors and factors for acquiring infections that may be transmitted through blood transfusions, and also on the capacity of the health systems to segregate high-risk donors and to perform laboratory analyses to determine if the collected blood could be the source of infections. The results achieved in promoting blood donation and conducting adequate laboratory processing of collected blood (screening it for infectious markers and separating it into its components) depend on the availability of financial resources and on how well organized blood services are.
This article has two objectives. One is to present data on the availability, safety, and quality of the blood used for transfusion in the countries of the Americas. A second objective is to address economic and organizational factors that need to be taken into consideration to plan interventions aimed at achieving national sufficiency in the blood needed for transfusion as well as attaining the highest possible levels of safety of blood components.
MATERIALS AND METHODS
The data on blood collection and processing included in this article have been provided to the Pan American Health Organization (PAHO) by national health officials from each of the countries in the Americas. Those officials provide that information to PAHO on a yearly basis, in a structured form that was developed by consensus following discussions that PAHO personnel had with the coordinators of national blood programs in Latin America and with the directors of national blood banks in the Caribbean. Complete data sets for either 2000 or 2001 were received from 43 of the 48 countries or territories; not covered in this analysis are Guadalupe, French Guiana, Martinique, Puerto Rico, and the U.S. Virgin Islands. Population and health data for our study were obtained from a PAHO publication, Health Situation in the Americas. Basic Indicators 2002 (3). The economic data for the study came from the World Development Report 2000/2001, a publication of the World Bank (2).
For the purpose of this article, data on the number of blood units collected per calendar year were used to estimate the availability of blood in each country. The World Health Organization (WHO) and the International Federation of Red Cross and Red Crescent Societies (IFRCRCS) have estimated that, for a nation to have sufficient blood to meet its blood-transfusion needs, the country's blood services must annually collect at least 50 blood units per 1 000 inhabitants (5). We used that figure as the standard for our study. In this article, the term "blood" is used generically for the blood components that are used for transfusion, including packed red blood cells, platelet concentrates, and plasma. We did not consider plasma derivatives that are produced by an industrial process, such as albumin and immunoglobulins.
The likelihood of an infection being transmitted through transfusion is minimized when all blood units are collected from voluntary nonremunerated altruistic (VNRA) donors (6). Therefore, we used the proportion of VNRA donors among all blood donors as one of our basic measures of blood safety. (While we had data on autologous donors in the Americas, those donors are not included in our category of "voluntary donors" since autologous donors are only donating blood for their own use and not for other patients.) A second measure we used was the coverage of blood screening, that is, the proportion of the collected blood units that were tested for infectious markers.
VNRA donors are safer for the blood-supply system than are individuals who are required to replace the blood used by relatives and friends or who are paid to donate blood. In pre-donation interviews, those replacement donors and paid donors are more likely to deny having risk factors and behaviors associated with transfusion-transmitted infections.
To examine the safety of blood, two documents were used: Estándares de trabajo para bancos de sangre [Work Standards for Blood Banks] (7) and Caribbean Regional Standards for Blood Banks and Transfusion Services (8). Published respectively by PAHO and by the Caribbean Epidemiology Centre, the two documents were produced with support from the American Association of Blood Banks and various international experts. The two documents attempt to set the basis for voluntary accreditation of blood services and to provide the general requirements for these services and for blood itself. The documents take into consideration the epidemiology of infectious diseases, the complexity of the health services, and the local facilities that exist in Latin America and the Caribbean, respectively. The Latin American standards require that all blood units be tested for human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B surface antigen (HBsAg), syphilis, and Trypanosoma cruzi. Testing for T. cruzi is not required by the Caribbean standards.
A third indicator of the safety of blood that we used in our study was the prevalence rate of antibodies against HIV, of antibodies against HCV, and of HBsAg among blood donors.
We estimated the "quality" of the blood using the proportion of the blood units that were separated into components (red blood cells, platelets, and plasma). The use of whole blood is recommended only for a minority of transfusions (9) and, therefore, at least 90% of collected units should be separated into components.
We used nonparametric statistical methods (10) to analyze correlations and the significance of differences in the availability of blood and in the proportions of VNRA donors in the countries. Using arbitrary breakpoints to categorize them, we created groups of countries according to: (1) GNP per capita, (2) availability of blood, and (3) the proportion of VNRA donors. The breakpoints for GNP per capita were, in US$: 10 000, 5 000, 3 000, 2 000, and 1 000. This produced both clear strata and also groups with similar sizes, of six to eight countries each. The breakpoints for availability of blood were 21.0, 12.5, 11.5, 9.0, and 5.0 units of blood collected annually per 1 000 inhabitants. In terms of voluntary blood donation, countries were divided into two groups: (a) those that had at least 90% VNRA donors and (b) those that were below that figure. The prevalence rates of infectious markers were not subjected to statistical analyses because the laboratory methodologies used for testing vary not only within a country but also among countries. Therefore, only tendencies are presented and described.
Availability of blood
Table 1 shows the availability of blood in 42 countries and territories in the Region of the Americas, expressed as donations of blood units per 1 000 inhabitants per year. (Tables 1, 2, and 3 omit information on Montserrat since information on the territory's GNP per capita was not available.) Only one country in the Region, Cuba, collects blood in amounts that meet the WHO/IFRCRCS standard of 50 blood units per 1 000 inhabitants annually. Six countries have blood donation rates that reach at least 60% of that goal: the United States (45.90 units per 1 000 inhabitants), Curaçao (40.70), Aruba and Uruguay (35.00), and Canada (32.70). In contrast, 19 countries in the Americas have donation rates under 10 per 1 000.
There is a high correlation between GNP per capita and blood donation rates (r = 0.6047, P < 0.001, Spearman's correlation test). When the 42 countries are grouped by GNP per capita, it can be seen that the 7 of them with a GNP above US$ 10 000 per capita have 38% of the inhabitants but collect 68% of the blood donations in the Region (Table 2). When the Regional proportions of blood donations for each of the six GNP groups (68.1%, 4.7%, 18.1%, 2.2%, 6.4%, and 0.5%) are divided by the Regional proportions of the population in each of the groups (38.0%, 5.0%, 37.9%, 4.1%, 12.3%, and 2.6%), the respective ratios for the six groups of countries are: 1.79, 0.93, 0.48, 0.55, 0.52, and 0.21. In other words, the highest-GNP countries have 8.5 times as much blood available per person as do the lowest-GNP countries (1.79/ 0.21 = 8.5; a similar result can be found by using the information on donation rates in Table 2: 43.89/5.14 = 8.5).
Furthermore, the countries in the highest per-capita GNP group have more-efficient blood collection systems than do the rest of the countries in the Region. For example, the 7 countries in the highest per-capita GNP group have only 18.5% of all the blood collecting centers in the Region but they collect 68.1% of the donations in the Region. In contrast, the 6 countries in the lowest GNP group have 3.6% of the Region's blood banks but collect only 0.5% of the blood (Table 2). Table 2 also provides data on the average (mean) number of blood donations per blood center for each of the six GNP groups that we analyzed.
Safety of blood
Only six countries in the Americas report 100% VNRA donation: Aruba, Canada, Cuba, Curaçao, Suriname and the United States (Table 1). Three other countries have VNRA donation rates of at least 90%: the Cayman Islands (99%), Bermuda (98%), and the British Virgin Islands (92%).
As shown in Table 3, the countries with a higher GNP per capita and more blood available are also more likely to have VNRA donors (chi-square (c2) = 29.6989, P < 0.0005, goodness-of-fit test).
Twenty-five countries screen all units of blood collected for HIV, HCV, and HBsAg (Table 1). However, there is no association between GNP per capita and applying all three of these tests with 100% of the blood units collected (Table 3, c2 = 2.907, P > 0.7, goodness-of-fit test).
Screening for T. cruzi infections (Chagas' disease) is the screening least commonly done in Latin America, with Mexico not screening close to 1 million units per year. Only Argentina, Brazil, El Salvador, Peru, Uruguay, and Venezuela report 100% screening for T. cruzi (Table 1).
Anguilla, Antigua, Belize, the British Virgin Islands, and Grenada have not implemented screening for HCV, and Bolivia tested only 49% of the blood units collected in 2000.
Overall, in 2001, over 99% of all the blood collected in the Region of the Americas was tested for HIV, HCV, and HBsAg. The prevalence of these three infectious markers is high among the donors in Latin America and the Caribbean (Table 4). With the exception of Cuba, countries with more than 90% VNRA donors tend to have lower prevalences of these three markers.
Also as shown in Table 4, five countries reported remunerated donors: Bolivia (12.6% of all blood donors), the Dominican Republic (2.6%), Honduras (4.8%), Panama (47.0%), and Peru (1.5%).
Quality of blood
A total of 35 countries made their data on the separation of blood units into components available to PAHO. For this article, only the data on the preparation of red blood cells were considered. Of these 35 countries, only 7 of them (Aruba, Canada, Curaçao, Panama, St. Lucia, Suriname, and the United States) reported preparing red blood cells from more than 90% of the units collected. The British Virgin Islands, Haiti, and the Turks and Caicos Islands did not separate blood into components at all. The countries with more blood available (that is, higher donations rates) were also more likely to prepare red blood cells (Table 5, c2 = 8.7494, 0.2 > P > 0.1, goodness-of-fit test).
The overall availability of blood for transfusion in the Americas is low. Considering the 42 countries and territories of the Region shown in Table 2, there is a total of just under 20 million units of blood collected annually for a population of a little over 815 million, for a donation rate of 24.5 units per 1 000 inhabitants. The blood donated in the Region of the Americas is 27% of the 75 million blood units available globally each year, according to the Global Data Base on Blood Safety, a report from the WHO that contains data on the availability of blood in countries around the world (11). While the WHO report differs from our analysis for the Americas in terms of specifically how a country's level of development is measured, both the WHO data and our data clearly indicate that countries with a higher level of economic development per capita have greater access to blood. This difference is further magnified because collected blood is separated into its components more frequently in countries with better collection rates.
Patients from countries of the Americas with a lower GNP per capita have limitations as to the quantity of blood available, and they are also more likely to receive whole blood when they are transfused. Paradoxically, countries in the Americas with a lower GNP per capita have proportionally more blood banks that actually collect blood than do countries with a higher GNP per capita. This shows that the efficiency of blood services in the Americas is higher in countries with more economic resources per capita. As shown in Table 2, the average number of blood units collected per blood bank in a year is 20 557 for the countries with a GNP per capita above US$ 10 000, and only 854 for those countries with a GNP per capita of less that US$ 1 000. To improve the utilization of resources in the Region of the Americas, efforts must be made to reduce the number of centers that collect and process blood.
In addition to overcoming the scarcity of blood for transfusion in the Americas, its safety needs to be improved. The shortage of voluntary blood donors increases the risk of transfusion-transmitted infections, as shown by the higher prevalence rates of infectious markers in countries where the proportion of VNRA donors is lower. In the five countries where remunerated donors were reported, the annual donation rates were 3.00, 5.00. 5.30. 9.70, and 15.30 units of blood per 1 000 inhabitants. These rates show that purchasing blood does not necessarily lead to sufficiency for a country. On the contrary, countries with paid donors tend to have prevalences of infectious markers that are far above the prevalence levels found in countries with a high proportion of voluntary donors (Table 4). With more voluntary donors, fewer blood units are discarded and the blood-supply system is more efficient. This is particularly critical as the five countries that reported remunerated blood collection all fall in the lower GNP groupings in our study. Interventions to promote voluntary blood donation will result in increased blood availability and safety as well as in a more-efficient use of limited resources.
Screening all blood units must be pursued as an attainable major and immediate goal for the Region of the Americas. Now, under 1% of the units collected in the Region are not tested for HIV, HCV, and HBsAg, and the high number of units not tested for T. cruzi is contributed mainly by Mexico. With a few exceptions, such as HCV in some Caribbean countries and Chagas' disease in Mexico, the inability of the systems to screen for infectious agents is mostly associated with a limited stock of blood in the blood banks and not with a lack of laboratory reagents. Promoting voluntary blood donation and reducing the number of blood processing centers will facilitate universal screening. Nevertheless, it is also necessary to consider the appropriateness of the kits used to screen donated blood for infectious agents as well as the performance of the testing centers.
Reducing the number of blood collection centers would improve access to both laboratory technology and qualified personnel. This step would also have a positive impact on the recruitment of VNRA donors because it would remove the pressure of blood collection from hospitals, where the requirement for blood replacement is strongly rooted. The role that the ministries of health play in setting the direction for blood systems is indispensable for the proper allocation and use of resources needed to attain sufficiency in the blood supply as well as the highest possible levels of safety and quality of blood used for transfusions in the Region. Analyzing the actual financial costs of the current blood-supply processes would allow for better planning as well as investment in VNRA donation programs, blood collection infrastructure, and training of personnel. All of these things are vitally needed in order to improve the availability, safety, and quality of blood used for transfusion in the Region of the Americas.
Acknowledgments. The authors acknowledge the contribution of the coordinators of the national blood programs from the Latin American countries and the directors of the national blood banks from the Caribbean for providing the data from each of their countries to PAHO.
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Manuscript received 16 December 2002 and accepted for publication on 2 January 2003
1 Send correspondence to: José Ramiro Cruz, Laboratory and Blood Services, Pan American Health Organization, 525 23rd Street, N.W., Washington, D.C. 20037, United States of America; telephone: (202) 974-3230; fax: (202) 974-3610; e-mail: firstname.lastname@example.org
2 For brevity, the rest of the article will just refer to "countries."